From precursors to myelinating oligodendrocytes: Contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

Neuroscience

Volumn 269, Issue , 2014, Pages 343-366

  Boulanger, J J ^a   Messier, C ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Multiple sclerosis; Myelin; Myelin remodeling; Oligodendrocyte; Plasticity; Remyelination

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYTOKINE; GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; RETINOID X RECEPTOR;

ADULT; ASTROCYTE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; DEMYELINATING DISEASE; EMBRYO DEVELOPMENT; GLIA CELL; HUMAN; METAMORPHOSIS; MICROGLIA; MYELINATION; NERVE CELL PLASTICITY; NEUROPHYSIOLOGICAL RECRUITMENT; NONMYELINATED NERVE; OLIGODENDROGLIA; PERINATAL PERIOD; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; WHITE MATTER; ANIMAL; BRAIN; MYELIN SHEATH; NEURAL STEM CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN; DEMYELINATING DISEASES; HUMANS; MYELIN SHEATH; NEURAL STEM CELLS; NEURONAL PLASTICITY; OLIGODENDROGLIA; WHITE MATTER;

EID: 84899138126     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.03.063     Document Type: Review

References (338)

1. Adams C.W., Poston R.N., Buk S.J. Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis. J Neurol Sci 1989, 92:291-306.
2. Ahrendsen J.T., Macklin W. Signaling mechanisms regulating myelination in the central nervous system. Neurosci Bull 2013, 29:199-215.
3. Akassoglou K., Bauer J., Kassiotis G., Pasparakis M., Lassmann H., Kollias G., Probert L. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice. Am J Pathol 1998, 153:801-813.
4. Albensi B.C., Mattson M.P. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse 2000, 35:151-159.
5. Albrecht P.J., Murtie J.C., Ness J.K., Redwine J.M., Enterline J.R., Armstrong R.C., Levison S.W. Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production. Neurobiol Dis 2003, 13:89-101.
6. Angel P., Karin M. The role of Jun, Fos and the Ap-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991, 1072:129-157.
7. Armstrong R.C. Growth factor regulation of remyelination: behind the growing interest in endogenous cell repair of the CNS. Future Neurol 2007, 2:689-697.
8. Armstrong R.C., Kim J.G., Hudson L.D. Expression of myelin transcription factor-I (Myti), a zinc-finger DNA-binding protein, in developing oligodendrocytes. Glia 1995, 14:303-321.
9. Arnett H.A., Mason J., Marino M., Suzuki K., Matsushima G.K., Ting J.P. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 2001, 4:1116-1122.
10. Arnett H.A., Wang Y., Matsushima G.K., Suzuki K., Ting J.P. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 2003, 23:9824-9832.
11. Arnett H.A., Fancy S.P.J., Alberta J.A., Zhao C., Plant S.R., Kaing S., Raine C.S., Rowitch D.H., Franklin R.J.M., Stiles C.D. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 2004, 306:2111-2115.
12. Asher R.A., Morgenstern D.A., Properzi F., Nishiyama A., Levine J.M., Fawcett J.W. Two separate metalloproteinase activities are responsible for the shedding and processing of the NG2 proteoglycan in vitro. Mol Cell Neurosci 2005, 29:82-96.
13. Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., OHagan D., Garbern J., Kamholz J. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. J Neurosci 1997, 17:6657-6668.
14. Baas D., Legrand C., Samarut J., Flamant F. Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors. Proc Natl Acad Sci U S A 2002, 99:2907-2911.
15. Back S.A., Tuohy T.M., Chen H., Wallingford N., Craig A., Struve J., Luo N.L., Banine F., Liu Y., Chang A., Trapp B.D., Bebo B.F., Rao M.S., Sherman L.S. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 2005, 11:966-972.
16. Baer A.S., Syed Y.A., Kang S.U., Mitteregger D., Vig R., Ffrench-Constant C., Franklin R.J., Altmann F., Lubec G., Kotter M.R. Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. Brain 2009, 132:465-481.
17. Baron W., Colognato H., Ffrench-Constant C. Integrin-growth factor interactions, as regulators of oligodendroglial development and function. Glia 2005, 49:467-479.
18. Barres B.A., Schmid R., Sendnter M., Raff M. Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 1993, 118:283-295.
19. Barres B.A., Lazar M.A., Raff M.C. A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development 1994, 120:1097-1108.
20. Barres B.A., Raff M.C., Gaese F., Bartke I., Dechant G., Barde Y.A. A crucial role for neurotrophin-3 in oligodendrocyte development. Nature 1994, 367:371-375.
21. Barres B.A., Burne J.F., Holtmann B., Thoenen H., Sendtner M., Raff M.C. Ciliary neurotrophic factor enhances the rate of oligodendrocyte generation. Mol Cell Neurosci 1996, 8:146-156.
22. Beck J., Rondot P., Catinot L., Falcoff E., Kirchner H., Wietzerbin J. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?. Acta Neurol Scand 1988, 78:318-323.
23. Belachew S., Aguirre A.A., Wang H., Vautier F., Yuan X., Anderson S., Kirby M., Gallo V. Cyclin-dependent kinase-2 controls oligodendrocyte progenitor cell cycle progression and is downregulated in adult oligodendrocyte progenitors. J Neurosci 2002, 22:8553-8562.
24. Belkadi A., LoPresti P. Truncated Tau with the Fyn-binding domain and without the microtubule-binding domain hinders the myelinating capacity of an oligodendrocyte cell line. J Neurochem 2008, 107:351-360.
25. Bellesi M., Pfister-Genskow M., Maret S., Keles S., Tononi G., Cirelli C. Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci 2013, 33:14288-14300.
26. Bengtsson S.L., Nagy Z., Skare S., Forsman L., Forssberg H., Ullen F. Extensive piano practicing has regionally specific effects on white matter development. Nat Neurosci 2005, 8:1148-1150.
27. Bennett IJ, Madden DJ (in press) Disconnected aging: cerebral white matter integrity and age-related differences in cognition. Neuroscience. http://dx.doi.org/10.1016/j.neuroscience.2013.11.026.
28. Berger T., Schnitzer J., Orkand P.M., Kettenmann H. Sodium and calcium currents in glial-cells of the mouse corpus-callosum slice. Eur J Neurosci 1992, 4:1271-1284.
29. Bergles D.E., Roberts J.D., Somogyi P., Jahr C.E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 2000, 405:187-191.
30. Bernardo A., Bianchi D., Magnaghi V., Minghetti L. Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. J Neuropathol Exp Neurol 2009, 68:797-808.
31. Bieber A.J., Kerr S., Rodriguez M. Efficient central nervous system remyelination requires T cells. Ann Neurol 2003, 53:680-684.
32. Billon N., Jolicoeur C., Tokumoto Y., Vennstrom B., Raff M. Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1). EMBO J 2002, 21:6452-6460.
33. Blakemore W.F. Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone. J Neurol Sci 1973, 20:73-83.
34. Blakemore W.F., Keirstead H.S. The origin of remyelinating cells in the central nervous system. J Neuroimmunol 1999, 98:69-76.
35. Blaschuk K.L., Frost E.E., ffrench-Constant C. The regulation of proliferation and differentiation in oligodendrocyte progenitor cells by alphaV integrins. Development 2000, 127:1961-1969.
36. Bogler O., Wren D., Barnett S.C., Land H., Noble M. Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Proc Natl Acad Sci U S A 1990, 87:6368-6372.
37. Boyd A., Zhang H., Williams A. Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol 2013, 125:841-859.
38. Brown M.A., Metcalf D., Gough N.M. Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation. Cytokine 1994, 6:300-309.
39. Caillava C., Baron-Van Evercooren A. Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation. Cell Div 2012, 7.
40. Caillava C., Vandenbosch R., Jablonska B., Deboux C., Spigoni G., Gallo V., Malgrange B., Baron-Van Evercooren A. Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system. J Cell Biol 2011, 193:397-407.
41. Calver A.R., Hall A.C., Yu W.P., Walsh F.S., Heath J.K., Betsholtz C., Richardson W.D. Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 1998, 20:869-882.
42. Calza L., Fernandez M., Giuliani A., D'Intino G., Pirondi S., Sivilia S., Paradisi M., Desordi N., Giardino L. Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease. Brain Res Brain Res Rev 2005, 48:339-346.
43. Calza L., Fernandez M., Giardino L. Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. J Mol Endocrinol 2010, 44:13-23.
44. Carbajal K.S., Miranda J.L., Tsukamoto M.R., Lane T.E. CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glia 2011, 59:1813-1821.
45. Carroll W.M., Jennings A.R. Early recruitment of oligodendrocyte precursors in CNS demyelination. Brain 1994, 117(Pt 3):563-578.
46. Carroll W.M., Jennings A.R., Ironside L.J. Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination. Brain 1998, 121(Pt 2):293-302.
47. Cenci di Bello I., Dawson M.R.L., Levine J.M., Reynolds R. Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat stem is associated with demyelination rather than inflammation. J Neurocytol 1999, 28:365-381.
48. Cerri C., Fabbri A., Vannini E., Spolidoro M., Costa M., Maffei L., Fiorentini C., Caleo M. Activation of Rho GTPases triggers structural remodeling and functional plasticity in the adult rat visual cortex. J Neurosci 2011, 31:15163-15172.
49. Chabas D., Baranzini S.E., Mitchell D., Bernard C.C.A., Rittling S.R., Denhardt D.T., Sobel R.A., Lock C., Karpuj M., Pedotti R., Heller R., Oksenberg J.R., Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001, 294:1731-1735.
50. Chang A., Nishiyama A., Peterson J., Prineas J., Trapp B.D. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 2000, 20:6404-6412.
51. Chang A., Tourtellotte W.W., Rudick R., Trapp B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 2002, 346:165-173.
52. Chari D.M., Zhao C., Kotter M.R., Blakemore W.F., Franklin R.J. Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. J Neurosci Res 2006, 83:594-605.
53. Charles P., Reynolds R., Seilhean D., Rougon G., Aigrot M.S., Niezgoda A., Zalc B., Lubetzki C. Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis?. Brain 2002, 125:1972-1979.
54. Chattopadhyay N., Espinosa-Jeffrey A., Tfelt-Hansen J., Yano S., Bandyopadhyay S., Brown E.M., de Vellis J. Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: Potential impact on reduced myelin basic protein in CaR-null mice. J Neurosci Res 2008, 86:2159-2167.
55. Cheng X., Wang Y., He Q., Qiu M., Whittemore S.R., Cao Q. Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells 2007, 25:3204-3214.
56. Chisholm A., Tessier-Lavigne M. Conservation and divergence of axon guidance mechanisms. Curr Opin Neurobiol 1999, 9:603-615.
57. Cimini A., Bernardo A., Cifone M.G., Di Marzio L., Di Loreto S. TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases. Glia 2003, 41:3-14.
58. Cui X.Y., Hu Q.D., Tekaya M., Shimoda Y., Ang B.T., Nie D.Y., Sun L., Hu W.P., Karsak M., Duka T., Takeda Y., Ou L.Y., Dawe G.S., Yu F.G., Ahmed S., Jin L.H., Schachner M., Watanabe K., Arsenijevic Y., Xiao Z.C. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem 2004, 279:25858-25865.
59. Cunliffe V.T., Casaccia-Bonnefil P. Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mech Dev 2006, 123:24-30.
60. Czopka T., Von Holst A., Schmidt G., Ffrench-Constant C., Faissner A. Tenascin C and Tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. Glia 2009, 57:1790-1801.
61. DaSilva A.G., Yong V.W. MMP-12 is beneficial in a model of ms through modulation of cytokines, chemokines and osteopontin. J Neuroimmunol 2008, 203:237-238.
62. Dawson M.R., Polito A., Levine J.M., Reynolds R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 2003, 24:476-488.
63. Dawson M.R.L., Polito A., Levine J.M., Reynolds R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 2003, 24:476-488.
64. de Wit J., Verhaagen J. Role of semaphorins in the adult nervous system. Prog Neurobiol 2003, 71:249-267.
65. Declercq W., Denecker G., Fiers W., Vandenabeele P. Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. J Immunol 1998, 161:390-399.
66. Deloulme J.C., Raponi E., Gentil B.J., Bertacchi N., Marks A., Labourdette G., Baudier J. Nuclear expression of S100B in oligodendrocyte progenitor cells correlates with differentiation toward the oligodendroglial lineage and modulates oligodendrocytes maturation. Mol Cell Neurosci 2004, 27:453-465.
67. Deverman B.E., Patterson P.H. Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination. J Neurosci 2012, 32:2100-2109.
68. Dubois-Dalcq M., Murray K. Why are growth factors important in oligodendrocyte physiology?. Pathol Biol (Paris) 2000, 48:80-86.
69. Dugas J.C., Ibrahim A., Barres B.A. A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation. J Neurosci 2007, 27:6185-6196.
70. Dugas J.C., Ibrahim A., Barres B.A. The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration. Mol Cell Neurosci 2012, 50:45-57.
71. Durand B., Raff M. A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays 2000, 22:64-71.
72. Durand B., Gao F.B., Raff M. Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J 1997, 16:306-317.
73. Ehninger D., Wang L.P., Klempin F., Romer B., Kettenmann H., Kempermann G. Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice. Cell Tissue Res 2011, 345:69-86.
74. Eugster H.-P., Frei K., Bachmann R., Bluethmann H., Lassmann H., Fontana A. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur J Immunol 1999, 29:626-632.
75. Fancy S.P., Zhao C., Franklin R.J. Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Mol Cell Neurosci 2004, 27:247-254.
76. Fancy S.P., Baranzini S.E., Zhao C., Yuk D.I., Irvine K.A., Kaing S., Sanai N., Franklin R.J., Rowitch D.H. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 2009, 23:1571-1585.
77. Fancy S.P., Kotter M.R., Harrington E.P., Huang J.K., Zhao C., Rowitch D.H., Franklin R.J. Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol 2010, 225:18-23.
78. Fancy S.P., Chan J.R., Baranzini S.E., Franklin R.J.M., Rowitch D.H. Myelin regeneration: a recapitulation of development?. Annu Rev Neurosci 2011, 34:21-43.
79. Feder L.S., Laskin D.L. Regulation of hepatic endothelial cell and macrophage proliferation and nitric oxide production by GM-CSF, M-CSF, and IL-1beta following acute endotoxemia. J Leukocyte Biol 1994, 55:507-513.
80. Feigenson K., Reid M., See J., Crenshaw I.E., Grinspan J.B. Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation. ASN Neuro 2011, 3:e00061.
81. Fernandez M., Giuliani A., Pirondi S., D'Intino G., Giardino L., Aloe L., Levi-Montalcini R., Calza L. Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease. Proc Natl Acad Sci U S A 2004, 101:16363-16368.
82. Ffrench-Constant C., Raff M.C. The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination. Nature 1986, 323:335-338.
83. Fields R.D. Myelination: an overlooked mechanism of synaptic plasticity?. Neuroscientist 2005, 11:528-531.
84. Fields R.D. Change in the brain's white matter. Science 2010, 330:768-769.
85. Flores A.I., Narayanan S.P., Morse E.N., Shick H.E., Yin X., Kidd G., Avila R.L., Kirschner D.A., Macklin W.B. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci 2008, 28:7174-7183.
86. Foote A.K., Blakemore W.F. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 2005, 128:528-539.
87. Foote A.K., Blakemore W.F. Repopulation of oligodendrocyte progenitor cell-depleted tissue in a model of chronic demyelination. Neuropathol Appl Neurobiol 2005, 31:374-383.
88. Fowlkes J.L., Serra D.M., Bunn R.C., Thrailkill K.M., Enghild J.J., Nagase H. Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes. Endocrinology 2004, 145:620-626.
89. Franco P.G., Silvestroff L., Soto E.F., Pasquini J.M. Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination. Exp Neurol 2008, 212:458-467.
90. Franklin R.J. Why does remyelination fail in multiple sclerosis?. Nat Rev Neurosci 2002, 3:705-714.
91. Franklin R.J., Blakemore W.F. To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions?. Mult Scler 1997, 3:84-87.
92. Franklin R.J., Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008, 9:839-855.
93. Franklin R.J., Kotter M.R. The biology of CNS remyelination: the key to therapeutic advances. J Neurol 2008, 255(Suppl 1):19-25.
94. Franklin R.J., Zhao C., Sim F.J. Ageing and CNS remyelination. Neuroreport 2002, 13:923-928.
95. Frost E.E., Nielsen J.A., Le T.Q., Armstrong R.C. PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination. J Neurobiol 2003, 54:457-472.
96. Fuster J.M. Frontal lobe and cognitive development. J Neurocytol 2002, 31:373-385.
97. Gallo V., Mangin J.M., Kukley M., Dietrich D. Synapses on NG2-expressing progenitors in the brain: multiple functions?. J Physiol Lond 2008, 586:3767-3781.
98. Gensert J.M., Goldman J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 1997, 19:197-203.
99. Glabinski A.R., O'Bryant S., Selmaj K., Ransohoff R.M. CXC chemokine receptors expression during chronic relapsing experimental autoimmune encephalomyelitis. Ann N Y Acad Sci 2000, 917:135-144.
100. Glezer I., Lapointe A., Rivest S. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J 2006, 20:750-752.
101. Gogate N., Verma L., Zhou J.M., Milward E., Rusten R., O'Connor M., Kufta C., Kim J., Hudson L., Dubois-Dalcq M. Plasticity in the adult human oligodendrocyte lineage. J Neurosci 1994, 14:4571-4587.
102. Gokhan S., Marin-Husstege M., Yung S.Y., Fontanez D., Casaccia-Bonnefil P., Mehler M.F. Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci 2005, 25:8311-8321.
103. Gold R., Linington C., Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129:1953-1971.
104. Goldschmidt T., Antel J., Konig F.B., Bruck W., Kuhlmann T. Remyelination capacity of the MS brain decreases with disease chronicity. Neurology 2009, 72:1914-1921.
105. Gottle P., Kremer D., Jander S., Odemis V., Engele J., Hartung H.P., Kury P. Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Ann Neurol 2010, 68:915-924.
106. Grinspan J.B., Edell E., Carpio D.F., Beesley J.S., Lavy L., Pleasure D., Golden J.A. Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage. J Neurobiol 2000, 43:1-17.
107. Gudz T.I., Komuro H., Macklin W.B. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. J Neurosci 2006, 26:2458-2466.
108. Hanafy K.A., Sloane J.A. Regulation of remyelination in multiple sclerosis. FEBS Lett 2011, 585:3821-3828.
109. Haridas V., Darnay B.G., Natarajan K., Renu H., Aggarwal B.B. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kB activation, and c-Jun kinase activation. J Immunol 1998, 160:3152-3162.
110. Hart I.K., Richardson W.D., Heldin C.H., Westermark B., Raff M.C. Pdgf receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2a) cell lineage. Development 1989, 105:595-603.
111. Haskell G.T., Maynard T.M., Shatzmiller R.A., Lamantia A.S. Retinoic acid signaling at sites of plasticity in the nervous mature central system. J Comp Neurol 2002, 452:228-241.
112. Heerens A.T., Ye P., D'Ercole A.J. IGF-1 increases the number of oligodendrocyte precursors in culture. Pediatr Res 2002, 51:63a.
113. Hickey W.F. The pathology of multiple sclerosis: a historical perspective. J Neuroimmunol 1999, 98:37-44.
114. Hinks G.L., Franklin R.J. Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination. Mol Cell Neurosci 1999, 14:153-168.
115. Hinks G.L., Franklin R.J. Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats. Mol Cell Neurosci 2000, 16:542-556.
116. Hinman J.D., Abraham C.R. What's behind the decline? The role of white matter in brain aging. Neurochem Res 2007, 32:2023-2031.
117. Hsieh J., Aimone J.B., Kaspar B.K., Kuwabara T., Nakashima K., Gage F.H. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol 2004, 164:111-122.
118. Huang J.K., Franklin R.J. Regenerative medicine in multiple sclerosis: identifying pharmacological targets of adult neural stem cell differentiation. Neurochem Int 2011, 59:329-332.
119. Huang J.K., Jarjour A.A., Nait Oumesmar B., Kerninon C., Williams A., Krezel W., Kagechika H., Bauer J., Zhao C., Evercooren A.B., Chambon P., Ffrench-Constant C., Franklin R.J. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci 2011, 14:45-53.
120. Huang H., Zhao X.F., Zheng K., Qiu M. Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives. Neurosci Bull 2013, 29:155-164.
121. Hughes E.G., Kang S.H., Fukaya M., Bergles D.E. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci 2013, 16:668-676.
122. Hur E.M., Youssef S., Haws M.E., Zhang S.Y., Sobel R.A., Steinman L. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 2007, 8:74-83.
123. Hvilsted Nielsen H., Toft-Hansen H., Lambertsen K.L., Owens T., Finsen B. Stimulation of adult oligodendrogenesis by myelin-specific T cells. Am J Pathol 2011, 179:2028-2041.
124. Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992, 69:11.
125. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
126. Ikeda O., Murakami M., Ino H., Yamazaki M., Nemoto T., Koda M., Nakayama C., Moriya H. Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol 2001, 102:239-245.
127. Ip N.Y., Wiegand S.J., Morse J., Rudge J.S. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur J Neurosci 1993, 5:25-33.
128. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990, 347:645-650.
129. Jablonska B., Aguirre A., Vandenbosch R., Belachew S., Berthet C., Kaldis P., Gallo V. Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone. J Cell Biol 2007, 179:1231-1245.
130. Jiang F., Levison S.W., Wood T.L. Ciliary neurotrophic factor induces expression of the IGF type I receptor and FGF receptor 1 mRNAs in adult rat brain oligodendrocytes. J Neurosci Res 1999, 57:447-457.
131. Johansen-Berg H. Structural plasticity: rewiring the brain. Curr Biol 2007, 17:R141-R144.
132. John G.R., Shankar S.L., Shafit-Zagardo B., Massimi A., Lee S.C., Raine C.S., Brosnan C.F. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med 2002, 8:1115-1121.
133. Johnson J.R., Chu A.K., Sato-Bigbee C. Possible role of CREB in the stimulation of oligodendrocyte precursor cell proliferation by neurotrophin-3. J Neurochem 2000, 74:1409-1417.
134. Kadi L., Selvaraju R., de Lys P., Proudfoot A.E., Wells T.N., Boschert U. Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro. J Neuroimmunol 2006, 174:133-146.
135. Keirstead H.S., Blakemore W.F. Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. J Neuropathol Exp Neurol 1997, 56:1191-1201.
136. Keirstead H.S., Levine J.M., Blakemore W.F. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 1998, 22:161-170.
137. Kerr B.J., Patterson P.H. Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. Exp Neurol 2004, 188:391-407.
138. Kerr B.J., Patterson P.H. Leukemia inhibitory factor promotes oligodendrocyte survival after spinal cord injury. Glia 2005, 51:73-79.
139. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E., Kolbeck R., Hoppe E., Oropeza-Wekerle R.L., Bartke I., Stadelmann C., Lassmann H., Wekerle H., Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J Exp Med 1999, 189:865-870.
140. Klein C., Kramer E.M., Cardine A.M., Schraven B., Brandt R., Trotter J. Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein Tau. J Neurosci 2002, 22:698-707.
141. Kotter M.R., Setzu A., Sim F.J., Van Rooijen N., Franklin R.J. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 2001, 35:204-212.
142. Kotter M.R., Zhao C., van Rooijen N., Franklin R.J. Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. Neurobiol Dis 2005, 18:166-175.
143. Kotter M.R., Li W.W., Zhao C., Franklin R.J. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci 2006, 26:328-332.
144. Kotter M.R., Li W.W., Zhao C., Franklin R.J.M. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci 2006, 26:328-332.
145. Kotter M.R., Stadelmann C., Hartung H.P. Enhancing remyelination in disease - can we wrap it up?. Brain 2011, 134:1882-1900.
146. Kramer A.F., Erickson K.I. Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn Sci 2007, 11:342-348.
147. Kremer D., Heinen A., Jadasz J., Gottle P., Zimmermann K., Zickler P., Jander S., Hartung H.P., Kury P. P57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. Proc Natl Acad Sci U S A 2009, 106:9087-9092.
148. Kremer D., Aktas O., Hartung H.P., Kury P. The complex world of oligodendroglial differentiation inhibitors. Ann Neurol 2011, 69:602-618.
149. Kuhlmann T., Miron V., Cui Q., Wegner C., Antel J., Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008, 131:1749-1758.
150. Kuhn H.G., Winkler J., Kempermann G., Thal L.J., Gage F.H. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci 1997, 17:5820-5829.
151. Kumar S., Biancotti J.C., Yamaguchi M., de Vellis J. Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model. Neurochem Res 2007, 32:783-797.
152. Labombarda F., Gonzalez S.L., Lima A., Roig P., Guennoun R., Schumacher M., de Nicola A.F. Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury. Glia 2009, 57:884-897.
153. Lappe-Siefke C., Goebbels S., Gravel M., Nicksch E., Lee J., Braun P.E., Griffiths I.R., Nave K.A. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 2003, 33:366-374.
154. Larsen P.H., Wells J.E., Stallcup W.B., Opdenakker G., Yong V.W. Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan. J Neurosci 2003, 23:11127-11135.
155. Levine J.M., Reynolds R. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 1999, 160:333-347.
156. Levine J.M., Stincone F., Lee Y.S. Development and differentiation of glial precursor cells in the rat cerebellum. Glia 1993, 7:307-321.
157. Levine J.M., Reynolds R., Fawcett J.W. The oligodendrocyte precursor cell in health and disease. Trends Neurosci 2001, 24:39-47.
158. Li W.W., Setzu A., Zhao C., Franklin R.J. Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination. J Neuroimmunol 2005, 158:58-66.
159. Liang X., Draghi N.A., Resh M.D. Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes. J Neurosci 2004, 24:7140-7149.
160. Liebetanz D., Merkler D. Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis. Exp Neurol 2006, 202:217-224.
161. Ligon K.L., Kesari S., Kitada M., Sun T., Arnett H.A., Alberta J.A., Anderson D.J., Stiles C.D., Rowitch D.H. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A 2006, 103:7853-7858.
162. Lin S.C., Bergles D.E. Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus. Nat Neurosci 2004, 7:24-32.
163. Lindner M., Trebst C., Heine S., Skripuletz T., Koutsoudaki P.N., Stangel M. The chemokine receptor CXCR2 is differentially regulated on glial cells in vivo but is not required for successful remyelination after cuprizone-induced demyelination. Glia 2008, 56:1104-1113.
164. Lingor P., Teusch N., Schwarz K., Mueller R., Mack H., Bahr M., Mueller B.K. Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem 2007, 103:181-189.
165. Linker R.A., Maurer M., Gaupp S., Martini R., Holtmann B., Giess R., Rieckmann P., Lassmann H., Toyka K.V., Sendtner M., Gold R. CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nat Med 2002, 8:620-624.
166. Liu J.L., Marino M.W., Wong G., Grail D., Dunn A., Bettadapura J., Slavin A.J., Old L., Bernard C.C.A. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998, 4:78-83.
167. Liu J., Dietz K., DeLoyht J.M., Pedre X., Kelkar D., Kaur J., Vialou V., Lobo M.K., Dietz D.M., Nestler E.J., Dupree J., Casaccia P. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci 2012, 15:1621-1623.
168. Locklsey R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001, 104:487-501.
169. Lorand L., Graham R.M. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 2003, 4:140-156.
170. Loughlin A.J., Copelman C.A., Hall A., Armer T., Young B.C., Landon D.N., Cuzner M.L. Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages. J Neurosci Res 1997, 47:384-392.
171. Lucchinetti C., Brück W., Parisi J., Scheithauer B., Rodriguez M., Lassmann H. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: a study of 113 cases. Brain 1999, 122:2279-2295.
172. Luyt K., Slade T.P., Dorward J.J., Durant C.F., Wu Y., Shigemoto R., Mundell S.J., Varadi A., Molnar E. Developing oligodendrocytes express functional GABA(B) receptors that stimulate cell proliferation and migration. J Neurochem 2007, 100:822-840.
173. Madden D.J., Spaniol J., Costello M.C., Bucur B., White L.E., Cabeza R., Davis S.W., Dennis N.A., Provenzale J.M., Huettel S.A. Cerebral white matter integrity mediates adult age differences in cognitive performance. J Cogn Neurosci 2009, 21:289-302.
174. Maimone D., Gregory S., Arnason B.G., Reder A.T. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol 1991, 32:67-74.
175. Mason J.L., Jones J.J., Taniike M., Morell P., Suzuki K., Matsushima G.K. Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. J Neurosci Res 2000, 61:251-262.
176. Mason J.L., Suzuki K., Chaplin D.D., Matsushima G.K. Interleukin-1 beta promotes repair of the CNS. J Neurosci 2001, 21:7046-7052.
177. Mason J.L., Xuan S., Dragatsis I., Efstratiadis A., Goldman J.E. Insulin-like growth factor (IGF) signaling through Type 1 IGF receptor plays an important role in remyelination. J Neurosci 2003, 23:7710-7718.
178. Mayer M., Bhakoo K., Noble M. Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro. Development 1994, 120:143-153.
179. McCawley L.J., Matrisian L.M. Matrix metalloproteinases: they're not just for matrix anymore!. Curr Opin Cell Biol 2001, 13:534-540.
180. Mckinnon R.D., Matsui T., Duboisdalcq M., Aaronson S.A. Fgf modulates the Pdgf-driven pathway of oligodendrocyte development. Neuron 1990, 5:603-614.
181. McKinnon R.D., Piras G., Ida J.A., Dubois-Dalcq M. A role for TGF-beta in oligodendrocyte differentiation. J Cell Biol 1993, 121:1397-1407.
182. McMorris F.A., Dubois-Dalcq M. Insulin-like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro. J Neurosci Res 1988, 21:199-209.
183. McMorris F.A., Smith T.M., DeSalvo S., Furlanetto R.W. Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development. Proc Natl Acad Sci U S A 1986, 83:822-826.
184. McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci 1998, 18:5354-5365.
185. Meighan S.E., Meighan P.C., Choudhury P., Davis C.J., Olson M.L., Zornes P.A., Wright J.W., Harding J.W. Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity. J Neurochem 2006, 96:1227-1241.
186. Messersmith D.J., Murtie J.C., Le T.Q., Frost E.E., Armstrong R.C. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J Neurosci Res 2000, 62:241-256.
187. Miller R.H., Mi S. Dissecting demyelination. Nat Neurosci 2007, 10:1351-1354.
188. Milner R., Edwards G., Streuli C., Ffrench-Constant C. A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors. J Neurosci 1996, 16:7240-7252.
189. Miron V.E., Kuhlmann T., Antel J.P. Cells of the oligodendroglial lineage, myelination, and remyelination. Biochim Biophys Acta 2011, 1812:184-193.
190. Mitew S., Hay C.M., Peckham H., Xiao J., Koenning M., Emery B. Mechanisms regulating the development of oligodendrocytes and central nervous system myelin. Neuroscience 2013, 10.1016/j.neuroscience.2013.11.029.
191. Moll N.M., Hong E., Fauveau M., Naruse M., Kerninon C., Tepavcevic V., Klopstein A., Seilhean D., Chew L.J., Gallo V., Oumesmar B.N. SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis. Glia 2013, 61:1659-1672.
192. Mosley K., Cuzner M.L. Receptor-mediated phagocytosis of myelin by macrophages and microglia: effect of opsonization and receptor blocking agents. Neurochem Res 1996, 21:481-487.
193. Murtie J.C., Zhou Y.X., Le T.Q., Vana A.C., Armstrong R.C. PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination. Neurobiol Dis 2005, 19:171-182.
194. Nait Oumesmar B., Vignais L., Duhamel-Clerin E., Avellana-Adalid V., Rougon G., Baron-Van Evercooren A. Expression of the highly polysialylated neural cell adhesion molecule during postnatal myelination and following chemically induced demyelination of the adult mouse spinal cord. Eur J Neurosci 1995, 7:480-491.
195. Nakahara J., Aiso S. Fc receptor-positive cells in remyelinating multiple sclerosis lesions. J Neuropathol Exp Neurol 2006, 65:582-591.
196. Nakahara J., Tan-Takeuchi K., Seiwa C., Gotoh M., Kaifu T., Ujike A., Inui M., Yagi T., Ogawa M., Aiso S., Takai T., Asou H. Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation. Dev Cell 2003, 4:841-852.
197. Nakahara J., Aiso S., Suzuki N. Factors that retard remyelination in multiple sclerosis with a focus on TIP30: a novel therapeutic target. Expert Opin Ther Targets 2009, 13:1375-1386.
198. Nathan C.F. Secretory products of macrophages. J Clin Invest 1987, 79:319-326.
199. Nelson W.J., Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004, 303:1483-1487.
200. Ness J., Wood T.L. Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis. Mol Cell Neurosci 2002, 20:476-488.
201. Nguyen D., Stangel M. Expression of the chemokine receptors CXCR1 and CXCR2 in rat oligodendroglial cells. Brain Res Dev Brain Res 2001, 128:77-81.
202. Nishiyama A. Polydendrocytes: NG2 cells with many roles in development and repair of the CNS. Neuroscientist 2007, 13:62-76.
203. Nishiyama A., Lin X.H., Giese N., Heldin C.H., Stallcup W.B. Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF. J Neurosci Res 1996, 43:315-330.
204. Nishiyama A., Yu M., Drazba J.A., Tuohy V.K. Normal and reactive NG2+ glial cells are distinct from resting and activated microglia. J Neurosci Res 1997, 48:299-312.
205. Nishiyama A., Watanabe M., Yang Z., Bu J. Identity, distribution, and development of polydendrocytes: NG2-epxressing glial cells. J Neurocytol 2002, 31:437-455.
206. Niu J.Q., Mei F., Wang L.Y., Liu S.B., Tian Y.P., Mo W., Li H.L., Lu Q.R., Xiao L. Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia 2012, 60:1427-1436.
207. Noble M., Murray K., Stroobant P., Waterfield M.D., Riddle P. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature 1988, 333:560-562.
208. Nunez J.L., Nelson J., Pych J.C., Kim J.H., Juraska J.M. Myelination in the splenium of the corpus callosum in adult male and female rats. Brain Res Dev Brain Res 2000, 120:87-90.
209. Oh L.Y.S., Larsen P.H., Krekoski C.A., Edwards D.R., Donovan F., Werb Z., Yong V.W. Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes. J Neurosci 1999, 19:8464-8475.
210. Oh L.Y., Denninger A., Colvin J.S., Vyas A., Tole S., Ornitz D.M., Bansal R. Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. J Neurosci 2003, 23:883-894.
211. Omari K.M., John G.R., Sealfon S.C., Raine C.S. CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain 2005, 128:1003-1015.
212. Omari K.M., John G., Lango R., Raine C.S. Role for CXCR2 and CXCL1 on glia in multiple sclerosis. Glia 2006, 53:24-31.
213. Omari K.M., Lutz S.E., Santambrogio L., Lira S.A., Raine C.S. Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol 2009, 174:164-176.
214. Paez P.M., Garcia C.I., Soto E.F., Pasquini J.M. Apotransferrin decreases the response of oligodendrocyte progenitors to PDGF and inhibits the progression of the cell cycle. Neurochem Int 2006, 49:359-371.
215. Paez P.M., Fulton D.J., Spreuer V., Handley V., Campagnoni C.W., Campagnoni A.T. Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins. ASN Neuro 2009, 1.
216. Pajevic S, Basser PJ, Fields RD (in press) Role of myelin plasticity in oscillations and synchrony of neuronal activity. Neuroscience. http://dx.doi.org/10.1016/j.neuroscience.2013.11.007.
217. Pallinger E., Csaba G. A hormone map of human immune cells showing the presence of adrenocorticotropic hormone, triiodothyronine and endorphin in immunophenotyped white blood cells. Immunology 2008, 123:584-589.
218. Patani R., Balaratnam M., Vora A., Reynolds R. Remyelination can be extensive in multiple sclerosis despite a long disease course. Neuropathol Appl Neurobiol 2007, 33:277-287.
219. Patel J.R., McCandless E.E., Dorsey D., Klein R.S. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc Natl Acad Sci U S A 2010, 107:11062-11067.
220. Patel J.R., Williams J.L., Muccigrosso M.M., Liu L., Sun T., Rubin J.B., Klein R.S. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathol 2012, 124:847-860.
221. Patrikios P., Stadelmann C., Kutzelnigg A., Rauschka H., Schmidbauer M., Laursen H., Sorensen P.S., Bruck W., Lucchinetti C., Lassmann H. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006, 129:3165-3172.
222. Pfeifenbring S., Metz I., Kremer D., Kury P., Hartung H.P., Bruck W. Oligodendroglial lineage cells express nuclear p57kip2 in multiple sclerosis lesions. Glia 2013, 61:1250-1260.
223. Piaton G., Gould R.M., Lubetzki C. Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair. J Neurochem 2010, 114:1243-1260.
224. Piaton G., Aigrot M.S., Williams A., Moyon S., Tepavcevic V., Moutkine I., Gras J., Matho K.S., Schmitt A., Soellner H., Huber A.B., Ravassard P., Lubetzki C. Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system. Brain 2011, 134:1156-1167.
225. Picard-Riera N., Decker L., Delarasse C., Goude K., Nait-Oumesmar B., Liblau R., Pham-Dinh D., Baron-Van Evercooren A. Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci U S A 2002, 99:13211-13216.
226. Plemel J.R., Manesh S.B., Sparling J.S., Tetzlaff W. Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression. Glia 2013, 61:1471-1487.
227. Polito A., Reynolds R. NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system. J Anat 2005, 207:707-716.
228. Prineas J.W., Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979, 5:22-31.
229. Prineas J.W., Graham J.S. Mutliple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 1981, 10:149-158.
230. Prineas J.W., Kwon E.E., Goldenberg P.Z., Ilyas A.A., Quarles R.H., Benjamins J.A., Sprinkle T.J. Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions. Lab Invest 1989, 61:489-503.
231. Prineas J.W., Barnard R.O., Kwon E.E., Sharer L.R., Cho E.S. Multiple sclerosis: remyelination of nascent lesions. Ann Neurol 1993, 33:137-151.
232. Qi Y.C., Cai J., Wu Y.Y., Wu R., Lee J., Fu H., Rao M., Sussel L., Rubenstein J. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 2001, 128:2723-2733.
233. Raine C.S., Wu E. Multiple sclerosis: remyelination in acute lesions. J Neuropathol Exp Neurol 1993, 52:199-204.
234. Rajasekharan S., Baker K.A., Horn K.E., Jarjour A.A., Antel J.P., Kennedy T.E. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development 2009, 136:415-426.
235. Ransohoff R.M. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci 2012, 15:1074-1077.
236. Redwine J.M., Armstrong R.C. In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination. J Neurobiol 1998, 37:413-428.
237. Reynolds R., Dawson M., Papadopoulos D., Polito A., Di Bello I.C., Pham-Dinh D., Levine J. The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS. J Neurocytol 2002, 31:523-536.
238. Rhodes K.E., Raivich G., Fawcett J.W. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience 2006, 140:87-100.
239. Richardson W.D., Pringle N., Mosley M.J., Westermark B., Duboisdalcq M. A role for platelet-derived growth-factor in normal gliogenesis in the central nervous-system. Cell 1988, 53:309-319.
240. Richardson W.D., Young K.M., Tripathi R.B., McKenzie I. NG2-glia as multipotent neural stem cells: fact or fantasy?. Neuron 2011, 70:661-673.
241. Rivers L.E., Young K.M., Rizzi M., Jamen F., Psachoulia K., Wade A., Kessaris N., Richardson W.D. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat Neurosci 2008, 11:1392-1401.
242. Robinson S., Miller R.H. Contact with central nervous system myelin inhibits oligodendrocyte progenitor maturation. Dev Biol 1999, 216:359-368.
243. Robinson S., Tani M., Strieter R.M., Ransohoff R.M., Miller R.H. The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation. J Neurosci 1998, 18:10457-10463.
244. Roth A.D., Leisewitz A.V., Jung J.E., Cassina P., Barbeito L., Inestrosa N.C., Bronfman M. PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. J Neurosci Res 2003, 72:425-435.
245. Saluja I., Granneman J.G., Skoff R.P. PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture. Glia 2001, 33:191-204.
246. Saneto R.P., Low K.G., Melner M.H., de Vellis J. Insulin/insulin-like growth factor I and other epigenetic modulators of myelin basic protein expression in isolated oligodendrocyte progenitor cells. J Neurosci Res 1988, 21:210-219.
247. Schulman I.G., Shao G., Heyman R.A. Transactivation by retinoid X receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) heterodimers: Intermolecular synergy requires only the PPAR gamma hormone-dependent activation function. Mol Cell Biol 1998, 18:3483-3494.
248. Seidl AH (in press) Regulation of conduction time along axons. Neuroscience. http://dx.doi.org/10.1016/j.neuroscience.2013.06.047.
249. Selmaj K., Raine C.S., Cannella B., Brosnan C.F. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis. J Clin Invest 1991, 87:949-954.
250. Selvaraju R., Bernasconi L., Losberger C., Graber P., Kadi L., Avellana-Adalid V., Picard-Riera N., Baron Van Evercooren A., Cirillo R., Kosco-Vilbois M., Feger G., Papoian R., Boschert U. Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro. Mol Cell Neurosci 2004, 25:707-721.
251. Sharief M.K., Phil M., Hentges R. Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med 1991, 325:467-472.
252. Shen S., Li J., Casaccia-Bonnefil P. Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J Cell Biol 2005, 169:577-589.
253. Shen S., Liu A., Li J., Wolubah C., Casaccia-Bonnefil P. Epigenetic memory loss in aging oligodendrocytes in the corpus callosum. Neurobiol Aging 2008, 29:452-463.
254. Shen S., Sandoval J., Li J., Dupree J., Franklin R., Casaccia-Bonnefil P. Epigenetic regulation of oligodendrocyte differentiation inhibitors is essential for successful remyelination. J Neurochem 2008, 104:94.
255. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G(1)-phase progression. Genes Dev 1999, 13:1501-1512.
256. Shi J., Marinovich A., Barres B.A. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve. J Neurosci 1998, 18:4627-4636.
257. Shiryaev S.A., Savinov A.Y., Cieplak P., Ratnikov B.I., Motamedchaboki K., Smith J.W., Strongin A.Y. Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis. PLoS One 2009, 4.
258. Silvestroff L., Bartucci S., Pasquini J., Franco P. Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination. Exp Neurol 2012, 235:357-367.
259. Sim F.J., Hinks G.L., Franklin R.J. The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain. Neuroscience 2000, 100:131-139.
260. Sim F.J., Zhao C., Li W.W., Lakatos A., Franklin R.J. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Mol Cell Neurosci 2002, 20:669-682.
261. Sim F.J., Zhao C., Penderis J., Franklin R.J.M. The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J Neurosci 2002, 22:2451-2459.
262. Singh U.S., Pan J., Kao Y.L., Joshi S., Young K.L., Baker K.M. Tissue transglutaminase mediates activation of RhoA and MAP kinase pathways during retinoic acid-induced neuronal differentiation of SH-SY5Y cells. J Biol Chem 2003, 278:391-399.
263. Skuljec J., Gudi V., Ulrich R., Frichert K., Yildiz O., Pul R., Voss E.V., Wissel K., Baumgartner W., Stangel M. Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter. J Neuropathol Exp Neurol 2011, 70:758-769.
264. Sloane J.A., Batt C., Ma Y., Harris Z.M., Trapp B., Vartanian T. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A 2010, 107:11555-11560.
265. Soliven B. Calcium signalling in cells of oligodendroglial lineage. Microsc Res Tech 2001, 52:672-679.
266. Soundarapandian M.M., Selvaraj V., Lo U.G., Golub M.S., Feldman D.H., Pleasure D.E., Deng W. Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Sci Rep 2011, 1:2.
267. Spassky N., de Castro F., Le Bras B., Heydon K., Queraud-LeSaux F., Bloch-Gallego E., Chedotal A., Zalc B., Thomas J.L. Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J Neurosci 2002, 22:5992-6004.
268. Sririam S., Rodriguez M. Indictment of the microglia as the villain in multiple sclerosis. Neurology 1997, 48:464-470.
269. Stevens B., Porta S., Haak L.L., Gallo V., Fields R.D. Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 2002, 36:855-868.
270. Stidworthy M.F., Genoud S., Li W.W., Leone D.P., Mantei N., Suter U., Franklin R.J. Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Brain 2004, 127:1928-1941.
271. Stolt C.C., Rehberg S., Ader M., Lommes P., Riethmacher D., Schachner M., Bartsch U., Wegner M. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev 2002, 16:165-170.
272. Sugimoto Y., Taniguchi M., Yagi T., Akagi Y., Nojyo Y., Tamamaki N. Guidance of glial precursor cell migration by secreted cues in the developing optic nerve. Development 2001, 128:3321-3330.
273. Sugiura S., Lahav R., Han J., Kou S.-Y., Banner L.R., De Pablo F., Patterson P.H. Leukemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro. Eur J Neurosci 2000, 12:457-466.
274. Suvannavejh G.C., Lee H.O., Padilla J., Dal Canto M.C., Barrett T.A., Miller S.D. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol 2000, 205:24-33.
275. Syed Y.A., Baer A.S., Lubec G., Hoeger H., Widhalm G., Kotter M.R. Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins. Neurosurg Focus 2008, 24:E5.
276. Syed Y.A., Hand E., Mobius W., Zhao C., Hofer M., Nave K.A., Kotter M.R. Inhibition of CNS remyelination by the presence of semaphorin 3A. J Neurosci 2011, 31:3719-3728.
277. Talbott J.F., Loy D.N., Liu Y., Qiu M.S., Bunge M.B., Rao M.S., Whittemore S.R. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol 2005, 192:11-24.
278. Talbott J.F., Cao Q., Bertram J., Nkansah M., Benton R.L., Lavik E., Whittemore S.R. CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp Neurol 2007, 204:485-489.
279. Tang Y., Nyengaard J.R., Pakkenberg B., Gundersen H.J. Age-induced white matter changes in the human brain: a stereological investigation. Neurobiol Aging 1997, 18:609-615.
280. Tang D.G., Tokumoto Y.M., Apperly J.A., Lloyd A.C., Raff M.C. Lack of replicative senescence in cultured rat - oligodendrocyte precursor cells. Science 2001, 291:868-871.
281. Taupin P. Thirteen compounds promoting oligodendrocyte progenitor cell differentiation and remyelination for treating multiple sclerosis: WO2010054307. Expert Opin Ther Pat 2010, 20:1767-1773.
282. Taveggia C., Zanazzi G., Petrylak A., Yano H., Rosenbluth J., Einheber S., Xu X., Esper R.M., Loeb J.A., Shrager P., Chao M.V., Falls D.L., Role L., Salzer J.L. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 2005, 47:681-694.
283. Taveggia C., Feltri M.L., Wrabetz L. Signals to promote myelin formation and repair. Nat Rev Neurol 2010, 6:276-287.
284. Temple S., Raff M.C. Clonal analysis of oligodendrocyte development in culture - evidence for a developmental clock that counts cell divisions. Cell 1986, 44:773-779.
285. Tian J.B., Bishop G.A. Stimulus-dependent activation of c-Fos in neurons and glia in the rat cerebellum. J Chem Neuroanat 2002, 23:157-170.
286. Tokumoto Y.M., Durand B., Raff M.C. An analysis of the early events when oligodendrocyte precursor cells are triggered to differentiate by thyroid hormone, retinoic acid, or PDGF withdrawal. Dev Biol 1999, 213:327-339.
287. Tokumoto Y.M., Tang D.G., Raff M.C. Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein. EMBO J 2001, 20:5261-5268.
288. Tokumoto Y.M., Apperly J.A., Gao F.B., Raff M.C. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Dev Biol 2002, 245:224-234.
289. Trotter J., Karram K., Nishiyama A. NG2 cells: properties, progeny and origin. Brain Res Rev 2010, 63:72-82.
290. Tsai H.H., Frost E., To V., Robinson S., ffrench-Constant C., Geertman R., Ransohoff R.M., Miller R.H. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell 2002, 110:373-383.
291. Tyler W.A., Gangoli N., Gokina P., Kim H.A., Covey M., Levison S.W., Wood T.L. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci 2009, 29:6367-6378.
292. Ulrich R., Baumgartner W., Gerhauser I., Seeliger F., Haist V., Deschl U., Alldinger S. MMP-12. MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis. J Neuropathol Exp Neurol 2006, 65:783-793.
293. Umemori H., Sato S., Yagi T., Aizawa S., Yamamoto T. Initial events of myelination involve Fyn tyrosine kinase signaling. Nature 1994, 367:572-576.
294. Umemori H., Kadowaki Y., Hirosawa K., Yoshida Y., Hironaka K., Okano H., Yamamoto T. Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. J Neurosci 1999, 19:1393-1397.
295. Van Strien M.E., Baron W., Bakker E.N., Bauer J., Bol J.G., Breve J.J., Binnekade R., Van Der Laarse W.J., Drukarch B., Van Dam A.M. Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination. Glia 2011, 59:1622-1634.
296. van Wijngaarden P., Franklin R.J. Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system. Development 2013, 140:2562-2575.
297. Vana A.C., Flint N.C., Harwood N.E., Le T.Q., Fruttiger M., Armstrong R.C. Platelet-derived growth factor promotes repair of chronically demyelinated white matter. J Neuropathol Exp Neurol 2007, 66:975-988.
298. Vana A.C., Lucchinetti C.F., Le T.Q., Armstrong R.C. Myelin transcription factor 1 (Myt1) demyelinated lesions of rodent and expression in human CNS. Glia 2007, 55:687-697.
299. Vos C.M.P., Sjulson L., Nath A., McArthur J.C., Pardo C.A., Rothstein J., Conant K. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Exp Neurol 2000, 163:324-330.
300. Vos C.M.P., van Haastert E.S., de Groot C.J.A., van der Valk P., de Vries H.E. Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol 2003, 138:106-114.
301. Voss E.V., Skuljec J., Gudi V., Skripuletz T., Pul R., Trebst C., Stangel M. Characterisation of microglia during de- and remyelination: can they create a repair promoting environment?. Neurobiol Dis 2012, 45:519-528.
302. Wagner E., Luo T., Drager U.C. Retinoic acid synthesis in the postnatal mouse brain marks distinct developmental stages and functional systems. Cereb Cortex 2002, 12:1244-1253.
303. Wagner E., Luo T., Sakai Y., Parada L.F., Drager U.C. Retinoic acid delineates the topography of neuronal plasticity in postnatal cerebral cortex. Eur J Neurosci 2006, 24:329-340.
304. Wake H., Lee P.R., Fields R.D. Control of local protein synthesis and initial events in myelination by action potentials. Science 2011, 333:1647-1651.
305. Wang S., Young K.M. White matter plasticity in adulthood. Neuroscience 2013, 10.1016/j.neuroscience.2013.10.018.
306. Watanabe M., Toyama Y., Nishiyama A. Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion. J Neurosci Res 2002, 69:826-836.
307. Watanabe M., Hadzic T., Nishiyama A. Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination. Glia 2004, 46:311-322.
308. Wei Q., Miskimins W.K., Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J Biol Chem 2005, 280:16284-16294.
309. Weiss T., Grell M., Siemienski K., Mühlenbeck F., Dürkop H., Pfizenmaier K., Scheurich P., Wajant H. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60. J Immunol 1998, 161:3136-3142.
310. White R., Gonsior C., Kramer-Albers E.M., Stohr N., Huttelmaier S., Trotter J. Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules. J Cell Biol 2008, 181:579-586.
311. Williams A., Piaton G., Aigrot M.S., Belhadi A., Theaudin M., Petermann F., Thomas J.L., Zalc B., Lubetzki C. Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?. Brain 2007, 130:2554-2565.
312. Williams A., Piaton G., Lubetzki C. Astrocytes - friends or foes in multiple sclerosis?. Glia 2007, 55:1300-1312.
313. Wolswijk G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci 1998, 18:601-609.
314. Wolswijk G. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain 2000, 123(Pt 1):105-115.
315. Wolswijk G. Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord. Brain 2002, 125:338-349.
316. Wolswijk G., Noble M. Cooperation between Pdgf and Fgf converts slowly dividing O-2a(adult) progenitor cells to rapidly dividing cells with characteristics of O-2a(perinatal) progenitor cells. J Cell Biol 1992, 118:889-900.
317. Woodruff R.H., Franklin R.J. The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination. Neuropathol Appl Neurobiol 1999, 25:226-235.
318. Woodruff R.H., Fruttiger M., Richardson W.D., Franklin R.J. Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. Mol Cell Neurosci 2004, 25:252-262.
319. Xiao J., Wong A.W., Willingham M.M., van den Buuse M., Kilpatrick T.J., Murray S.S. Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes. Neurosignals 2010, 18:186-202.
320. Xin M., Yue T., Ma Z., Wu F.F., Gow A., Lu Q.R. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci 2005, 25:1354-1365.
321. Yasuda M., Johnson-Venkatesh E.M., Zhang H., Parent J.M., Sutton M.A., Umemori H. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Neuron 2011, 70:1128-1142.
322. Ye P., D'Ercole A.J. Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-alpha-induced injury. Endocrinology 1999, 140:3063-3072.
323. Ye P., Li L.Q., Richards R.G., DiAugustine R.P., D'Ercole A.J. Myelination is altered in insulin-like growth factor-I null mutant mice. J Neurosci 2002, 22:6041-6051.
324. Yin X., Baek R.C., Kirschner D.A., Peterson A., Fujii Y., Nave K.A., Macklin W.B., Trapp B.D. Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol 2006, 172:469-478.
325. Yong V.W., Power C., Forsyth P., Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2001, 2:502-511.
326. Young K.M., Psachoulia K., Tripathi R.B., Dunn S.J., Cossell L., Attwell D., Tohyama K., Richardson W.D. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013, 77:873-885.
327. Yu H.J., Fei J., Chen X.S., Cai Q.Y., Liu H.L., Liu G.D., Yao Z.X. Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein. Neurosci Lett 2010, 476:42-45.
328. Zatorre R.J., Fields R.D., Johansen-Berg H. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat Neurosci 2012, 15:528-536.
329. Zhang H., Vutskits L., Calaora V., Durbec P., Kiss J.Z. A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells. J Cell Sci 2004, 117:93-103.
330. Zhang Y., Argaw A.T., Gurfein B.T., Zameer A., Snyder B.J., Ge C., Lu Q.R., Rowitch D.H., Raine C.S., Brosnan C.F., John G.R. Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A 2009, 106:19162-19167.
331. Zhao C., Fancy S.P., Kotter M.R., Li W.W., Franklin R.J. Mechanisms of CNS remyelination - the key to therapeutic advances. J Neurol Sci 2005, 233:87-91.
332. Zhao C., Li W.W., Franklin R.J. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol Aging 2006, 27:1298-1307.
333. Zhao C., Fancy S.P., ffrench-Constant C., Franklin R.J. Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination. Neurobiol Dis 2008, 31:209-217.
334. Zhao C., Fancy S.P., Franklin R.J., ffrench-Constant C. Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination. J Neurosci Res 2009, 87:3447-3455.
335. Zhou Q., Wang S.L., Anderson D.J. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 2000, 25:331-343.
336. Zhou Q., Choi G., Anderson D.J. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 2001, 31:791-807.
337. Zhu X.Q., Bergles D.E., Nishiyama A. NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 2008, 135:145-157.
338. Ziv Y., Avidan H., Pluchino S., Martino G., Schwartz M. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A 2006, 103:13174-13179.