Cellular approaches to central nervous system remyelination stimulation: Thyroid hormone to promote myelin repair via endogenous stem and precursor cells

Journal of Molecular Endocrinology

Volumn 44, Issue 1, 2010, Pages 13-23

  Calzà, Laura ^a   Fernandez, Mercedes ^a   Giardino, Luciana ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; THYROID HORMONE; THYROXINE;

AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASE; HOMEOSTASIS; HORMONE ACTION; HUMAN; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; STEM CELL;

ANIMALS; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASES; HUMANS; MYELIN SHEATH; NERVE REGENERATION; OLIGODENDROGLIA; RECEPTORS, THYROID HORMONE; STEM CELLS; THYROID HORMONES; TISSUE THERAPY;

EID: 74749090493     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0067     Document Type: Review

References (131)

1. Abeliovich A & Doege CA 2009 Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease. Neuron 61 337-339.
2. Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff B & Ben-Hur T 2008 Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS ONE 3 e3145.
3. Arai K & Lo EH 2009 An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. Journal of Neuroscience 29 4351-4355.
4. Baas D, Bourbeau D, Sarlieve LL, Ittel ME, Dussault JH & Puymirat J 1997 Oligodendrocyte maturation and progenitor cell proliferation are independently regulated by thyroid hormone. Glia 19 324-332.
5. Baas D, Legrand C, Samarut J & Flamant F 2002 Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors. PNAS 99 2907-2911.
6. Baracskay KL, Kidd GJ, Miller RH & Trapp BD 2007 NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia 55 1001-1010.
7. Barnett MH & Prineas JW 2004 Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Annals of Neurology 55 458-468.
8. Barnett MH & Sutton I 2006 The pathology of multiple sclerosis: a paradigm shift. Current Opinion in Neurology 19 242-247.
9. Bassett JH, Harvey CB & Williams GR 2003 Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions. Molecular and Cellular Endocrinology 213 1-11.
10. Baumann N & Pham-Dinh D 2001 Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiological Reviews 81 871-927.
11. Baur A, Bauer K, Jarry H & Köhrle J 2000 Effects of proinflammatory cytokines on anterior pituitary 5′-deiodinase type I and type II. Journal of Endocrinology 167 505-515.
12. Berbel P, Guadaño-Ferraz A, Angulo A & Ramón Cerezo J 1994 Role of thyroid hormones in the maturation of interhemispheric connections in rats. Behavioural Brain Research 64 9-14.
13. Bernal J 2002 Action of thyroid hormone in brain. Journal of Endocrinological Investigation 25 268-288.
14. Bernal J 2007 Thyroid hormone receptors in brain development and function. Nature Clinical Practice. Endocrinology and Metabolism 3 249-259.
15. Bernal J, Guadaño-Ferraz A & Morte B 2003 Perspectives in the study of thyroid hormone action on brain development and function. Thyroid 13 1005-1012.
16. Bianco AC & Kim BW 2006 Deiodinases: implications of the local control of thyroid hormone action. Journal of Clinical Investigation 16 2571-2579.
17. Boelaert K & Franklyn JA 2005 Thyroid hormone in health and disease. Journal of Endocrinology 187 1-15.
18. Boelen A, Kwakkel J, Platvoet-ter Schiphorst M, Mentrup B, Baur A, Koehrle J & Wiersinga WM 2004 Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. European Journal of Endocrinology 151 497-502.
19. Boelen A, Kwakkel J, Wiersinga WM & Fliers E 2006 Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. Journal of Endocrinology 191 707-714.
20. Calzà L, Aloe L & Giardino L 1997 Thyroid hormone-induced plasticity in the adult rat brain. Brain Research Bulletin 44 549-557.
21. Calzà L, Giardino L, Pozza M, Bettelli C, Micera A & Aloe L 1998a Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor. PNAS 95 3209-3214.
22. Calzà L, Giardino L & Hokfelt T 1998b Thyroid hormone-dependent regulation of galanin synthesis in neurons and glial cells after colchicines administration. Neuroendocrinology 68 428-436.
23. Calzà L, Forrest D, Vennstrom B & Hokfelt T 2000 Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors. Neuroscience 101 1001-1012.
24. Calzà L, Fernández M, Giuliani A, Aloe L & Giardino L 2002 Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. PNAS 99 3258-3263.
25. Calzà L, Fernandez M, Giuliani A, Pirondi S, D'Intino G,Manservigi M, DeSordi N & Giardino L 2004 Stem cells and nervous tissue repair: from in vitro to in vivo. In NGF and Related Molecules in Health and Disease, Progress in Brain Research, vol 146, pp 75-91. Eds L Aloe & L Calzà. Amsterdam: Elsevier.
26. Calzà L, Fernandez M, Giuliani A, D'Intino G, Pirondi S, Sivilia S, Paradisi M, De Sordi N & Giardino L 2005 Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease. Brain Research Reviews 48 339-346.
27. Camara J & ffrench-Constant C 2007 Lesson from oligodendrocyte biology on promoting repair in multiple sclerosis. Journal of Neurology 254 I15-I22.
28. de Castro F & Bribián A 2005 The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Research. Brain Research Reviews 49 227-241.
29. Chandran S, Hunt D, Joannides A, Zhao C, Compston A & Franklin RJ 2008 Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 363 171-183.
30. Chanoine JP, Alex S, Fang SL, Stone S, Leonard JL, Körhle J & Braverman LE 1992 Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain. Endocrinology 130 933-938.
31. Chen RL, Kassem NA & Preston JE 2006 Dose-dependent transthyretin inhibition of T4 uptake from cerebrospinal fluid in sheep. Neuroscience Letters 396 7-11.
32. Chew LJ, King WC, Kennedy A & Gallo V 2005 Interferon-g inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells. Glia 52 127-143.
33. Compston A & Coles A 2002 Multiple sclerosis. Lancet 359 1221-1231.
34. Darras VM 2008 Endocrine disrupting polyhalogenated organic pollutants interfere with thyroid hormone signalling in the developing brain. Cerebellum 7 26-37.
35. Davis PJ, Davis FB & Cody V 2005 Membrane receptors mediating thyroid hormone action. Trends in Endocrinology and Metabolism 16 429-435.
36. Dawson MR, Levine JM & Reynolds R 2000 NG2-expressing cells in the central nervous system: are they oligodendroglial progenitors? Journal of Neuroscience Research 61 471-479.
37. Dong H, Yauk CL, Rowan-Carroll A, You SH, Zoeller RT, Lambert I & Wade MG 2009 Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum. PLoS ONE 4 e4610.
38. Dubois-Dalcq M, Ffrench-Constant C & Franklin RJ 2005 Enhancing central nervous system remyelination in multiple sclerosis. Neuron 48 9-12.
39. Dubois-Dalcq M, Williams A, Stadelmann C, Stankoff B, Zalc B & Lubetzki C 2008 From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases. Brain 131 1686-1700.
40. Duncan ID 2008 Replacing cells in multiple sclerosis. Journal of the Neurological Sciences 265 89-92.
41. Duncan ID, Goldman S, Macklin WB, Rao M, Weiner LP & Reingold SC 2008 Stem cell therapy in multiple sclerosis: promise and controversy. Multiple Sclerosis 14 541-546.
42. Durand B & Raff V 2000 A cell-intrinsic timer that operates during oligodendrocyte development. BioEssays 22 64-71.
43. Durand B, Gao FB & Raff M 1997 Accumulation of the cyclindependent kinase inhibitor p27/kip1 and the timing of oligodendrocyte differentiation. EMBO Journal 16 306-317.
44. Einstein O & Ben-Hur T 2008 The changing face of neural stem cell therapy in neurologic diseases. Archives of Neurology 65 452-456.
45. Einstein O, Fainstein N, Vaknin I, Mizrachi-Kol R, Reihartz E, Grigoriadis N, Lavon I, Baniyash M, Lassmann H & Ben-Hur T 2007 Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Annals of Neurology 61 209-218.
46. Fekete C, Marks DL, Sarkar S, Emerson CH, Rand WM, Cone RD & Lechan RM 2004 Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology 145 1649-1655.
47. Fernández M, Giuliani A, Pirondi S, D'Intino G, Giardino L, Aloe L, Levi-Montalcini R & Calzà L 2004a Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease. PNAS 101 16363-16368.
48. Fernández M, Pirondi S, Manservigi M, Giardino L & Calzà L 2004b Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. European Journal of Neuroscience 20 2059-2070.
49. Foote AK & Blakemore WF 2005 Inflammation stimulates remyelination in areas of chronic demyelination. Brain 128 528-539.
50. Forrest D, Sjoberg M & Vennstrom B 1990 Contrasting developmental and tissue-specific expression of a and b thyroid hormone receptor genes. EMBO Journal 9 1519-1528.
51. Forrest D, Hallbook F, Persson H & Vennstrom B 1991 Distinct functions for thyroid hormone receptors a and b in brain development indicated by differential expression of receptor genes. EMBO Journal 10 269-275.
52. Franco PG, Silvestroff L, Soto EF & Pasquini JM 2008 Thyroid hormones promote differentiation of oligodendrocyte progenitors cells and improve remyelination after cuprizone-induced demyelination. Experimental Neurology 212 458-467.
53. Franklin RJ & Ffrench-Constant C 2008 Remyelination in the CNS: from biology to therapy. Nature Reviews. Neuroscience 9 839-855.
54. Frohman EM, Racke MK & Raine CS 2006 Multiple sclerosis - the plaque and its pathogenesis. New England Journal of Medicine 354 942-955.
55. Furlow JD & Neff ES 2006 A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis. Trends in Endocrinology and Metabolism 17 40-47.
56. Gao FB, Apperly J & Raff V 1998 Cell-intrinsic timers and thyroid hormone regulate the probability of cell-cycle withdrawal and differentiation of oligodendrocyte precursor cells. Developmental Biology 197 54-66.
57. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A & Bianco AC 2008 Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocrine Reviews 29 898-938.
58. St Germain DL, Galton VA & Hernandez A 2009 Minireview: defining the roles of the iodothyronine deiodinases: current concepts and challenges. Endocrinology 150 1097-1107.
59. Giardino L, D'Intino G, Lorenzini L, Del Vecchio G, Perretta G, Tagioni A, Villoslada P & Calzà L 2007 Thyroid hormone administration favours remyelination in experimental allergic encephalomyelitis in the non human primate marmoset (Callithrix jacchus) 37th meeting of the Society for Neuroscience 335.2.
60. Guadaño Ferraz A, Escobar del Rey F, Morreale de Escobar G, Innocenti GM & Berbel P 1994 The development of the anterior commissure in normal and hypothyroid rats. Brain Research. Developmental Brain Research 81 293-308.
61. Harsan LA, Steibel J, Zaremba A, Agin A, Sapin R, Poulet P, Guignard B, Parizel N, Grucker D, Boehm N et al. 2008 Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging. Journal of Neuroscience 28 14189-14201.
62. Heuer H & Visser TJ 2009 Minireview: pathophysiological importance of thyroid hormone transporters. Endocrinology 150 1078-1083.
63. Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR & Zalutsky R 2007 How common are the 'common' neurologic disorders? Neurology 68 326-337.
64. Hommes OR 2008 Can we pass from the experimental to the clinical phase in MS stem cell research? Journal of the Neurological Sciences 265 136-139.
65. Howdeshell KL 2002 A model of the development of the brain as a construct of the thyroid system. Environmental Health Perspectives 110 337-348.
66. Jagannathan NR, Tandon N, Raghunathan P & Kochupillai N 1998 Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proto magnetic resonance spectroscopy (MRS) study. Developmental Brain Research 109 179-186.
67. Jansen J, Friesema EC, Milici C & Visser TJ 2005 Thyroid hormone transporters in health and disease. Thyroid 15 57-68.
68. Karussis D & Kassis I 2008 The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience. Clinical Neurology and Neurosurgery 110 889-896.
69. Kassem NA, Deane R, Segal MB & Preston JE 2006 Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 291 R1310-R1315.
70. Klecha AJ, Genaro AM, Gorelik G, Barreiro Arcos ML, Silberman DM, Schuman M, Garcia SI, Pirola C & Cremaschi GA 2006 Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. Journal of Endocrinology 189 45-55.
71. Koenig S & Neto VM 2002 Thyroid hormone actions on neural cells. Cellular and Molecular Neurobiology 22 517-544.
72. Koibuchi N & Chin WW 2000 Thyroid hormone action and brain development. Trends in Endocrinology and Metabolism 11 123-128.
73. Komitova M, Zhu X, Serwanski DR & Nishiyama A 2009 NG2 cells are distinct from neurogenic cells in the postnatal mouse subventricular zone. Journal of Comparative Neurology 512 702-716.
74. Kotter MR, Zhao C, van Rooijen N & Franklin RJ 2005 Macrophagedepletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. Neurobiological Disorders 18 166-175.
75. Kuhlmann T, Miron V, Cuo Q, Wegner C, Antel J & Brück W 2008 Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131 1749-1758.
76. Kulbatski I, Mothe AJ, Parr AM, Kim H, Kang CE, Bozkurt G & Tator CH 2008 Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis. Progress in Histochemistry and Cytochemistry 43 123-176.
77. Kwakkel J, Wiersinga WM & Boelen A 2006 Differential involvement of nuclear factor-kB and activator protein-1 pathways in the interleukin-1b- mediated decrease of deiodinase type 1 and thyroid hormone receptor b1 mRNA. Journal of Endocrinology 189 37-44.
78. Kwakkel J, Wiersinga WM & Boelen A 2007 Interleukin-1 beta modulates endogenous thyroid hormone alpha gene transcription in liver cells. Journal of Endocrinology 194 257-265.
79. Lassmann H, Brück W & Lucchinetti CF 2007 The immunopathology of multiple sclerosis: an overview. Brain Pathology 17 210-218.
80. Lemkine GF, Raj A, Alfama G, Turque N, Hassani Z, Alegria-Prévot O, Samarut J, Levi G & Demeneix BA 2005 Adult neural stem cell cycling in vivo requires thyroid hormone and its α receptor. FASEB Journal 19 863-865.
81. Levine JM, Reynolds R & Fawcett JW 2001 The oligodendrocyte precursor cell in health and disease. Trends in Neurosciences 24 39-47.
82. Lindvall O & Kokaia Z 2006 Stem cells for the treatment of neurological disorders. Nature 441 1094-1096.
83. Lopez-Diego RS & Weiner HL 2008 Novel therapeutic strategies for multiple sclerosis - a multifaceted adversary. Nature Reviews. Drug Discovery 7 909-925.
84. Lu H-Z, Wang Y-X, Li Y, Fu S-L, Hang Q & Lu P-H 2008 Proliferation and differentiation of oligodendrocyte progenitor cells induced from rat embryonic neural precursor cells followed by flow cytometry. Cytometry 73A 754-760.
85. Maier O, van der Heide T, van Dam AM, Baron W, de Vries H & Hoekstra D 2005 Alteration of the extracellular matrix interferes with raft association of neurofascin in oligodendrocytes. Potential significance for multiple sclerosis? Molecular and Cellular Neurosciences 28 390-401.
86. Margaill I, Royer J, Lerouet D, Ramaugé M, Le Goascogne C, Li WW, Plotkine M, Pierre M & Courtin F 2005 Induction of type 2 iodothyronine deiodinase in astrocytes after transient focal cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism 25 468-476.
87. Maruvada P, Dmitrieva NI, East-Palmer J & Yen PM 2004 Cell cycle-dependent expression of thyroid hormone receptor-b is a mechanism for variable hormone sensitivity. Molecular Biology of the Cell 15 1895-1903.
88. Mason JL, Suzuki K, Chaplin DD & Matsushima GK 2001 Interleukin-1β promotes repair of the CNS. Journal of Neuroscience 21 7046-7052.
89. McQualter JL & Bernard CC 2007 Multiple sclerosis: a battle between destruction and repair. Journal of Neurochemistry 100 295-306.
90. McTigue DM & Tripathi RB 2008 The life, death, and replacement of oligodendrocytes in the adult CNS. Journal of Neurochemistry 107 1-19.
91. Mendes-de-Aguiar CB, Costa-Silva B, Alvarez-Silva M, Tasca CI & Trentin AG 2008 Thyroid hormone mediates syndecan expression in rat neonatal cerebellum. Cellular and Molecular Neurobiology 28 795-801.
92. Miller RH &Mi S 2007 Dissecting demyelination. Nature Neuroscience 10 1351-1354.
93. Muller DM, Pender MP & Greer JM 2005 Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement. Journal of Neuroimmunology 160 162-169.
94. Nait-Oumesmar B, Picard-Riera N, Kerninon C, Decker L, Seilhean D, Höglinger GU, Hirsch EC, Reynolds R & Baron-Van Evercooren A 2007 Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. PNAS 104 4694-4699.
95. Nishiyama A, Chang A & Trapp BD 1999 NG2+ glial cells: a novel glial cell population in the adult brain. Journal of Neuropathology and Experimental Neurology 58 1113-1124.
96. Obregon MJ, Calvo RM, Del Rey FE & de Escobar GM 2007 Ontogenesis of thyroid function and interactions with maternal function. Endocrine Development 10 86-98.
97. Oppenheimer JH & Schwartz HL 1997 Molecular basis of thyroid hormone-dependent brain development. Endocrine Reviews 18 462-475.
98. O'Shea PJ &Williams GR 2002 Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. Journal of Endocrinology 175 553-570.
99. Pállinger E & Csaba G 2008 A hormone map of human immune cells showing the presence of adrenocorticotropic hormone, triiodothyronine and endorphin in immunophenotyped white blood cells. Immunology 123 584-589.
100. Papaioannou M, Melle C & Baniahmad A 2007 The coregulator Alien. Nuclear Receptor Signaling 5 e008.
101. Papanicolau DA 2000 Euthyroid sick syndrome and the role of cytokines. Reviews in Endocrine and Metabolic Disorders 1 43-48.
102. Payne N, Siatskas C & Bernard CC 2008 The promise of stem cell and regenerative therapies for multiple sclerosis. Journal of Autoimmunity 31 288-294.
103. Picard-Riera N, Decker L, Delarasse C, Goude K, Nait-Oumesmar B, Liblau R, Pham-Dinh D & Evercooren AB 2002 Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. PNAS 99 13211-13216.
104. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A et al. 2003 Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422 688-694.
105. Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R et al. 2005 Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 436 266-271.
106. Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E, Cavasinni F, Bergamaschi A et al. 2008 Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain 131 2564-2578.
107. Puymirat J, l'Hereault S & Dussault JH 1992 Expression of thyroid hormone receptors mRNAs in rat cerebral hemisphere neuronal cultures. Brain Research. Developmental Brain Research 69 173-177.
108. Raff M 2006 The mystery of intracellular developmental programmes and timers. Biochemical Society Transactions 34 663-670.
109. Rodriguez M 2007 Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis. Brain Pathology 17 219-229.
110. Rodriguez-Pena A 1999 Oligodendrocyte development and thyroid hormone. Journal of Neurobiology 40 497-512.
111. Rogister B, Ben-Hur T & Dubois-Dalcq M 1999 From neural stem cells to myelinating oligodendrocytes. Molecular and Cellular Neurosciences 14 287-300.
112. Rosser AE, Zietlow R & Dunnett SB 2007 Stem cell transplantation for neurodegenerative diseases. Current Opinion in Neurology 20 688-692.
113. Rudick RA, Mi S & Shandrock AW Jr 2008 LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence. Expert Opinion in Biology and Therapy 8 1561-1570.
114. Sanders P & De Keyser J 2007 Janus faces of microglia in multiple sclerosis. Brain Research Reviews 54 274-285.
115. Schenker M, Riederer BM, Kuntzer T & Barakat-Walter I 2002 Thyroid hormones stimulate expression and modification of cytoskeletal protein during rat sciatic nerve regeneration. Brain Research 957 259-270.
116. Sarlieve LL, Rodriguez-Pena A & Langley K 2004 Expression of thyroid hormone receptor isoforms in the oligodendrocyte lineage. Neurochemical Research 29 903-922.
117. Schonberg DL, Popovich PG & McTigue DM 2007 Oligodendrocyte generation is differentially influenced by toll-like receptor (TLR) 2 and TLR4-mediated intraspinal macrophage activation. Journal of Neuropathology and Experimental Neurology 66 1124-1135.
118. Setzu A, Lathia JD, Zhao C, Wells K, Rao MS, Ffrench-Constant C & Franklin RJ 2006 Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells. Glia 54 297-303.
119. Sher F, Balasubramaniyan V, Boddeke E & Copray S 2008 Oligodendrocyte differentiation and implantation: new insights for remyelinating cell therapy. Current Opinion in Neurology 21 607-614.
120. Simons M & Trotter J 2007 Wrapping it up: the cell biology of myelination. Current Opinion in Neurobiology 17 533-540.
121. Tauchmanovà L, Selleri C, De Rosa G, Esposito M, Di Somma C, Orio F, Palomba S, Lombardi G, Rotoli B & Colao A 2005 Endocrine disorders during the first year after autologous stem-cell transplant. American Journal of Medicine 118 664-670.
122. Taylor PM & Ritchie JW 2007 Tissue uptake of thyroid hormone by amino acid transporters. Best Practice and Research. Clinical Endocrinology and Metabolism 21 237-251.
123. Trentin AG 2006 Thyroid hormone and astrocyte morphogenesis. Journal of Endocrinology 189 189-197.
124. Tsui KH, Hsieh WC, Lin MH, Chang PL & Juang HH 2008 Triiodothyronine modulates cell proliferation of human prostatic carcinoma cells by downregulation of the B-cell translocation gene 2. Prostate 68 610-619.
125. Visser WE, Friesema EC, Jansen J & Visser TJ 2008 Thyroid hormone transport in and out of cells. Trends in Endocrinology and Metabolism 19 50-56.
126. Williams GR 2000 Cloning and characterization of two novel thyroid hormone receptor b isoforms. Molecular and Cellular Biology 20 8329-8342.
127. Wilson HC, Scolding NJ & Raine CS 2006 Co-expression of PDGFa receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. Journal of Neuroimmunology 176 162-173.
128. Wolswijk G 2002 Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord. Brain 125 338-349.
129. Yang J, Rostami A & Zhang GX 2009 Cellular remyelinating therapy in multiple sclerosis. Journal of the Neurological Sciences 276 1-5.
130. Yen PM 2001 Physiological and molecular basis of thyroid hormone action. Physiological Reviews 81 1097-1142.
131. Zoeller RT & Rovet J 2004 Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. Journal of Neuroendocrinology 16 809-818.