The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain

Neuroscience

Volumn 100, Issue 1, 2000, Pages 131-139

  Sim, F J ^a   Hinks, G L ^a   Franklin, R J M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Ageing; Demyelination; In situ hybridization; Myelin basic protein; Oligodendrocyte; Proteolipid protein

Indexed keywords

MESSENGER RNA; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; TRANSCRIPTION FACTOR;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DEMYELINATION; FEMALE; GENE CONTROL; GENE EXPRESSION; IN SITU HYBRIDIZATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REMYELINIZATION;

AGING; ANIMALS; BRAIN; DEMYELINATING DISEASES; FEMALE; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MYELIN BASIC PROTEINS; MYELIN PROTEOLIPID PROTEIN; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0034618841     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00252-9     Document Type: Article

References (33)

1. Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., OqHagan D., Garbern J., Kamholz J. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. J. Neurosci. 17:1997;6657-6668.
2. Bartholdi D., Schwab M.E. Oligodendroglial reaction following spinal cord injury in rat: transient upregulation of MBP mRNA. Glia. 23:1998;278-284.
3. Carson J.H., Nielson M.L., Barbarese E. Developmental regulation of myelin basic protein expression in mouse brain. Devl Biol. 96:1983;485-492.
4. De Ferra F., Engh H., Hudson L., Kamholz J., Puckett C., Molineaux S., Lazzarini R.A. Alternative splicing accounts for the four forms of myelin basic protein. Cell. 43:1985;721-727.
5. Dickinson P.J., Fanarraga M.L., Griffiths I.R., Barrie J.M., Kyriakides E., Montague P. Oligodendrocyte progenitors in the embryonic spinal cord express DM-20. Neuropath. appl. Neurobiol. 22:1996;188-198.
6. Dubois-Dalcq M., Armstrong R. The cellular and molecular events of central nervous system remyelination. Bioessays. 12:1990;569-576.
7. Franklin R.J.M., Hinks G.L. Understanding CNS remyelination - clues from developmental and regeneration biology. J. Neurosci. Res. 58:1999;207-213.
8. Griffiths I.R., Dickinson P., Montague P. Expression of the proteolipid protein gene in glial cells of the post-natal peripheral nervous system of rodents. Neuropath. appl. Neurobiol. 21:1995;97-110.
9. Griffiths I.R., Mitchell L.S., McPhilemy K., Morrison S., Kyriakides E., Barrie J.A. Expression of myelin protein genes in Schwann cells. J. Neurocytol. 18:1989;345-352.
10. Hinks G.L., Franklin R.J.M. Distinctive patterns of PDGF-A, FGF-2, IGF-I and TGF-β1 gene expression during remyelination of experimentally-induced spinal cord demyelination. Molec. Cell. Neurosci. 14:1999;153-168.
11. Hudson L.D., Berndt J.A., Puckett C., Kozak C.A., Lazzarini R.A. Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse. Proc. natn Acad. Sci. USA. 84:1987;1454-1458.
12. Hudson L. D., Kim J. G., Wiese C., Yao D.-L., Liu X., Webster H. D., Agoston D. V. and Armstrong R. (1997) Transcriptional controls in the oligodendrocyte lineage. In Molecular Signalling and Regulation in Glial Cells (eds Jeserich G., Althaus H. H., Richter-Landsberg C. and Heumann R.), pp. 182-190. Springer, Berlin.
13. Jordan C., Friedrich V., Dubois-Dalcq M. In situ hybridization analysis of myelin gene transcripts in developing mouse spinal cord. J. Neurosci. 9:1989;248-257.
14. Jordan C.A., Friedrich V.L., Godfraind C., Cardellechio C.B., Holmes K.V., Dubois-Dalcq M. Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus. Glia. 2:1989;318-329.
15. Keirstead H.S., Blakemore W.F. Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. J. Neuropath. exp. Neurol. 56:1997;1191-1201.
16. Komoly S., Hudson L.D., Webster H.D., Bondy C.A. Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Proc. natn. Acad. Sci. USA. 89:1992;1894-1898.
17. Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S. Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. Eur. molec. Biol. Org. J. 12:1993;1387-1401.
18. Melcangi R.C., Magnaghi V., Cavarretta I., Martini L., Piva F. Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives. Neuroscience. 85:1998;569-578.
19. Nadon N.L., Duncan I.D. Gene expression and oligodendrocyte development in the myelin deficient rat. J. Neurosci. Res. 41:1995;96-104.
20. Nait Oumesmar B., Vignais L., Duhamel-Clérin E., Avellana-Adalid V., Rougon G., Baron-Van Evercooren A. Expression of the highly polysialylated neural cell adhesion molecule during postnatal myelination and following chemically induced demyelination of the adult mouse spinal cord. Eur. J. Neurosci. 7:1995;480-491.
21. Papavassiliou A.G. Transcription-factor-modulating agents: precision and selectivity in drug design. Molec. Med. Today. 4:1998;358-366.
22. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd edn. 1986;Academic Press, San Diego.
23. Prayoonwiwat N., Rodriguez M. The potential for oligodendrocyte proliferation during demyelinating disease. J. Neuropath. exp. Neurol. 52:1993;55-63.
24. Redwine J.M., Armstrong R.C. In vivo proliferation of oligodendrocyte progenitors expressing PDGF-alphaR during early remyelination. J. Neurobiol. 37:1998;413-428.
25. Shields S.A., Gilson J.M., Blakemore W.F., Franklin R.J.M. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination. Glia. 28:1999;77-83.
26. Timsit S., Martinez S., Allinquant B., Peyron F., Puelles L., Zalc B. Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J. Neurosci. 15:1995;1012-1024.
27. Trapp B.D., Moench T., Pulley M., Barbosa E., Tennekoon G., Griffin J. Spatial segregation of mRNA encoding myelin-specific proteins. Proc. natn. Acad. Sci. USA. 84:1987;7773-7777.
28. Wegner M. Transcriptional control in myelinating glia: the basic recipe. Glia. 29:2000;118-123.
29. Woodruff R.H., Franklin R.J.M. The expression of myelin basic protein exon 1 and exon 2 during myelination of the neonatal rat spinal cord - an in situ hybridisation study. J. Neurocytol. 27:1998;683-693.
30. Woodruff R.H., Franklin R.J.M. Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide and complement/anti-galactocerebroside - a comparative study. Glia. 25:1999;216-228.
31. Woodruff R.H., Franklin R.J.M. The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination. Neuropath. appl. Neurobiol. 25:1999;226-235.
32. Wrathall J.R., Li W., Hudson L.D. Myelin gene expression after experimental contusive spinal cord injury. J. Neurosci. 18:1998;8780-8793.
33. Zeller N.K., Hunkeler M.J., Campagnoni A.T., Sprague J., Lazzarini R.A. Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone. Proc. natn. Acad. Sci. USA. 81:1984;18-22.