Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints

Journal of Clinical Biochemistry and Nutrition

Volumn 47, Issue 3, 2010, Pages 246-255

  Kato Kataoka, Akito ^a   Sakai, Masashi ^a   Ebina, Rika ^a   Nonaka, Chiaki ^a   Asano, Tsuguyoshi ^b   Miyamori, Takashi ^c  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b Asano Institute of Preventive Medicine   (Japan)

^c TOKAI UNIVERSITY   (Japan)

Author keywords

Delayed verbal recall; Elderly; Memory functions; Phosphatidylserine; Soybean

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BIOCHEMICAL MARKER; CREATINE KINASE; CREATININE; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PLACEBO; PS 20L; SERINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DEMENTIA; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ERYTHROCYTE COUNT; FEMALE; FOOD SAFETY; GLUCOSE BLOOD LEVEL; HEART RATE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; JAPANESE; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEMORY; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TEST; RANDOMIZED CONTROLLED TRIAL; RECALL; SIDE EFFECT; SOYBEAN; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; VERBAL MEMORY; VITAL SIGN;

GLYCINE MAX;

EID: 78049454477     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.10-62     Document Type: Article

References (39)

1. Wheeler, K.P. and Whittam, R.: ATPase activity of the sodium pump needs phosphatidylserine. Nature, 225, 449-450, 1970.
2. Bruni, A., Toffano, G., Leon, A., and Boarato, E.: Pharmacological effects of phosphatidylserine liposomes. Nature, 260, 331-333, 1976.
3. Drago, F., Canonico, P.L., and Scapagnini, U.: Behavioral effects of phosphatidylserine in aged rats. Neurobiol. Aging, 2, 209-213, 1981.
4. +)-stimulated ATPase and acetylcholinesterase activities of dog synaptosomal plasma membranes. Biochem. J., 220, 301-307, 1984.
5. Zanotti, A., Valzelli, L., and Toffano, G.: Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology, 99, 316-321, 1989.
6. Delwaide, P.J., Gyselynck-Mambourg, A.M., Hurlet, A., and Ylieff, M.: Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta. Neurol. Scand., 73, 136-140, 1986.
7. Cenacchi, T., Bertoldin, T., Farina, C., Fiori, M.G., and Crepaldi, G.: Cognitive decline in the elderly: a double-blind, placebocontrolled multicenter study on efficacy of phosphatidylserine administration. Aging Clin. Exp. Res., 5, 123-133, 1993.
8. Amaducci, L., and the SMID group: Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol. Bull., 24, 130-134, 1988.
9. Engel, R.R., Satzger, W., Günther, W., Kathmann, N., Bove, D., Gerke, S., Münch, U., and Hippius, H.: Double-blind cross-over study of phosphatidyl-serine vs. placebo in patients with early dementia of Alzheimer type. Eur. Neuropsychopharmacol., 2, 149-155, 1992.
10. Crook, T.H., Tinklenberg, J., Yesavage, J., Petrie, W., Nunzi, M.G., and Massari, D.C.: Effects of phosphatidylserine in age-associated memory impairment. Neurology, 41, 644-649, 1991.
11. Prusiner, S.B.: Molecular biology of prion disease. Science, 252, 1515-1522, 1991.
12. Kudo, S.: Biosurfactants as food additives. Proceedings of the World Conference on Biotechnology for the Fats and Oils Industry, American Oil Chemist's Society, Hamburg, Germany, pp. 195-201, 1987.
13. Sakai, M., Yamatoya, H., and Kudo, S.: Pharmacological effects of Phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J. Nutr. Sci. Vitaminol. (Tokyo), 42, 47-54, 1996.
14. Furushiro, M., Suzuki, S., Shishido, Y., Sakai, M., Yamatoya, H., Kudo, S., Hashimoto, S., and Yokokura, T.: Effect of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice. Jpn. J. Pharmacol., 75, 447-450, 1997.
15. Suzuki, S., Kataoka, A., and Furushiro, M.: Effect of intracerebroventricular administration of soybean lecithin transphosphatidylated phosphatidylserine on scopolamine-induced amnesic mice. Jpn. J. Pharmacol., 84, 86-88, 2000.
16. Suzuki, S., Yamatoya, H., Sakai, M., Kataoka, A., Furushiro, M., and Kudo, S.: Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats. J. Nutr., 131, 2951-2956, 2001.
17. Gindin, J., Novikov, M., Dedar, D., Walter-Ginzburg, A., Naor, S., and Levi, S.: The effect of plant phosphatidylserine of age - associated memory impairment and mood in the functioning elderly. The Geriatric Institute for Education and Research, and Department Geriatrics, Kapran Hospital, Rehovot, Israel, 1995.
18. Crook, T.H.: Treatment of age-related cognitive decline: effects of phosphatidylserine, in Anti-Aging Medical Therapeutics. Vol. II, eds. By Katz, R.M. and Goldman, R., Health Quest Publications, Marina del Rey, Carfornia, pp. 20-28, 1998.
19. Schreiber, S., Kampf-Sherf, O., Gorfine, M., Kelly, D., Oppenheim, Y., and Lerer, B.: An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr. J. Psychiatr. Relat. Sci., 37, 302-307, 2000.
20. Jorissen, B.L., Brouns, F., Van Boxtel, M.P., Ponds, R.W., Verhey, F.R., Jolles, J., and Riedel, W.J.: The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr. Neurosci., 4, 121-134, 2001.
21. Asano, T., Kato-Kataoka, A., Sakai, M., Tsuji, A., Ebina, R., Nonaka, C., and Takamizawa, K.: The effect of soybean derived phosphatidylserine on the cognitive function of the elderly. Jpn. J. Nutr. Ass., 24, 165-170, 2005.
22. Wilson, B., Cockburn, J., Baddeley, A., and Hiorns, R.: The development and validation of a test battery for detecting and monitoring everyday memory problems. J. Clin. Exp. Neuropsychol., 11, 855-870, 1989.
23. Folstein, M.F., Folstein, S.E., and McHugh, P.R.: "Minimental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12, 189-198, 1975.
24. Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M., and Leirer, V.O.: Development and validation of a geriatric depression screening scale: a preliminary report. J. Psychiatr. Res., 17, 37-49, 1983.
25. Sakai, M., Ebina, R., Yamatoya, H., and Kudo, S., inventor; Kabushiki Kaisha Yakult Honsha, assignee. Method for producing phospholipid. United States patent 7695944, 2010 Apr 13.
26. Kazui, H., Watamori, T.S., Honda, R., Tokimasa, A., Hirono, N., and Mori, E.: The validation of the Japanese version of the Rivermead Behavioural Memory Test - A test for everyday memory - . Adv. Neurol. Sci., 46, 307-318, 2002.
27. Imai, Y. and Hasegawa, K.: The reviced Hasegawa's dementia scale (HDS-R): evaluation of its usefulness as a screening test for dementia. J. Hong Kong Coll. Psychiatr., 4, 20-24, 1994.
28. Kazui, H., Watamori, T.S., Honda, R., and Mori, E.: The validation of the Japanese version of the Everyday Memory Checklist. Brain and Nerve, 55, 317-325, 2003.
29. McDaniel, M.A., Maier, S.F., and Einstein, G.O.: "Brain- specific" nutrient: a memory cure? Nutrition, 19, 957-975, 2003.
30. Tombaugh, T.N. and McIntyre, N.J.: The mini-mental state examination: a comprehensive review. J. Am. Geriatr. Soc., 40, 922-935, 1992.
31. Arnaiz, E. and Almkvist, O.: Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease. Acta. Neurol. Scand. Suppl., 179, 34-41, 2003.
32. Toffano, G., Battistella, A., and Orlando, P.: Pharmacokinetics of radiorabelled brain phosphatidylserine. Clin. Trial. J., 24, 18-24, 1987.
33. Kawai, Y., Kiyokawa, H., Kimura, Y., Kato, Y., Tsuchiya, K., and Terao, J.: Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation. Biochemistry, 45, 14201-14211, 2006.
34. Hashioka, S., Han, Y.H., Fujii, S., Kato, T., Monji, A., Utsumi, H., Sawada, M., Nakanishi, H., and Kanba, S.: Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Free Radic. Biol. Med., 42, 945-954, 2007.
35. Satoh, A., Tsuji, S., Okada, Y., Murakami, N., Urami, M., Nakagawa, K., Ishikura, M., Katagiri, M., Koga, Y., and Shirasawa, T.: Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Haematococcus pluvialis extract. J. Clin. Biochem. Nutr., 44, 280-284, 2009.
36. Nunzi, M.G., Milan, F., Guidolin, D., and Toffano, G.: Dendritic spine loss in hippocampus of aged rats. Effect of brain phosphatidylserine administration. Neurobiol. Aging, 8, 501-510, 1987.
37. Little, A., Levy, R., Chuaqui-Kidd, P., and Hand, D.: A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry, 48, 736-742, 1985.
38. Reger, M.A., Henderson, S.T., Hale, C., Cholerton, B., Baker, L.D., Watson, G.S., Hyde, K., Chapman, D., and Craft, S.: Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol. Aging, 25, 311-314, 2004.
39. Sano, M., Ernesto, C., Thomas, R.G., Klauber, M.R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C.W., Pfeiffer, E., Schneider, L.S., and Thal, L.J.: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N. Engl. J. Med., 336, 1216-1222, 1997.