Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS

Molecular and Cellular Neuroscience

Volumn 27, Issue 3, 2004, Pages 247-254

  Fancy, Stephen P J ^a   Zhao, Chao ^a   Franklin, Robin J M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; DATA ANALYSIS; DEMYELINATION; DEVELOPMENT; EMBRYO; FEMALE; HUMAN; HYPOTHESIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REMYELINIZATION; STEM CELL;

ANIMALIA; ERINACEIDAE; RODENTIA;

EID: 7244226354     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2004.06.015     Document Type: Article

References (42)

1. R.C. Armstrong, T.Q. Le, E.E. Frost, R.C. Borke, and A.C. Vana Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter J. Neurosci. 22 2002 8574 8585
2. H.A. Arnett, J. Mason, M. Marino, K. Suzuki, G.K. Matsushima, and J.P.Y. Ting TNFα promotes proliferation of oligodendrocyte progenitors and remyelination Nat. Neurosci. 4 2001 1116 1122
3. H.A. Arnett, Y. Wang, G.K. Matsushima, K. Suzuki, and J.P. Ting Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration J. Neurosci. 23 2003 9824 9832
4. N.C. Bambakidis, R.Z. Wang, L. Franic, and R.H. Miller Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury J. Neurosurg. 9 2003 70 75
5. S. Belachew, R. Chittajallu, A.A. Aguirre, X. Yuan, M. Kirby, S. Anderson, and V. Gallo Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons J. Cell Biol. 161 2003 169 186
6. J. Briscoe, L. Sussel, P. Serup, D. Hartigan-O'Connor, T.M. Jessell, J.L. Rubenstein, and J. Ericson Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling Nature 398 1999 622 627
7. S. Chandran, H. Kato, D. Gerreli, A. Compston, C.N. Svendsen, and N.D. Allen FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway Development 130 2003 6599 6609
8. A. Chang, A. Nishiyama, J. Peterson, J. Prineas, and B.D. Trapp NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions J. Neurosci. 20 2000 6404 6412
9. M.R.L. Dawson, A. Polito, J.M. Levine, and R. Reynolds NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS Mol. Cell. Neurosci. 24 2003 476 488
10. C. ffrench-Constant, and M.C. Raff Proliferating bipotential glial progenitor cells in adult rat optic nerve Nature 319 1986 499 502
11. R.J.M. Franklin Why does remyelination fail in multiple sclerosis? Nat. Rev., Neurosci. 3 2002 705 714
12. H. Fu, Y. Qi, M. Tan, J. Cai, H. Takebayashi, M. Nakafuku, W. Richardson, and M. Qiu Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation Development 129 2002 681 693
13. J.M. Gensert, and J.E. Goldman Endogenous progenitors remyelinate demyelinated axons in the adult CNS Neuron 19 1997 197 203
14. J.M. Gensert, and J.E. Goldman Heterogeneity of cycling glial progenitors in the adult mammalian cortex and white matter J. Neurobiol. 48 2001 75 86
15. G.L. Hinks, and R.J.M. Franklin Distinctive patterns of PDGF-A, FGF-2, IGF-I and TGF-beta1 gene expression during remyelination of experimentally- induced spinal cord demyelination Mol. Cell. Neurosci. 14 1999 153 168
16. P.J. Horner, A.E. Power, G. Kempermann, H.G. Kuhn, T.D. Palmer, J. Winkler, L.J. Thal, and F.H. Gage Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord J. Neurosci. 20 2000 2218 2228
17. T. Kondo, and M. Raff Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells Science 289 2000 1754 1757
18. J.M. Levine, and R. Reynolds Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination Exp. Neurol. 160 1999 333 347
19. Y. Liu, and M. Rao Oligodendrocytes, GRPs and MNOPs Trends Neurosci. 26 2003 410 412
20. Q.R. Lu, D. Yuk, J.A. Alberta, Z. Zhu, I. Pawlitsky, J. Chan, A.P. McMahon, C.D. Stiles, and D.H. Rowitch Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system Neuron 25 2000 317 329
21. Q.R. Lu, T. Sun, Z. Zhu, N. Ma, M. Garcia, C.D. Stiles, and D.H. Rowitch Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection Cell 109 2002 75 86
22. J.L. Mason, P. Ye, K. Suzuki, A.J. D'Ercole, and G.K. Matsushima Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination J. Neurosci. 20 2000 5703 5708
23. J.L. Mason, K. Suzuki, D.D. Chaplin, and G.K. Matsushima Interleukin-1beta promotes repair of the CNS J. Neurosci. 21 2001 7046 7052
24. M. Noble, C. Proschel, and M. Mayer-Proschel Getting a GR(i)P on oligodendrocyte development Dev. Biol. 265 2004 33 52
25. J. Penderis, S.A. Shields, and R.J.M. Franklin Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat CNS Brain 126 2003 1382 1391
26. Y. Qi, J. Cai, Y. Wu, R. Wu, J. Lee, H. Fu, M. Rao, L. Sussel, J. Rubenstein, and M. Qiu Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor Development 128 2001 2723 2733
27. W.D. Richardson, H.K. Smith, T. Sun, N.P. Pringle, A. Hall, and R.H. Woodruff Oligodendrocyte lineage and the motor neuron connection Glia 29 2000 136 142
28. F.J. Sim, G.L. Hinks, and R.J.M. Franklin The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally-induced demyelinating lesions in young and old rat brain Neurosci. 100 2000 131 139
29. F.J. Sim, C. Zhao, J. Penderis, and R.J.M. Franklin The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation J. Neurosci. 22 2002 2451 2459
30. F.J. Sim, C. Zhao, W-W. Li, A. Lakatos, and R.J.M. Franklin Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS Mol. Cell. Neurosci. 20 2002 669 682
31. N. Spassky, C. Goujet-Zalc, E. Parmantier, C. Olivier, S. Martinez, A. Ivanova, K. Ikenaka, W. Macklin, I. Cerruti, B. Zalc, and J.L. Thomas Multiple restricted origin of oligodendrocytes J. Neurosci. 18 1998 8331 8343
32. T. Sun, Y. Echelard, R. Lu, D.I. Yuk, S. Kaing, C.D. Stiles, and D.H. Rowitch Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube Curr. Biol. 11 2001 1413 1420
33. T. Sun, H. Dong, L. Wu, M. Kane, D.H. Rowitch, and C.D. Stiles Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex J. Neurosci. 23 2003 9547 9556
34. H. Takebayashi, Y. Nabeshima, S. Yoshida, O. Chisaka, K. Ikenaka, and Y. Nabeshima The basic helixâ€"loopâ€"helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages Curr. Biol. 12 2002 1157 1163
35. E. Traiffort, K.L. Moya, H. Faure, R. Hassig, and M. Ruat High expression and anterograde axonal transport of aminoterminal Sonic hedgehog in the adult hamster brain Eur. J. Neurosci. 14 2001 839 850
36. M. Watanabe, Y. Toyama, and A. Nishiyama Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion J. Neurosci. Res. 69 2002 826 836
37. M. Watanabe, T. Hadzic, and A. Nishiyama Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination Glia 46 2004 311 322
38. G. Wolswijk Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells J. Neurosci. 18 1998 601 609
39. R.H. Woodruff, and R.J.M. Franklin Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide and complement/anti- galactocerebrosideâ€"A comparative study Glia 25 1999 216 228
40. R.H. Woodruff, M. Fruttiger, W.D. Richardson, and R.J.M. Franklin Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination Mol. Cell. Neurosci. 25 2003 252 262
41. Q. Zhou, S. Wang, and D.J. Anderson Identification of a novel family of oligodendrocyte lineage-specific basic helixâ€"loop†"helix transcription factors Neuron 25 2000 331 343
42. Q. Zhou, G. Choi, and D.J. Anderson The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2 Neuron 31 2001 791 807