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Volumn 15, Issue 8, 2012, Pages 1074-1077

Animal models of multiple sclerosis: The good, the bad and the bottom line

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CUPRIZONE; CXCL13 CHEMOKINE; DIPHTHERIA TOXIN; ETHIDIUM BROMIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 23; LYSOPHOSPHATIDYLCHOLINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; RANTES; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR;

EID: 84864446952     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3168     Document Type: Article
Times cited : (271)

References (50)
  • 1
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer, S. et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 2
    • 34447508481 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors
    • Ascherio, A. & Munger, K.L. Environmental risk factors for multiple sclerosis. Part II: noninfectious factors. Ann. Neurol. 61, 504-513 (2007).
    • (2007) Ann. Neurol. , vol.61 , pp. 504-513
    • Ascherio, A.1    Munger, K.L.2
  • 3
    • 34247590137 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part I: The role of infection
    • Ascherio, A. & Munger, K.L. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann. Neurol. 61, 288-299 (2007).
    • (2007) Ann. Neurol. , vol.61 , pp. 288-299
    • Ascherio, A.1    Munger, K.L.2
  • 4
    • 84856249964 scopus 로고    scopus 로고
    • Fingolimod for multiple sclerosis
    • Pelletier, D. & Hafler, D.A. Fingolimod for multiple sclerosis. N. Engl. J. Med. 366, 339-347 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 339-347
    • Pelletier, D.1    Hafler, D.A.2
  • 5
    • 0019469331 scopus 로고
    • Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown
    • Prineas, J.W. & Graham, J.S. Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann. Neurol. 10, 149-158 (1981).
    • (1981) Ann. Neurol. , vol.10 , pp. 149-158
    • Prineas, J.W.1    Graham, J.S.2
  • 6
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis - The plaque and its pathogenesis
    • Frohman, E.M., Racke, M.K. & Raine, C.S. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354, 942-955 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 7
    • 0034021267 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis
    • Zhang, G.X., Baker, C.M., Kolson, D.L. & Rostami, A.M. Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis. Mult. Scler. 6, 3-13 (2000).
    • (2000) Mult. Scler. , vol.6 , pp. 3-13
    • Zhang, G.X.1    Baker, C.M.2    Kolson, D.L.3    Rostami, A.M.4
  • 8
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesions of multiple sclerosis
    • Trapp, B.D. et al. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338, 278-285 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 278-285
    • Trapp, B.D.1
  • 9
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson, B., Matyszak, M.K., Esiri, M.M. & Petty, V.H. Axonal damage in acute multiple sclerosis lesions. Brain 120, 393-399 (1997).
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Petty, V.H.4
  • 10
    • 14244254361 scopus 로고    scopus 로고
    • Mitochondrial damage and histotoxic hypoxia: A pathway of tissue injury in inflammatory brain disease?
    • Aboul-Enein, F. & Lassmann, H. Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease? Acta Neuropathol. 109, 49-55 (2005).
    • (2005) Acta Neuropathol. , vol.109 , pp. 49-55
    • Aboul-Enein, F.1    Lassmann, H.2
  • 11
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti, C. et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47, 707-717 (2000).
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1
  • 12
    • 83155173565 scopus 로고    scopus 로고
    • Inflammatory cortical demyelination in early multiple sclerosis
    • Lucchinetti, C.F. et al. Inflammatory cortical demyelination in early multiple sclerosis. N. Engl. J. Med. 365, 2188-2197 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2188-2197
    • Lucchinetti, C.F.1
  • 13
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek, B. et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol. 157, 267-276 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 267-276
    • Kornek, B.1
  • 14
    • 33845294412 scopus 로고    scopus 로고
    • Remyelination is extensive in a subset of multiple sclerosis patients
    • Patrikios, P. et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 129, 3165-3172 (2006).
    • (2006) Brain , vol.129 , pp. 3165-3172
    • Patrikios, P.1
  • 15
    • 0016746673 scopus 로고
    • Theiler′s virus infection in mice: An unusual biphasic disease process leading to demyelination
    • Lipton, H.L. Theiler′s virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect. Immun. 11, 1147-1155 (1975).
    • (1975) Infect. Immun. , vol.11 , pp. 1147-1155
    • Lipton, H.L.1
  • 16
    • 78650169672 scopus 로고    scopus 로고
    • Mouse models for multiple sclerosis: Historical facts and future implications
    • Croxford, A.L., Kurschus, F.C. & Waisman, A. Mouse models for multiple sclerosis: historical facts and future implications. Biochim. Biophys. Acta 1812, 177-183 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 177-183
    • Croxford, A.L.1    Kurschus, F.C.2    Waisman, A.3
  • 17
    • 84961059865 scopus 로고
    • A histologic study of the early lesion in experimental allergic encephalomyelitis
    • Waksman, B.H. & Adams, R.D. A histologic study of the early lesion in experimental allergic encephalomyelitis. Am. J. Pathol. 41, 135-162 (1962).
    • (1962) Am. J. Pathol. , vol.41 , pp. 135-162
    • Waksman, B.H.1    Adams, R.D.2
  • 18
    • 0016801036 scopus 로고
    • Experimental allergic encephalomyelitis (EAE) in mice. I. Induction of EAE with mouse spinal cord homogenate and myelin basic protein
    • Yasuda, T., Tsumita, T., Nagai, Y., Mitsuzawa, E. & Ohtani, S. Experimental allergic encephalomyelitis (EAE) in mice. I. Induction of EAE with mouse spinal cord homogenate and myelin basic protein. Jpn. J. Exp. Med. 45, 423-427 (1975).
    • (1975) Jpn. J. Exp. Med. , vol.45 , pp. 423-427
    • Yasuda, T.1    Tsumita, T.2    Nagai, Y.3    Mitsuzawa, E.4    Ohtani, S.5
  • 19
    • 0017148455 scopus 로고
    • T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice
    • Bernard, C.C., Leydon, J. & Mackay, I.R. T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice. Eur. J. Immunol. 6, 655-660 (1976).
    • (1976) Eur. J. Immunol. , vol.6 , pp. 655-660
    • Bernard, C.C.1    Leydon, J.2    MacKay, I.R.3
  • 20
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman, L. & Zamvil, S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 60, 12-21 (2006).
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 21
    • 0028872064 scopus 로고
    • Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theiler′s murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison
    • Dal Canto, M.C., Melvold, R.W., Kim, B.S. & Miller, S.D. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler′s murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc. Res. Tech. 32, 215-229 (1995).
    • (1995) Microsc. Res. Tech. , vol.32 , pp. 215-229
    • Dal Canto, M.C.1    Melvold, R.W.2    Kim, B.S.3    Miller, S.D.4
  • 23
    • 0031858641 scopus 로고    scopus 로고
    • Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: A correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus)
    • Hart, B.A. et al. Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus). Am. J. Pathol. 153, 649-663 (1998).
    • (1998) Am. J. Pathol. , vol.153 , pp. 649-663
    • Hart, B.A.1
  • 24
    • 84963011788 scopus 로고
    • Smadel memorial lecture: Neuroimmunologic diseases of animals and humans
    • Paterson, P.Y. & Joseph, E. Smadel Memorial Lecture: neuroimmunologic diseases of animals and humans. Rev. Infect. Dis. 1, 468-482 (1979).
    • (1979) Rev. Infect. Dis. , vol.1 , pp. 468-482
    • Paterson, P.Y.1    Joseph, E.2
  • 25
    • 0032892537 scopus 로고    scopus 로고
    • Demyelinating disease: Evolution of a paradigm
    • Waksman, B.H. Demyelinating disease: evolution of a paradigm. Neurochem. Res. 24, 491-495 (1999).
    • (1999) Neurochem. Res. , vol.24 , pp. 491-495
    • Waksman, B.H.1
  • 26
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
    • Yednock, T.A. et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 356, 63-66 (1992).
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1
  • 27
    • 1342345214 scopus 로고    scopus 로고
    • The CD4-th1 model for multiple sclerosis: A crucial re-appraisal
    • Lassmann, H. & Ransohoff, R.M. The CD4-Th1 model for multiple sclerosis: a crucial re-appraisal. Trends Immunol. 25, 132-137 (2004).
    • (2004) Trends Immunol , vol.25 , pp. 132-137
    • Lassmann, H.1    Ransohoff, R.M.2
  • 28
    • 67349179231 scopus 로고    scopus 로고
    • From genes to function: The next challenge to understanding multiple sclerosis
    • Fugger, L., Friese, M.A. & Bell, J.I. From genes to function: the next challenge to understanding multiple sclerosis. Nat. Rev. Immunol. 9, 408-417 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 408-417
    • Fugger, L.1    Friese, M.A.2    Bell, J.I.3
  • 29
    • 0035186414 scopus 로고    scopus 로고
    • Regulatory T cells in spontaneous autoimmune encephalomyelitis
    • De Camargo Furtado, G. et al. Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol. Rev. 182, 122-134 (2001).
    • (2001) Immunol. Rev. , vol.182 , pp. 122-134
    • De Camargo Furtado, G.1
  • 30
    • 33748304330 scopus 로고    scopus 로고
    • A mighty mouse: Building a better model of multiple sclerosis
    • Ransohoff, R.M. A mighty mouse: building a better model of multiple sclerosis. J. Clin. Invest. 116, 2313-2316 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2313-2316
    • Ransohoff, R.M.1
  • 31
    • 0036838576 scopus 로고    scopus 로고
    • Growth factor treatment of demyelinating disease: At last, a leap into the light
    • Ransohoff, R.M., Howe, C.L. & Rodriguez, M. Growth factor treatment of demyelinating disease: at last, a leap into the light. Trends Immunol. 23, 512-516 (2002).
    • (2002) Trends Immunol , vol.23 , pp. 512-516
    • Ransohoff, R.M.1    Howe, C.L.2    Rodriguez, M.3
  • 32
    • 0034618094 scopus 로고    scopus 로고
    • + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192, 393-404 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 393-404
    • Babbe, H.1
  • 33
    • 0035801332 scopus 로고    scopus 로고
    • + T cells in a model for multiple sclerosis
    • + T cells in a model for multiple sclerosis. J. Exp. Med. 194, 669-676 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 669-676
    • Huseby, E.S.1
  • 34
    • 79956310999 scopus 로고    scopus 로고
    • B cells in spontaneous autoimmune diseases of the central nervous system
    • Berer, K., Wekerle, H. & Krishnamoorthy, G. B cells in spontaneous autoimmune diseases of the central nervous system. Mol. Immunol. 48, 1332-1337 (2011).
    • (2011) Mol. Immunol. , vol.48 , pp. 1332-1337
    • Berer, K.1    Wekerle, H.2    Krishnamoorthy, G.3
  • 35
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser, S.L. et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N. Engl. J. Med. 358, 676-688 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 676-688
    • Hauser, S.L.1
  • 36
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with theiler′s virus leads to CNS autoimmunity via epitope spreading
    • Miller, S.D. et al. Persistent infection with Theiler′s virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3, 1133-1136 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 1133-1136
    • Miller, S.D.1
  • 37
    • 0345432117 scopus 로고    scopus 로고
    • Absence of neurological deficits following extensive demyelination in a class i-deficient murine model of multiple sclerosis
    • Rivera-Quiñones, C. et al. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nat. Med. 4, 187-193 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 187-193
    • Rivera-Quiñones, C.1
  • 38
    • 31544476315 scopus 로고    scopus 로고
    • Coronavirus infection of the central nervous system: Host-virus stand-off
    • Bergmann, C.C., Lane, T.E. & Stohlman, S.A. Coronavirus infection of the central nervous system: host-virus stand-off. Nat. Rev. Microbiol. 4, 121-132 (2006).
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 121-132
    • Bergmann, C.C.1    Lane, T.E.2    Stohlman, S.A.3
  • 39
    • 0035198691 scopus 로고    scopus 로고
    • The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    • Matsushima, G.K. & Morell, P. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol. 11, 107-116 (2001).
    • (2001) Brain Pathol , vol.11 , pp. 107-116
    • Matsushima, G.K.1    Morell, P.2
  • 40
    • 80053995816 scopus 로고    scopus 로고
    • De-and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected
    • Skripuletz, T., Gudi, V., Hackstette, D. & Stangel, M. De-and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected. Histol. Histopathol. 26, 1585-1597 (2011).
    • (2011) Histol. Histopathol. , vol.26 , pp. 1585-1597
    • Skripuletz, T.1    Gudi, V.2    Hackstette, D.3    Stangel, M.4
  • 41
    • 33845429949 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase plays a key role in CNS demyelination
    • Liñares, D. et al. Neuronal nitric oxide synthase plays a key role in CNS demyelination. J. Neurosci. 26, 12672-12681 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 12672-12681
    • Liñares, D.1
  • 42
    • 77649131914 scopus 로고    scopus 로고
    • Cxcr2-positive neutrophils are essential for cuprizone-induced demyelination: Relevance to multiple sclerosis
    • Liu, L. et al. CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nat. Neurosci. 13, 319-326 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 319-326
    • Liu, L.1
  • 43
    • 0035705454 scopus 로고    scopus 로고
    • Tnfα promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett, H.A. et al. TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4, 1116-1122 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1116-1122
    • Arnett, H.A.1
  • 44
    • 0018234553 scopus 로고
    • Central nervous system demyelination and remyelination in the mouse: An ultrastructural study of cuprizone toxicity
    • Ludwin, S.K. Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity. Lab. Invest. 39, 597-612 (1978).
    • (1978) Lab. Invest. , vol.39 , pp. 597-612
    • Ludwin, S.K.1
  • 45
    • 39549095800 scopus 로고    scopus 로고
    • Remyelination in experimental models of toxin-induced demyelination
    • Blakemore, W.F. & Franklin, R.J. Remyelination in experimental models of toxin-induced demyelination. Curr. Top. Microbiol. Immunol. 318, 193-212 (2008).
    • (2008) Curr. Top. Microbiol. Immunol. , vol.318 , pp. 193-212
    • Blakemore, W.F.1    Franklin, R.J.2
  • 46
    • 15044357461 scopus 로고    scopus 로고
    • Inflammation stimulates remyelination in areas of chronic demyelination
    • Foote, A.K. & Blakemore, W.F. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 128, 528-539 (2005).
    • (2005) Brain , vol.128 , pp. 528-539
    • Foote, A.K.1    Blakemore, W.F.2
  • 47
    • 0017682881 scopus 로고
    • Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin
    • Blakemore, W.F., Eames, R.A., Smith, K.J. & McDonald, W.I. Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J. Neurol. Sci. 33, 31-43 (1977).
    • (1977) J. Neurol. Sci. , vol.33 , pp. 31-43
    • Blakemore, W.F.1    Eames, R.A.2    Smith, K.J.3    McDonald, W.I.4
  • 48
    • 77956507890 scopus 로고    scopus 로고
    • Restoring the balance between disease and repair in multiple sclerosis: Insights from mouse models
    • Miller, R.H. & Fyffe-Maricich, S.L. Restoring the balance between disease and repair in multiple sclerosis: insights from mouse models. Dis. Model. Mech. 3, 535-539 (2010).
    • (2010) Dis. Model. Mech. , vol.3 , pp. 535-539
    • Miller, R.H.1    Fyffe-Maricich, S.L.2
  • 49
    • 78751501874 scopus 로고    scopus 로고
    • Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage
    • Pohl, H.B. et al. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J. Neurosci. 31, 1069-1080 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 1069-1080
    • Pohl, H.B.1
  • 50
    • 77957658807 scopus 로고    scopus 로고
    • A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination
    • Traka, M. et al. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. Brain 133, 3017-3029 (2010).
    • (2010) Brain , vol.133 , pp. 3017-3029
    • Traka, M.1


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