Phospholipids and lipid droplets

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 3, 2013, Pages 589-594

  Penno, Anke ^a   Hackenbroich, Gregor ^b   Thiele, Christoph ^a  

^a UNIVERSITY OF BONN   (Germany)

^b SAP RESEARCH   (Germany)

Author keywords

Keywords; Lipid droplet; Phosphatidylcholine; Steatosis

Indexed keywords

FAT DROPLET; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ENDOPLASMIC RETICULUM; LIPID COMPOSITION; LIPID METABOLISM; LIPID MONOLAYER; NONHUMAN; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CYTOPLASMIC VESICLES; HUMANS; LIPID METABOLISM; ORGANELLE SHAPE; PHOSPHATIDYLCHOLINES; SACCHAROMYCES CEREVISIAE;

EID: 84873104814     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.12.001     Document Type: Review

References (58)

1. S. Martin, and R.G. Parton Lipid droplets: a unified view of a dynamic organelle Nat. Rev. Mol. Cell Biol. 7 2006 373 378
2. C. Thiele, and J. Spandl Cell biology of lipid droplets Curr. Opin. Cell Biol. 20 2008 378 385
3. J.M. Goodman Demonstrated and inferred metabolism associated with cytosolic lipid droplets J. Lipid Res. 50 2009 2148 2156
4. M. Suzuki, Y. Shinohara, Y. Ohsaki, and T. Fujimoto Lipid droplets: size matters J. Electron Microsc. (Tokyo) 60 Suppl. 1 2011 S101 S116
5. A.S. Greenberg, R.A. Coleman, F.B. Kraemer, J.L. McManaman, M.S. Obin, V. Puri, Q.W. Yan, H. Miyoshi, and D.G. Mashek The role of lipid droplets in metabolic disease in rodents and humans J. Clin. Invest. 121 2011 2102 2110
6. T.C. Walther, and R.V. Farese Jr. Lipid droplets and cellular lipid metabolism Annu. Rev. Biochem. 81 2012 687 714
7. K. Tauchi-Sato, S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition J. Biol. Chem. 277 2002 44507 44512
8. R. Leber, E. Zinser, G. Zellnig, F. Paltauf, and G. Daum Characterization of lipid particles of the yeast, Saccharomyces cerevisiae Yeast 10 1994 1421 1428
9. R. Bartz, W.H. Li, B. Venables, J.K. Zehmer, M.R. Roth, R. Welti, R.G. Anderson, P. Liu, and K.D. Chapman Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic J. Lipid Res. 48 2007 837 847
10. C. Chitraju, M. Trotzmuller, J. Hartler, H. Wolinski, G.G. Thallinger, A. Lass, R. Zechner, R. Zimmermann, H.C. Kofeler, and F. Spener Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress J. Lipid Res. 53 2012 2141 2152
11. N. Krahmer, Y. Guo, F. Wilfling, M. Hilger, S. Lingrell, K. Heger, H.W. Newman, M. Schmidt-Supprian, D.E. Vance, M. Mann, R.V. Farese Jr., and T.C. Walther Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase Cell Metab. 14 2011 504 515
12. A.L. McIntosh, S.M. Storey, and B.P. Atshaves Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity Lipids 45 2010 465 477
13. C.M. Blouin, S. Le Lay, A. Eberl, H.C. Kofeler, I.C. Guerrera, C. Klein, X. Le Liepvre, F. Lasnier, O. Bourron, J.F. Gautier, P. Ferre, E. Hajduch, and I. Dugail Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects J. Lipid Res. 51 2010 945 956
14. L. Kuerschner, C. Moessinger, and C. Thiele Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets Traffic 9 2008 338 352
15. P.T. Kovanen, E.A. Nikkila, and T.A. Miettinen Regulation of cholesterol synthesis and storage in fat cells J. Lipid Res. 16 1975 211 223
16. S. Prattes, G. Horl, A. Hammer, A. Blaschitz, W.F. Graier, W. Sattler, R. Zechner, and E. Steyrer Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures J. Cell Sci. 113 Pt 17 2000 2977 2989
17. Y. Ohsaki, J. Cheng, M. Suzuki, Y. Shinohara, A. Fujita, and T. Fujimoto Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure Biochim. Biophys. Acta 1791 2009 399 407
18. Y. Guo, T.C. Walther, M. Rao, N. Stuurman, G. Goshima, K. Terayama, J.S. Wong, R.D. Vale, P. Walter, and R.V. Farese Functional genomic screen reveals genes involved in lipid-droplet formation and utilization Nature 453 2008 657 661
19. C. Moessinger, L. Kuerschner, J. Spandl, A. Shevchenko, and C. Thiele Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine J. Biol. Chem. 286 2011 21330 21339
20. G. Horl, A. Wagner, L.K. Cole, R. Malli, H. Reicher, P. Kotzbeck, H. Kofeler, G. Hofler, S. Frank, J.G. Bogner-Strauss, W. Sattler, D.E. Vance, and E. Steyrer Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo J. Biol. Chem. 286 2011 17338 17350
21. R.L. Jacobs, Y. Zhao, D.P. Koonen, T. Sletten, B. Su, S. Lingrell, G. Cao, D.A. Peake, M.S. Kuo, S.D. Proctor, B.P. Kennedy, J.R. Dyck, and D.E. Vance Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity J. Biol. Chem. 285 2010 22403 22413
22. C.J. DeLong, Y.J. Shen, M.J. Thomas, and Z. Cui Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway J. Biol. Chem. 274 1999 29683 29688
23. A. Gubern, J. Casas, M. Barcelo-Torns, D. Barneda, X. de la Rosa, R. Masgrau, F. Picatoste, J. Balsinde, M.A. Balboa, and E. Claro Group IVA phospholipase A2 is necessary for the biogenesis of lipid droplets J. Biol. Chem. 283 2008 27369 27382
24. C. Guijas, G. Perez-Chacon, A.M. Astudillo, J.M. Rubio, L. Gil-de-Gomez, M.A. Balboa, and J. Balsinde Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase a2-dependent synthesis of lipid droplets in human monocytes J. Lipid Res. 53 2012 2343 2454
25. R.E. Duncan, E. Sarkadi-Nagy, K. Jaworski, M. Ahmadian, and H.S. Sul Identification and functional characterization of adipose-specific phospholipase A2 AdPLA J. Biol. Chem. 283 2008 25428 25436
26. K. Jaworski, M. Ahmadian, R.E. Duncan, E. Sarkadi-Nagy, K.A. Varady, M.K. Hellerstein, H.Y. Lee, V.T. Samuel, G.I. Shulman, K.H. Kim, S. de Val, C. Kang, and H.S. Sul AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency Nat. Med. 15 2009 159 168
27. L.R. McLean, and M.C. Phillips Kinetics of phosphatidylcholine and lysophosphatidylcholine exchange between unilamellar vesicles Biochemistry 23 1984 4624 4630
28. J.B. Massey, D.H. Bick, and H.J. Pownall Spontaneous transfer of monoacyl amphiphiles between lipid and protein surfaces Biophys. J. 72 1997 1732 1743
29. A.E. Thumser, J.E. Voysey, and D.C. Wilton The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin Biochem. J. 301 Pt 3 1994 801 806
30. S. Lev Non-vesicular lipid transport by lipid-transfer proteins and beyond Nat. Rev. Mol. Cell Biol. 11 2010 739 750
31. J.C. Holthuis, and T.P. Levine Lipid traffic: floppy drives and a superhighway Nat. Rev. Mol. Cell Biol. 6 2005 209 220
32. M.A. Olayioye, S. Vehring, P. Muller, A. Herrmann, J. Schiller, C. Thiele, G.J. Lindeman, J.E. Visvader, and T. Pomorski StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein J. Biol. Chem. 280 2005 27436 27442
33. Y. Horibata, and H. Sugimoto StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria J. Biol. Chem. 285 2010 7358 7365
34. H.W. Kang, J. Wei, and D.E. Cohen PC-TP/StARD2: of membranes and metabolism Trends Endocrinol. Metab. 21 2010 449 456
35. K. Hanada, K. Kumagai, S. Yasuda, Y. Miura, M. Kawano, M. Fukasawa, and M. Nishijima Molecular machinery for non-vesicular trafficking of ceramide Nature 426 2003 803 809
36. A. van Helvoort, A. de Brouwer, R. Ottenhoff, J.F. Brouwers, J. Wijnholds, J.H. Beijnen, A. Rijneveld, T. van der Poll, M.A. van der Valk, D. Majoor, W. Voorhout, K.W. Wirtz, R.P. Elferink, and P. Borst Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces Proc. Natl. Acad. Sci. U. S. A. 96 1999 11501 11506
37. K.M. Szymanski, D. Binns, R. Bartz, N.V. Grishin, W.P. Li, A.K. Agarwal, A. Garg, R.G. Anderson, and J.M. Goodman The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology Proc. Natl. Acad. Sci. U. S. A. 104 2007 20890 20895
38. W. Fei, G. Shui, B. Gaeta, X. Du, L. Kuerschner, P. Li, A.J. Brown, M.R. Wenk, R.G. Parton, and H. Yang Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast J. Cell Biol. 180 2008 473 482
39. Y. Ohsaki, J. Cheng, M. Suzuki, A. Fujita, and T. Fujimoto Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100 J. Cell Sci. 121 2008 2415 2422
40. D.L. Brasaemle Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis J. Lipid Res. 48 2007 2547 2559
41. S. Jackowski, J. Wang, and I. Baburina Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells Biochim. Biophys. Acta 1483 2000 301 315
42. J.M. Caviglia, I.N. De Gomez Dumm, R.A. Coleman, and R.A. Igal Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells J. Lipid Res. 45 2004 1500 1509
43. Y. Li, K. Na, H.J. Lee, E.Y. Lee, and Y.K. Paik Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans J. Biochem. 149 2011 529 538
44. A.K. Walker, R.L. Jacobs, J.L. Watts, V. Rottiers, K. Jiang, D.M. Finnegan, T. Shioda, M. Hansen, F. Yang, L.J. Niebergall, D.E. Vance, M. Tzoneva, A.C. Hart, and A.M. Naar A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans Cell 147 2011 840 852
45. P. Bostrom, L. Andersson, M. Rutberg, J. Perman, U. Lidberg, B.R. Johansson, J. Fernandez-Rodriguez, J. Ericson, T. Nilsson, J. Boren, and S.O. Olofsson SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity Nat. Cell Biol. 9 2007 1286 1293
46. S. Murphy, S. Martin, and R.G. Parton Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens PLoS One 5 2010 e15030
47. J. Gong, Z. Sun, L. Wu, W. Xu, N. Schieber, D. Xu, G. Shui, H. Yang, R.G. Parton, and P. Li Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites J. Cell Biol. 195 2011 953 963
48. M. Paar, C. Jungst, N.A. Steiner, C. Magnes, F. Sinner, D. Kolb, A. Lass, R. Zimmermann, A. Zumbusch, S.D. Kohlwein, and H. Wolinski Remodeling of lipid droplets during lipolysis and growth in adipocytes J. Biol. Chem. 287 2012 11164 11173
49. N. Ariotti, S. Murphy, N.A. Hamilton, L. Wu, K. Green, N.L. Schieber, P. Li, S. Martin, and R.G. Parton Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes Mol. Biol. Cell 23 2012 1826 1837
50. K. Grillitsch, M. Connerth, H. Kofeler, T.N. Arrey, B. Rietschel, B. Wagner, M. Karas, and G. Daum Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome Biochim. Biophys. Acta 1811 2011 1165 1176
51. W. Fei, L. Zhong, M.T. Ta, G. Shui, M.R. Wenk, and H. Yang The size and phospholipid composition of lipid droplets can influence their proteome Biochem. Biophys. Res. Commun. 415 2011 455 462
52. T.O. Eichmann, M. Kumari, J.T. Haas, R.V. Farese Jr., R. Zimmermann, A. Lass, and R. Zechner Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O- acyltransferases J. Biol. Chem. 287 2012 41446 41457
53. J.R. Skinner, T.M. Shew, D.M. Schwartz, A. Tzekov, C.M. Lepus, N.A. Abumrad, and N.E. Wolins Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization J. Biol. Chem. 284 2009 30941 30948
54. N.E. Wolins, B.K. Quaynor, J.R. Skinner, M.J. Schoenfish, A. Tzekov, and P.E. Bickel S3-12, Adipophilin, and TIP47 package lipid in adipocytes J. Biol. Chem. 280 2005 19146 19155
55. A.L. McIntosh, S. Senthivinayagam, K.C. Moon, S. Gupta, J.S. Lwande, C.C. Murphy, S.M. Storey, and B.P. Atshaves Direct interaction of Plin2 with lipids on the surface of lipid droplets: a live cell FRET analysis Am. J. Physiol. Cell Physiol. 303 2012 C728 C742
56. S.M. Storey, A.L. McIntosh, S. Senthivinayagam, K.C. Moon, and B.P. Atshaves The phospholipid monolayer associated with perilipin-enriched lipid droplets is a highly organized rigid membrane structure Am. J. Physiol. Endocrinol. Metab. 301 2011 E991 E1003
57. K. Hsieh, Y.K. Lee, C. Londos, B.M. Raaka, K.T. Dalen, and A.R. Kimmel Perilipin family members preferentially sequester to either triacylglycerol- specific or cholesteryl-ester-specific intracellular lipid storage droplets J. Cell Sci. 125 2012 4067 4076
58. M.A. Mitsche, L. Wang, and D.M. Small Adsorption of egg phosphatidylcholine to an air/water and triolein/water bubble interface: use of the 2-dimensional phase rule to estimate the surface composition of a phospholipid/triolein/water surface as a function of surface pressure J. Phys. Chem. B 114 2010 3276 3284