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Volumn 9, Issue 5, 1999, Pages 603-615

Conservation and divergence of axon guidance mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; RECEPTOR;

EID: 0032873838     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)00021-5     Document Type: Review
Times cited : (206)

References (106)
  • 1
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne M, Goodman CS The molecular biology of axon guidance. Science. 274:1996;1123-1133.
    • (1996) Science , vol.274 , pp. 1123-1133
    • Tessier-Lavigne, M.1    Goodman, C.S.2
  • 2
    • 0033603541 scopus 로고    scopus 로고
    • Early animal evolution: Emerging views from comparative biology and geology
    • Knoll AH, Carroll SB Early animal evolution: emerging views from comparative biology and geology. Science. 284:1999;2129-2137.
    • (1999) Science , vol.284 , pp. 2129-2137
    • Knoll, A.H.1    Carroll, S.B.2
  • 4
    • 0031569832 scopus 로고    scopus 로고
    • The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3
    • Van Raay TJ, Foskett SM, Connors TD, Klinger KW, Landes GM, Burn TC The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Genomics. 41:1997;279-282.
    • (1997) Genomics , vol.41 , pp. 279-282
    • Van Raay, T.J.1    Foskett, S.M.2    Connors, T.D.3    Klinger, K.W.4    Landes, G.M.5    Burn, T.C.6
  • 5
    • 0345711648 scopus 로고    scopus 로고
    • Divergent properties of mouse netrins
    • Puschel AW Divergent properties of mouse netrins. Mech Dev. 83:1999;65-75.
    • (1999) Mech Dev , vol.83 , pp. 65-75
    • Puschel, A.W.1
  • 6
    • 0033564372 scopus 로고    scopus 로고
    • Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors
    • Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J Neurosci. 19:1999;4938-4947.
    • (1999) J Neurosci , vol.19 , pp. 4938-4947
    • Wang, H.1    Copeland, N.G.2    Gilbert, D.J.3    Jenkins, N.A.4    Tessier-Lavigne, M.5
  • 7
    • 0345279113 scopus 로고
    • Madrid: Instituto Ramon y Cajal dal Consejo Superior de Investigaciones Cientificas; [Title translation: Histology of the vertebrate nervous system.]
    • Ramon y Cajal S: Histologie du Systeme Nerveux des Vertebres, vol 1. Madrid: Instituto Ramon y Cajal dal Consejo Superior de Investigaciones Cientificas; 1909:1952-1955. [Title translation: Histology of the vertebrate nervous system.].
    • (1909) Histologie du Systeme Nerveux des Vertebres , vol.1 , pp. 1952-1955
    • Ramon, Y.1    Cajal, S.2
  • 10
    • 0030885519 scopus 로고    scopus 로고
    • Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia
    • Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan DW Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 19:1997;575-589.
    • (1997) Neuron , vol.19 , pp. 575-589
    • Deiner, M.S.1    Kennedy, T.E.2    Fazeli, A.3    Serafini, T.4    Tessier-Lavigne, M.5    Sretavan, D.W.6
  • 11
    • 0030062518 scopus 로고    scopus 로고
    • Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
    • Wadsworth WG, Bhatt H, Hedgecock EM Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron. 16:1996;35-46.
    • (1996) Neuron , vol.16 , pp. 35-46
    • Wadsworth, W.G.1    Bhatt, H.2    Hedgecock, E.M.3
  • 12
    • 0032524324 scopus 로고    scopus 로고
    • Genetic analysis of the mechanisms controlling target selection: Complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    • First demonstration of a repulsive action of a netrin in Drosophila and of the combinatorial effects of netrins, semaphorins and Ig superfamily members in motor axon targeting.
    • Winberg ML, Mitchell KJ, Goodman CS Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs. Cell. 93:1998;581-591. First demonstration of a repulsive action of a netrin in Drosophila and of the combinatorial effects of netrins, semaphorins and Ig superfamily members in motor axon targeting.
    • (1998) Cell , vol.93 , pp. 581-591
    • Winberg, M.L.1    Mitchell, K.J.2    Goodman, C.S.3
  • 13
    • 0029971793 scopus 로고    scopus 로고
    • Functions of netrins and semaphorins in axon guidance
    • Culotti JG, Kolodkin AL Functions of netrins and semaphorins in axon guidance. Curr Opin Neurobiol. 6:1996;81-88.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 81-88
    • Culotti, J.G.1    Kolodkin, A.L.2
  • 17
    • 0031964951 scopus 로고    scopus 로고
    • Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary
    • Provides a detailed phenotypic analysis of mice carrying a mutation in the Unc5h3/Rcm gene that supports the hypothesis that UNC5H3 may function as a repulsive netrin receptor in guiding pre-cerebellar neurons.
    • Przyborski SA, Knowles BB, Ackerman SL Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development. 125:1998;41-50. Provides a detailed phenotypic analysis of mice carrying a mutation in the Unc5h3/Rcm gene that supports the hypothesis that UNC5H3 may function as a repulsive netrin receptor in guiding pre-cerebellar neurons.
    • (1998) Development , vol.125 , pp. 41-50
    • Przyborski, S.A.1    Knowles, B.B.2    Ackerman, S.L.3
  • 18
    • 0033603256 scopus 로고    scopus 로고
    • A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
    • This paper provides the first direct evidence that vertebrate UNC-5 family proteins have a conserved role in axonal repulsion. Conversion of the effect of netrin-1 from attraction to repulsion is shown to be mediated by the formation of a receptor complex of DCC and UNC-5 family proteins, with association of their cytoplasmic domains.
    • Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 97:1999;927-941. This paper provides the first direct evidence that vertebrate UNC-5 family proteins have a conserved role in axonal repulsion. Conversion of the effect of netrin-1 from attraction to repulsion is shown to be mediated by the formation of a receptor complex of DCC and UNC-5 family proteins, with association of their cytoplasmic domains.
    • (1999) Cell , vol.97 , pp. 927-941
    • Hong, K.1    Hinck, L.2    Nishiyama, M.3    Poo, M.M.4    Tessier-Lavigne, M.5    Stein, E.6
  • 19
    • 0025332245 scopus 로고
    • The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    • Hedgecock EM, Culotti JG, Hall DH The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron. 4:1990;61-85.
    • (1990) Neuron , vol.4 , pp. 61-85
    • Hedgecock, E.M.1    Culotti, J.G.2    Hall, D.H.3
  • 20
    • 0033152382 scopus 로고    scopus 로고
    • Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons
    • Presents a phenotypic analysis of olivary neuron migration in netrin-1 knockout mice that supports the hypothesis that netrin-1 guides cell migrations in vertebrates.
    • Bloch-Gallego E, Ezan F, Tessier-Lavigne M, Sotelo C Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. J Neurosci. 19:1999;4407-4420. Presents a phenotypic analysis of olivary neuron migration in netrin-1 knockout mice that supports the hypothesis that netrin-1 guides cell migrations in vertebrates.
    • (1999) J Neurosci , vol.19 , pp. 4407-4420
    • Bloch-Gallego, E.1    Ezan, F.2    Tessier-Lavigne, M.3    Sotelo, C.4
  • 21
    • 0032914453 scopus 로고    scopus 로고
    • The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system
    • Demonstrates that the netrin receptor frazzled in Drosophila is required for retinal axon targeting, and describes the surprising discovery that it is required in the target, not the neurons. This result suggests that frazzled is functioning in a capacity other than as a receptor, perhaps as a ligand detected by some other axonal receptor.
    • Gong Q, Rangarajan R, Seeger M, Gaul U The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system. Development. 126:1999;1451-1456. Demonstrates that the netrin receptor frazzled in Drosophila is required for retinal axon targeting, and describes the surprising discovery that it is required in the target, not the neurons. This result suggests that frazzled is functioning in a capacity other than as a receptor, perhaps as a ligand detected by some other axonal receptor.
    • (1999) Development , vol.126 , pp. 1451-1456
    • Gong, Q.1    Rangarajan, R.2    Seeger, M.3    Gaul, U.4
  • 22
    • 0025608587 scopus 로고
    • Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
    • Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev. 4:1990;2169-2187.
    • (1990) Genes Dev , vol.4 , pp. 2169-2187
    • Rothberg, J.M.1    Jacobs, J.R.2    Goodman, C.S.3    Artavanis-Tsakonas, S.4
  • 23
    • 0032570050 scopus 로고    scopus 로고
    • Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system
    • Itoh A, Miyabayashi T, Ohno M, Sakano S Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res Mol Brain Res. 62:1998;175-186.
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 175-186
    • Itoh, A.1    Miyabayashi, T.2    Ohno, M.3    Sakano, S.4
  • 24
    • 0032416836 scopus 로고    scopus 로고
    • Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis
    • Holmes GP, Negus K, Burridge L, Raman S, Algar E, Yamada T, Little MH Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mech Dev. 79:1998;57-72.
    • (1998) Mech Dev , vol.79 , pp. 57-72
    • Holmes, G.P.1    Negus, K.2    Burridge, L.3    Raman, S.4    Algar, E.5    Yamada, T.6    Little, M.H.7
  • 25
    • 0032127297 scopus 로고    scopus 로고
    • Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
    • Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Genomics. 51:1998;27-34.
    • (1998) Genomics , vol.51 , pp. 27-34
    • Nakayama, M.1    Nakajima, D.2    Nagase, T.3    Nomura, N.4    Seki, N.5    Ohara, O.6
  • 26
    • 0033582914 scopus 로고    scopus 로고
    • Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
    • Describes the cloning of three mammalian Slit genes, and demonstrates that both Drosophila and vertebrate Slit proteins bind Robo receptors. In addition, the authors provide evidence of a conserved function for Slit proteins in repelling axons in vertebrates. They report that a mammalian Slit protein binds to netrin-1
    • Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 96:1999;795-806. Describes the cloning of three mammalian Slit genes, and demonstrates that both Drosophila and vertebrate Slit proteins bind Robo receptors. In addition, the authors provide evidence of a conserved function for Slit proteins in repelling axons in vertebrates. They report that a mammalian Slit protein binds to netrin-1.
    • (1999) Cell , vol.96 , pp. 795-806
    • Brose, K.1    Bland, K.S.2    Wang, K.H.3    Arnott, D.4    Henzel, W.5    Goodman, C.S.6    Tessier-Lavigne, M.7    Kidd, T.8
  • 27
    • 0033582927 scopus 로고    scopus 로고
    • Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
    • Description of several vertebrate Slit proteins. This study also demonstrates the repulsive activity of a Slit protein on olfactory bulb axons and its binding to a Robo receptor.
    • Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick Cet al. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell. 96:1999;807-818. Description of several vertebrate Slit proteins. This study also demonstrates the repulsive activity of a Slit protein on olfactory bulb axons and its binding to a Robo receptor.
    • (1999) Cell , vol.96 , pp. 807-818
    • Li, H.S.1    Chen, J.H.2    Wu, W.3    Fagaly, T.4    Zhou, L.5    Yuan, W.6    Dupuis, S.7    Jiang, Z.H.8    Nash, W.9    Gick, C.10
  • 28
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E Mutations affecting segment number and polarity in Drosophila. Nature. 287:1980;795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 29
    • 0028266853 scopus 로고
    • Mesectodermal cell fate analysis in Drosophila midline mutants
    • Sonnenfeld MJ, Jacobs JR Mesectodermal cell fate analysis in Drosophila midline mutants. Mech Dev. 46:1994;3-13.
    • (1994) Mech Dev , vol.46 , pp. 3-13
    • Sonnenfeld, M.J.1    Jacobs, J.R.2
  • 30
    • 0033582907 scopus 로고    scopus 로고
    • Slit is the midline repellent for the robo receptor in Drosophila
    • Using a clever set of inferences, the authors identify Slit as the midline repellent functioning via the Robo receptor in Drosophila. Slit is also shown to function in repulsion of mesodermal cells away from the midline.
    • Kidd T, Bland KS, Goodman CS Slit is the midline repellent for the robo receptor in Drosophila. Cell. 96:1999;785-794. Using a clever set of inferences, the authors identify Slit as the midline repellent functioning via the Robo receptor in Drosophila. Slit is also shown to function in repulsion of mesodermal cells away from the midline.
    • (1999) Cell , vol.96 , pp. 785-794
    • Kidd, T.1    Bland, K.S.2    Goodman, C.S.3
  • 31
    • 0032559219 scopus 로고    scopus 로고
    • Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
    • ••]). Midline crossing is regulated by specific targeting of Robo to particular axonal domains.
    • ••]). Midline crossing is regulated by specific targeting of Robo to particular axonal domains.
    • (1998) Cell , vol.92 , pp. 205-215
    • Kidd, T.1    Brose, K.2    Mitchell, K.J.3    Fetter, R.D.4    Tessier-Lavigne, M.5    Goodman, C.S.6    Tear, G.7
  • 32
    • 0027481755 scopus 로고
    • Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
    • Seeger M, Tear G, Ferres-Marco D, Goodman CS Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron. 10:1993;409-426.
    • (1993) Neuron , vol.10 , pp. 409-426
    • Seeger, M.1    Tear, G.2    Ferres-Marco, D.3    Goodman, C.S.4
  • 33
    • 0031952106 scopus 로고    scopus 로고
    • Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline
    • Midline crossing in Drosophila is controlled by the repulsive Robo receptor, whose expression on axons is shown to be downregulated by the Commissureless protein, allowing axonal passage across the midline.
    • Kidd T, Russell C, Goodman CS, Tear G Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Neuron. 20:1998;25-33. Midline crossing in Drosophila is controlled by the repulsive Robo receptor, whose expression on axons is shown to be downregulated by the Commissureless protein, allowing axonal passage across the midline.
    • (1998) Neuron , vol.20 , pp. 25-33
    • Kidd, T.1    Russell, C.2    Goodman, C.S.3    Tear, G.4
  • 34
    • 0033029784 scopus 로고    scopus 로고
    • Axon repulsion from the midline of the Drosophila CNS requires slit function
    • Provides confirmation of the repulsive role of Drosophila Slit, with the demonstration that ectopic expression of Slit redirects axons away from the site of Slit expression.
    • Battye R, Stevens A, Jacobs JR Axon repulsion from the midline of the Drosophila CNS requires slit function. Development. 126:1999;2475-2481. Provides confirmation of the repulsive role of Drosophila Slit, with the demonstration that ectopic expression of Slit redirects axons away from the site of Slit expression.
    • (1999) Development , vol.126 , pp. 2475-2481
    • Battye, R.1    Stevens, A.2    Jacobs, J.R.3
  • 35
    • 0032559170 scopus 로고    scopus 로고
    • The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
    • A genetic screen for axon guidance mutants in C. elegans identified the conserved Robo family member SAX-3 as a receptor controlling multiple axon guidance events.
    • Zallen JA, Yi BA, Bargmann CI The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Cell. 92:1998;217-227. A genetic screen for axon guidance mutants in C. elegans identified the conserved Robo family member SAX-3 as a receptor controlling multiple axon guidance events.
    • (1998) Cell , vol.92 , pp. 217-227
    • Zallen, J.A.1    Yi, B.A.2    Bargmann, C.I.3
  • 36
    • 0033104416 scopus 로고    scopus 로고
    • Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos
    • Yuan SS, Cox LA, Dasika GK, Lee EY Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 207:1999;62-75.
    • (1999) Dev Biol , vol.207 , pp. 62-75
    • Yuan, S.S.1    Cox, L.A.2    Dasika, G.K.3    Lee, E.Y.4
  • 37
    • 0003008043 scopus 로고    scopus 로고
    • Slit2-mediated chemorepulsion and collapse of developing forebrain axons
    • Reports that Slit-2 repels axons in the forebrain (olfactory bulb and hippocampal axons). This is the first demonstration that a Slit protein also has collapse-inducing activity (in addition to repulsive activity).
    • Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, Sotelo C, Chedotal A Slit2-mediated chemorepulsion and collapse of developing forebrain axons. Neuron. 22:1999;463-473. Reports that Slit-2 repels axons in the forebrain (olfactory bulb and hippocampal axons). This is the first demonstration that a Slit protein also has collapse-inducing activity (in addition to repulsive activity).
    • (1999) Neuron , vol.22 , pp. 463-473
    • Nguyen Ba-Charvet, K.T.1    Brose, K.2    Marillat, V.3    Kidd, T.4    Goodman, C.S.5    Tessier-Lavigne, M.6    Sotelo, C.7    Chedotal, A.8
  • 38
    • 0033603247 scopus 로고    scopus 로고
    • Chimeric axon guidance receptors: The cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    • Structure/function analysis and domain-swapping experiments are used to show that the 'sign' of the repulsive Slit receptor Robo and the attractive netrin receptor frazzled is dictated by their cytoplasmic domains.
    • Bashaw GJ, Goodman CS Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion. Cell. 97:1999;917-926. Structure/function analysis and domain-swapping experiments are used to show that the 'sign' of the repulsive Slit receptor Robo and the attractive netrin receptor frazzled is dictated by their cytoplasmic domains.
    • (1999) Cell , vol.97 , pp. 917-926
    • Bashaw, G.J.1    Goodman, C.S.2
  • 39
    • 0033595192 scopus 로고    scopus 로고
    • Directional guidance of neuronal migration in the olfactory system by the protein Slit
    • A mammalian Slit protein is shown to function in repulsion of migrating neurons, providing a molecular basis for a previously described chemorepulsive activity.
    • Wu W, Wong K, Chen J-H, Jiang Z-H, Dupuis S, Wu JY, Rao Y Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 400:1999;331-336. A mammalian Slit protein is shown to function in repulsion of migrating neurons, providing a molecular basis for a previously described chemorepulsive activity.
    • (1999) Nature , vol.400 , pp. 331-336
    • Wu, W.1    Wong, K.2    Chen, J.-H.3    Jiang, Z.-H.4    Dupuis, S.5    Wu, J.Y.6    Rao, Y.7
  • 40
    • 0033166879 scopus 로고    scopus 로고
    • Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex
    • ••], but on a different population of neurons.
    • ••], but on a different population of neurons.
    • (1999) Neuron , vol.23 , pp. 473-485
    • Zhu, Y.1    Li, H.2    Zhou, L.3    Wu, J.Y.4    Rao, Y.5
  • 41
    • 0033180233 scopus 로고    scopus 로고
    • Chemorepulsion of neuronal migration by slit-2 in the developing mammalian forebrain
    • •], this paper describes the repulsive action of a Slit protein on migrating neurons. The paper is notable for the fact that the author (who first described chemorepulsion of migrating neurons) actually purified the Slit protein using a bioassay for chemorepulsion.
    • •], this paper describes the repulsive action of a Slit protein on migrating neurons. The paper is notable for the fact that the author (who first described chemorepulsion of migrating neurons) actually purified the Slit protein using a bioassay for chemorepulsion.
    • (1999) Neuron , vol.23 , pp. 703-711
    • Hu, H.1
  • 43
    • 0033582915 scopus 로고    scopus 로고
    • Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
    • The authors demonstrate the existence of an activity in brain that can stimulate the branching and elongation of sensory axons. They purified the factor and found that it is an amino-terminal fragment of Slit-2. The study is the first to identify a factor that can stimulate interstitial axon branching, and also demonstrates that Slit proteins are bifunctional.
    • Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell. 96:1999;771-784. The authors demonstrate the existence of an activity in brain that can stimulate the branching and elongation of sensory axons. They purified the factor and found that it is an amino-terminal fragment of Slit-2. The study is the first to identify a factor that can stimulate interstitial axon branching, and also demonstrates that Slit proteins are bifunctional.
    • (1999) Cell , vol.96 , pp. 771-784
    • Wang, K.H.1    Brose, K.2    Arnott, D.3    Kidd, T.4    Goodman, C.S.5    Henzel, W.6    Tessier-Lavigne, M.7
  • 44
    • 0033360412 scopus 로고    scopus 로고
    • Neuronal growth cone collapse triggers lateral extensions along trailing axons
    • Provides the remarkable demonstration of a link between growth cone repulsion and axonal branching. Collapse of retinal axons in response to ephrins or mechanical probing leads to lateral extesion of filopodia and lamellipodia hundreds of microns behind the lead growth cone. [Published erratum appears in Nat Neurosci 1999
    • Davenport RW, Thies E, Cohen ML Neuronal growth cone collapse triggers lateral extensions along trailing axons. Nat Neurosci. 2:1999;254-259. [Published erratum appears in Nat Neurosci 1999, 2(5):485]. Provides the remarkable demonstration of a link between growth cone repulsion and axonal branching. Collapse of retinal axons in response to ephrins or mechanical probing leads to lateral extesion of filopodia and lamellipodia hundreds of microns behind the lead growth cone.
    • (1999) Nat Neurosci , vol.2 , pp. 254-259
    • Davenport, R.W.1    Thies, E.2    Cohen, M.L.3
  • 45
    • 0031922119 scopus 로고    scopus 로고
    • The ephrins and Eph receptors in neural development
    • Flanagan JG, Vanderhaeghen P The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 21:1998;309-345.
    • (1998) Annu Rev Neurosci , vol.21 , pp. 309-345
    • Flanagan, J.G.1    Vanderhaeghen, P.2
  • 46
    • 0032966750 scopus 로고    scopus 로고
    • Eph receptors and ephrins in neural development
    • O'Leary DD, Wilkinson DG Eph receptors and ephrins in neural development. Curr Opin Neurobiol. 9:1999;65-73.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 65-73
    • O'Leary, D.D.1    Wilkinson, D.G.2
  • 47
    • 0033016108 scopus 로고    scopus 로고
    • Eph receptors and ephrins: Effectors of morphogenesis
    • An excellent and comprehensive review of the functions of ephrins in axon guidance and in other tissues.
    • Holder N, Klein R Eph receptors and ephrins: effectors of morphogenesis. Development. 126:1999;2033-2044. An excellent and comprehensive review of the functions of ephrins in axon guidance and in other tissues.
    • (1999) Development , vol.126 , pp. 2033-2044
    • Holder, N.1    Klein, R.2
  • 48
    • 0029082312 scopus 로고
    • In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
    • Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M, Bonhoeffer F In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
    • (1995) Cell , vol.82 , pp. 359-370
    • Drescher, U.1    Kremoser, C.2    Handwerker, C.3    Loschinger, J.4    Noda, M.5    Bonhoeffer, F.6
  • 49
    • 0033587129 scopus 로고    scopus 로고
    • In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
    • An exciting report showing that bidirectional signaling across rhombomere boundaries between EphB receptors and their ephrin-B ligands can result in cell sorting to prevent intermixing between adjacent rhombomeres.
    • Xu Q, Mellitzer G, Robinson V, Wilkinson DG In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature. 399:1999;267-271. An exciting report showing that bidirectional signaling across rhombomere boundaries between EphB receptors and their ephrin-B ligands can result in cell sorting to prevent intermixing between adjacent rhombomeres.
    • (1999) Nature , vol.399 , pp. 267-271
    • Xu, Q.1    Mellitzer, G.2    Robinson, V.3    Wilkinson, D.G.4
  • 50
    • 0033082959 scopus 로고    scopus 로고
    • Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
    • Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13:1999;295-306.
    • (1999) Genes Dev , vol.13 , pp. 295-306
    • Adams, R.H.1    Wilkinson, G.A.2    Weiss, C.3    Diella, F.4    Gale, N.W.5    Deutsch, U.6    Risau, W.7    Klein, R.8
  • 51
    • 0033560751 scopus 로고    scopus 로고
    • Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins
    • Huynh-Do U, Stein E, Lane AA, Liu H, Cerretti DP, Daniel TO Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins. EMBO J. 18:1999;2165-2173.
    • (1999) EMBO J , vol.18 , pp. 2165-2173
    • Huynh-Do, U.1    Stein, E.2    Lane, A.A.3    Liu, H.4    Cerretti, D.P.5    Daniel, T.O.6
  • 52
    • 0032489430 scopus 로고    scopus 로고
    • The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans
    • Describes the genetic and molecular analysis of a C. elegans Eph receptor, VAB-1. Mutations in vab-1 were isolated on the basis of morphogenetic defects in epidermal cells. Expression and genetic mosaic analyses show that VAB-1 function is required non-autonomously in underlying neuronal precursors for epidermal morphogenesis. Analysis of a large set of partialloss-of-function mutations in vab-1 suggests that VAB-1 may have both kinase-dependent and kinase-independent functions in signalling.
    • George SE, Simokat K, Hardin J, Chisholm AD The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell. 92:1998;633-643. Describes the genetic and molecular analysis of a C. elegans Eph receptor, VAB-1. Mutations in vab-1 were isolated on the basis of morphogenetic defects in epidermal cells. Expression and genetic mosaic analyses show that VAB-1 function is required non-autonomously in underlying neuronal precursors for epidermal morphogenesis. Analysis of a large set of partialloss-of-function mutations in vab-1 suggests that VAB-1 may have both kinase-dependent and kinase-independent functions in signalling.
    • (1998) Cell , vol.92 , pp. 633-643
    • George, S.E.1    Simokat, K.2    Hardin, J.3    Chisholm, A.D.4
  • 53
    • 0032993165 scopus 로고    scopus 로고
    • Isolation and characterization of Dek, a Drosophila Eph receptor tyrosine kinase
    • Scully A, McKeown M, Thomas J Isolation and characterization of Dek, a Drosophila Eph receptor tyrosine kinase. Mol Cell Neurosci. 13:1999;337-347.
    • (1999) Mol Cell Neurosci , vol.13 , pp. 337-347
    • Scully, A.1    McKeown, M.2    Thomas, J.3
  • 54
    • 0033035138 scopus 로고    scopus 로고
    • Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra
    • Suga H, Koyanagi M, Hoshiyama D, Ono K, Iwabe N, Kuma K, Miyata T Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra. J Mol Evol. 48:1999;646-653.
    • (1999) J Mol Evol , vol.48 , pp. 646-653
    • Suga, H.1    Koyanagi, M.2    Hoshiyama, D.3    Ono, K.4    Iwabe, N.5    Kuma, K.6    Miyata, T.7
  • 55
    • 0032103082 scopus 로고    scopus 로고
    • Signaling by Eph receptors and their ephrin ligands
    • Bruckner K, Klein R Signaling by Eph receptors and their ephrin ligands. Curr Opin Neurobiol. 8:1998;375-382.
    • (1998) Curr Opin Neurobiol , vol.8 , pp. 375-382
    • Bruckner, K.1    Klein, R.2
  • 56
    • 0033103887 scopus 로고    scopus 로고
    • EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
    • An important paper that addresses the mechanism of reverse signaling by transmembrane ephrins. Ephrin-Bs were found to localise to membrane rafts in cell culture and to bind PDZ-domain-containing proteins at their carboxyl termini, thereby recruiting an as yet unidentified serine/threonine kinase. Stimulation by EphB receptors caused coalescence of these rafts into large membrane patches, potentially acting as signaling centers.
    • Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 22:1999;511-524. An important paper that addresses the mechanism of reverse signaling by transmembrane ephrins. Ephrin-Bs were found to localise to membrane rafts in cell culture and to bind PDZ-domain-containing proteins at their carboxyl termini, thereby recruiting an as yet unidentified serine/threonine kinase. Stimulation by EphB receptors caused coalescence of these rafts into large membrane patches, potentially acting as signaling centers.
    • (1999) Neuron , vol.22 , pp. 511-524
    • Bruckner, K.1    Pablo Labrador, J.2    Scheiffele, P.3    Herb, A.4    Seeburg, P.H.5    Klein, R.6
  • 57
    • 0032408173 scopus 로고    scopus 로고
    • PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
    • Demonstrates that both Eph receptors and ephrin-Bs can bind PDZ domain proteins, and makes the striking observation that both receptors, ligands and PDZ proteins colocalise at synapses in cultured neurons, suggesting novel roles for Eph signaling in synaptogenesis.
    • Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 21:1998;1453-1463. Demonstrates that both Eph receptors and ephrin-Bs can bind PDZ domain proteins, and makes the striking observation that both receptors, ligands and PDZ proteins colocalise at synapses in cultured neurons, suggesting novel roles for Eph signaling in synaptogenesis.
    • (1998) Neuron , vol.21 , pp. 1453-1463
    • Torres, R.1    Firestein, B.L.2    Dong, H.3    Staudinger, J.4    Olson, E.N.5    Huganir, R.L.6    Bredt, D.S.7    Gale, N.W.8    Yancopoulos, G.D.9
  • 58
    • 0033525063 scopus 로고    scopus 로고
    • The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
    • Demonstrates that ephrin-Bs can bind several PDZ-domain-containing proteins, including syntenin.
    • Lin D, Gish GD, Songyang Z, Pawson T The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem. 274:1999;3726-3733. Demonstrates that ephrin-Bs can bind several PDZ-domain-containing proteins, including syntenin.
    • (1999) J Biol Chem , vol.274 , pp. 3726-3733
    • Lin, D.1    Gish, G.D.2    Songyang, Z.3    Pawson, T.4
  • 59
    • 0032849015 scopus 로고    scopus 로고
    • Genes required for axon pathfinding and extension in the C. elegans nerve ring
    • Describes genetic analysis of several new genes identified through their roles in sensory neuron axon guidance. The authors used double-mutant analysis to show that the C. elegans Eph (VAB-1), SAX-3, and netrin pathways appear to act (at least partly) in parallel to direct axon guidance.
    • Zallen JA, Kirch SA, Bargmann CI Genes required for axon pathfinding and extension in the C. elegans nerve ring. Development. 126:1999;3679-3692. Describes genetic analysis of several new genes identified through their roles in sensory neuron axon guidance. The authors used double-mutant analysis to show that the C. elegans Eph (VAB-1), SAX-3, and netrin pathways appear to act (at least partly) in parallel to direct axon guidance.
    • (1999) Development , vol.126 , pp. 3679-3692
    • Zallen, J.A.1    Kirch, S.A.2    Bargmann, C.I.3
  • 61
    • 0031893255 scopus 로고    scopus 로고
    • Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
    • Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem. 273:1998;1303-1308.
    • (1998) J Biol Chem , vol.273 , pp. 1303-1308
    • Stein, E.1    Huynh-Do, U.2    Lane, A.A.3    Cerretti, D.P.4    Daniel, T.O.5
  • 62
    • 0029943447 scopus 로고    scopus 로고
    • Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
    • Garrity PA, Rao Y, Salecker I, McGlade J, Pawson T, Zipursky SL Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell. 85:1996;639-650.
    • (1996) Cell , vol.85 , pp. 639-650
    • Garrity, P.A.1    Rao, Y.2    Salecker, I.3    McGlade, J.4    Pawson, T.5    Zipursky, S.L.6
  • 63
    • 0033603254 scopus 로고    scopus 로고
    • Pak functions downstream of dock to regulate photoreceptor axon guidance in Drosophila
    • An elegant and comprehensive analysis of the role of the Pak (p21-activated) kinase in signaling downstream of Dock/Nck in Drosophila axon guidance.
    • Hing H, Xiao J, Harden N, Lim L, Zipursky SL Pak functions downstream of dock to regulate photoreceptor axon guidance in Drosophila. Cell. 97:1999;853-863. An elegant and comprehensive analysis of the role of the Pak (p21-activated) kinase in signaling downstream of Dock/Nck in Drosophila axon guidance.
    • (1999) Cell , vol.97 , pp. 853-863
    • Hing, H.1    Xiao, J.2    Harden, N.3    Lim, L.4    Zipursky, S.L.5
  • 64
    • 0000969241 scopus 로고    scopus 로고
    • Unified nomenclature for the semaphorins/collapsins
    • Unified nomenclature for the semaphorins/collapsins. Cell. 97:1999;551-552.
    • (1999) Cell , vol.97 , pp. 551-552
  • 66
    • 0030987542 scopus 로고    scopus 로고
    • Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection
    • Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 19:1997;519-530.
    • (1997) Neuron , vol.19 , pp. 519-530
    • Taniguchi, M.1    Yuasa, S.2    Fujisawa, H.3    Naruse, I.4    Saga, S.5    Mishina, M.6    Yagi, T.7
  • 67
    • 0032005462 scopus 로고    scopus 로고
    • The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance
    • Genetic analysis of Sema-1a in Drosophila provides direct and convincing evidence that Sema-1a functions as a repellent that drives axon defasciculation.
    • Yu HH, Araj HH, Ralls SA, Kolodkin AL The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance. Neuron. 20:1998;207-220. Genetic analysis of Sema-1a in Drosophila provides direct and convincing evidence that Sema-1a functions as a repellent that drives axon defasciculation.
    • (1998) Neuron , vol.20 , pp. 207-220
    • Yu, H.H.1    Araj, H.H.2    Ralls, S.A.3    Kolodkin, A.L.4
  • 68
    • 0342872023 scopus 로고    scopus 로고
    • Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
    • [Published erratum appears in Neuron 1997
    • Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 19:1997;547-559. [Published erratum appears in Neuron 1997, 19(3):559].
    • (1997) Neuron , vol.19 , pp. 547-559
    • Chen, H.1    Chedotal, A.2    He, Z.3    Goodman, C.S.4    Tessier-Lavigne, M.5
  • 69
    • 0032176852 scopus 로고    scopus 로고
    • Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors \[see comments]
    • Provides direct evidence, through expression of ectopic neuropilin, to support the model that the specificity of neuronal responses to class 3 semaphorins is dictated by the complement of neuropilins expresed by the neurons.
    • Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors \[see comments]. Nat Neurosci. 1:1998;487-493. Provides direct evidence, through expression of ectopic neuropilin, to support the model that the specificity of neuronal responses to class 3 semaphorins is dictated by the complement of neuropilins expresed by the neurons.
    • (1998) Nat Neurosci , vol.1 , pp. 487-493
    • Takahashi, T.1    Nakamura, F.2    Jin, Z.3    Kalb, R.G.4    Strittmatter, S.M.5
  • 70
    • 0032215144 scopus 로고    scopus 로고
    • Neuropilin-2 is a receptor for semaphorin IV: Insight into the structural basis of receptor function and specificity [see comments]
    • Presents structure/function analysis of neuropilins and evidence in support of the hypothesis that neuropilin-2 is a necessary receptor for semaphorin IV (Sema3F).
    • Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity [see comments]. Neuron. 21:1998;1079-1092. Presents structure/function analysis of neuropilins and evidence in support of the hypothesis that neuropilin-2 is a necessary receptor for semaphorin IV (Sema3F).
    • (1998) Neuron , vol.21 , pp. 1079-1092
    • Giger, R.J.1    Urquhart, E.R.2    Gillespie, S.K.3    Levengood, D.V.4    Ginty, D.D.5    Kolodkin, A.L.6
  • 71
    • 0032215735 scopus 로고    scopus 로고
    • Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse [see comments]
    • Demonstrates that the cytoplasmic domain of neuropilin-1 is not required for its function as a semaphorin receptor, supporting the existence of a distinct signaling receptor that mediates class 3 semaphorin effects.
    • Nakamura F, Tanaka M, Takahashi T, Kalb RG, Strittmatter SM Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse [see comments]. Neuron. 21:1998;1093-1100. Demonstrates that the cytoplasmic domain of neuropilin-1 is not required for its function as a semaphorin receptor, supporting the existence of a distinct signaling receptor that mediates class 3 semaphorin effects.
    • (1998) Neuron , vol.21 , pp. 1093-1100
    • Nakamura, F.1    Tanaka, M.2    Takahashi, T.3    Kalb, R.G.4    Strittmatter, S.M.5
  • 72
    • 0032408496 scopus 로고    scopus 로고
    • Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins
    • Presents structure/function and loss-of-function data supporting the hypothesis that the responses of neurons to class 3 semaphorins are dictated by the complement of neuropilin receptors expressed by the neurons.
    • Chen H, He Z, Bagri A, Tessier-Lavigne M Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron. 21:1998;1283-1290. Presents structure/function and loss-of-function data supporting the hypothesis that the responses of neurons to class 3 semaphorins are dictated by the complement of neuropilin receptors expressed by the neurons.
    • (1998) Neuron , vol.21 , pp. 1283-1290
    • Chen, H.1    He, Z.2    Bagri, A.3    Tessier-Lavigne, M.4
  • 73
    • 0032433853 scopus 로고    scopus 로고
    • Plexin A is a neuronal semaphorin receptor that controls axon guidance
    • Demonstrates that a plexin protein, plexin A, is the receptor that mediates the axon guidance functions of the transmembrane semaphorin Sema-1a in Drosophila.
    • Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 95:1998;903-916. Demonstrates that a plexin protein, plexin A, is the receptor that mediates the axon guidance functions of the transmembrane semaphorin Sema-1a in Drosophila.
    • (1998) Cell , vol.95 , pp. 903-916
    • Winberg, M.L.1    Noordermeer, J.N.2    Tamagnone, L.3    Comoglio, P.M.4    Spriggs, M.K.5    Tessier-Lavigne, M.6    Goodman, C.S.7
  • 75
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Presents surprising finding that neuropilin-1 and -2, receptors for class 3 semaphorins, are also receptors for a specific heparin-binding isoform of vascular endothelial growth factor (VEGF), apparently cooperating with the signal VEGF receptor KDR, a receptor tyrosine kinase.
    • Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 92:1998;735-745. Presents surprising finding that neuropilin-1 and -2, receptors for class 3 semaphorins, are also receptors for a specific heparin-binding isoform of vascular endothelial growth factor (VEGF), apparently cooperating with the signal VEGF receptor KDR, a receptor tyrosine kinase.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 76
    • 0033549556 scopus 로고    scopus 로고
    • Neuropilin-1 mediates collapsin-1/Semaphorin III inhibition of endothelial cell motility. Functional competition of collapsin-1 and vascular endothelial growth factor-165
    • Sema3A (collapsin/Sema III), which is already known to function in axonal repulsion, is shown here to function in repulsion and inhibition of endothelial cell migration and angiogenesis. This possibility had been raised by the fact that the Sema3A receptor neuropilin is expressed by endothelial cells, and is the first example of a non-neural function of Sema3A.
    • Miao HQ, Soker S, Feiner L, Alonso JL, Raper JA, Klagsbrun M Neuropilin-1 mediates collapsin-1/Semaphorin III inhibition of endothelial cell motility. Functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol. 146:1999;233-242. Sema3A (collapsin/Sema III), which is already known to function in axonal repulsion, is shown here to function in repulsion and inhibition of endothelial cell migration and angiogenesis. This possibility had been raised by the fact that the Sema3A receptor neuropilin is expressed by endothelial cells, and is the first example of a non-neural function of Sema3A.
    • (1999) J Cell Biol , vol.146 , pp. 233-242
    • Miao, H.Q.1    Soker, S.2    Feiner, L.3    Alonso, J.L.4    Raper, J.A.5    Klagsbrun, M.6
  • 77
    • 0033362351 scopus 로고    scopus 로고
    • Hepatocyte growth factor, a versatile signal for developing neurons
    • Maina F, Klein R Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci. 2:1999;213-217.
    • (1999) Nat Neurosci , vol.2 , pp. 213-217
    • Maina, F.1    Klein, R.2
  • 79
    • 0032077285 scopus 로고    scopus 로고
    • Multiple roles for hepatocyte growth factor in sympathetic neuron development
    • Maina F, Hilton MC, Andres R, Wyatt S, Klein R, Davies AM Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron. 20:1998;835-846.
    • (1998) Neuron , vol.20 , pp. 835-846
    • Maina, F.1    Hilton, M.C.2    Andres, R.3    Wyatt, S.4    Klein, R.5    Davies, A.M.6
  • 81
    • 0031051796 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and axon guidance: Of mice and flies
    • Desai CJ, Sun Q, Zinn K Tyrosine phosphorylation and axon guidance: of mice and flies. Curr Opin Neurobiol. 7:1997;70-74.
    • (1997) Curr Opin Neurobiol , vol.7 , pp. 70-74
    • Desai, C.J.1    Sun, Q.2    Zinn, K.3
  • 82
    • 0032103772 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases and neural development
    • Stoker A, Dutta R Protein tyrosine phosphatases and neural development. Bioessays. 20:1998;463-472.
    • (1998) Bioessays , vol.20 , pp. 463-472
    • Stoker, A.1    Dutta, R.2
  • 83
    • 15444357989 scopus 로고    scopus 로고
    • The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR
    • Reports the identification of a ligand for a LAR type phosphatase. The extracellular matrix complex laminin-nidogen was found to bind the fifth fibronectin type III repeat of LAR in vitro; interestingly, alternative splicing of exons encoding this repeat can modulate the interaction with laminin-nidogen.
    • O'Grady P, Thai TC, Saito H The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. J Cell Biol. 141:1998;1675-1684. Reports the identification of a ligand for a LAR type phosphatase. The extracellular matrix complex laminin-nidogen was found to bind the fifth fibronectin type III repeat of LAR in vitro; interestingly, alternative splicing of exons encoding this repeat can modulate the interaction with laminin-nidogen.
    • (1998) J Cell Biol , vol.141 , pp. 1675-1684
    • O'Grady, P.1    Thai, T.C.2    Saito, H.3
  • 85
    • 0031031229 scopus 로고    scopus 로고
    • Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation
    • Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. J Neurosci Res. 47:1997;348-360.
    • (1997) J Neurosci Res , vol.47 , pp. 348-360
    • Yeo, T.T.1    Yang, T.2    Massa, S.M.3    Zhang, J.S.4    Honkaniemi, J.5    Butcher, L.L.6    Longo, F.M.7
  • 87
    • 0033051169 scopus 로고    scopus 로고
    • Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ
    • •] describe the phenotypes of mice mutant for LAR-like RPTPσ. The mutant mice display an incompletely penetrant neonatal mortality, growth retardation, and neurological defects. These phenotypes appear to result from a variety of cellular defects, including reduced cell proliferation in the brain. Aberrant axon pathfinding was observed in some cases, although it remains uncertain if this is a primary defect.
    • •] describe the phenotypes of mice mutant for LAR-like RPTPσ. The mutant mice display an incompletely penetrant neonatal mortality, growth retardation, and neurological defects. These phenotypes appear to result from a variety of cellular defects, including reduced cell proliferation in the brain. Aberrant axon pathfinding was observed in some cases, although it remains uncertain if this is a primary defect.
    • (1999) Nat Genet , vol.21 , pp. 334-338
    • Wallace, M.J.1    Batt, J.2    Fladd, C.A.3    Henderson, J.T.4    Skarnes, W.5    Rotin, D.6
  • 88
    • 0030974135 scopus 로고    scopus 로고
    • Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila
    • Desai CJ, Krueger NX, Saito H, Zinn K Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila. Development. 124:1997;1941-1952.
    • (1997) Development , vol.124 , pp. 1941-1952
    • Desai, C.J.1    Krueger, N.X.2    Saito, H.3    Zinn, K.4
  • 89
    • 0032549710 scopus 로고    scopus 로고
    • UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans
    • Reports the cloning of C. elegans unc-73, identified genetically as being required for cell and growth cone migrations. UNC-73 is the worm homolog of the vertebrate proteins TRIO and kalirin, and encodes multiple protein isoforms with numerous domains, including a DH domain with Rho/Rac-specific GEF activity. UNC-73 is shown to function cell autonomously in axon guidance.
    • Steven R, Kubiseski TJ, Zheng H, Kulkarni S, Mancillas J, Ruiz Morales A, Hogue CW, Pawson T, Culotti J UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell. 92:1998;785-795. Reports the cloning of C. elegans unc-73, identified genetically as being required for cell and growth cone migrations. UNC-73 is the worm homolog of the vertebrate proteins TRIO and kalirin, and encodes multiple protein isoforms with numerous domains, including a DH domain with Rho/Rac-specific GEF activity. UNC-73 is shown to function cell autonomously in axon guidance.
    • (1998) Cell , vol.92 , pp. 785-795
    • Steven, R.1    Kubiseski, T.J.2    Zheng, H.3    Kulkarni, S.4    Mancillas, J.5    Ruiz Morales, A.6    Hogue, C.W.7    Pawson, T.8    Culotti, J.9
  • 90
    • 0029952315 scopus 로고    scopus 로고
    • The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
    • Debant A, Serra-Pages C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci USA. 93:1996;5466-5471.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5466-5471
    • Debant, A.1    Serra-Pages, C.2    Seipel, K.3    O'Brien, S.4    Tang, M.5    Park, S.H.6    Streuli, M.7
  • 91
    • 0032523935 scopus 로고    scopus 로고
    • Clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
    • An elegant demonstration using genetic analysis of an antagonistic relationship between a receptor tyrosine kinase (EGL-15) and a receptor tyrosine phosphatase (CLR-1).
    • Kokel M, Borland CZ, DeLong L, Horvitz HR, Stern MJ clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12:1998;1425-1437. An elegant demonstration using genetic analysis of an antagonistic relationship between a receptor tyrosine kinase (EGL-15) and a receptor tyrosine phosphatase (CLR-1).
    • (1998) Genes Dev , vol.12 , pp. 1425-1437
    • Kokel, M.1    Borland, C.Z.2    Delong, L.3    Horvitz, H.R.4    Stern, M.J.5
  • 92
    • 0031439129 scopus 로고    scopus 로고
    • Neural cell adhesion molecules of the immunoglobulin superfamily: Role in axon growth and guidance
    • Walsh FS, Doherty P Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu Rev Cell Dev Biol. 13:1997;425-456.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 425-456
    • Walsh, F.S.1    Doherty, P.2
  • 93
    • 0028786671 scopus 로고
    • An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
    • DeVore DL, Horvitz HR, Stern MJ An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell. 83:1995;611-620.
    • (1995) Cell , vol.83 , pp. 611-620
    • Devore, D.L.1    Horvitz, H.R.2    Stern, M.J.3
  • 94
    • 0033082439 scopus 로고    scopus 로고
    • The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    • The cytoplasmic tyrosine kinase Abl and its substrate enabled (Ena) are shown to function in axon guidance by binding to and antagonizing the function of the LAR phosphatase.
    • Wills Z, Bateman J, Korey CA, Comer A, Van Vactor D The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron. 22:1999;301-312. The cytoplasmic tyrosine kinase Abl and its substrate enabled (Ena) are shown to function in axon guidance by binding to and antagonizing the function of the LAR phosphatase.
    • (1999) Neuron , vol.22 , pp. 301-312
    • Wills, Z.1    Bateman, J.2    Korey, C.A.3    Comer, A.4    Van Vactor, D.5
  • 95
    • 0033083179 scopus 로고    scopus 로고
    • Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
    • The actin-binding protein profilin is shown to be required for the same axon guidance decisions as Abl. Mutations Abl are dosage-sensitive enhancers of axon guidance defects in profilin mutants, suggesting that they function in a common process of guidance. However, the Abl ; profilin double mutant displays more extreme axon guidance defects than either single mutant, suggesting that these proteins may also function in parallel pathways.
    • Wills Z, Marr L, Zinn K, Goodman CS, Van Vactor D Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron. 22:1999;291-299. The actin-binding protein profilin is shown to be required for the same axon guidance decisions as Abl. Mutations Abl are dosage-sensitive enhancers of axon guidance defects in profilin mutants, suggesting that they function in a common process of guidance. However, the Abl ; profilin double mutant displays more extreme axon guidance defects than either single mutant, suggesting that these proteins may also function in parallel pathways.
    • (1999) Neuron , vol.22 , pp. 291-299
    • Wills, Z.1    Marr, L.2    Zinn, K.3    Goodman, C.S.4    Van Vactor, D.5
  • 96
    • 0033082452 scopus 로고    scopus 로고
    • Mena is required for neurulation and commissure formation
    • Presents the analysis of the phenotypes of mice lacking Mena, the mammalian Ena homolog. Mena mutant mice have axon guidance defects. Lack of one copy of profilin in a Mena mutant background causes embryonic lethality due to neurulation defects, indicating that Mena and profilin have synergistic roles in neurulation.
    • Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, Kwiatkowski D, Soriano P, Gertler FB Mena is required for neurulation and commissure formation. Neuron. 22:1999;313-325. Presents the analysis of the phenotypes of mice lacking Mena, the mammalian Ena homolog. Mena mutant mice have axon guidance defects. Lack of one copy of profilin in a Mena mutant background causes embryonic lethality due to neurulation defects, indicating that Mena and profilin have synergistic roles in neurulation.
    • (1999) Neuron , vol.22 , pp. 313-325
    • Lanier, L.M.1    Gates, M.A.2    Witke, W.3    Menzies, A.S.4    Wehman, A.M.5    Macklis, J.D.6    Kwiatkowski, D.7    Soriano, P.8    Gertler, F.B.9
  • 98
    • 0032055881 scopus 로고    scopus 로고
    • Vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity
    • The vab-8 locus, which is required for posteriorly directed axon and cell migrations, encodes multiple proteins. Isoforms bearing a kinesin motor like domain are shown to be specifically required in growth cone movement. Ectopic expression of VAB-8 is sufficient to redirect an anteriorly growing axon posteriorly.
    • Wolf FW, Hung MS, Wightman B, Way J, Garriga G vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Neuron. 20:1998;655-666. The vab-8 locus, which is required for posteriorly directed axon and cell migrations, encodes multiple proteins. Isoforms bearing a kinesin motor like domain are shown to be specifically required in growth cone movement. Ectopic expression of VAB-8 is sufficient to redirect an anteriorly growing axon posteriorly.
    • (1998) Neuron , vol.20 , pp. 655-666
    • Wolf, F.W.1    Hung, M.S.2    Wightman, B.3    Way, J.4    Garriga, G.5
  • 99
    • 0028998860 scopus 로고
    • Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
    • Callahan CA, Muralidhar MG, Lundgren SE, Scully AL, Thomas JB Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. Nature. 376:1995;171-174.
    • (1995) Nature , vol.376 , pp. 171-174
    • Callahan, C.A.1    Muralidhar, M.G.2    Lundgren, S.E.3    Scully, A.L.4    Thomas, J.B.5
  • 100
    • 0030582672 scopus 로고    scopus 로고
    • The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points
    • Fambrough D, Goodman CS The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Cell. 87:1996;1049-1058.
    • (1996) Cell , vol.87 , pp. 1049-1058
    • Fambrough, D.1    Goodman, C.S.2
  • 101
    • 0031795610 scopus 로고    scopus 로고
    • Eukaryote genome duplication - where's the evidence?
    • Skrabanek L, Wolfe KH Eukaryote genome duplication - where's the evidence? Curr Opin Genet Dev. 8:1998;694-700.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 694-700
    • Skrabanek, L.1    Wolfe, K.H.2
  • 102
    • 0032998405 scopus 로고    scopus 로고
    • Multiple protein tyrosine phosphatases in sponges and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split
    • Ono K, Suga H, Iwabe N, Kuma K, Miyata T Multiple protein tyrosine phosphatases in sponges and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split. J Mol Evol. 48:1999;654-662.
    • (1999) J Mol Evol , vol.48 , pp. 654-662
    • Ono, K.1    Suga, H.2    Iwabe, N.3    Kuma, K.4    Miyata, T.5
  • 103
    • 0344223266 scopus 로고    scopus 로고
    • Comparison of early nerve cord development in insects and vertebrates
    • Arendt D, Nübler-Jung K Comparison of early nerve cord development in insects and vertebrates. Development. 126:1999;2309-2325.
    • (1999) Development , vol.126 , pp. 2309-2325
    • Arendt, D.1    Nübler-Jung, K.2
  • 106
    • 0032006352 scopus 로고    scopus 로고
    • Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans
    • Using a powerful suppressor screen, the authors identified eight genes that interact with unc-5. They confirmed the requirement of unc-40 for unc-5 function in many axon guidance events.
    • Colavita A, Culotti JG Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 194:1998;72-85. Using a powerful suppressor screen, the authors identified eight genes that interact with unc-5. They confirmed the requirement of unc-40 for unc-5 function in many axon guidance events.
    • (1998) Dev Biol , vol.194 , pp. 72-85
    • Colavita, A.1    Culotti, J.G.2


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