Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination

Journal of Neuroscience

Volumn 17, Issue 17, 1997, Pages 6657-6668

  Awatramani, R ^a   Scherer, S S ^a   Grinspan, Judith B ^a   Collarini, E ^a   Skoff, R ^a   O'Hagan, D ^a   Garbern, J ^a   Kamholz, J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain development; DnA binding; Gene expression; Gtx; Myelination; Oligodendrocytes

Indexed keywords

DNA BINDING PROTEIN; DNA FRAGMENT; HOMEODOMAIN PROTEIN; MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BINDING SITE; BRAIN DEVELOPMENT; DNA BINDING; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; MYELINATION; NONHUMAN; NORTHERN BLOTTING; OLIGODENDROGLIA; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RAT; REGULATORY MECHANISM; SCHWANN CELL; WHITE MATTER;

EID: 16944363712     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-17-06657.1997     Document Type: Article

References (22)

1. Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in PFP1/PDX1-deficient mice. Development 122:1409-1416.
2. Armstrong RC, Kim JG, Hudson LD (1995) Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-Binding protein, in developing oligodendrocytes. Glia 14:303-321.
3. Arroyo EJ, Wegener M, Rosenfeld MG, Kamholz J, Scherer SS (1994) Oligodendrocyte precursors express Tst-1 (SCIP/Oct-6) in vivo. Soc Neurosci Abstr 20:456.
4. Berndt JA, Kim JG, Hudson LD (1992) Identification of cis-regulatory elements in the myelin proteolipid protein (PLP) gene. J Biol Chem 267:14730-14737.
5. Bernier L, Alvarez F, Norgard EM, Raible DW, Mentaberry A, Schembri JG, Sabatini DD, Colman DR (1987) Molecular cloning of a 2′,3′-cyclic nucleotide 3′-phosphodiesterase: mRNAs with different 5′ ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci 7:2703-2710.
6. Bermingham JR, Scherer SS, O'Connell S, Arroyo E, Kalla KK, Powell FL, Rosenfeld MG (1996) Tst-1/Oct-6/SCIP reglates a unique step in peripheral myelination and is required for normal respiration. Genes Dev 10:1751-1762.
7. Bharucha VA, Peden KWC, Tennekoon GI (1994) SV40 large T antigen with c-Jun downregulates myelin Po gene expression: a mechanism for papovaviral T antigen-mediated demyelination. Neuron 12:627-637.
8. Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN (1988) Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature 333:629-635.
9. Boison D, Stoffel W (1989) Myelin-deficient rat: a point mutation in exon III (A - C, Thr75 - Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. EMBO J 8:3295-3302.
10. Brenner M, Kisseberth WC, Su Y, Besnard F, Messing A (1994) GFAP promoter directs astrocyte-specific expression in transgenic mice. J Neurosci 14:1030-1037.
11. Bruno MD, Bohinski RJ, Muelsman KM, Whitsett JA, Korfhagen TR (1995) Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1. J Biol Chem 270:6531-6536.
12. Campagnoni AT (1988) Molecular biology of myelin proteins from the central nervous system. J Neurochem 51:1-14.
13. Chirgwin JM, Przbyla AE, MacDonald RJ, Rutter W (1979) Isoation of biologoically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
14. Civitareale R, Lonigro R, Sinclair MJ, DiLauro R (1989) A thyroid-nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J 8:2537-2542.
15. Collarini EJ, Kuhn R, Marshall CJ, Monuki ES, Lemke G, Richardson WD (1992) Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development 116:193-200.
16. Dubois-Dalcq M, Behar T, Hudson L, Lazzarini RA (1986) Emergence of three myelin proteins in oligodendrocytes cultured without neurons. J Cell Biol 102:384-392.
17. Ellis D, Malcom S (1994) Proteolipid protein gene dosage effect in Pelizaeus-Merzbacher disease. Nat Genet 6:333-334.
18. Foran DR, Peterson AC (1992) Myelin acquisition in the central nervous system of the mousee revealed by an MBP-Lac Z transgene. J Neurosci 12:4890-4897.
19. Garafalo L, Foran D, Peterson A (1995) Myelin basic protein promoter elements resulting in high level sustained expression in oligodendrocytes and Schwann cells in transgenic mice. Soc Neurosci Abstr 21:320.
20. Wright PA, Duchala CS, Readhead C, Macklin WB (1993) A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol 123:443-454.
21. Yu WP, Collarini EJ, Pringle NP, Richardson WD (1994) Embryonic expression of myelin genes: evidence for a focal source of oligodendrocyte precursors in the ventricular zone of the neural tube. Neuron 12:1353-1362.
22. Zeller NK, Hunkeler MJ, Campagnoni AT, Sprague J, Lazzarini RA (1984) Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone. Proc Natl Acad Sci USA 81:18-21.