bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS

Science

Volumn 306, Issue 5704, 2004, Pages 2111-2115

  Arnett, Heather A ^a,e   Fancy, Stephen P J ^b   Alberta, John A ^a   Zhao, Chao ^b   Plant, Sheila R ^c   Kaing, Sovann ^a   Raine, Cedric S ^d   Rowitch, David H ^a   Franklin, Robin J M ^b   Stiles, Charles D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; FUNCTIONS; GENES; NEUROLOGY; PATIENT MONITORING;

BASIC HELIX-LOOP-HELIX (BHLH); CENTRAL NERVOUS SYSTEM (CNS); LESIONS; PROGENITOR CELLS;

CELLS;

HELIX LOOP HELIX PROTEIN; MYELIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OLIG1; UNCLASSIFIED DRUG;

NERVOUS SYSTEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; TRANSCRIPTION REGULATION;

ANIMALS; ANIMALS, NEWBORN; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN; CELL NUCLEUS; CUPRIZONE; CYTOPLASM; DEMYELINATING DISEASES; DNA-BINDING PROTEINS; ETHIDIUM; HUMANS; LYSOPHOSPHATIDYLCHOLINES; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYELIN SHEATH; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; STEM CELLS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 19944413626     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103709     Document Type: Article

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30. We thank R. L. Moore, M. Peacock, E. Jerszyk B. Cannella, and M. Pakingan for assistance with experiments. Supported by the National Multiple Sclerosis Society through a Collaborative Research Center award (C.D.S., D.H.R., C.S.R.), Harry Weaver Neuroscience Scholar Award (D.H.R.), and grant nos. FG1522A1, (H.A.A.) and RG1785E5 (S.R.P.); NIH grant nos. NS08952 (C.S.R.), NS11920 (C.S.R.), and NS4051 (D.H.R.); and grants from the Wellcome Trust, the Multiple Sclerosis Society of Great Britain and Northern Ireland, and the UK Biotechnology and Biological Sciences Research Council (R.J.M.F.). MS tissue sections for some of these studies were obtained from the UK Multiple Sclerosis Tissue Bank, which is supported by the Multiple Sclerosis Society of Great Britain and Northern Ireland.