Integrins: Bidirectional, allosteric signaling machines

Cell

Volumn 110, Issue 6, 2002, Pages 673-687

  Hynes, Richard O ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; INTEGRIN; INTEGRIN RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1;

ALLOSTERISM; ALPHA CHAIN; AUTOIMMUNE DISEASE; BINDING SITE; BLOOD CELL; CELL ADHESION; CELL FUNCTION; CELL MEMBRANE; CELL STRUCTURE; CONFORMATIONAL TRANSITION; CYTOLOGY; CYTOSKELETON; GLANZMANN DISEASE; HUMAN; LIGAND BINDING; METAZOON; MODEL; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOSIS;

METAZOA;

EID: 0037145037     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00971-6     Document Type: Article

References (119)

1. Alonso J.L., Essafi M., Xiong J.P., Stehle T., Arnaout M.A. Does the integrin alphaA domain act as a ligand for its betaA domain? Curr. Biol. 12:2002;R340-R342.
2. Armulik A., Nilsson I., von Heijne G., Johansson S. Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits. J. Biol. Chem. 274:1999;37030-37034.
3. Assoian R.K. Anchorage-dependent cell cycle progression. J. Cell Biol. 136:1997;1-4.
4. Bajt M.L., Loftus J.C. Mutation of a ligand binding domain of beta 3 integrin. Integral role of oxygenated residues in alpha IIb beta 3 (GPIIb-IIIa) receptor function. J. Biol. Chem. 269:1994;20913-20919.
5. Bazzoni G., Hemler M.E. Are changes in integrin affinity and conformation overemphasized? Trends Biochem. Sci. 23:1998;30-34.
6. Beer J.H., Springer K.T., Coller B.S. Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor. Blood. 79:1992;117-128.
7. Beglova N., Blacklow S.C., Takagi J., Springer T.A. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat. Struct. Biol. 9:2002;282-287.
8. Bertoni A., Tadokoro S., Eto K., Pampori N., Parise L.V., White G.C., Shattil S.J. Relationships between Rap1b, affinity modulation of integrin aIIbB3 and the actin cytoskeleton. J. Biol. Chem. 277:2002;25715-25721.
9. Bos J.L., de Rooij J., Reedquist K.A. Rap1 signalling. adhering to new models Nat. Rev. Mol. Cell. Biol. 2:2001;369-377.
10. Bouvard D., Brakebusch C., Gustafsson E., Aszodi A., Bengtsson T., Berna A., Fassler R. Functional consequences of integrin gene mutations in mice. Circ. Res. 89:2001;211-223.
11. Brown E.J., Frazier W.A. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11:2001;130-135.
12. Burke R.D. Invertebrate integrins. structure, function, and evolution Int. Rev. Cytol. 191:1999;257-284.
13. Burridge K., Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12:1996;463-518.
14. Calderwood D.A., Zent R., Grant R., Rees D.J., Hynes R.O., Ginsberg M.H. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J. Biol. Chem. 274:1999;28071-28074.
15. Calderwood D.A., Shattil S.J., Ginsberg M.H. Integrins and actin filaments. reciprocal regulation of cell adhesion and signaling J. Biol. Chem. 275:2000;22607-22610.
16. Calderwood D.A., Yan B., de Pereda J.M., Alvarez B.G., Fujioka Y., Liddington R.C., Ginsberg M.H. The phosphotyrosine binding-like domain of talin activates integrins. J. Biol. Chem. 277:2002;21749-21758.
17. Clark E.A., Brugge J.S. Integrins and signal transduction pathways. the road taken Science. 268:1995;233-239.
18. Clark, E.A., and Hynes, R.O. (1997). Meeting report. 1997 Keystone symposium on signal transduction by cell adhesion receptors. BBA Reviews on Cancer. 1333: R9-R16.
19. Coller B.S. Activation affects access to the platelet receptor for adhesive glycoproteins. J. Cell Biol. 103:1986;451-456.
20. Coller B.S. Platelet GPIIb/IIIa antagonists. the first anti-integrin receptor therapeutics J. Clin. Invest. 99:1997;1467-1471.
21. Critchley D.R., Holt M.R., Barry S.T., Priddle H., Hemmings L., Norman J. Integrin-mediated cell adhesion. the cytoskeletal connection Biochem. Soc. Symp. 65:1999;79-99.
22. Danen E.H., Yamada K.M. Fibronectin, integrins, and growth control. J. Cell. Physiol. 189:2001;1-13.
23. De Arcangelis A., Georges-Labouesse E. Integrin and ECM functions. roles in vertebrate development Trends Genet. 16:2000;389-395.
24. D'Souza S.E., Ginsberg M.H., Burke T.A., Lam S.C., Plow E.F. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science. 242:1988;91-93.
25. Du X., Gu M., Weisel J.W., Nagaswami C., Bennett J.S., Bowditch R., Ginsberg M.H. Long range propagation of conformational changes in integrin alpha IIb beta 3. J. Biol. Chem. 268:1993;23087-23092.
26. Emsley J., King S.L., Bergelson J.M., Liddington R.C. Crystal structure of the I domain from integrin alpha2beta1. J. Biol. Chem. 272:1997;28512-28517.
27. Emsley J., Knight C.G., Farndale R.W., Barnes M.J., Liddington R.C. Structural basis of collagen recognition by integrin alpha2beta1. Cell. 101:2000;47-56.
28. Etzioni A., Doerschuk C.M., Harlan J.M. Of man and mouse. leukocyte and endothelial adhesion molecule deficiencies Blood. 94:1999;3281-3288.
29. Fenczik C.A., Sethi T., Ramos J.W., Hughes P.E., Ginsberg M.H. Complementation of dominant suppression implicates CD98 in integrin activation. Nature. 390:1997;81-85.
30. Frisch S.M., Screaton R.A. Anoikis mechanisms. Curr. Opin. Cell Biol. 13:2001;555-562.
31. Garcia A.J., Schwarzbauer J.E., Boettiger D. Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry. 41:2002;9063-9069.
32. Giancotti F.G., Ruoslahti E. Integrin signaling. Science. 285:1999;1028-1032.
33. Ginsberg M.H., Du X., Plow E.F. Inside-out integrin signalling. Curr. Opin. Cell Biol. 4:1992;766-771.
34. Gottlieb A., Krueger J.G., Bright R., Ling M., Lebwohl M., Kang S., Feldman S., Spellman M., Wittkowski K., Ochs H.D.et al. Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis. J. Am. Acad. Dermatol. 42:2000;428-435.
35. Hantgan R.R., Paumi C., Rocco M., Weisel J.W. Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization. Biochemistry. 38:1999;14461-14474.
36. 3. J. Cell Biol. 141:1998;1685-1695.
37. Hemler M.E. Integrin associated proteins. Curr. Opin. Cell Biol. 10:1998;578-585.
38. Hemler M.E. Integrins. Anchor and Adhesion Proteins T., Kreis and R., Vale Guidebook to the Extracellular Matrix. 1999;Sambrook and Tooze Publication at Oxford University Press, Oxford. 196-212.pp.
39. Hemler M.E. Specific tetraspanin functions. J. Cell Biol. 155:2001;1103-1107.
40. Hogg N., Bates P.A. Genetic analysis of integrin function in man. LAD-1 and other syndromes Matrix Biol. 19:2000;211-222.
41. Huang C., Zang Q., Takagi J., Springer T.A. Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain. J. Biol. Chem. 275:2000;21514-21524.
42. Hughes A.L. Evolution of the integrin alpha and beta protein families. J. Mol. Evol. 52:2001;63-72.
43. Hughes P.E., Pfaff M. Integrin affinity modulation. Trends Cell Biol. 8:1998;359-364.
44. Hughes P.E., O'Toole T.E., Ylanne J., Shattil S.J., Ginsberg M.H. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J. Biol. Chem. 270:1995;12411-12417.
45. Hughes P.E., Diaz-Gonzalez F., Leong L., Wu C., McDonald J.A., Shattil S.J., Ginsberg M.H. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J. Biol. Chem. 271:1996;6571-6574.
46. Hughes P.E., Renshaw M.W., Pfaff M., Forsyth J., Keivens V.M., Schwartz M.A., Ginsberg M.H. Suppression of integrin activation. a novel function of a Ras/Raf-initiated MAP kinase pathway Cell. 88:1997;521-530.
47. Humphries M.J. Integrin structure. Biochem. Soc. Trans. 28:2000;311-339.
48. Humphries M.J. Insights into integrin-ligand binding and activation from the first crystal structure. Arthritis Res. 4:2002;S69-S78.
49. Hynes R.O. Integrins. a family of cell surface receptors Cell. 48:1987;549-554.
50. Hynes R.O. Integrins. versatility, modulation, and signaling in cell adhesion Cell. 69:1992;11-25.
51. Hynes R.O. Targeted mutations in cell adhesion genes. what have we learned from them? Dev. Biol. 180:1996;402-412.
52. Hynes R.O. A reevaluation of integrins as regulators of angiogenesis. Nat. Med. 8:2002;918-921.
53. Hynes R.O., Zhao Q. The evolution of cell adhesion. J. Cell Biol. 150:2000;F89-F96.
54. Jackson D.Y. Alpha 4 integrin antagonists. Curr. Pharm. Des. 8:2002;1229-1253.
55. Katagiri K., Hattori M., Minato N., Irie S., Takatsu K., Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein.kinase C and phosphatidylinositol-3-OH kinase. Mol. Cell. Biol. 20:2000;1956-1969.
56. Kato A. The biologic and clinical spectrum of Glanzmann's thrombasthenia. implications of integrin alpha IIb beta 3 for its pathogenesis Crit. Rev. Oncol. Hematol. 26:1997;1-23.
57. Kolesnikova T.V., Mannion B.A., Berditchevski F., Hemler M.E. Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem. 2:2001;10-20.
58. Lambright D.G., Sondek J., Bohm A., Skiba N.P., Hamm H.E., Sigler P.B. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature. 379:1996;311-319.
59. Lauffenburger D.A., Horwitz A.F. Cell migration. a physically integrated molecular process Cell. 84:1996;359-369.
60. Lee J.O., Bankston L.A., Arnaout M.A., Liddington R.C. Two conformations of the integrin A-domain (I-domain). a pathway for activation? Structure. 3:1995;1333-1340. a.
61. Lee J.O., Rieu P., Arnaout M.A., Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell. 80:1995;631-638. b.
62. Li R., Babu C.R., Lear J.D., Wand A.J., Bennett J.S., DeGrado W.F. Oligomerization of the integrin alphaIIbbeta3. roles of the transmembrane and cytoplasmic domains Proc. Natl. Acad. Sci. USA. 98:2001;12462-12467.
63. Liddington R.C. Will the real integrin please stand up? Structure. 10:2002;605-607.
64. Liddington R.C., Ginsberg M.H. Integrin activation takes shape. J. Cell Biol. 158:2002;833-839.
65. Loftus J.C., Liddington R.C. Cell adhesion in vascular biology. New insights into integrin-ligand interaction. J. Clin. Invest. 99:1997;2302-2306.
66. Loftus J.C., Smith J.W., Ginsberg M.H. Integrin-mediated cell adhesion. the extracellular face J. Biol. Chem. 269:1994;25235-25238.
67. Lu C., Shimaoka M., Ferzly M., Oxvig C., Takagi J., Springer T.A. An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond. Proc. Natl. Acad. Sci. USA. 98:2001;2387-2392. a.
68. Lu C., Takagi J., Springer T.A. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. J. Biol. Chem. 276:2001;14642-14648. b.
69. Lu C., Shimaoka M., Zang Q., Takagi J., Springer T.A. Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains. Proc. Natl. Acad. Sci. USA. 98:2001;2393-2398. c.
70. Martel V., Racaud-Sultan C., Dupe S., Marie C., Paulhe F., Galmiche A., Block M.R., Albiges-Rizo C. Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J. Biol. Chem. 276:2001;21217-21227.
71. Miranti C.K., Brugge J.S. Sensing the environment. a historical perspective on integrin signal transduction Nat. Cell Biol. 4:2002;E83-E90.
72. Mould A.P., Askari J.A., Aota S., Yamada K.M., Irie A., Takada Y., Mardon H.J., Humphries M.J. Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit. J. Biol. Chem. 272:1997;17283-17292.
73. Mould A.P., Askari J.A., Barton S., Kline A.D., McEwan P.A., Craig S.E., Humphries M.J. Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. J. Biol. Chem. 277:2002;19800-19805.
74. O'Neill S., Robinson A., Deering A., Ryan M., Fitzgerald D.J., Moran N. The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity. J. Biol. Chem. 275:2000;36984-36990.
75. O'Toole T.E., Mandelman D., Forsyth J., Shattil S.J., Plow E.F., Ginsberg M.H. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science. 254:1991;845-847.
76. O'Toole T.E., Katagiri Y., Faull R.J., Peter K., Tamura R., Quaranta V., Loftus J.C., Shattil S.J., Ginsberg M.H. Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124:1994;1047-1059.
77. Patil S., Jedsadayanmata A., Wencel-Drake J.D., Wang W., Knezevic I., Lam S.C. Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail. J. Biol. Chem. 274:1999;28575-28583.
78. Pearson M.A., Reczek D., Bretscher A., Karplus P.A. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell. 101:2000;259-270.
79. Plow E.F., Haas T.A., Zhang L., Loftus J., Smith J.W. Ligand binding to integrins. J. Biol. Chem. 275:2000;21785-21788.
80. Pulkkinen L., Uitto J. Mutation analysis and molecular genetics of epidermolysis bullosa. Matrix Biol. 18:1999;29-42.
81. Qu A., Leahy D.J. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc. Natl. Acad. Sci. USA. 92:1995;10277-10281.
82. Qu A., Leahy D.J. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure. 4:1996;931-942.
83. Rosenkranz A.R., Mayadas T.N. Leukocyte-endothelial cell interactions - lessons from knockout mice. Exp. Nephrol. 7:1999;125-136.
84. Scarborough R.M., Gretler D.D. Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers. novel parenteral and potential oral antithrombotic agents J. Med. Chem. 43:2000;3453-3473.
85. Schoenwaelder S.M., Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11:1999;274-286.
86. Schwartz M.A., Assoian R.K. Integrins and cell proliferation. regulation of cyclin-dependent kinases via cytoplasmic signaling pathways J. Cell Sci. 114:2001;2553-2560.
87. Schwartz M.A., Ginsberg M.H. Networks and crosstalk. integrin signalling spreads Nat. Cell Biol. 4:2002;E65-E68.
88. Schwartz M.A., Schaller M.D., Ginsberg M.H. Integrins. emerging paradigms of signal transduction Annu. Rev. Cell Dev. Biol. 11:1995;549-599.
89. Sheppard D. In vivo functions of integrins. lessons from null mutations in mice Matrix Biol. 19:2000;203-209.
90. Shimaoka M., Lu C., Palframan R.T., von Andrian U.H., McCormack A., Takagi J., Springer T.A. Reversibly locking a protein fold in an active conformation with a disulfide bond. integrin alphaL I domains with high affinity and antagonist activity in vivo Proc. Natl. Acad. Sci. USA. 98:2001;6009-6014.
91. Shimaoka M., Takagi J., Springer T.A. Conformational regulation of integrin structure and function. Annu. Rev. Biophys. Biomol. Struct. 31:2002;485-516.
92. Sondek J., Bohm A., Lambright D.G., Hamm H.E., Sigler P.B. Crystal structure of a G-protein beta gamma dimer at 2.1 Å resolution. Nature. 379:1996;369-374.
93. Springer T.A. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc. Natl. Acad. Sci. USA. 94:1997;65-72.
94. Takada Y., Puzon W. Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268:1993;17597-17601.
95. Takagi J., Erickson H.P., Springer T.A. C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. Nat. Struct. Biol. 8:2001;412-416.
96. Takagi J., Petre B.M., Walz T., Springer T.A. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 110:2002;599-611.
97. Tozer E.C., Liddington R.C., Sutcliffe M.J., Smeeton A.H., Loftus J.C. Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit. J. Biol. Chem. 271:1996;21978-21984.
98. Tuckwell D. Evolution of von Willebrand factor A (VWA) domains. Biochem. Soc. Trans. 27:1999;835-840.
99. Tuckwell D.S., Humphries M.J. A structure prediction for the ligand-binding region of the integrin beta subunit. evidence for the presence of a von Willebrand factor A domain FEBS Lett. 400:1997;297-303.
100. Ulmer T.S., Yaspan B., Ginsberg M.H., Campbell I.D. NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry. 40:2001;7498-7508.
101. Vallar L., Melchior C., Plancon S., Drobecq H., Lippens G., Regnault V., Kieffer N. Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein. J. Biol. Chem. 274:1999;17257-17266.
102. van der Flier A., Sonnenberg A. Function and interactions of integrins. Cell Tissue Res. 305:2001;285-298.
103. 3 "inside-out" activation as regulated by its cytoplasmic face. Cell. 110:2002;587-597.
104. Wall M.A., Coleman D.E., Lee E., Iniguez-Lluhi J.A., Posner B.A., Gilman A.G., Sprang S.R. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 83:1995;1047-1058.
105. Weisel J.W., Nagaswami C., Vilaire G., Bennett J.S. Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy. J. Biol. Chem. 267:1992;16637-16643.
106. Weljie A.M., Hwang P.M., Vogel H.J. Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits. Proc. Natl. Acad. Sci. USA. 99:2002;5878-5883.
107. Whittaker C.A., Hynes R.O. Distribution and evolution of the von Willebrand/Integrin A domain. a widely dispersed domain with roles in cell adhesion and elsewhere Mol. Biol. Cell. in press, published online August 6,2002. 10.1091/mbc.E02-05-0259
108. Williams M.J., Hughes P.E., O'Toole T.E., Ginsberg M.H. The inner world of cell adhesion. integrin cytoplasmic domains Trends Cell Biol. 4:1994;109-112.
109. Woodside D.G., Liu S., Ginsberg M.H. Integrin activation. Thromb. Haemost. 86:2001;316-323.
110. Wu C., Dedhar S. Integrin-linked kinase (ILK) and its interactors. a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes J. Cell Biol. 155:2001;505-510.
111. Xiong J.P., Li R., Essafi M., Stehle T., Arnaout M.A. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J. Biol. Chem. 275:2000;38762-38767.
112. Xiong J.P., Stehle T., Diefenbach B., Zhang R., Dunker R., Scott D.L., Joachimiak A., Goodman S.L., Arnaout M.A. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 294:2001;339-345.
113. Xiong J.P., Stehle T., Zhang R., Joachimiak A., Frech M., Goodman S.L., Arnaout M.A. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 296:2002;151-155.
114. Yamada K.M., Miyamoto S. Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7:1995;681-689.
115. Yan B., Smith J.W. A redox site involved in integrin activation. J. Biol. Chem. 275:2000;39964-39972.
116. Yan B., Smith J.W. Mechanism of integrin activation by disulfide bond reduction. Biochemistry. 40:2001;8861-8867.
117. Yan B., Calderwood D.A., Yaspan B., Ginsberg M.H. Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J. Biol. Chem. 276:2001;28164-28170.
118. Zamir E., Geiger B. Molecular complexity and dynamics of cell-matrix adhesions. J. Cell Sci. 114:2001;3583-3590.
119. Zhang Z., Vuori K., Wang H., Reed J.C., Ruoslahti E. Integrin activation by R-ras. Cell. 85:1996;61-69.