Coffee and cancer risk, epidemiological evidence, and molecular mechanisms

Molecular Nutrition and Food Research

Volumn 58, Issue 5, 2014, Pages 915-930

  Bøhn, Siv Kjølsrud ^a   Blomhoff, Rune ^a,b   Paur, Ingvild ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cancer; Coffee; Inflammation; Phytochemicals; Stress defense

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; COFFEE; PLANT MEDICINAL PRODUCT;

BREAST NEOPLASMS; CHEMOPROPHYLAXIS; COFFEE; COLORECTAL NEOPLASMS; FEMALE; HUMAN; LIVER NEOPLASMS; MALE; META ANALYSIS (TOPIC); PROSTATIC NEOPLASMS; RISK FACTOR;

ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BREAST NEOPLASMS; CHEMOPREVENTION; COFFEE; COLORECTAL NEOPLASMS; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; META-ANALYSIS AS TOPIC; PHYTOCHEMICALS; PROSTATIC NEOPLASMS; RISK FACTORS;

EID: 84898952377     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300526     Document Type: Review

References (130)

1. Halvorsen, B. L., Carlsen, M. H., Phillips, K. M. et al., Content of redox-active compounds (i.e., antioxidants) in foods consumed in the United States. Am. J. Clin. Nutr. 2006, 84, 95-135.
2. Svilaas, A., Sakhi, A. K., Andersen, L. F., Svilaas, T. et al., Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J. Nutr. 2004, 134, 562-567.
3. Barone, J. J., Roberts, H. R., Caffeine consumption. Food Chem. Toxicol. 1996, 34, 119-129.
4. Urgert, R., Katan, M. B., The cholesterol-raising factor from coffee beans. Annu. Rev. Nutr. 1997, 17, 305-324.
5. Mattila, P., Hellstrom, J., Torronen, R., Phenolic acids in berries, fruits, and beverages. J. Agric. Food Chem. 2006, 54, 7193-7199.
6. Clifford, M. N., Chlorogenic acids and other cinnamates-nature, occurrence and dietary burden. J. Sci. Food Agric. 1999, 79, 362-372.
7. Bekedam, E. K., Loots, M. J., Schols, H. A., Van Boekel, M. A. et al., Roasting effects on formation mechanisms of coffee brew melanoidins. J. Agric. Food Chem. 2008, 56, 7138-7145.
8. Lantz, I., Ternite, R., Wilkens, J., Hoenicke, K. et al., Studies on acrylamide levels in roasting, storage and brewing of coffee. Mol. Nutr. Food Res. 2006, 50, 1039-1046.
9. Houessou, J. K., Maloug, S., Leveque, A. S., Delteil, C. et al., Effect of roasting conditions on the polycyclic aromatic hydrocarbon content in ground Arabica coffee and coffee brew. J. Agric. Food Chem. 2007, 55, 9719-9726.
10. Butt, M. S., Sultan, M. T., Coffee and its consumption: benefits and risks. Crit. Rev. Food Sci. Nutr. 2011, 51, 363-373.
11. World Cancer Research Fund, Health professionals "less aware than public" on myth that coffee increases risk of cancer. 2009. Available from: http://www.wcrf.org/cancer_research/cup/key_findings/endometrial_cancer.php
12. Floegel, A., Pischon, T., Bergmann, M. M., Teucher, B. et al., Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am. J. Clin. Nutr. 2012, 95, 901-908.
13. World Cancer Research Fund. Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. AICR, Washington, DC 2007.
14. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project report. Food, nutrition, physical activity, and the prevention of endometrial cancer. 2013.
15. Jiang, W., Wu, Y., Jiang, X., Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol. Oncol. 2013, 129, 620-629.
16. Li, X. J., Ren, Z. J., Qin, J. W., Zhao, J. H. et al., Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLoS One 2013, 8, e52681.
17. Yu, X., Bao, Z., Zou, J., Dong, J., Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 2011, 11, 96. doi: 10.1186/1471-2407-11-96.
18. Tang, N., Zhou, B., Wang, B., Yu, R., Coffee consumption and risk of breast cancer: a meta-analysis. Am. J. Obstet. Gynecol. 2009, 200, 290-299.
19. Lowcock, E. C., Cotterchio, M., Anderson, L. N., Boucher, B. A. et al., High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Nutr. Cancer 2013, 65, 398-409.
20. Simonsson, M., Soderlind, V., Henningson, M., Hjertberg, M. et al., Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status. Cancer Causes Control 2013, 24, 929-940.
21. Park, C. H., Myung, S. K., Kim, T. Y., Seo, H. G. et al., Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies. BJU Int. 2010, 106, 762-769.
22. Discacciati, A., Orsini, N., Andersson, S. O., Andren, O. et al., Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study. Ann. Oncol. 2013, 24, 1912-1918.
23. Nilsson, L. M., Johansson, I., Lenner, P., Lindahl, B. et al., Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes Control 2010, 21, 1533-1544.
24. Shafique, K., McLoone, P., Qureshi, K., Leung, H. et al., Coffee consumption and prostate cancer risk: further evidence for inverse relationship. Nutr. J. 2012, 11, 42. doi: 10.1186/1475-2891-11-42.
25. Bosire, C., Stampfer, M. J., Subar, A. F., Wilson, K. M. et al., Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control 2013, 24, 1527-1534.
26. Wilson, K. M., Kasperzyk, J. L., Rider, J. R., Kenfield, S. et al., Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study. J. Natl. Cancer Inst. 2011, 103, 876-884.
27. Li, Q., Kakizaki, M., Sugawara, Y., Tomata, Y. et al., Coffee consumption and the risk of prostate cancer: the Ohsaki cohort study. Br. J. Cancer 2013, 108, 2381-2389.
28. Iso, H., Kubota, Y., Nutrition and disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). Asian Pac. J. Cancer Prev. 2007, 8(Suppl), 35-80.
29. Wilson, K. M., Balter, K., Moller, E., Adami, H. O. et al., Coffee and risk of prostate cancer incidence and mortality in the Cancer of the Prostate in Sweden Study. Cancer Causes Control 2013, 24, 1575-1581.
30. Ganesh, B., Saoba, S. L., Sarade, M. N., Pinjari, S. V., Risk factors for prostate cancer: an hospital-based case-control study from Mumbai, India. Indian J. Urol. 2011, 27, 345-350.
31. Geybels, M. S., Neuhouser, M. L., Stanford, J. L., Associations of tea and coffee consumption with prostate cancer risk. Cancer Causes Control 2013, 24, 941-948.
32. Arab, L., Su, L. J., Steck, S. E., Ang, A. et al., Coffee consumption and prostate cancer aggressiveness among African and Caucasian Americans in a population-based study. Nutr. Cancer 2012, 64, 637-642.
33. Geybels, M. S., Neuhouser, M. L., Wright, J. L., Stott-Miller, M. et al., Coffee and tea consumption in relation to prostate cancer prognosis. Cancer Causes Control 2013, 24, 1947-1954.
34. Sang, L. X., Chang, B., Li, X. H., Jiang, M., Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol. 2013, 13, 34. doi: 10.1186/1471-230X-13-34.
35. Bravi, F., Bosetti, C., Tavani, A., Bagnardi, V. et al., Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology 2007, 46, 430-435.
36. Larsson, S. C., Wolk, A., Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology 2007, 132, 1740-1745.
37. Lai, G. Y., Weinstein, S. J., Albanes, D., Taylor, P. R. et al., The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers. Br. J. Cancer 2013, 109, 1344-1351.
38. Tian, C., Wang, W., Hong, Z., Zhang, X., Coffee consumption and risk of colorectal cancer: a dose-response analysis of observational studies. Cancer Causes Control 2013, 24, 1265-1268.
39. Li, G., Ma, D., Zhang, Y., Zheng, W., Wang, P., Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies. Public Health Nutr. 2013, 16, 346-357.
40. Galeone, C., Turati, F., La, V. C., Tavani, A., Coffee consumption and risk of colorectal cancer: a meta-analysis of case-control studies. Cancer Causes Control 2010, 21, 1949-1959.
41. Zhang, X., Albanes, D., Beeson, W. L., Van den Brandt, P. A. et al., Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J. Natl. Cancer Inst. 2010, 102, 771-783.
42. Je, Y., Liu, W., Giovannucci, E., Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective cohort studies. Int. J. Cancer 2009, 124, 1662-1668.
43. Giovannucci, E., Meta-analysis of coffee consumption and risk of colorectal cancer. Am. J. Epidemiol. 1998, 147, 1043-1052.
44. Kontou, N., Psaltopoulou, T., Soupos, N., Polychronopoulos, E. et al., The role of number of meals, coffee intake, salt and type of cookware on colorectal cancer development in the context of the Mediterranean diet. Public Health Nutr. 2013, 16, 928-935.
45. Wang, Z. J., Ohnaka, K., Morita, M., Toyomura, K. et al., Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study. World J. Gastroenterol. 2013, 19, 2683-2690.
46. Sugiyama, K., Kuriyama, S., Akhter, M., Kakizaki, M. et al., Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J. Nutr. 2010, 140, 1007-1013.
47. Mathers, J. C., Strathdee, G., Relton, C. L., Induction of epigenetic alterations by dietary and other environmental factors. Adv. Genet. 2010, 71, 3-39.
48. Surh, Y. J., Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3, 768-780.
49. Andersen, L. F., Jacobs, D. R. Jr., Carlsen, M. H., Blomhoff, R., Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study. Am. J. Clin. Nutr. 2006, 83, 1039-1046.
50. Svilaas, A., Sakhi, A. K., Andersen, L. F., Svilaas, T. et al., Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J. Nutr. 2004, 134, 562-567.
51. Mursu, J., Voutilainen, S., Nurmi, T., Alfthan, G. et al., The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial. Free Radic. Biol. Med. 2005, 38, 527-534.
52. Kempf, K., Herder, C., Erlund, I., Kolb, H. et al., Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am. J. Clin. Nutr. 2010, 91, 950-957.
53. Manzocco, L., Calligaris, S., Mastrocola, D., Nicoli, M. C. et al., Review of non-enzymatic browning and antioxidant capacity in processed foods. Trends Food Sci. Technol. 2000, 11, 340-346.
54. Paur, I., Balstad, T. R., Blomhoff, R., Degree of roasting is the main determinant of the effects of coffee on NF-kappaB and EpRE. Free Radic. Biol. Med. 2010, 48, 1218-1227.
55. Wei, F., Furihata, K., Koda, M., Hu, F., Miyakawa, T. et al., Roasting process of coffee beans as studied by nuclear magnetic resonance: time course of changes in composition. J. Agric. Food Chem. 2012, 60, 1005-1012.
56. Nunes, F. M., Coimbra, M. A., Melanoidins from coffee infusions. Fractionation, chemical characterization, and effect of the degree of roast. J. Agric. Food Chem. 2007, 55, 3967-3977.
57. Chen, J. H., Hales, C. N., Ozanne, S. E., DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 2007, 35, 7417-7428.
58. Xu, C., Li, C. Y., Kong, A. N., Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 2005, 28, 249-268.
59. Balstad, T. R., Carlsen, H., Myhrstad, M. C., Kolberg, M. et al., Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo-studies in electrophile response element transgenic mice. Mol. Nutr. Food Res. 2011, 55, 185-197.
60. Volz, N., Boettler, U., Winkler, S., Teller, N. et al., Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo. J. Agric. Food Chem. 2012, 60, 9631-9641.
61. Boettler, U., Volz, N., Teller, N., Haupt, L. M. et al., Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype? Mol. Biol. Rep. 2012, 39, 7155-7162.
62. Higgins, L. G., Cavin, C., Itoh, K., Yamamoto, M. et al., Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol. Appl. Pharmacol. 2008, 226, 328-337.
63. Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P. et al., Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology 2010, 139, 1699-1710.
64. Bakuradze, T., Boehm, N., Janzowski, C., Lang, R. et al., Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: results from an intervention study. Mol. Nutr. Food Res. 2011, 55, 793-797.
65. Somoza, V., Five years of research on health risks and benefits of Maillard reaction products: an update. Mol. Nutr. Food Res. 2005, 49, 663-672.
66. Boettler, U., Volz, N., Pahlke, G., Teller, N. et al., Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Mol. Nutr. Food Res. 2011, 55, 798-802.
67. Boettler, U., Sommerfeld, K., Volz, N., Pahlke, G. et al., Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J. Nutr. Biochem. 2011, 22, 426-440.
68. Kotyczka, C., Boettler, U., Lang, R., Stiebitz, H. et al., Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers. Mol. Nutr. Food Res. 2011, 55, 1582-1586.
69. Steinkellner, H., Hoelzl, C., Uhl, M., Cavin, C. et al., Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7, 8-dihydrodiol-9, 10-epoxide induced DNA-damage: results of controlled human intervention trials. Mutat. Res. 2005, 591, 264-275.
70. Feng, R., Lu, Y., Bowman, L. L., Qian, Y. et al., Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280, 27888-27895.
71. Isshiki, M., Ohta, H., Tamura, H., Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells. Biol. Pharm. Bull. 2013, 36, 299-304.
72. Huber, W. W., Scharf, G., Nagel, G., Prustomersky, S. et al., Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver-comparison with phase II xenobiotic metabolism. Mutat. Res. 2003, 522, 57-68.
73. Cavin, C., Bezencon, C., Guignard, G., Schilter, B., Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems. Biochem. Biophys. Res. Commun. 2003, 306, 488-495.
74. Huber, W. W., Prustomersky, S., Delbanco, E., Uhl, M. et al., Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol. Arch. Toxicol. 2002, 76, 209-217.
75. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S. A. et al., The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 2001, 61, 3299-3307.
76. Scharf, G., Prustomersky, S., Knasmuller, S., Schulte-Hermann, R. et al., Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr. Cancer 2003, 45, 74-83.
77. Hwang, Y. P., Jeong, H. G., The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress. FEBS Lett. 2008, 582, 2655-2662.
78. Bichler, J., Cavin, C., Simic, T., Chakraborty, A. et al., Coffee consumption protects human lymphocytes against oxidative and 3-amino-1-methyl-5H-pyrido[4, 3-b]indole acetate (Trp-P-2) induced DNA-damage: results of an experimental study with human volunteers. Food Chem. Toxicol. 2007, 45, 1428-1436.
79. Misik, M., Hoelzl, C., Wagner, K. H., Cavin, C. et al., Impact of paper filtered coffee on oxidative DNA-damage: results of a clinical trial. Mutat. Res. 2010, 692, 42-48.
80. Cardin, R., Piciocchi, M., Martines, D., Scribano, L.et al., Effects of coffee consumption in chronic hepatitis C: a randomized controlled trial. Dig. Liver Dis. 2013, 45, 499-504.
81. Majer, B. J., Hofer, E., Cavin, C., Lhoste, E. et al., Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2). Food Chem. Toxicol. 2005, 43, 433-441.
82. Morii, H., Kuboyama, A., Nakashima, T., Kawai, K. et al., Effects of instant coffee consumption on oxidative DNA damage, DNA repair, and redox system in mouse liver. J. Food Sci. 2009, 74, H155-H161.
83. Mercer, J. R., Gray, K., Figg, N., Kumar, S. et al., The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice. Arterioscler. Thromb. Vasc. Biol. 2012, 32, 2461-2467.
84. Balkwill, F., Mantovani, A., Inflammation and cancer: back to Virchow? Lancet 2001, 357, 539-545.
85. Mantovani, A., Allavena, P., Sica, A., Balkwill, F., Cancer-related inflammation. Nature 2008, 454, 436-444.
86. Lopez-Garcia, E., van Dam, R. M., Qi, L., Hu, F. B., Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am. J. Clin. Nutr. 2006, 84, 888-893.
87. Kempf, K., Herder, C., Erlund, I., Kolb, H. et al., Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am. J Clin. Nutr. 2010, 91, 950-957.
88. Zampelas, A., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C. et al., Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am. J. Clin. Nutr. 2004, 80, 862-867.
89. Correa, T. A., Rogero, M. M., Mioto, B. M., Tarasoutchi, D. et al., Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: a clinical trial. Nutrition 2013, 29, 977-981.
90. Yamashita, K., Yatsuya, H., Muramatsu, T., Toyoshima, H. et al., Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr. Diabetes 2012, 2, e33.
91. Paur, I., Balstad, T. R., Kolberg, M., Pedersen, M. K. et al., Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice. Cancer Prev. Res. (Phil.) 2010, 3, 653-663.
92. Katayama, M., Donai, K., Sakakibara, H., Ohtomo, Y. et al., Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat. Clin. Nutr. 2013. doi: 10.1016/j.clnu.2013.05.006.
93. Shin, J. W., Wang, J. H., Kang, J. K., Son, C. G., Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats. J. Sci. Food Agric. 2010, 90, 450-455.
94. Shim, S. G., Jun, D. W., Kim, E. K., Saeed, W. K. et al., Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model. J. Gastroenterol. Hepatol. 2013, 28, 1877-1884.
95. Furtado, K. S., Prado, M. G., Aguiar, E., Silva, M. A. et al., Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats. Basic Clin. Pharmacol. Toxicol. 2012, 111, 339-347.
96. Ohta, A., Lukashev, D., Jackson, E. K., Fredholm, B. B., et al., 3, 7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. J. Immunol. 2007, 179, 7431-7438.
97. Poyrazoglu, O. K., Bahcecioglu, I. H., Ataseven, H., Metin, K. et al., Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats. Inflammation 2008, 31, 408-413.
98. Shi, H., Dong, L., Jiang, J., Zhao, J. et al., Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology 2013, 303, 107-114.
99. Karin, M., Greten, F. R., NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5, 749-759.
100. Chang, W. C., Chen, C. H., Lee, M. F., Chang, T., et al., Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells. Eur. J. Nutr. 2010, 49, 267-275.
101. Lee, C. H., Yoon, S. J., Lee, S. M., Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis. Mol. Med. 2012, 18, 1437-1448.
102. Kwak, S. C., Lee, C., Kim, J. Y., Oh, H. M. et al., Chlorogenic acid inhibits of osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-b ligand-induced nuclear factor of activated T cells c1 expression. Biol. Pharm. Bull. 2013, 36, 1779-1786.
103. Chung, T. W., Moon, S. K., Chang, Y. C., Ko, J. H. et al., Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J. 2004, 18, 1670-1681.
104. Bufalo, M. C., Ferreira, I., Costa, G., Francisco, V. et al., Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-kappaB and MAPK activation in macrophages. J. Ethnopharmacol. 2013, 149, 84-92.
105. Kim, S. R., Jung, Y. R., Kim, D. H., An, H. J. et al., Caffeic acid regulates LPS-induced NF-kappaB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells. Arch. Pharm. Res. 2013. doi: 10.1007/s12272-013-0211-6.
106. Bessler, H., Salman, H., Bergman, M., Djaldetti, M., Caffeine alters cytokine secretion by PBMC induced by colon cancer cells. Cancer Invest. 2012, 30, 87-91.
107. Kang, C. H., Jayasooriya, R. G., Dilshara, M. G., Choi, Y. H. et al., Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation. Food Chem. Toxicol. 2012, 50, 4270-4276.
108. Li, X. Y., Xu, L., Lin, G. S., Li, X. Y. et al., Protective effect of caffeine administration on myocardial ischemia/reperfusion injury in rats. Shock 2011, 36, 289-294.
109. Kim, J. Y., Jung, K. S., Jeong, H. G., Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. FEBS Lett. 2004, 569, 321-326.
110. Kim, H. G., Kim, J. Y., Hwang, Y. P., Lee, K. J. et al., The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. Toxicol. Appl. Pharmacol. 2006, 217, 332-341.
111. Anton, P. M., Craus, A., Niquet-Leridon, C., Tessier, F. J., Highly heated food rich in Maillard reaction products limit an experimental colitis in mice. Food Funct. 2012, 3, 941-949.
112. Vitaglione, P., Morisco, F., Mazzone, G., Amoruso, D. C. et al., Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010, 52, 1652-1661.
113. Conney, A. H., Lu, Y. P., Lou, Y. R., Kawasumi, M. et al., Mechanisms of caffeine-induced inhibition of UVB carcinogenesis. Front Oncol. 2013, 3, 144. doi: 10.3389/fonc.2013.00144.
114. Ong, K. W., Hsu, A., Tan, B. K., Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLoS. One 2012, 7, e32718.
115. Lou, Y., Peng, Q., Li, T., Nolan, B. et al., Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. Nutr. Cancer 2013, 65, 1002-1013.
116. Choi, M. J., Park, E. J., Oh, J. H., Min, K. J. et al., Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chem. Biol. Interact. 2011, 190, 102-108.
117. Merighi, S., Benini, A., Mirandola, P., Gessi, S. et al., Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Mol. Pharmacol. 2007, 72, 395-406.
118. Honn, K. V., Tang, D. G., Crissman, J. D., Platelets and cancer metastasis: a causal relationship? Cancer Metastasis Rev. 1992, 11, 325-351.
119. Natella, F., Nardini, M., Belelli, F., Pignatelli, P. et al., Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. Br. J. Nutr. 2008, 100, 1276-1282.
120. Bhaskar, S., Rauf, A. A., Modulatory effect of coffee on platelet function. Indian J. Physiol. Pharmacol. 2010, 54, 141-148.
121. Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M. et al., Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol. Appl. Pharmacol. 2007, 222, 122-128.
122. Mattson, M. P, Calabrese, E. J., Hormesis: what it is and why it matters. In: Mattson, M. P., Calabrese, E. J. (Eds.), Hormesis: A Revolution in Biology, Toxicology and Medicine, Humana Press, London 2010, pp. 1-13.
123. Bøhn, S. K., Myhrstad, M. C., Thoresen, M., Holden, M. et al., Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers. BMC Med. 2010, 8, 54. doi: 10.1186/1741-7015-8-54.
124. Pahl, H. L., Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18, 6853-6866.
125. Muscat, S., Pelka, J., Hegele, J., Weigle, B. et al., Coffee and Maillard products activate NF-kappaB in macrophages via H2O2 production. Mol. Nutr. Food Res. 2007, 51, 525-535.
126. Sauer, T., Raithel, M., Kressel, J., Muscat, S. et al., Nuclear translocation of NF-kappaB in intact human gut tissue upon stimulation with coffee and roasting products. Food Funct. 2011, 2, 529-540.
127. Yang, R. C., Chen, H. W., Lu, T. S., Hsu, C., Potential protective effect of NF-kappaB activity on the polymicrobial sepsis of rats preconditioning heat shock treatment. Clin. Chim. Acta 2000, 302, 11-22.
128. Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D. et al., Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc. Natl. Acad. Sci. USA 2005, 102, 4584-4589.
129. Del Pino-Garcia, R., Gonzalez-San Jose, M. L., Rivero-Perez, M. D., Muniz, P., Influence of the degree of roasting on the antioxidant capacity and genoprotective effect of instant coffee: contribution of the melanoidin fraction. J. Agric. Food Chem. 2012, 60, 10530-10539.
130. Bøhn, S. K., Ward, N. C., Hodgson, J. M., Croft, K. D., Effects of tea and coffee on cardiovascular disease risk. Food Funct. 2012, 3, 575-591.