Efficient central nervous system remyelination requires T cells

Annals of Neurology

Volumn 53, Issue 5, 2003, Pages 680-684

  Bieber, Allan J ^a   Kerr, Scott ^a   Rodriguez, Moses ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; LYSOPHOSPHATIDYLCHOLINE; RAG1 PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BRAIN INJURY; CENTRAL NERVOUS SYSTEM; DEMYELINATION; GENETIC ANALYSIS; IMMUNE FUNCTION TEST; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REMYELINIZATION; SPINAL CORD; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TISSUE REPAIR;

ANIMALS; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DEMYELINATING DISEASES; LYSOPHOSPHATIDYLCHOLINES; MICE; MICE, INBRED C57BL; MYELIN SHEATH;

EID: 0038077547     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10578     Document Type: Article

References (14)

1. Njenga MK, Murray PD, McGavern D, et al. Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus. J Neuropathol Exp Neurol 1999;58:78-91.
2. Schwartz M, Moalem G, Leibowitz-Amit R, Cohen IR. Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci 1999;22:295-299.
3. Arnett HA, Mason J, Marino M, et al. TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 2001;4:1116-1122.
4. Kotter MR, Setzu A, Sim FJ, et al. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 2001;35:204-212.
5. Bieber AJ, Warrington A, Pease LR, Rodriguez M. Humoral autoimmunity as a mediator of CNS repair. Trends Neurosci 2001;24:S39-S44.
6. Bieber AJ, Warrington A, Asakura K, et al. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia 2002;37:241-249.
7. Pavelko KD, van Engelen BG, Rodriguez M. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J Neurosci 1998;18:2498-2505.
8. McGavern DB, Murray PD, Rodriguez M. Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury. J Neurosci Res 1999;58:492-504.
9. Mombaerts P, Iacomini J, Johnson RS, et al. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 1992;68:869-877.
10. Ousman SS, David S. Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord. Glia 2000;30:92-104.
11. Ousman SS, David S. MIP-1α, MCP-1, GM-CSF, and TNF-α control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord. J Neurosci 2001;21:4649-4656.
12. Hohlfeld R, Kerschensteiner M, Stadelmann C, et al. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J Neuroimmunol 2000;107:161-166.
13. Barouch R, Schwartz M. Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: implications for protective autoimmunity. FASEB J 2002;16:1304-1306.
14. Franklin RJ, Hinks GL, Woodruff RH, et al. What roles do growth factors play in CNS remyelination? Prog Brain Res 2001;132:185-193.