메뉴 건너뛰기




Volumn 5, Issue 3, 2002, Pages 265-270

Skeletal muscle uncoupling protein 3 (UCP3): Mitochondrial uncoupling protein in search of a function

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DNA; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; CARRIER PROTEIN; FATTY ACID; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; UNCOUPLING PROTEIN;

EID: 0036584955     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200205000-00005     Document Type: Review
Times cited : (28)

References (47)
  • 1
    • 0013942130 scopus 로고
    • Chemiosmotic coupling in oxidative and photosynthetic phosphorylation
    • Mitchell P. Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. Biol Rev Camb Philos Soc 1966; 41:445-502.
    • (1966) Biol Rev Camb Philos Soc , vol.41 , pp. 445-502
    • Mitchell, P.1
  • 2
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe DFS, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 1997; 77:731-758.
    • (1997) Physiol Rev , vol.77 , pp. 731-758
    • Rolfe, D.F.S.1    Brown, G.C.2
  • 3
    • 0017927437 scopus 로고
    • The identification of the component in the inner membrane responsible for regulating energy dissipation
    • Girardier L, Seydoux J (editors). Basel: Birkhauser Verlag
    • Nicholls D, Bernson V, Heaton G. The identification of the component in the inner membrane responsible for regulating energy dissipation. In: Effectors of thermogenesis. Girardier L, Seydoux J (editors). Basel: Birkhauser Verlag; 1978. pp. 89-93.
    • (1978) Effectors of Thermogenesis , pp. 89-93
    • Nicholls, D.1    Bernson, V.2    Heaton, G.3
  • 5
    • 0040931083 scopus 로고    scopus 로고
    • Fatty acid cycling mechanism and mitochondrial uncoupling proteins
    • Jezek P, Engstová H, Zácková M, et al. Fatty acid cycling mechanism and mitochondrial uncoupling proteins. Biochim Biophys Acta 1998; 1365:319-327.
    • (1998) Biochim Biophys Acta , vol.1365 , pp. 319-327
    • Jezek, P.1    Engstová, H.2    Zácková, M.3
  • 6
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury C, Neverova M, Collins S, et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997; 15:269-273.
    • (1997) Nat Genet , vol.15 , pp. 269-273
    • Fleury, C.1    Neverova, M.2    Collins, S.3
  • 7
    • 0030988140 scopus 로고    scopus 로고
    • Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
    • Boss O, Samec S, Paoloni-Giacobino A, et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 1997; 408:39-42.
    • (1997) FEBS Lett , vol.408 , pp. 39-42
    • Boss, O.1    Samec, S.2    Paoloni-Giacobino, A.3
  • 8
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
    • Gong D-W, He Y, Karas M, Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. J Biol Chem 1997; 272:24129-24132.
    • (1997) J Biol Chem , vol.272 , pp. 24129-24132
    • Gong, D.-W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 9
    • 0034717015 scopus 로고    scopus 로고
    • Energy metabolism in uncoupling protein 3 gene knockout mice
    • Vidal-Puig AJ, Grujic D, Zhang CY, et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 2000; 275:16258-16266. A report on the creation of UCP3 knockout mice. The mitochondria of these mice indeed showed improved coupling, but the major finding is that these mice have no apparent phenotype, i.e. are not obese.
    • (2000) J Biol Chem , vol.275 , pp. 16258-16266
    • Vidal-Puig, A.J.1    Grujic, D.2    Zhang, C.Y.3
  • 10
    • 0006877856 scopus 로고    scopus 로고
    • Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    • Clapham JC, Arch JR, Chapman H, et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 2000; 406:415-418. Mice overexpressing human UCP3 were created. These mice are hyperphagic but lean, indicating an increased metabolic rate. UCP3 overexpression improved glucose handling, suggesting a role for UCP3 in glucose metabolism.
    • (2000) Nature , vol.406 , pp. 415-418
    • Clapham, J.C.1    Arch, J.R.2    Chapman, H.3
  • 11
    • 0035827595 scopus 로고    scopus 로고
    • In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism
    • Cline GW, Vidal-Puig AJ, Dufour S, et al. In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem 2001; 276:20240-20244. Further characterization of the UCP3 knockout mice previously described in Ref. [9]. In-vivo uncoupling was determined by measuring the rate of ATP synthesis and TCA cycle flux using NMR. The results show the first evidence for in-vivo uncoupling activity of UCP3 in skeletal muscle.
    • (2001) J Biol Chem , vol.276 , pp. 20240-20244
    • Cline, G.W.1    Vidal-Puig, A.J.2    Dufour, S.3
  • 12
    • 0030729552 scopus 로고    scopus 로고
    • Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    • Bouchard C, Pérusse L, Chagnon YC, et al. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 1997; 6:1887-1889.
    • (1997) Hum Mol Genet , vol.6 , pp. 1887-1889
    • Bouchard, C.1    Pérusse, L.2    Chagnon, Y.C.3
  • 13
    • 0034883804 scopus 로고    scopus 로고
    • Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and type II diabetes
    • Dalgaard LT, Pedersen O. Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type II diabetes. Diabetologia 2001; 44:946-965.
    • (2001) Diabetologia , vol.44 , pp. 946-965
    • Dalgaard, L.T.1    Pedersen, O.2
  • 14
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J 2000; 345:161-179. An excellent and extensive review of the current state of knowledge of mitochondrial uncoupling proteins.
    • (2000) Biochem J , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 15
    • 0032933115 scopus 로고    scopus 로고
    • Skeletal muscle UCP3 expression is a determinant of energy expenditure in Pima Indians
    • Schrauwen P, Xia J, Bogardus C, et al. Skeletal muscle UCP3 expression is a determinant of energy expenditure in Pima Indians. Diabetes 1999; 48:146-149.
    • (1999) Diabetes , vol.48 , pp. 146-149
    • Schrauwen, P.1    Xia, J.2    Bogardus, C.3
  • 16
    • 0032867904 scopus 로고    scopus 로고
    • Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects
    • Schrauwen P, Troost FJ, Xia J, et al. Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects. Int J Obes Relat Metab Disord 1999; 23:966-972.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 966-972
    • Schrauwen, P.1    Troost, F.J.2    Xia, J.3
  • 17
    • 0033752878 scopus 로고    scopus 로고
    • The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in type II diabetic subjects
    • Schrauwen P, Schaart G, Saris WHM, et al. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in type II diabetic subjects. Diabetologia 2000; 43:1408-1416. The UCP3 protein content was reduced after weight reduction in type 2 diabetic subjects. The degree of reduction was related to the degree of weight loss, with the subjects that lost most weight having the least change in UCP3 protein. The results suggest that high levels of UCP3 protein might facilitate weight loss.
    • (2000) Diabetologia , vol.43 , pp. 1408-1416
    • Schrauwen, P.1    Schaart, G.2    Saris, W.H.M.3
  • 18
    • 0035371770 scopus 로고    scopus 로고
    • Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles
    • Simonyan RA, Jimenez M, Ceddia RB, et al. Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles. Biochim Biophys Acta 2001; 1505:271-279.
    • (2001) Biochim Biophys Acta , vol.1505 , pp. 271-279
    • Simonyan, R.A.1    Jimenez, M.2    Ceddia, R.B.3
  • 19
    • 0031758640 scopus 로고    scopus 로고
    • Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model
    • Sanchís D, Busquets S, Alvarez B, et al. Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model. FEBS Lett 1998; 436:415-418.
    • (1998) FEBS Lett , vol.436 , pp. 415-418
    • Sanchís, D.1    Busquets, S.2    Alvarez, B.3
  • 20
    • 0034925407 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone
    • de Lange P, Lanni A, Beneduce L, et al. Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone. Endocrinology 2001; 142:3414-3420. The time course of resting metabolic rate and UCP3 protein content in response to triiodothyronine injection in rats showed striking similarities, with highest resting metabolic rate and UCP3 protein 65 h after injection. The study suggests that UCP3 might be involved in thyroid-induced thermogenesis.
    • (2001) Endocrinology , vol.142 , pp. 3414-3420
    • De Lange, P.1    Lanni, A.2    Beneduce, L.3
  • 21
    • 0034799676 scopus 로고    scopus 로고
    • Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle
    • Lebon V, Dufour S, Petersen KF, et al. Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest 2001; 108:733-737. Human subjects were treated for 3 days with triiodothyronine hormone, and mitochondrial coupling was measured using NMR. Triiodothyronine treatment improved in-vivo mitochondrial coupling in human skeletal muscle, possibly as a result of increased UCP3 (not measured).
    • (2001) J Clin Invest , vol.108 , pp. 733-737
    • Lebon, V.1    Dufour, S.2    Petersen, K.F.3
  • 22
    • 0034717074 scopus 로고    scopus 로고
    • Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    • Gong DW, Monemdjou S, Gavrilova O, et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 2000; 275:16251-16257. Detailed phenotypical characterization of UCP3 knockout mice. The results indicate that UCP3 is responsible for a great part of the proton leak in muscle, but that the lack of UCP3 does not affect body weight, body temperature or oxidative capacity in response to fasting and thyroid hormone.
    • (2000) J Biol Chem , vol.275 , pp. 16251-16257
    • Gong, D.W.1    Monemdjou, S.2    Gavrilova, O.3
  • 23
    • 0031437096 scopus 로고    scopus 로고
    • Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
    • Millet L, Vidal H, Andreelli F, et al. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest 1997; 100:2665-2670.
    • (1997) J Clin Invest , vol.100 , pp. 2665-2670
    • Millet, L.1    Vidal, H.2    Andreelli, F.3
  • 24
  • 25
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • Skulachev VP. Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta 1998; 1363:100-124.
    • (1998) Biochim Biophys Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 26
    • 0035204656 scopus 로고    scopus 로고
    • Aging skeletal muscle mitochondria in the rat: Decreased uncoupling protein-3 content
    • Kerner J, Turkaly PJ, Minkler PE, Hoppel CL. Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content. Am J Physiol Endocrinol Metab 2001; 281:E1054-E1062. Aging decreases UCP3 content and state 4 respiration in rats.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Kerner, J.1    Turkaly, P.J.2    Minkler, P.E.3    Hoppel, C.L.4
  • 27
    • 0033679675 scopus 로고    scopus 로고
    • Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    • Pilegaard H, Ordway GA, Saltin B, Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 2000; 279:E806-E814.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Pilegaard, H.1    Ordway, G.A.2    Saltin, B.3    Neufer, P.D.4
  • 28
    • 0036072873 scopus 로고    scopus 로고
    • The effect of acute exercise on uncoupling protein 3 is a fat metabolism mediated effect
    • Schrauwen P, Hesselink MKC, Vaartjes I, et al. The effect of acute exercise on uncoupling protein 3 is a fat metabolism mediated effect. Am J Physiol Endocrinol Metab 2002; 282:E11-E17. Acute exercise increased UCP3 mRNA expression 4 hours post-exercise in untrained human subjects. The increase was prevented by administration of glucose drinks, suggesting that the exercise-induced increase in UCP3 is related to changes in free fatty acids and/or fat oxidation.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Schrauwen, P.1    Hesselink, M.K.C.2    Vaartjes, I.3
  • 29
    • 0344183101 scopus 로고    scopus 로고
    • Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB
    • Maziere C, Conte MA, Degonville J, et al. Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB. Biochem Biophys Res Commun 1999; 265:116-122.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 116-122
    • Maziere, C.1    Conte, M.A.2    Degonville, J.3
  • 30
    • 0027532692 scopus 로고
    • Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells
    • Bashan N, Burdett E, Guma A, et al. Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. Am J Physiol 1993; 264:C430-C440.
    • (1993) Am J Physiol , vol.264
    • Bashan, N.1    Burdett, E.2    Guma, A.3
  • 31
    • 0035918162 scopus 로고    scopus 로고
    • Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism
    • Huppertz C, Fischer BM, Kim YB, et al. Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem 2001; 276:12520-12529. The overexpression of human UCP3 in L6 myotubes increases glucose uptake. The effect could be prevented by wortmannin, suggesting that UCP3 increases glucose uptake via the phosphatidylinositol 3 kinase-dependent pathway.
    • (2001) J Biol Chem , vol.276 , pp. 12520-12529
    • Huppertz, C.1    Fischer, B.M.2    Kim, Y.B.3
  • 32
    • 0034800518 scopus 로고    scopus 로고
    • Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro
    • Pedersen SB, Lund S, Buhl ES, Richelsen B. Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro. Biochem Biophys Res Commun 2001; 283:19-25. The first report showing that insulin is able to induce UCP3 expression rapidly in rat skeletal muscle in vitro.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 19-25
    • Pedersen, S.B.1    Lund, S.2    Buhl, E.S.3    Richelsen, B.4
  • 33
    • 0033406189 scopus 로고    scopus 로고
    • A novel polymorphism in the proximal UCP3 promoter region: Effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians
    • Schrauwen P, Xia J, Walder K, et al. A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. Int J Obes Relat Metab Disord 1999; 23:1242-1245.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 1242-1245
    • Schrauwen, P.1    Xia, J.2    Walder, K.3
  • 34
    • 0033735893 scopus 로고    scopus 로고
    • An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type II diabetes and with atherogenic lipid profile in a French cohort
    • Meirhaeghe A, Amouyel P, Helbecque N, et al. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia 2000; 43:1424-1428. An association study, examining a C to T substitution in the promotor of UCP3. The T-allele frequency, previously associated with increased UCP3 mRNA expression, was lower in diabetic subjects.
    • (2000) Diabetologia , vol.43 , pp. 1424-1428
    • Meirhaeghe, A.1    Amouyel, P.2    Helbecque, N.3
  • 35
    • 0035654002 scopus 로고    scopus 로고
    • Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes mellitus
    • Schrauwen P, Hesselink MKC, Blaak EE, et al. Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes mellitus. Diabetes 2001; 50:2870-2873. UCP3 protein content was twofold lower in patients with type 2 diabetes compared with controls, independent of body mass index.
    • (2001) Diabetes , vol.50 , pp. 2870-2873
    • Schrauwen, P.1    Hesselink, M.K.C.2    Blaak, E.E.3
  • 36
    • 0035319476 scopus 로고    scopus 로고
    • Protein expression of UCP3 differs between human type 1, type 2a and type 2b fibers
    • Hesselink MKC, Keizer HA, Borghouts LB, et al. Protein expression of UCP3 differs between human type 1, type 2a and type 2b fibers. FASEB J 2001; 15:1071-1073. Immunofluoresence was combined with conventional fibre typing to study fibre type and UCP3 expression in human vastus lateralis muscle concurrently. UCP3 protein expression was most abundant in type 2b fibres, less in type 2a fibres, and only moderately expressed in type 1 fibres.
    • (2001) FASEB J , vol.15 , pp. 1071-1073
    • Hesselink, M.K.C.1    Keizer, H.A.2    Borghouts, L.B.3
  • 37
    • 0034870748 scopus 로고    scopus 로고
    • Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle
    • Winder WW. Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 2001; 91:1017-1028. An excellent review of the suggested mechanisms and putative functions of AMPK.
    • (2001) J Appl Physiol , vol.91 , pp. 1017-1028
    • Winder, W.W.1
  • 38
    • 0034891713 scopus 로고    scopus 로고
    • Uncoupling proteins: Their roles in adaptive thermogenesis and substrate metabolism reconsidered
    • Dulloo AG, Samec S. Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. Br J Nutr 2001; 86:123-139. A recent review on the putative roles of UCP2 and UCP3. It was concluded that UCP3 is involved in the flux of lipid substrates across the mitochondria.
    • (2001) Br J Nutr , vol.86 , pp. 123-139
    • Dulloo, A.G.1    Samec, S.2
  • 39
    • 0032189845 scopus 로고    scopus 로고
    • Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
    • Argyropoulos G, Brown AM, Willi SM, et al. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J Clin Invest 1998; 102:1345-1351.
    • (1998) J Clin Invest , vol.102 , pp. 1345-1351
    • Argyropoulos, G.1    Brown, A.M.2    Willi, S.M.3
  • 40
    • 0035195527 scopus 로고    scopus 로고
    • Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
    • Bezaire V, Hofmann W, Kramer JK, et al. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. Am J Physiol Endocrinol Metab 2001; 281:E975-E982. UCP3 knockout mice showed reduced resting respiratory quotient, implying a role for UCP3 in fatty acid metabolism. State 4 respiration was not altered in UCP3 knockout mice.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Bezaire, V.1    Hofmann, W.2    Kramer, J.K.3
  • 41
    • 0035074179 scopus 로고    scopus 로고
    • Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet
    • Schrauwen P, Hoppeler H, Billeter R, et al. Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet. Int J Obes Relat Metab Disord 2001; 25:449-456. In human subjects, 4 weeks of high-fat diet increased UCP3 mRNA expression. The increase was most pronounced in subjects with a high percentage of type IIa muscle fibres.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 449-456
    • Schrauwen, P.1    Hoppeler, H.2    Billeter, R.3
  • 42
    • 0035860391 scopus 로고    scopus 로고
    • Hyperlipemia: A role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia?
    • Busquets S, Carbo N, Almendro V, et al. Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia? FEBS Lett 2001; 505:255-258. This study indicates that the increased expression of UCP3 in the cancer cachexia state in rats is related to high plasma free fatty acid levels. The administration of nicotonic acid, to lower plasma free fatty acid levels, reduced UCP3 expression.
    • (2001) FEBS Lett , vol.505 , pp. 255-258
    • Busquets, S.1    Carbo, N.2    Almendro, V.3
  • 43
    • 0035162543 scopus 로고    scopus 로고
    • An alternative function for human uncoupling protein 3: Protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix
    • Schrauwen P, Saris WH, Hesselink MK. An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix. FASEB J 2001; 15:2497-2502. A critical review and analysis of the available human UCP3 data. On the basis of the present data it is suggested that UCP3 might act as a transporter of fatty acid anions out of the mitochondrial matrix, thereby protecting mitochondria against accumulations of fatty acids.
    • (2001) FASEB J , vol.15 , pp. 2497-2502
    • Schrauwen, P.1    Saris, W.H.2    Hesselink, M.K.3
  • 44
    • 0035133171 scopus 로고    scopus 로고
    • Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
    • Himms-Hagen J, Harper ME. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 2001; 226:78-84. A hypothesis on the putative function of UCP3 as a transporter of fatty acid anions out of the mitochondrial matrix. It proposes that excess acyl-coenzyme A within the mitochondria is hydrolysed by a mitochondrial acyl-coenzyme A thioesterase, yielding fatty acid anion and the sulfhydryl group of coenzyme A.
    • (2001) Exp Biol Med (Maywood) , vol.226 , pp. 78-84
    • Himms-Hagen, J.1    Harper, M.E.2
  • 45
    • 0034805871 scopus 로고    scopus 로고
    • Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA
    • Moore GB, Himms-Hagen J, Harper ME, Clapham JC. Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA. Biochem Biophys Res Commun 2001; 283:785-790. This study provides evidence for the hypothesis in Ref [44]. Mice overexpressing UCP3 have increased thioesterase mRNA expression, to make fatty acid anions available for UCP3.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 785-790
    • Moore, G.B.1    Himms-Hagen, J.2    Harper, M.E.3    Clapham, J.C.4
  • 46
    • 0035850745 scopus 로고    scopus 로고
    • Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice
    • Clapham JC, Coulthard VH, Moore GB. Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Biochem Biophys Res Commun 2001; 287:1058-1062. See Ref. [44]. Thioesterase expression was related to UCP3 expression.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 1058-1062
    • Clapham, J.C.1    Coulthard, V.H.2    Moore, G.B.3
  • 47
    • 0035967794 scopus 로고    scopus 로고
    • Uncoupling protein-3 mRNA upregulation in C2C12 myotubes after etomoxir treatment
    • Cabrero A, Alegret M, Sanchez R, et al. Uncoupling protein-3 mRNA upregulation in C2C12 myotubes after etomoxir treatment. Biochim Biophys Acta 2001; 1532:195-202. Etomoxir, a blocker of carnitine palmitoyl transferase 1, which thereby prevented the entry of fatty acids into the mitochondria, resulted in increased UCP3 expression. This fits with the hypothesis in Ref. [43], but not with the hypothesis in Ref. [44].
    • (2001) Biochim Biophys Acta , vol.1532 , pp. 195-202
    • Cabrero, A.1    Alegret, M.2    Sanchez, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.