Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation

Journal of Neurocytology

Volumn 28, Issue 4-5, 1999, Pages 365-381

  Cenci Di Bello, I ^a   Dawson, M R L ^a   Levine, J M ^b   Reynolds, R ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; DEMYELINATION; FEMALE; HISTOPATHOLOGY; MICROGLIA; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; STEM CELL; SYMPTOM;

ANIMALS; ANTIBODIES, MONOCLONAL; AXONS; BRAIN STEM; CELL DIFFERENTIATION; DEMYELINATING DISEASES; ENCEPHALITIS; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; MACROPHAGES; MICROGLIA; MICROSCOPY, CONFOCAL; MYELIN BASIC PROTEINS; MYELIN SHEATH; NEUROFILAMENT PROTEINS; OLIGODENDROGLIA; RATS; RATS, INBRED LEW; STEM CELLS; T-LYMPHOCYTES;

EID: 0033511223     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. ARENELLA, L. & HERNDON, R. (1984) Mature oligodendrocytes. Division following experimental demyelination in adult animals. Archives in Neurology 41, 1162-1165.
2. ARMSTRONG, R. C., DORN, H. H., KUFTA, C. V., FRIEDMAN, E. & DUBOIS-DALCQ, M. E. (1992) Preoligodendrocytes from adult human CNS. Journal of Neuroscience 12, 1538-1547.
3. BARRES, B. A. & RAFF, M. C. (1994) Control of oligodendrocyte number in the developing rat optic nerve. Neuron 12, 935-942.
4. BLAKEMORE, W. F. (1974) Remyelination of the superior cerebellar peduncle in the mouse induced by cuprizone. Journal of Neurological Sciences 20, 63-72.
5. BRÜCK, W., SCHMIED, M., SUCHANEK, G., BRÜCK, T., BREITSCHOPF, H., POSER, S., PIDDLESDEN, S. & LASSMANN, H. (1994) Oligodendrocytes in the early course of multiple sclerosis. Annals of Neurology 35, 65-73.
6. CANOLL, P. D., MUSACCHIO, J. M., HARDY, R., REYNOLDS, R., MARCHIONNI, M. A. & SALZER, J. L. (1996) GGF/Neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17, 229-243.
7. CARROLL, W. & JENNINGS, A. (1994) Early recruitment of oligodendrocyte precursors in CNS demyelination. Brain 117, 563-578.
8. CARROLL, W. M., JENNINGS, A. R. & IRONSIDE, L. J. (1998) Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination. Brain 121, 293-302.
9. ENGEL, U. & WOLSWIJK, G. (1996) Oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells derived from adult rat spinal cord: in vitro characteristics and response to PDGF, bFGF and NT-3. Glia 16, 16-26.
10. FFRENCH-CONSTANT, C. & RAFF, M. C. (1986) Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature 319, 499-502.
11. FRANKLIN, R. J. M. & BLAKEMORE, W. F. (1995) Glial cell transplantation and plasticity in the O-2A lineage - implications for CNS repair. Trends in Neuroscicnce 18, 151-156.
12. FRANKLIN, R. J. M., GILSON, J. M. & BLAKEMORE W. F. (1997) Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system. Journal of Neuroscience Research 50, 337-344.
13. GENSERT, J. M. & GOLDMAN, J. E. (1997). Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 19, 197-203.
14. GODFRAIND, C., FRIEDRICH, V. L., HOLMES, K. V. & DUBOIS-DALCQ, M. (1989) In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice. Journal of Cell Biology 109, 2405-2416.
15. HARDY, R. & REYNOLDS, R. (1993) Rat cerebral cortical neurons in primary culture release a mitogen specific for early (GD3+/04-) oligodendroglial progenitors, Journal of Neuroscience Research 34, 589-600.
16. KEIRSTEAD, H. S. & BLAKEMORE, W. F. (1997) Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. Journal of Neuropathology and Experimental Neurology 56, 1191-1201.
17. KEIRSTEAD, H. S., LEVINE, J. M. & BLAKEMORE, W. F. (1998) Response of the oligodendrocyte progenitor cell (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 22, 161-170.
18. LEVINE, J. M. (1994) Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury. Journal of Neuroscience 14, 4716-4730.
19. LEVINE, J. M., ENQUIST, L. W. & CARD, J. P. (1998) Reactions of oligodendrocyte precursor cells to alpha herpesvirus infection of the central nervous system. Glia 23, 316-328.
20. LEVINE, J. M. & REYNOLDS, R. (1999) Activation and proliferation of endogenous oligodendrocytc precursor cells during ethidium bromide induced demyelination. In press in Experimental Neurology.
21. LEVINE, J. M., STINCONE, F. & LEE, Y.-S. (1993) Development and differentiation of glial precursor cells in the rat cerebellum. Glia 7, 307-321.
22. LININGTON, C., BRADL, M., LASSMANN, H., BRUNNER, C. & VASS, K. (1988) Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. American Journal of Pathology 130, 443-454.
23. LUDWIN, S. (1978) Central nervous system demyelination and remyelination in the mouse. An ultrastructural study of cuprizone toxicity. Laboratory Investigation 39, 597-612.
24. MEESON, A., PIDDLESDEN, S., MORGAN, B. & REYNOLDS, R. (1994) The distribution of inflammatory demyelinated lesions in the central nervous system of rats with antibody-augmented demyelinating allergic encephalomyelitis. Experimental Neurology 129, 299-310.
25. + glial cells are distinct from resting and activated microglia. Journal of Neuroscience Research 48, 299-312.
26. O'LEARY, M. T. & BLAKEMORE, W. F. (1997) Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system. Journal of Neuroscience Research 48, 159-167.
27. OZAWA, K., SUCHANEK, G., BREITSCHOPF, H., BRÜCK, W., BUDKA, H., JELLINGER, K. & LASSMANN, H. (1994) Patterns of oligodendroglia pathology in multiple sclerosis. Brain 117, 1311-1322.
28. PRINEAS, J., BARNARD, R., KWON, E., SHARER, L. & CHO, E. (1993a) Multiple sclerosis. Pathology of recurrent lesions. Brain 116, 681-693.
29. PRINEAS, J., BARNARD, R., KWON, E., SHARER, L. & CHO, E. (1993b) Multiple sclerosis: remyelination of nascent lesions. Annals of Neurology 33, 137-151.
30. PRINEAS, J. & CONNELL, F. (1979) Remyelination in multiple sclerosis. Annals of Neurology 5, 22-31.
31. RAINE, C., SCHEINBERG, L. & WALTZ, J. (1981) Multiple sclerosis: oligodendrocyte survival and proliferation in an active established lesion. Laboratory Investigation 45, 534-546.
32. REYNOLDS, R., CENCI DI BELLO, I., MEESON, A. & PIDDLESDEN, S. (1996) Comparison of a chemically mediated and an immunologically mediated demyelinating lesion model. Methods: A Companion to Methods in Enzymology 10, 440-452.
33. REYNOLDS, R. & HARDY, R. (1997) Oligodendroglial progenitors labelled with the O4 antibody persist in the adult rat cerebral cortex in vivo. Journal of Neuroscience Research 47, 455-470.
34. REYNOLDS, R. & WILKIN, G. (1993) Cellular reaction to an acute demyelinating/remyelinnting lesion of the rat brain stem: localisation of GD3 immunoreactivity. Journal of Neuroscience Research 36, 405-122.
35. REYNOLDS, R. & WILKIN, G. P. (1988) Development of macroglial cells in rat cerebellum. II. An in situ immunohistochemicdl study of oligodendroglial lineage from precursor to mature myelinating cell. Development 102, 409-425.
36. RODRIGUEZ, M. (1992) Central nervous system demyelination and remyelination in multiple sclerosis and viral models of the disease. J. Neuroimmunology 40, 255-264.
37. SHI, J., MARINOVICH, A. & BARRES, B. A. (1998) Purification and characterisation of adult oligodendrocyte precursor cells from the rat optic nerve. Journal of Neuroscience 18, 4627-4636.
38. + cells in the adult optic nerve are ramified microglia rather than O-2A adult progenitor cells. Glia 10, 244-249.
39. WOLSWIJK, G. (1998) Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. Journal of Neuroscience 18, 601-609.
40. WOLSWIJK, G. & NOBLE, M. (1989) Identification of an adult-specific glial progenitor cell. Development 105, 387-400.
41. WOOD, P. M. & BUNGE, R. P. (1991) The origin of remyelinating cells in the adult central nervous system: The role of the mature oligodendrocyte. Glin 4, 225-232.
42. WREN, D., WOLSWIJK, G. & NOBLE, M. (1992) In vitro analysis of the origin and maintenance of O2A adult progenitor cells. Journal of Cell Biology 116, 167-176.