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Volumn 9, Issue 3, 2008, Pages 281-285

Phospholipids as cardiovascular therapeutics

Author keywords

Apolipoprotein A I; Dyslipidemia; HDL cholesterol; Linoleic acid; Peroxisome proliferator activated receptor ; Phospholipid

Indexed keywords

APOLIPOPROTEIN A1; CLOFIBRATE; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LINOLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID;

EID: 40049086366     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (22)

References (31)
  • 1
    • 0022572067 scopus 로고
    • Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation
    • Brook JG, Linn S, Aviram M: Dietary soya lecithin decreases plasma triglyceride levels and inhibits collagen- and ADP-induced platelet aggregation. Biochem Med Metab Biol (1986) 35(1):31-39.
    • (1986) Biochem Med Metab Biol , vol.35 , Issue.1 , pp. 31-39
    • Brook, J.G.1    Linn, S.2    Aviram, M.3
  • 3
    • 0019510770 scopus 로고
    • The contrasting effects of a dietary soya lecithin product and corn oil on lipoprotein lipids in normolipidemic and familial hypercholesterolemic subjects
    • Childs MT, Bowlin JA, Ogilvie JT, Hazzard WR, Albers JJ: The contrasting effects of a dietary soya lecithin product and corn oil on lipoprotein lipids in normolipidemic and familial hypercholesterolemic subjects. Atherosclerosis (1981) 38(1-2):217-228.
    • (1981) Atherosclerosis , vol.38 , Issue.1-2 , pp. 217-228
    • Childs, M.T.1    Bowlin, J.A.2    Ogilvie, J.T.3    Hazzard, W.R.4    Albers, J.J.5
  • 4
    • 0018893163 scopus 로고
    • Effects of long-term ingestion of soya phospholipids on serum lipids in humans
    • Significant reductions in serum cholesterol and triglycerides were reported in this clinical trial of large-dose soy lecithin, ••
    • Tompkins RK, Parkin LG: Effects of long-term ingestion of soya phospholipids on serum lipids in humans. Am J Surg (1980) 140(3):360-364. •• Significant reductions in serum cholesterol and triglycerides were reported in this clinical trial of large-dose soy lecithin.
    • (1980) Am J Surg , vol.140 , Issue.3 , pp. 360-364
    • Tompkins, R.K.1    Parkin, L.G.2
  • 5
    • 0032171286 scopus 로고    scopus 로고
    • Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: Beyond linoleate
    • Wilson TA, Meservey CM, Nicolosi RJ: Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: Beyond linoleate. Atherosclerosis (1998) 140(1):147-153.
    • (1998) Atherosclerosis , vol.140 , Issue.1 , pp. 147-153
    • Wilson, T.A.1    Meservey, C.M.2    Nicolosi, R.J.3
  • 6
    • 0023726696 scopus 로고
    • Influence of dietary soybean and egg lecithins on lipid responses in cholesterol-fed guinea pigs
    • O'Brien BC, Corrigan SM: Influence of dietary soybean and egg lecithins on lipid responses in cholesterol-fed guinea pigs. Lipids (1988) 23(7):647-650.
    • (1988) Lipids , vol.23 , Issue.7 , pp. 647-650
    • O'Brien, B.C.1    Corrigan, S.M.2
  • 7
    • 0021965771 scopus 로고
    • Hyperlipoproteinemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin
    • Hunt CE, Duncan LA: Hyperlipoproteinemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin. Br J Exp Pathology (1985) 66(1):35-46.
    • (1985) Br J Exp Pathology , vol.66 , Issue.1 , pp. 35-46
    • Hunt, C.E.1    Duncan, L.A.2
  • 8
    • 1442282934 scopus 로고    scopus 로고
    • New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments
    • Lieber CS: New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. Curr Gastroenterol Rep (2004) 6(1):60-65.
    • (2004) Curr Gastroenterol Rep , vol.6 , Issue.1 , pp. 60-65
    • Lieber, C.S.1
  • 10
    • 0142010568 scopus 로고    scopus 로고
    • Phosphatidylinositol promotes cholesterol transport and excretion
    • Soy PI was shown to stimulate reverse cholesterol transport in New Zealand White rabbits. PI was also shown to act via cell surface ATP-binding cassette transporters and signaling pathways to regulate both cellular and intravascular cholesterol homeostasis, ••
    • Burgess JW, Boucher J, Neville TA, Rouillard P, Stamler C, Zachariah S, Sparks DL: Phosphatidylinositol promotes cholesterol transport and excretion. J Lipid Res (2003) 44(7):1355-1363. •• Soy PI was shown to stimulate reverse cholesterol transport in New Zealand White rabbits. PI was also shown to act via cell surface ATP-binding cassette transporters and signaling pathways to regulate both cellular and intravascular cholesterol homeostasis.
    • (2003) J Lipid Res , vol.44 , Issue.7 , pp. 1355-1363
    • Burgess, J.W.1    Boucher, J.2    Neville, T.A.3    Rouillard, P.4    Stamler, C.5    Zachariah, S.6    Sparks, D.L.7
  • 11
    • 13944252471 scopus 로고    scopus 로고
    • Phosphatidylinositol increases HDL-C levels in humans
    • This study provides evidence of the safety and HDL-elevating efficacy of soy phosphatidylinositol, when administered orally to normolipidemic individuals for 2 weeks, ••
    • Burgess JW, Neville TA, Rouillard P, Harder Z, Beanlands DS, Sparks DL: Phosphatidylinositol increases HDL-C levels in humans. J Lipid Res (2005) 46(2):350-355. •• This study provides evidence of the safety and HDL-elevating efficacy of soy phosphatidylinositol, when administered orally to normolipidemic individuals for 2 weeks.
    • (2005) J Lipid Res , vol.46 , Issue.2 , pp. 350-355
    • Burgess, J.W.1    Neville, T.A.2    Rouillard, P.3    Harder, Z.4    Beanlands, D.S.5    Sparks, D.L.6
  • 12
    • 40049089598 scopus 로고    scopus 로고
    • Phosphatidylinositol acts through mitogen and stress activated protein kinase pathways to stimulate secretion of apoA-I
    • This paper reports on how phosphatidylinositol impacts MAPK secretion of apoA-I from HepG2 cells without changes in apoA-I transcription, ••
    • Hopewell SJ, Malone K, Grimwood B, Sinclair P, Burgess J, Sparks DL: Phosphatidylinositol acts through mitogen and stress activated protein kinase pathways to stimulate secretion of apoA-I. Circulation (2006) 114(Suppl):18. •• This paper reports on how phosphatidylinositol impacts MAPK secretion of apoA-I from HepG2 cells without changes in apoA-I transcription.
    • (2006) Circulation , vol.114 , Issue.SUPPL. , pp. 18
    • Hopewell, S.J.1    Malone, K.2    Grimwood, B.3    Sinclair, P.4    Burgess, J.5    Sparks, D.L.6
  • 13
    • 38949197831 scopus 로고    scopus 로고
    • Pandey NR, Renwick J, Misquith A, Sokoll K, Sparks DL: Linoleic acid-enriched phospholipids act on PPAR? to stimulate hepatic apoA-I synthesis and secretion. Biochemistry (2008) 47(6):1579-1587. •• This paper reports on the impact of phosphatidylinositol on MAPK and PPARα pathways to stimulate the secretion of apoA-I from HepG2 cells.
    • Pandey NR, Renwick J, Misquith A, Sokoll K, Sparks DL: Linoleic acid-enriched phospholipids act on PPAR? to stimulate hepatic apoA-I synthesis and secretion. Biochemistry (2008) 47(6):1579-1587. •• This paper reports on the impact of phosphatidylinositol on MAPK and PPARα pathways to stimulate the secretion of apoA-I from HepG2 cells.
  • 14
  • 15
    • 0022353138 scopus 로고
    • The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin
    • Dawson RM, Hemington N, Irvine RF: The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin. Biochem J (1985) 230(1):61-68.
    • (1985) Biochem J , vol.230 , Issue.1 , pp. 61-68
    • Dawson, R.M.1    Hemington, N.2    Irvine, R.F.3
  • 16
    • 23744458518 scopus 로고    scopus 로고
    • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents
    • Asokan A, Cho MJ: Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. J Control Release (2005) 106(1-2):146-153.
    • (2005) J Control Release , vol.106 , Issue.1-2 , pp. 146-153
    • Asokan, A.1    Cho, M.J.2
  • 17
    • 0019759561 scopus 로고
    • Dietary choline: Biochemistry, physiology, and pharmacology
    • Zeisel SH: Dietary choline: Biochemistry, physiology, and pharmacology. Ann Rev Nutr (1981) 1:95-121.
    • (1981) Ann Rev Nutr , vol.1 , pp. 95-121
    • Zeisel, S.H.1
  • 19
    • 0033579432 scopus 로고    scopus 로고
    • The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase
    • Coe NR, Smith AJ, Frohnert BI, Watkins PA, Bernlohr DA: The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase. J Biol Chem (1999) 274(51):36300-36304.
    • (1999) J Biol Chem , vol.274 , Issue.51 , pp. 36300-36304
    • Coe, N.R.1    Smith, A.J.2    Frohnert, B.I.3    Watkins, P.A.4    Bernlohr, D.A.5
  • 22
    • 0037687369 scopus 로고    scopus 로고
    • Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice
    • This study demonstrated the role of ABCG5 and ABCG8 in the regulation of biliary cholesterol secretion in mice, •
    • Kosters A, Frijters RJ, Schaap FG, Vink E, Plösch T, Ottenhoff R, Jirsa M, De Cuyper IM, Kuipers F, Groen AK: Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol (2003) 38(6): 710-716. • This study demonstrated the role of ABCG5 and ABCG8 in the regulation of biliary cholesterol secretion in mice.
    • (2003) J Hepatol , vol.38 , Issue.6 , pp. 710-716
    • Kosters, A.1    Frijters, R.J.2    Schaap, F.G.3    Vink, E.4    Plösch, T.5    Ottenhoff, R.6    Jirsa, M.7    De Cuyper, I.M.8    Kuipers, F.9    Groen, A.K.10
  • 23
    • 0036733630 scopus 로고    scopus 로고
    • Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH: Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest (2002) 110(5):671-680. • This study showed that the increased expression of ABCG5 and ABCG8 selectively drives biliary neutral sterol secretion and reduces intestinal cholesterol absorption in transgenic mice.
    • Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH: Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest (2002) 110(5):671-680. • This study showed that the increased expression of ABCG5 and ABCG8 selectively drives biliary neutral sterol secretion and reduces intestinal cholesterol absorption in transgenic mice.
  • 24
    • 0023239987 scopus 로고
    • Toxicology of a phosphatidylserine preparation from bovine brain (BC-PS)
    • 50 values were high and suggested that soy lecithin extracts are safe, •
    • 50 values were high and suggested that soy lecithin extracts are safe.
    • (1987) Clin Trials J , vol.24 , Issue.1 , pp. 25-32
    • Heywood, R.1    Cozens, D.D.2    Richold, M.3
  • 25
    • 0036843479 scopus 로고    scopus 로고
    • Effects of fibrates on metabolism of statins in human hepatocytes
    • This study investigated the metabolic interaction between fibrates (gemfibrozil) and statin hydroxy acids in human hepatocytes. The study showed that fibrates differ in their ability to affect the pharmacokinetics of statins, •
    • Prueksaritanont T, Tang C, Oui Y, Mu L, Subramanian R, Lin RH: Effects of fibrates on metabolism of statins in human hepatocytes. Drug Metab Dispos (2002) 30(11):1280-1287. • This study investigated the metabolic interaction between fibrates (gemfibrozil) and statin hydroxy acids in human hepatocytes. The study showed that fibrates differ in their ability to affect the pharmacokinetics of statins.
    • (2002) Drug Metab Dispos , vol.30 , Issue.11 , pp. 1280-1287
    • Prueksaritanont, T.1    Tang, C.2    Oui, Y.3    Mu, L.4    Subramanian, R.5    Lin, R.H.6
  • 27
    • 0013301537 scopus 로고    scopus 로고
    • Statin-fibrate combination: Therapy for hyperlipidemia: A review
    • This review provides an overview of major concerns and safety guidelines for the use of statin-fibrate combination therapy, ••
    • Wierzbicki AS, Mikhailidis DP, Wray R, Schacter M, Cramb R, Simpson WG, Byrne CB: Statin-fibrate combination: Therapy for hyperlipidemia: A review. Curr Med Res Opin (2003) 19(3): 155-168. •• This review provides an overview of major concerns and safety guidelines for the use of statin-fibrate combination therapy.
    • (2003) Curr Med Res Opin , vol.19 , Issue.3 , pp. 155-168
    • Wierzbicki, A.S.1    Mikhailidis, D.P.2    Wray, R.3    Schacter, M.4    Cramb, R.5    Simpson, W.G.6    Byrne, C.B.7
  • 28
    • 0034924212 scopus 로고    scopus 로고
    • Statin-fibrate combination therapy
    • Shek A, Ferrill MJ: Statin-fibrate combination therapy. Ann Pharmacother (2001) 35(7-8):908-917.
    • (2001) Ann Pharmacother , vol.35 , Issue.7-8 , pp. 908-917
    • Shek, A.1    Ferrill, M.J.2
  • 29
    • 0028962401 scopus 로고
    • Fibrates and statins in the treatment of hyperlipidaemia: An appraisal of their efficacy and safety
    • Shepherd J: Fibrates and statins in the treatment of hyperlipidaemia: An appraisal of their efficacy and safety. Eur Heart J (1995) 16(1):5-13.
    • (1995) Eur Heart J , vol.16 , Issue.1 , pp. 5-13
    • Shepherd, J.1
  • 30
    • 33644878086 scopus 로고    scopus 로고
    • Differential expression of peroxisomal proliferator activated receptors ? and ? in skeletal muscle in response to changes in diet and exercise
    • Fibrate and exercise were used as combination therapy and were shown to be potentially effective in the management of metabolic syndrome, •
    • Kannisto K, Chibalin A, Glinghammar B, Zierath JR, Hamsten A, Ehrenborg E: Differential expression of peroxisomal proliferator activated receptors ? and ? in skeletal muscle in response to changes in diet and exercise. Int J Mol Med (2006) 17(1):45-52. • Fibrate and exercise were used as combination therapy and were shown to be potentially effective in the management of metabolic syndrome.
    • (2006) Int J Mol Med , vol.17 , Issue.1 , pp. 45-52
    • Kannisto, K.1    Chibalin, A.2    Glinghammar, B.3    Zierath, J.R.4    Hamsten, A.5    Ehrenborg, E.6
  • 31
    • 40049089428 scopus 로고
    • The effect of combination therapy with exercise and fenofibrate for the metabolic syndrome in rats
    • Abs
    • Kim DK, Young JA, Park M: The effect of combination therapy with exercise and fenofibrate for the metabolic syndrome in rats. Am Meet Diabetes Assoc (2005) 65: Abs 1794.
    • (1794) Am Meet Diabetes Assoc , vol.65
    • Kim, D.K.1    Young, J.A.2    Park, M.3


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