The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination

Neuropathology and Applied Neurobiology

Volumn 25, Issue 3, 1999, Pages 226-235

  Woodruff, R H ^a   Franklin, R J M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Demyelination; In situ hybridization; Lysolecithin; Myelin basic protein; Proteolipid protein; Remyelination

Indexed keywords

LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; TOLONIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; EXON; GENE EXPRESSION; MYELIN SHEATH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REMYELINIZATION; SPINAL CORD; WHITE MATTER;

ANIMALS; AUTORADIOGRAPHY; DEMYELINATING DISEASES; EXONS; FEMALE; IN SITU HYBRIDIZATION; LYSOPHOSPHATIDYLCHOLINES; MYELIN BASIC PROTEINS; MYELIN PROTEINS; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; OLIGONUCLEOTIDE PROBES; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SPINAL CORD;

EID: 0032967144     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.1999.00172.x     Document Type: Article

References (41)

1. Aruga J, Okano H, Mikoshiba K. Identification of the new isoforms of mouse myelin basic protein: the existence of exon 5a. J Neurochem 1991; 56: 1222-6
2. Barbarese E, Carson JH, Braun PE. Accumulation of the four myelin basic proteins in mouse brain during development. J Neurochem 1978; 31: 779-82
3. Blakemore WF. Invasion of Schwann cells into the spinal cord of the rat following local injections of lysolecithin. Neuropathol App Neurobiol 1976; 2: 21-39
4. Campagnoni AT. Molecular biology of myelination. In Neuroglia. Eds Kettenmann H, Ransom BR. Oxford: Oxford University Press, 1995: 555-70
5. Campagnoni AT, Pribyl TM, Campagnoni CW et al. Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J Biol Chem 1993; 268: 4930-8
6. Capello E, Voskuhl RR, McFarland HF, Raine CS. Multiple sclerosis: re-expression of a developmental gene in chronic lesions correlates with remyelination. Ann Neurol 1997; 41: 797-805
7. De Ferra F, Engh H, Hudson L et al. Alternative splicing accounts for the four forms of myelin basic protein. Cell 1985; 43: 721-7
8. de Vries H, de Jonge JC, Schrage C, van der Haar ME, Hoekstra D. Differential and cell development-dependant localization of myelin mRNAs in oligodendrocytes. J Neurosc Res 1997; 47: 479-88
9. Dickinson PJ, Fanarraga ML, Griffiths IR, Barrie JM, Kyriakides E, Montague P. Oligodendrocyte progenitors in the embryonic spinal cord express DM-20. Neuropathol Appl Neurobiol 1996; 22: 188-98
10. Diehl HJ, Schaich M, Budzinski RM, Stoffel W. Individual exons encode the integral membrane domains of human myelin proteolipid protein. Proc Natl Acad Sci USA 1986; 83: 9807-11
11. Dubois-Dalcq M, Armstrong R. The cellular and molecular events of central nervous system remyelination. Bioessays 1990; 12: 569-76
12. Fanarraga ML, Dickinson PJ, Sommer I, Montague P, Kyriakides E, Griffiths IR. Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene. Glia 1996; 18: 282-92
13. Franklin RJM. Remyelination - a regenerative process in the CNS. Neuroscientist 1999; 5: 184-91
14. Franklin RJM, Crang AJ, Blakemore WF. Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord. J Neurocytol 1991; 20: 420-30
15. Franklin RJM, Crang AJ, Blakemore WF. Repairing CNS demyelination by glial cell transplantation. In Weir's Handbook of Experimental Immunology. Eds Herzenberg LA, Weir DA, Herzenberg CA, Blackwell C. Oxford: Blackwell, 1997: 1-10
16. Gilson J, Blakemore WF. Failure of remyelination in areas of demyelination produced in the spinal cord of old rats. Neuropathol Appl Neurobiol 1993; 19: 173-81
17. Griffiths IR, Dickinson P, Montague P. Expression of the proteolipid protein gene in glial cells of the post-natal peripheral nervous system of rodents. Neuropathol Appl Neurobiol 1995; 21: 97-110
18. Griffiths IR, Montague P, Dickinson P. The proteolipid protein gene. Neuropathol Appl Neurobiol 1995; 21: 85-96
19. Hall SM, Gregson NA. The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse. J Cell Sci 1971; 9: 769-89
20. Ikenaka K, Okano H, Tamura T, Mikoshiba K. Recent advances in studies on genes for myelin proteins. Dev Growth Differ 1991; 33: 181-92
21. Jordan CA, Friedrich VL, De Ferra F, Weismiller DG, Holmes KV, Dubois-Dalcq M. Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination. Cell Mol Neurobiol 1990; 10: 3-18
22. Jordan CA, Friedrich VL, Godfraind C, Cardellechio CB, Holmes KV, Dubois-Dalcq M. Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus. Glia 1989; 2: 318-29
23. Kreutzberg GW, Blakemore WF, Graeber MB. Cellular pathology of the central nervous system. In Greenfield's Neuropathology. Eds Graham DI, Lantos PL. London: Arnold 1997: 85-156
24. Kristensson K, Holmes KV, Duchala CS, Zeller NK, Lazzarini RA, Dubois-Dalcq M. Increased levels of myelin basic protein transcripts gene in virus-induced demyelination. Nature 1986; 322: 544-7
25. Lemke G. Unwrapping the genes of myelin. Neuron 1988; 1: 535-43
26. Macklin WB, Campagnoni CW, Deininger PL, Gardinier MV. Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res 1987; 18: 383-94
27. McKay JS, Blakemore WF, Franklin RJM. The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS. Neuropath App Neurobiol 1997; 23: 50-8
28. Milner RJ, Lai C, Nave KA, Lenoir D, Ogata J, Sutcliffe JG. Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell 1985; 42: 931-9
29. Nagasato K, Farris RW, Dubois-Dalcq M, Voskuhl RR. Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE). J Neuroimmunol 1997; 72: 21-5
30. Nave KA, Lai C, Bloom FE, Milner RJ. Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. Proc Natl Acad Sci USA 1987; 84: 5665-9
31. Newman S, Kitamura K, Campagnoni AT. Identification of a cDNA coding for a fifth form of myelin basic protein in mouse. Proc Natl Acad Sci USA 1987; 84: 886-90
32. Roach A, Boylan K, Horvath S, Prusiner SB, Hood LE. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell 1983; 34: 799-806
33. Rodriguez M, Prayoonwiwat N, Howe C, Sanborn K. Proteolipid protein gene expression in demyelination and remyelination of the central nervous system: a model for multiple sclerosis. J Neuropath Exp Neurol 1994; 55: 136-43
34. Sternberger NH, Itoyama Y, Kies MW, Webster HD. Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation. Proc Natl Acad Sci USA 1978; 75: 2521-4
35. Takahashi N, Roach A, Teplow DB, Prusiner SB, Hood L. Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell 1985; 42: 139-48
36. Timsit S, Martinez S, Allinquant B, Peyron F, Puelles L, Zalc B. Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J Neurosci 1995; 15: 1012-24
37. Timsit S, Sinoway MP, Levy L et al. The DM20 protein of myelin: intracellular and surface expression patterns in transfectants. J Neurochem 1992; 58: 1936-42
38. Willard HF, Riordan JR. Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. Science 1985; 230: 940-2
39. Woodruff RH, Franklin RJM. Growth factors and remyelination in the CNS. Histol Histopath 1997; 12: 459-66
40. Woodruff RH, Franklin RJM. The expression of myelin basic protein exon 1 and exon 2 during myelination of the neonatal rat spinal cord - an in situ hybridisation study. J Neurocytol 1998; 27: 683-93
41. Yao D-L, Liu X, Hudson LD, Webster Hd. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 1995; 92: 6190-4