Matrix metalloproteinases: They're not just for matrix anymore!

Current Opinion in Cell Biology

Volumn 13, Issue 5, 2001, Pages 534-540

  McCawley, L J ^a   Matrisian, L M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 17; MATRIX METALLOPROTEINASE 19; MATRIX METALLOPROTEINASE 20; MATRIX METALLOPROTEINASE 23; MATRIX METALLOPROTEINASE 24; MATRIX METALLOPROTEINASE 25; MATRIX METALLOPROTEINASE 26; MATRIX METALLOPROTEINASE 28; NEUTROPHIL COLLAGENASE; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER INVASION; CELL COMMUNICATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; REVIEW; TISSUE INJURY; TISSUE REPAIR; TUMOR GROWTH;

EID: 0035479845     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00248-9     Document Type: Review

References (76)

1. Matrix metalloproteinases: Multifunctional contributors to tumor progression
2. Matrix metalloproteinases: Effectors of development and normal physiology
3. Matrix metalloproteinases as mediators of reproductive function
4. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
5. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
6. Impaired wound contraction in stromelysin-1-deficient mice
7. Matrilysin expression and function in airway epithelium
8. Extracellular matrix signaling: Integration of form and function in normal and malignant cells
9. ECM and cell surface proteolysis: Regulating cellular ecology
10. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
11. Degradation of decorin by matrix metalloproteinases: Identification of the cleavage sites, kinetic analyses and transforming growth factor-beta 1 release
12. Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures
13. Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: A role for matrix metalloproteinases
14. Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation
15. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1
16. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site
17. Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin
18. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
19. Generation of biologically active IL-1β by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1β processing
20. A novel role of metalloproteinase in cancer-mediated immunosuppression
21. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1
22. Integrins and anoikis
23. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinase-1 transgene
24. Metalloproteinase-mediated release of human Fas ligand
25. The metalloproteinase matrilysin (MMP-7) proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
26. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity
27. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
28. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
29. Cleavage of β4 integrin by matrilysin
30. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
31. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
32. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones
33. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption
34. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
35. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
36. MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
37. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-α in a model of herniated disc resorption
38. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells
39. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
40. Antibodies to plasminogen activator inhibit human tumor metastasis
41. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
42. Changing views of the role of matrix metalloproteinases in metastasis
43. Matrix metalloproteinases: Biologic activity and clinical implications
44. Matrix metalloproteinases as emerging targets in anticancer therapy: Status and prospects
45. Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis
46. The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis
47. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
48. Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice
49. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
50. In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy
51. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
52. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
53. The protease consortium: An alliance to advance the understanding of proteolytic enzymes as therapeutic targets for cancer
54. Functional overlap between two classes of matrix-degrading proteases in wound healing
55. Matrix metalloproteinases generate angiostatin: Effects on neovascularization
56. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
57. Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3)
58. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/ type IV collagenase (MMP-9)
59. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization
60. Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor
61. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity
62. Cloning of MMP-26. A novel matrilysin-like proteinase
63. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27Kip1
64. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
65. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
66. Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion
67. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors
68. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP
69. Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain
70. Human MT6-matrix metalloproteinase: Identification, progelatinase A activation, and expression in brain tumors
71. Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25)
72. CA-MMP: A matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch
73. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme
74. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)