Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis

Experimental Neurology

Volumn 202, Issue 1, 2006, Pages 217-224

  Liebetanz, David ^a   Merkler, Doron ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Cuprizone; Demyelination; Mice; Motor learning; Multiple sclerosis; Remyelination; Wheel running

Indexed keywords

CUPRIZONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; DIET; HABITUATION; KNOCKOUT MOUSE; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; MULTIPLE SCLEROSIS; MUSCULOSKELETAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; REMYELINIZATION; TRANSGENIC MOUSE; TREATMENT WITHDRAWAL; WITHDRAWAL SYNDROME;

ANALYSIS OF VARIANCE; ANIMALS; CORPUS CALLOSUM; CUPRIZONE; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MONOAMINE OXIDASE INHIBITORS; MOTOR SKILLS; MULTIPLE SCLEROSIS; TIME FACTORS;

EID: 33748420494     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.05.032     Document Type: Article

References (20)

1. Arnett H.A., Mason J., Marino M., Suzuki K., Matsushima G.K., and Ting J.P. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4 (2001) 1116-1122
2. Barkhof F., Bruck W., de Groot C.J., Bergers E., Hulshof S., Geurts J., Polman C.H., and van der Valk P. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch. Neurol. 60 (2003) 1073-1081
3. Bishop K.M., Kruyer A., and Wahlsten D. Agenesis of the corpus callosum and voluntary wheel running in mice. Psychobiology 24 (1996) 187-194
4. Boehm S.L., Schafer G.L., Phillips T.J., Browman K.E., and Crabbe J.C. Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behav. Neurosci. 114 (2000) 401-409
5. Bruck W., Kuhlmann T., and Stadelmann C. Remyelination in multiple sclerosis. J. Neurol. Sci. 206 (2003) 181-185
6. Frohman E.M., Racke M.K., and Raine C.S. Multiple sclerosis-The plaque and its pathogenesis. N. Engl. J. Med. 354 (2006) 942-955
7. Grillner S., and Wallen P. Central pattern generators for locomotion, with special reference to vertebrates. Annu. Rev. Neurosci. 8 (1985) 233-261
8. Hiremath M.M., Saito Y., Knapp G.W., Ting J.P., Suzuki K., and Matsushima G.K. Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice. J. Neuroimmunol. 92 (1998) 38-49
9. Liebetanz D., Hagemann K., von Lewinski F., Kahler E., and Paulus W. Extensive exercise is not harmful in amyotrophic lateral sclerosis. Eur. J. Neurosci. 20 (2004) 3115-3120
10. Lipp H.P., and Wahlsten D. In: Driscoll P. (Ed). Absence of the Corpus Callosum (1992), Birkhäuser, Basel 217-252
11. Mason J.L., Langaman C., Morell P., Suzuki K., and Matsushima G.K. Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol. Appl. Neurobiol. 27 (2001) 50-58
12. Matsushima G.K., and Morell P. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol. 11 (2001) 107-116
13. Merkler D., Boretius S., Stadelmann C., Ernsting T., Michaelis T., Frahm J., and Bruck W. Multicontrast MRI of remyelination in the central nervous system. NMR Biomed. 18 (2005) 395-403
14. Morell P., Barrett C.V., Mason J.L., Toews A.D., Hostettler J.D., Knapp G.W., and Matsushima G.K. Gene expression in brain during cuprizone-induced demyelination and remyelination. Mol. Cell. Neurosci. 12 (1998) 220-227
15. Pearson, K., 1976. The control of walking. Sci. Am. 235, 72-82, 83.
16. Prineas J.W., and Connell F. Remyelination in multiple sclerosis. Ann. Neurol. 5 (1979) 22-31
17. Rossignol S., Dubuc R., and Gossard J.P. Dynamic sensorimotor interactions in locomotion. Physiol. Rev. 86 (2006) 89-154
18. Rustay N.R., Wahlsten D., and Crabbe J.C. Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behav. Brain Res. 141 (2003) 237-249
19. Schalomon P.M., and Wahlsten D. Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum. Brain Res. Bull. 57 (2002) 27-33
20. Wahlsten D., Crabbe J.C., and Dudek B.C. Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum. Behav. Brain Res. 125 (2001) 23-32