Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

Neuroscience

Volumn 276, Issue , 2014, Pages 29-47

  Mitew, S ^a   Hay, C M ^a   Peckham, H ^a   Xiao, J ^a   Koenning, M ^a   Emery, B ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Differentiation; Myelination; Olig2; Oligodendrocyte; Transcription factors

Indexed keywords

CHEMOATTRACTANT; CHEMOREPELLENT; FIBROBLAST GROWTH FACTOR 2; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 17; LIGAND; LIOTHYRONINE; MEMBRANE PROTEIN; MYELIN; NERVE CELL ADHESION MOLECULE; NOTCH1 RECEPTOR; OLIGODENDROCYTE TRANSCRIPTION FACTOR 1; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PLATELET DERIVED GROWTH FACTOR AA; PROTEIN KINASE FYN; PROTEIN LINGO1; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR SOX10; UNCLASSIFIED DRUG; WNT PROTEIN;

CELL ADHESION; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; EXTRACELLULAR SPACE; HUMAN; INTRACELLULAR SIGNALING; MYELINATION; NERVE CELL DIFFERENTIATION; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION; WNT SIGNALING PATHWAY; ANIMAL; BRAIN; CELL MOTION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MYELIN SHEATH; NERVE FIBER; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD; ULTRASTRUCTURE;

ANIMALS; AXONS; BRAIN; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MYELIN SHEATH; OLIGODENDROGLIA; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSCRIPTION FACTORS;

EID: 84906791093     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.11.029     Document Type: Review

References (236)

1. Armendáriz B.G., Bribián A., Pérez-Martínez E., Martínez A., de Castro F., Soriano E., Burgaya F. Expression of Semaphorin 4F in neurons and brain oligodendrocytes and the regulation of oligodendrocyte precursor migration in the optic nerve. Mol Cell Neurosci 2012, 49:54-67.
2. Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., O'Hagan D., Garbern J., Kamholz J. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. J Neurosci 1997, 17:6657-6668.
3. Back S.A., Luo N.L., Borenstein N.S., Volpe J.J., Kinney H.C. Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis. J Neuropathol Exp Neurol 2002, 61:197-211.
4. Bacon C., Lakics V., Machesky L., Rumsby M. N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells - implications for axon ensheathment at myelination. Glia 2007, 55:844-858.
5. Bansal R., Kumar M., Murray K., Morrison R.S., Pfeiffer S.E. Regulation of FGF receptors in the oligodendrocyte lineage. Mol Cell Neurosci 1996, 7:263-275.
6. Baron W., Colognato H., Ffrench-Constant C. Integrin-growth factor interactions as regulators of oligodendroglial development and function. Glia 2005, 49:467-479.
7. Baron W., Decker L., Colognato H., Ffrench-Constant C. Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomains. Curr Biol 2003, 13:151-155.
8. Baron W., Metz B., Bansal R., Hoekstra D., de Vries H. PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways. Mol Cell Neurosci 2000, 15:314-329.
9. Baron W., Shattil S.J., Ffrench-Constant C. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J 2002, 21:1957-1966.
10. Barres B.A., Hart I.K., Coles H.S., Burne J.F., Voyvodic J.T., Richardson W.D., Raff M.C. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 1992, 70:31-46.
11. Barres B.A., Lazar M.A., Raff M.C. A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development 1994, 120:1097-1108.
12. Barros C.S., Nguyen T., Spencer K.S.R., Nishiyama A., Colognato H., Muller U. β1 Integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 2009, 136:2717-2724.
13. Bartzokis G., Lu P.H., Heydari P., Couvrette A., Lee G.J., Kalashyan G., Freeman F., Grinstead J.W., Villablanca P., Finn J.P., Mintz J., Alger J.R., Altshuler L.L. Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals. Biol Psychiatry 2012, 72:1026-1034.
14. Battiste J., Helms A.W., Kim E.J., Savage T.K., Lagace D.C., Mandyam C.D., Eisch A.J., Miyoshi G., Johnson J.E. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 2007, 134:285-293.
15. Bauer N.G., Richter-Landsberg C., Ffrench-Constant C. Role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia 2009, 57:1691-1705.
16. Benninger Y., Colognato H., Thurnherr T., Franklin R.J.M., Leone D.P., Atanasoski S., Nave K.-A., Ffrench-Constant C., Suter U., Relvas J.B. Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination. J Neurosci 2006, 26:7665-7673.
17. Bernard F., Moreau-Fauvarque C., Heitz-Marchaland C., Zagar Y., Dumas L., Fouquet S., Lee X., Shao Z., Mi S., Chédotal A. Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination. Glia 2012, 60:1590-1604.
18. Bibollet-Bahena O., Almazan G. IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways. J Neurochem 2009, 109:1440-1451.
19. Bilican B., Fiore-Heriche C., Compston A., Allen N.D., Chandran S. Induction of Olig2+ precursors by FGF involves BMP signalling blockade at the Smad level. PLoS One 2008, 3:e2863.
20. Biname F., Sakry D., Dimou L., Jolivel V., Trotter J. NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins. J Neurosci 2013, 33:10858-10874.
21. Bribián A., Barallobre M.J., Soussi-Yanicostas N., de Castro F. Anosmin-1 modulates the FGF-2-dependent migration of oligodendrocyte precursors in the developing optic nerve. Mol Cell Neurosci 2006, 33:2-14.
22. Bribián A., Esteban P.F., Clemente D., Soussi-Yanicostas N., Thomas J.L., Zalc B., de Castro F. A novel role for anosmin-1 in the adhesion and migration of oligodendrocyte precursors. Dev Neurobiol 2008, 68:1503-1516.
23. Brinkmann B.G., Agarwal A., Sereda M.W., Garratt A.N., Müller T., Wende H., Stassart R.M., Nawaz S., Humml C., Velanac V., Radyushkin K., Goebbels S., Fischer T.M., Franklin R.J., Lai C., Ehrenreich H., Birchmeier C., Schwab M.H., Nave K.-A. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 2008, 59:581-595.
24. Brody B.A., Kinney H.C., Kloman A.S., Gilles F.H. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 1987, 46:283-301.
25. Bujalka H., Koenning M., Jackson S., Perreau V.M., Pope B., Hay C.M., Mitew S., Hill A.F., Lu Q.R., Wegner M., Srinivasan R., Svaren J., Willingham M., Barres B.A., Emery B. MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol 2013, 11:e1001625.
26. Cahoy J.D., Emery B., Kaushal A., Foo L.C., Zamanian J.L., Christopherson K.S., Xing Y., Lubischer J.L., Krieg P.A., Krupenko S.A., Thompson W.J., Barres B.A. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 2008, 28:264-278.
27. Cai J., Qi Y., Hu X., Tan M., Liu Z., Zhang J., Li Q., Sander M., Qiu M. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 2005, 45:41-53.
28. Cai J., Zhu Q., Zheng K., Li H., Qi Y., Cao Q., Qiu M. Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. Glia 2010, 58:458-468.
29. Calver A.R., Hall A.C., Yu W.P., Walsh F.S., Heath J.K., Betsholtz C., Richardson W.D. Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 1998, 20:869-882.
30. Camara J., Wang Z., Nunes-Fonseca C., Friedman H.C., Grove M., Sherman D.L., Komiyama N.H., Grant S.G., Brophy P.J., Peterson A., Ffrench-Constant C. Integrin-mediated axoglial interactions initiate myelination in the central nervous system. J Cell Biol 2009, 185:699-712.
31. Canoll P.D., Kraemer R., Teng K.K., Marchionni M.A., Salzer J.L. GGF/neuregulin induces a phenotypic reversion of oligodendrocytes. Mol Cell Neurosci 1999, 13:79-94.
32. Carson M.J., Behringer R.R., Brinster R.L., McMorris F.A. Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 1993, 10:729-740.
33. Chandran S., Kato H., Gerreli D., Compston A., Svendsen C.N., Allen N.D. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development 2003, 130:6599-6609.
34. Charles P., Hernandez M.P., Stankoff B., AIGROT M.S., Colin C., Rougon G., Zalc B., Lubetzki C. Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule. Proc Natl Acad Sci U S A 2000, 97:7585-7590.
35. Chen Y., Wu H., Wang S., Koito H., Li J., Ye F., Hoang J., Escobar S.S., Gow A., Arnett H.A., Trapp B.D., Karandikar N.J., Hsieh J., Lu Q.R. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci 2009, 12:1398-1406.
36. Cheng X., Wang Y., He Q., Qiu M., Whittemore S.R., Cao Q. Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells 2007, 25:3204-3214.
37. Chew L.J., Shen W., Ming X., Senatorov V.V., Chen H.L., Cheng Y., Hong E., Knoblach S., Gallo V. SRY-box containing gene 17 regulates the Wnt/beta-catenin signaling pathway in oligodendrocyte progenitor cells. J Neurosci 2011, 31:13921-13935.
38. Chong S.Y.C., Rosenberg S.S., Fancy S.P.J., Zhao C., Shen Y.-A.A., Hahn A.T., McGee A.W., Xu X., Zheng B., Zhang L.I., Rowitch D.H., Franklin R.J.M., Lu Q.R., Chan J.R. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A 2012, 109:1299-1304.
39. Chun S.J., Rasband M.N., Sidman R.L., Habib A.A., Vartanian T. Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. J Cell Biol 2003, 163:397-408.
40. Clarke L.E., Young K.M., Hamilton N.B., Li H., Richardson W.D., Attwell D. Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse. J Neurosci 2012, 32:8173-8185.
41. Colognato H., Baron W., Avellana-Adalid V., Relvas J.B., Evercooren A.B.-V., Georges-Labouesse E., Ffrench-Constant C. CNS integrins switch growth factor signalling to promote target-dependent survival. Nat Cell Biol 2002, 4:833-841.
42. Colognato H., Galvin J., Wang Z., Relucio J., Nguyen T., Harrison D., Yurchenco P.D., Ffrench-Constant C. Identification of dystroglycan as a second laminin receptor in oligodendrocytes, with a role in myelination. Development 2007, 134:1723-1736.
43. Colognato H., Ramachandrappa S., Olsen I.M., Ffrench-Constant C. Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J Cell Biol 2004, 167:365-375.
44. Cui Q.L., Fragoso G., Miron V.E., Darlington P.J., Mushynski W.E., Antel J., Almazan G. Response of human oligodendrocyte progenitors to growth factors and axon signals. J Neuropathol Exp Neurol 2010, 69:930-944.
45. Czopka T., Ffrench-Constant C., Lyons D.A. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev Cell 2013, 25:599-609.
46. de Castro F., Bribián A., Ortega M.C. Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology. Cell Mol Life Sci 2013, 70:4355-4368.
47. Decker L., Avellana-Adalid V., Nait-Oumesmar B., Durbec P., Baron-Van Evercooren A. Oligodendrocyte precursor migration and differentiation: combined effects of PSA residues, growth factors, and substrates. Mol Cell Neurosci 2000, 16:422-439.
48. Decker L., Ffrench-Constant C. Lipid rafts and integrin activation regulate oligodendrocyte survival. J Neurosci 2004, 24:3816-3825.
49. Durand B., Fero M.L., Roberts J.M., Raff M.C. P27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation. Curr Biol 1998, 8:431-440.
50. Durand B., Gao F.B., Raff M. Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J 1997, 16:306-317.
51. Durand B., Raff M. A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays 2000, 22:64-71.
52. Dziembowska M., Tham T.N., Lau P., Vitry S., Lazarini F., Dubois-Dalcq M. A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors. Glia 2005, 50:258-269.
53. Emery B., Agalliu D., Cahoy J.D., Watkins T.A., Dugas J.C., Mulinyawe S.B., Ibrahim A., Ligon K.L., Rowitch D.H., Barres B.A. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 2009, 138:172-185.
54. Eyermann C., Czaplinski K., Colognato H. Dystroglycan promotes filopodial formation and process branching in differentiating oligodendroglia. J Neurochem 2012, 120:928-947.
55. Fancy S.P., Baranzini S.E., Zhao C., Yuk D.I., Irvine K.A., Kaing S., Sanai N., Franklin R.J., Rowitch D.H. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 2009, 23:1571-1585.
56. Farhadi H.F., Lepage P., Forghani R., Friedman H.C., Orfali W., Jasmin L., Miller W., Hudson T.J., Peterson A.C. A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J Neurosci 2003, 23:10214-10223.
57. Fernandez P.A., Tang D.G., Cheng L., Prochiantz A., Mudge A.W., Raff M.C. Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 2000, 28:81-90.
58. Fewou S.N., Ramakrishnan H., Bussow H., Gieselmann V., Eckhardt M. Down-regulation of polysialic acid is required for efficient myelin formation. J Biol Chem 2007, 282:16700-16711.
59. Flores A.I., Mallon B.S., Matsui T., Ogawa W., Rosenzweig A., Okamoto T., Macklin W.B. Akt-mediated survival of oligodendrocytes induced by neuregulins. J Neurosci 2000, 20:7622-7630.
60. Flores A.I., Narayanan S.P., Morse E.N., Shick H.E., Yin X., Kidd G., Avila R.L., Kirschner D.A., Macklin W.B. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci 2008, 28:7174-7183.
61. Fogarty M., Richardson W.D., Kessaris N. A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord. Development 2005, 132:1951-1959.
62. Fortin D., Rom E., Sun H., Yayon A., Bansal R. Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage. J Neurosci 2005, 25:7470-7479.
63. Frederick T.J., Min J., Altieri S.C., Mitchell N.E., Wood T.L. Synergistic induction of cyclin D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathways. Glia 2007, 55:1011-1022.
64. Frederick T.J., Wood T.L. IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells. Mol Cell Neurosci 2004, 25:480-492.
65. Frost E., Kiernan B.W., Faissner A., Ffrench-Constant C. Regulation of oligodendrocyte precursor migration by extracellular matrix: evidence for substrate-specific inhibition of migration by tenascin-C. Dev Neurosci 1996, 18:266-273.
66. Fruttiger M., Karlsson L., Hall A.C., Abramsson A., Calver A.R., Boström H., Willetts K., Bertold C.H., Heath J.K., Betsholtz C., Richardson W.D. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 1999, 126:457-467.
67. Fu H., Kesari S., Cai J. Tcf7l2 is tightly controlled during myelin formation. Cell Mol Neurobiol 2012, 32:345-352.
68. Fumagalli M., Daniele S., Lecca D., Lee P.R., Parravicini C., Fields R.D., Rosa P., Antonucci F., Verderio C., Trincavelli M.L., Bramanti P., Martini C., Abbracchio M.P. Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J Biol Chem 2011, 286:10593-10604.
69. Funfschilling U., Supplie L.M., Mahad D., Boretius S., Saab A.S., Edgar J., Brinkmann B.G., Kassmann C.M., Tzvetanova I.D., Mobius W., Diaz F., Meijer D., Suter U., Hamprecht B., Sereda M.W., Moraes C.T., Frahm J., Goebbels S., Nave K.A. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012, 485:517-521.
70. Furusho M., Dupree J.L., Nave K.-A., Bansal R. Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness. J Neurosci 2012, 32:6631-6641.
71. Furusho M., Kaga Y., Ishii A., Hébert J.M., Bansal R. Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. J Neurosci 2011, 31:5055-5066.
72. Galvin J., Eyermann C., Colognato H. Dystroglycan modulates the ability of insulin-like growth factor-1 to promote oligodendrocyte differentiation. J Neurosci Res 2010, 88:3295-3307.
73. Gao F.B., Durand B., Raff M. Oligodendrocyte precursor cells count time but not cell divisions before differentiation. Curr Biol 1997, 7:152-155.
74. Garcia-Lopez R., Martinez S. Oligodendrocyte precursors originate in the parabasal band of the basal plate in prosomere 1 and migrate into the alar prosencephalon during chick development. Glia 2010, 58:1437-1450.
75. Garcion E., Faissner A., Ffrench-Constant C. Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration. Development 2001, 128:2485-2496.
76. Genoud S., Lappe-Siefke C., Goebbels S., Radtke F., Aguet M., Scherer S.S., Suter U., Nave K.-A., Mantei N. Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol 2002, 158:709-718.
77. Goddard D.R., Berry M., Butt A.M. In vivo actions of fibroblast growth factor-2 and insulin-like growth factor-I on oligodendrocyte development and myelination in the central nervous system. J Neurosci Res 1999, 57:74-85.
78. Goto J., Tezuka T., Nakazawa T., Sagara H., Yamamoto T. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Mol Cell Neurosci 2008, 38:203-212.
79. Guardiola-Diaz H.M., Ishii A., Bansal R. Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation. Glia 2012, 60:476-486.
80. Gupta R.K., Bhatia V., Poptani H., Gujral R.B. Brain metabolite changes on in vivo proton magnetic resonance spectroscopy in children with congenital hypothyroidism. J Pediatr 1995, 126:389-392.
81. Hornig J., Fröb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M. The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet 2013, 9:e1003907.
82. Hoshina N., Tezuka T., Yokoyama K., Kozuka-Hata H., Oyama M., Yamamoto T. Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Genes Cells 2007, 12:1245-1254.
83. Howng S.Y., Avila R.L., Emery B., Traka M., Lin W., Watkins T., Cook S., Bronson R., Davisson M., Barres B.A., Popko B. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev 2010, 24:10.
84. Hsieh J., Aimone J.B., Kaspar B.K., Kuwabara T., Nakashima K., Gage F.H. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol 2004, 164:111-122.
85. Hu J., Deng L., Wang X., Xu X.-M. Effects of extracellular matrix molecules on the growth properties of oligodendrocyte progenitor cells in vitro. J Neurosci Res 2009, 87:2854-2862.
86. Hu Q.-D., Ang B.-T., Karsak M., Hu W.-P., Cui X.-Y., Duka T., Takeda Y., Chia W., Sankar N., Ng Y.-K., Ling E.-A., Maciag T., Small D., Trifonova R., Kopan R., Okano H., Nakafuku M., Chiba S., Hirai H., Aster J.C., Schachner M., Pallen C.J., Watanabe K., Xiao Z.-C. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 2003, 115:163-175.
87. Hughes E.G., Kang S.H., Fukaya M., Bergles D.E. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci 2013, 16:10.
88. Ibarrola N., Rodriguez-Pena A. Hypothyroidism coordinately and transiently affects myelin protein gene expression in most rat brain regions during postnatal development. Brain Res 1997, 752:285-293.
89. Ishii A., Furusho M., Bansal R. Sustained activation of ERK1/2 MAPK in oligodendrocytes and Schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion. J Neurosci 2013, 33:175-186.
90. Jagannathan N.R., Tandon N., Raghunathan P., Kochupillai N. Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proton magnetic resonance spectroscopy (MRS) study. Brain Res Dev Brain Res 1998, 109:179-186.
91. Jarjour A.A., Manitt C., Moore S.W., Thompson K.M., Yuh S.J., Kennedy T.E. Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord. J Neurosci 2003, 23:3735-3744.
92. Jepson S., Vought B., Gross C.H., Gan L., Austen D., Frantz J.D., Zwahlen J., Lowe D., Markland W., Krauss R. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions. J Biol Chem 2012, 287:22184-22195.
93. Kang S.H., Fukaya M., Yang J.K., Rothstein J.D., Bergles D.E. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 2010, 68:668-681.
94. Kerstetter A.E., Padovani-Claudio D.A., Bai L., Miller R.H. Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis. Experimental Neurology 2009, 220:44-56.
95. Kessaris N., Fogarty M., Iannarelli P., Grist M., Wegner M., Richardson W.D. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 2006, 9:173-179.
96. Kim H., Shin J., Kim S., Poling J., Park H.-C., Appel B. Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Dev Dyn 2008, 237:2081-2089.
97. Kippert A., Trajkovic K., Rajendran L., Ries J., Simons M. Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells. J Neurosci 2007, 27:3560-3570.
98. Kirby B.B., Takada N., Latimer A.J., Shin J., Carney T.J., Kelsh R.N., Appel B. In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nat Neurosci 2006, 9:1506-1511.
99. Kitada M., Rowitch D.H. Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia 2006, 54:35-46.
100. Koenning M., Jackson S., Hay C.M., Faux C., Kilpatrick T.J., Willingham M., Emery B. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci 2012, 32:12528-12542.
101. Kondo T., Raff M. Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation. Development 2000, 127:2989-2998.
102. Lafrenaye A.D., Fuss B. Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes. J Neurochem 2010, 115:269-282.
103. Langseth A.J., Munji R.N., Choe Y., Huynh T., Pozniak C.D., Pleasure S.J. Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon. J Neurosci 2010, 30:13367-13372.
104. Laursen L.S., Chan C.W., Ffrench-Constant C. An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation. J Neurosci 2009, 29:9174-9185.
105. Lebel C., Walker L., Leemans A., Phillips L., Beaulieu C. Microstructural maturation of the human brain from childhood to adulthood. Neuroimage 2008, 40:1044-1055.
106. Leber S.M., Sanes J.R. Migratory paths of neurons and glia in the embryonic chick spinal cord. J Neurosci 1995, 15:1236-1248.
107. LeBlanc S.E., Jang S.W., Ward R.M., Wrabetz L., Svaren J. Direct regulation of myelin protein zero expression by the Egr2 transactivator. J Biol Chem 2006, 281:5453-5460.
108. Lee K.K., de Repentigny Y., Saulnier R., Rippstein P., Macklin W.B., Kothary R. Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity. Glia 2006, 53:836-844.
109. Lee S., Leach M.K., Redmond S.A., Chong S.Y.C., Mellon S.H., Tuck S.J., Feng Z.-Q., Corey J.M., Chan J.R. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods 2012, 9:917-922.
110. Lee S.K., Lee B., Ruiz E.C., Pfaff S.L. Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev 2005, 19:282-294.
111. Lewallen K.A., Shen Y.A., De la Torre A.R., Ng B.K., Meijer D., Chan J.R. Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination. J Neurosci 2011, 31:3032-3043.
112. Li H., de Faria J.P., Andrew P., Nitarska J., Richardson W.D. Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch. Neuron 2011, 69:918-929.
113. Li H., Lu Y., Smith H.K., Richardson W.D. Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. J Neurosci 2007, 27:14375-14382.
114. Liang X., Draghi N.A., Resh M.D. Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes. J Neurosci 2004, 24:7140-7149.
115. Ligon K.L., Kesari S., Kitada M., Sun T., Arnett H.A., Alberta J.A., Anderson D.J., Stiles C.D., Rowitch D.H. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A 2006, 103:7853-7858.
116. Liu A., Li J., Marin-Husstege M., Kageyama R., Fan Y., Gelinas C., Casaccia-Bonnefil P. A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J 2006, 25:4833-4842.
117. Liu R., Cai J., Hu X., Tan M., Qi Y., German M., Rubenstein J., Sander M., Qiu M. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development 2003, 130:6221-6231.
118. Liu X., Bates R., Yin D.M., Shen C., Wang F., Su N., Kirov S.A., Luo Y., Wang J.Z., Xiong W.C., Mei L. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci 2011, 31:8491-8501.
119. Liu X.X., Lu Y.Y., Zhang Y.Y., Li Y.Y., Zhou J.J., Yuan Y.Y., Gao X.X., Su Z.Z., He C.C. Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signalling. J Biol Chem 2012, 287:17503-17516.
120. Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002, 109:75-86.
121. Lu Q.R., Yuk D., Alberta J.A., Zhu Z., Pawlitzky I., Chan J., McMahon A.P., Stiles C.D., Rowitch D.H. Sonic hedgehog - regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000, 25:317-329.
122. Maire C.L., Wegener A., Kerninon C., Nait Oumesmar B. Gain-of-function of Olig transcription factors enhances oligodendrogenesis and myelination. Stem Cells 2010, 28:1611-1622.
123. Makinodan M., Rosen K.M., Ito S., Corfas G. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science 2012, 337:1357-1360.
124. Marta C.B., Adamo A.M., Soto E.F., Pasquini J.M. Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system. J Neurosci Res 1998, 53:251-259.
125. McKinnon R.D., Matsui T., Dubois-Dalcq M., Aaronson S.A. FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron 1990, 5:603-614.
126. Mecklenburg N., Garcia-Lopez R., Puelles E., Sotelo C., Martinez S. Cerebellar oligodendroglial cells have a mesencephalic origin. Glia 2011, 59:1946-1957.
127. Megason S.G., McMahon A.P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 2002, 129:2087-2098.
128. Mehler M.F., Mabie P.C., Zhu G., Gokhan S., Kessler J.A. Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate. Dev Neurosci 2000, 22:74-85.
129. Mei F., Wang H., Liu S., Niu J., Wang L., He Y., Etxeberria A., Chan J.R., Xiao L. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J Neurosci 2013, 33:8454-8462.
130. Mekki-Dauriac S., Agius E., Kan P., Cochard P. Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord. Development 2002, 129:5117-5130.
131. Memezawa A., Takada I., Takeyama K., Igarashi M., Ito S., Aiba S., Kato S., Kouzmenko A.P. Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes. Oncogene 2007, 26:5038-5045.
132. Merchán P., Bribián A., Sánchez-Camacho C., Lezameta M., Bovolenta P., de Castro F. Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors. Mol Cell Neurosci 2007, 36:355-368.
133. Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., Pepinsky R.B. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 2004, 7:221-228.
134. Mi S., Miller R.H., Lee X., Scott M.L., Shulag-Morskaya S., Shao Z., Chang J., Thill G., Levesque M., Zhang M., Hession C., Sah D., Trapp B.D., He Z., Jung V., McCoy J.M., Pepinsky R.B. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 2005, 8:745-751.
135. Miller R.H., Ono K. Morphological analysis of the early stages of oligodendrocyte development in the vertebrate central nervous system. Microsc Res Tech 1998, 41:441-453.
136. Milner R., Edwards G., Streuli C., Ffrench-Constant C. A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors. J Neurosci 1996, 16:7240-7252.
137. Miyamoto Y., Yamauchi J., Tanoue A. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J Neurosci 2008, 28:8326-8337.
138. Morissette N., Carbonetto S. Laminin alpha 2 chain (M chain) is found within the pathway of avian and murine retinal projections. J Neurosci 1995, 15:8067-8082.
139. Nakatani H., Martin E., Hassani H., Clavairoly A., Maire C.L., Viadieu A., Kerninon C., Delmasure A., Frah M., Weber M., Nakafuku M., Zalc B., Thomas J.L., Guillemot F., Nait-Oumesmar B., Parras C. Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination. J Neurosci 2013, 33:9752-9768.
140. Narayanan S.P., Flores A.I., Wang F., Macklin W.B. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci 2009, 29:6860-6870.
141. Naruse M., Nakahira E., Miyata T., Hitoshi S., Ikenaka K., Bansal R. Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2. Dev Biol 2006, 297:262-273.
142. Niu J., Mei F., Wang L., Liu S., Tian Y., Mo W., Li H., Lu Q.R., Xiao L. Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia 2012, 60:1427-1436.
143. Noble M., Murray K., Stroobant P., Waterfield M.D., Riddle P. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature 1988, 333:560-562.
144. O'Meara R.W., Michalski J.P., Anderson C., Bhanot K., Rippstein P., Kothary R. Integrin-linked kinase regulates process extension in oligodendrocytes via control of actin cytoskeletal dynamics. J Neurosci 2013, 33:9781-9793.
145. Olivier C., Cobos I., Perez Villegas E.M., Spassky N., Zalc B., Martinez S., Thomas J.L. Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo. Development 2001, 128:1757-1769.
146. Ono K., Bansal R., Payne J., Rutishauser U., Miller R.H. Early development and dispersal of oligodendrocyte precursors in the embryonic chick spinal cord. Development 1995, 121:1743-1754.
147. Ono K., Yasui Y., Rutishauser U., Miller R.H. Focal ventricular origin and migration of oligodendrocyte precursors into the chick optic nerve. Neuron 1997, 19:283-292.
148. Orentas D.M., Hayes J.E., Dyer K.L., Miller R.H. Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. Development 1999, 126:2419-2429.
149. Orentas D.M., Miller R.H. The origin of spinal cord oligodendrocytes is dependent on local influences from the notochord. Dev Biol 1996, 177:43-53.
150. Ortega M.C., Bribián A., Peregrín S., Gil M.T., Marín O., de Castro F. Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development. Exp Neurol 2012, 235:610-620.
151. Osterhout D.J., Ebner S., Xu J., Ornitz D.M., Zazanis G.A., McKinnon R.D. Transplanted oligodendrocyte progenitor cells expressing a dominant-negative FGF receptor transgene fail to migrate in vivo. J Neurosci 1997, 17:9122-9132.
152. Osterhout D.J., Wolven A., Wolf R.M., Resh M.D., Chao M.V. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. J Cell Biol 1999, 145:1209-1218.
153. Padovani-Claudio D.A., Liu L., Ransohoff R.M., Miller R.H. Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2. Glia 2006, 54:471-483.
154. Pang Y., Zheng B., Fan L.-W., Rhodes P.G., Cai Z. IGF-1 protects oligodendrocyte progenitors against TNFα-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Glia 2007, 55:1099-1107.
155. Park H.-C., Boyce J., Shin J., Appel B. Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. J Neurosci 2005, 25:6836-6844.
156. Parras C.M., Hunt C., Sugimori M., Nakafuku M., Rowitch D., Guillemot F. The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. J Neurosci 2007, 27:4233-4242.
157. Patel J.R., McCandless E.E., Dorsey D., Klein R.S. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc Natl Acad Sci U S A 2010, 107:11062-11067.
158. Patel J.R., Williams J.L., Muccigrosso M.M., Liu L., Sun T., Rubin J.B., Klein R.S. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathol 2012, 124:847-860.
159. Payne H.R., Hemperly J.J., Lemmon V. N-cadherin expression and function in cultured oligodendrocytes. Brain Res Dev Brain Res 1996, 97:9-15.
160. Petryniak M.A., Potter G.B., Rowitch D.H., Rubenstein J.L. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron 2007, 55:417-433.
161. Pombo P.M., Ibarrola N., Alonso M.A., Rodriguez-Pena A. Thyroid hormone regulates the expression of the MAL proteolipid, a component of glycolipid-enriched membranes, in neonatal rat brain. J Neurosci Res 1998, 52:584-590.
162. Poncet C., Soula C., Trousse F., Kan P., Hirsinger E., Pourquie O., Duprat A.M., Cochard P. Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog. Mech Dev 1996, 60:13-32.
163. Prestoz L., Chatzopoulou E., Lemkine G., Spassky N., Lebras B., Kagawa T., Ikenaka K., Zalc B., Thomas J.L. Control of axonophilic migration of oligodendrocyte precursor cells by Eph-ephrin interaction. Neuron Glia Biol 2004, 1:73-83.
164. Pringle N.P., Mudhar H.S., Collarini E.J., Richardson W.D. PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development 1992, 115:535-551.
165. Pringle N.P., Yu W.P., Guthrie S., Roelink H., Lumsden A., Peterson A.C., Richardson W.D. Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 1996, 177:30-42.
166. Qi Y., Cai J., Wu Y., Wu R., Lee J., Fu H., Rao M., Sussel L., Rubenstein J., Qiu M. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 2001, 128:2723-2733.
167. Qi Y., Tan M., Hui C.C., Qiu M. Gli2 is required for normal Shh signaling and oligodendrocyte development in the spinal cord. Mol Cell Neurosci 2003, 23:440-450.
168. Rajasekharan S., Baker K.A., Horn K.E., Jarjour A.A., Antel J.P., Kennedy T.E. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development 2009, 136:415-426.
169. Relucio J., Menezes M.J., Miyagoe-Suzuki Y., Takeda S., Colognato H. Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone. Glia 2012, 60:1451-1467.
170. Relucio J., Tzvetanova I.D., Ao W., Lindquist S., Colognato H. Laminin alters Fyn regulatory mechanisms and promotes oligodendrocyte development. J Neurosci 2009, 29:11794-11806.
171. Richardson W.D., Kessaris N., Pringle N. Oligodendrocyte wars. Nat Rev Neurosci 2006, 7:11-18.
172. Richardson W.D., Pringle N., Mosley M.J., Westermark B., Dubois-Dalcq M. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 1988, 53:309-319.
173. Robertson C.P., Braun M.M., Roelink H. Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3-like signal. Dev Dyn 2004, 229:510-519.
174. Rodriguez-Pena A., Ibarrola N., Iniguez M.A., Munoz A., Bernal J. Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain. J Clin Invest 1993, 91:812-818.
175. Romanelli R.J., Mahajan K.R., Fulmer C.G., Wood T.L. Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes. J Neurosci Res 2009, 87:3369-3377.
176. Rowitch D.H., Kriegstein A.R. Developmental genetics of vertebrate glial-cell specification. Nature 2010, 468:214-222.
177. Samanta J., Kessler J.A. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development 2004, 131:4131-4142.
178. Schnadelbach O., Fawcett J.W. Astrocyte influences on oligodendrocyte progenitor migration. Prog Brain Res 2001, 132:97-102.
179. Schnädelbach O., Blaschuk O.W., Symonds M., Gour B.J., Doherty P., Fawcett J.W. N-cadherin influences migration of oligodendrocytes on astrocyte monolayers. Mol Cell Neurosci 2000, 15:288-302.
180. Schoonover C.M., Seibel M.M., Jolson D.M., Stack M.J., Rahman R.J., Jones S.A., Mariash C.N., Anderson G.W. Thyroid hormone regulates oligodendrocyte accumulation in developing rat brain white matter tracts. Endocrinology 2004, 145:5013-5020.
181. Shimizu T., Kagawa T., Wada T., Muroyama Y., Takada S., Ikenaka K. Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol 2005, 282:397-410.
182. Small R.K., Riddle P., Noble M. Evidence for migration of oligodendrocyte - type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 1987, 328:155-157.
183. Southwood C., He C., Garbern J., Kamholz J., Arroyo E., Gow A. CNS myelin paranodes require Nk6-2 homeoprotein transcriptional activity for normal structure. J Neurosci 2004, 24:11215-11225.
184. Spassky N., de Castro F., Le Bras B., Heydon K., Queraud-LeSaux F., Bloch-Gallego E., Chedotal A., Zalc B., Thomas J.L. Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J Neurosci 2002, 22:5992-6004.
185. Spassky N., Heydon K., Mangatal A., Jankovski A., Olivier C., Queraud-Lesaux F., Goujet-Zalc C., Thomas J.L., Zalc B. Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. Development 2001, 128:4993-5004.
186. Srinivasan R., Sun G., Keles S., Jones E.A., Jang S.W., Krueger C., Moran J.J., Svaren J. Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve. Nucleic Acids Res 2012, 40:6449-6460.
187. Stegmuller J., Schneider S., Hellwig A., Garwood J., Trotter J. AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. J Neurocytol 2002, 31:497-505.
188. Stolt C.C., Rehberg S., Ader M., Lommes P., Riethmacher D., Schachner M., Bartsch U., Wegner M. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev 2002, 16:165-170.
189. Sugimori M., Nagao M., Parras C.M., Nakatani H., Lebel M., Guillemot F., Nakafuku M. Ascl1 is required for oligodendrocyte development in the spinal cord. Development 2008, 135:1271-1281.
190. Sugimoto Y., Taniguchi M., Yagi T., Akagi Y., Nojyo Y., Tamamaki N. Guidance of glial precursor cell migration by secreted cues in the developing optic nerve. Development 2001, 128:3321-3330.
191. Sun Y., Meijer D.H., Alberta J.A., Mehta S., Kane M.F., Tien A.C., Fu H., Petryniak M.A., Potter G.B., Liu Z., Powers J.F., Runquist I.S., Rowitch D.H., Stiles C.D. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron 2011, 69:906-917.
192. Takada N., Kucenas S., Appel B. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia 2010, 58:996-1006.
193. Tan M., Hu X., Qi Y., Park J., Cai J., Qiu M. Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants. Brain Res 2006, 1067:158-163.
194. Taniguchi S., Liu H., Nakazawa T., Yokoyama K., Tezuka T., Yamamoto T. P250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem Biophys Res Commun 2003, 306:151-155.
195. Taniguchi Y., Amazaki M., Furuyama T., Yamaguchi W., Takahara M., Saino O., Wada T., Niwa H., Tashiro F., Miyazaki J.-I., Kogo M., Matsuyama T., Inagaki S. Sema4D deficiency results in an increase in the number of oligodendrocytes in healthy and injured mouse brains. J Neurosci Res 2009, 87:2833-2841.
196. Taveggia C., Thaker P., Petrylak A., Caporaso G.L., Toews A., Falls D.L., Einheber S., Salzer J.L. Type III neuregulin-1 promotes oligodendrocyte myelination. Glia 2007, 56:284-293.
197. Tekki-Kessaris N., Woodruff R., Hall A.C., Gaffield W., Kimura S., Stiles C.D., Rowitch D.H., Richardson W.D. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 2001, 128:2545-2554.
198. Tiwari-Woodruff S., Beltran-Parrazal L., Charles A., Keck T., Vu T., Bronstein J. K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development. Am J Physiol Cell Physiol 2006, 291:C687-698.
199. Tiwari-Woodruff S.K., Buznikov A.G., Vu T.Q., Micevych P.E., Chen K., Kornblum H.I., Bronstein J.M. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. J Cell Biol 2001, 153:295-305.
200. Tokumoto Y.M., Tang D.G., Raff M.C. Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein. EMBO J 2001, 20:5261-5268.
201. Trapp B.D., Nishiyama A., Cheng D., Macklin W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol 1997, 137:459-468.
202. Tripathi R.B., Clarke L.E., Burzomato V., Kessaris N., Anderson P.N., Attwell D., Richardson W.D. Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts. J Neurosci 2011, 31:6809-6819.
203. Tsai H.H., Frost E., To V., Robinson S., Ffrench-Constant C., Geertman R., Ransohoff R.M., Miller R.H. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell 2002, 110:373-383.
204. Tsai H.H., Macklin W.B., Miller R.H. Netrin-1 is required for the normal development of spinal cord oligodendrocytes. J Neurosci 2006, 26:1913-1922.
205. Tsai H.H., Tessier-Lavigne M., Miller R.H. Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Development 2003, 130:2095-2105.
206. Umemori H., Sato S., Yagi T., Aizawa S., Yamamoto T. Initial events of myelination involve Fyn tyrosine kinase signalling. Nature 1994, 367:572-576.
207. Vallstedt A., Klos J.M., Ericson J. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 2005, 45:55-67.
208. van Heyningen P., Calver A.R., Richardson W.D. Control of progenitor cell number by mitogen supply and demand. Curr Biol 2001, 11:232-241.
209. Vogl M.R., Reiprich S., Kuspert M., Kosian T., Schrewe H., Nave K.A., Wegner M. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci 2013, 33:6679-6690.
210. Vondran M.W., Clinton-Luke P., Honeywell J.Z., Dreyfus C.F. BDNF+/-mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain. Glia 2010, 58:848-856.
211. Wang S., Sdrulla A.D., diSibio G., Bush G., Nofziger D., Hicks C., Weinmaster G., Barres B.A. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron 1998, 21:63-75.
212. Wang S.Z., Dulin J., Wu H., Hurlock E., Lee S.E., Jansson K., Lu Q.R. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Development 2006, 133:3389-3398.
213. Wang Z., Colognato H., Ffrench-Constant C. Contrasting effects of mitogenic growth factors on myelination in neuron-oligodendrocyte co-cultures. Glia 2007, 55:537-545.
214. Watkins T.A., Emery B., Mulinyawe S., Barres B.A. Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron 2008, 60:555-569.
215. Wei Q., Miskimins W.K., Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J Biol Chem 2005, 280:16284-16294.
216. Wolf R.M., Wilkes J.J., Chao M.V., Resh M.D. Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. J Neurobiol 2001, 49:62-78.
217. Wolswijk G., Noble M. Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells. J Cell Biol 1992, 118:889-900.
218. Wong A.W., Xiao J., Kemper D., Kilpatrick T.J., Murray S.S. Oligodendroglial expression of TrkB independently regulates myelination and progenitor cell proliferation. J Neurosci 2013, 33:4947-4957.
219. Xiao J., Ferner A.H., Wong A.W., Denham M., Kilpatrick T.J., Murray S.S. Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro. J Neurochem 2012, 122:1167-1180.
220. Xiao J., Wong A.W., Willingham M.M., van den Buuse M., Kilpatrick T.J., Murray S.S. Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes. Neurosignals 2010, 18:186-202.
221. Xin M., Yue T., Ma Z., Wu F.F., Gow A., Lu Q.R. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci 2005, 25:1354-1365.
222. Yakovlev P.A., Lecours I.R. The myelogenetic cycles of regional maturation of the brain. Regional development of the brain in early life 1967, Blackwell, Oxford. A. Minkowski (Ed.).
223. Yamaguchi W., Tamai R., Kageura M., Furuyama T., Inagaki S. Sema4D as an inhibitory regulator in oligodendrocyte development. Mol Cell Neurosci 2012, 49:290-299.
224. Yan H., Rivkees S.A. Hepatocyte growth factor stimulates the proliferation and migration of oligodendrocyte precursor cells. J Neurosci Res 2002, 69:597-606.
225. Ye F., Chen Y., Hoang T., Montgomery R.L., Zhao X.H., Bu H., Hu T., Taketo M.M., van Es J.H., Clevers H., Hsieh J., Bassel-Duby R., Olson E.N., Lu Q.R. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 2009, 12:829-838.
226. Ye P., Carson J., D'Ercole A.J. In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice. J Neurosci 1995, 15:7344-7356.
227. Ye P., Li L., Richards R.G., DiAugustine R.P., D'Ercole A.J. Myelination is altered in insulin-like growth factor-I null mutant mice. J Neurosci 2002, 22:6041-6051.
228. Yiu G., He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006, 7:617-627.
229. Young K.M., Psachoulia K., Tripathi R.B., Dunn S.-J., Cossell L., Attwell D., Tohyama K., Richardson W.D. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013, 77:873-885.
230. Yu K., McGlynn S., Matise M.P. Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development 2013, 140:1594-1604.
231. Yu Y., Chen Y., Kim B., Wang H., Zhao C., He X., Liu L., Liu W., Wu L.M., Mao M., Chan J.R., Wu J., Lu Q.R. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell 2013, 152:248-261.
232. Yuelling L.W., Waggener C.T., Afshari F.S., Lister J.A., Fuss B. Autotaxin/ENPP2 regulates oligodendrocyte differentiation in vivo in the developing zebrafish hindbrain. Glia 2012, 60:1605-1618.
233. Zeger M., Popken G., Zhang J., Xuan S., Lu Q.R., Schwab M.H., Nave K.-A., Rowitch D., D'Ercole A.J., Ye P. Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination. Glia 2007, 55:400-411.
234. Zhang H., Vutskits L., Calaora V., Durbec P., Kiss J.Z. A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells. J Cell Sci 2004, 117:93-103.
235. Zhou Q., Anderson D.J. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 2002, 109:61-73.
236. Ziskin J.L., Nishiyama A., Rubio M., Fukaya M., Bergles D.E. Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 2007, 10:321-330.