Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis

New England Journal of Medicine

Volumn 346, Issue 3, 2002, Pages 165-173

  Chang, Ansi ^a   Tourtellotte, Wallace W ^b   Rudick, Richard ^a   Trapp, Bruce D ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL INTERACTION; CELL TRANSPLANTATION; CONFOCAL MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; MULTIPLE SCLEROSIS; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; STEM CELL;

ADULT; AGED; ANTIGENS; AXONS; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; PROTEOGLYCANS; STEM CELLS;

EID: 0037122960     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa010994     Document Type: Article

References (38)

1. Multiple sclerosis
2. Multiple sclerosis: Immune system molecule expression in the central nervous system
3. Axonal damage in acute multiple sclerosis lesions
4. Axonal transection in the lesions of multiple sclerosis
5. The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability
6. Demyelinating diseases - New pathological insights, new therapeutic targets
7. Neurodegeneration in multiple sclerosis: Relationship to neurological disability
8. Remyelination in multiple sclerosis
9. Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques
10. Multiple sclerosis: Remyelination in acute lesions
11. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: A study of 113 cases
12. Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord
13. Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain
14. Interaction between NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells is required for optimal response to PDGF
15. Pre-oligodendrocytes from adult human CNS
16. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
17. Plasticity in the adult human oligodendrocyte lineage
18. Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
19. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
20. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
21. Proliferating bipotential glial progenitor cells in adult rat optic nerve
22. Identification of an adult-specific glial progenitor cell
23. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve
24. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain
25. Cell death and control of cell survival in the oligodendrocyte lineage
26. Repair of myelin disease: Strategies and progress in animal models
27. Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS)
28. The oligodendrocyte and its many cellular processes
29. Multiple sclerosis: Oligodendrocyte proliferation and differentiation in fresh lesions
30. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
31. Patterns of oligodendroglia pathology in multiple sclerosis
32. Oligodendrocytes in the early course of multiple sclerosis
33. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
34. Does oligodendrocyte survival depend on axons?
35. Rat optic nerve oligodendrocytes develop in the absence of viable retinal ganglion cell axons
36. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination
37. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
38. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis