Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Molecular Nutrition and Food Research

Volumn 55, Issue 5, 2011, Pages 798-802

  Boettler, Ute ^a   Volz, Nadine ^a   Pahlke, Gudrun ^a   Teller, Nicole ^a   Kotyczka, Christine ^b   Somoza, Veronika ^a,b   Stiebitz, Herbert ^c   Bytof, Gerhard ^c   Lantz, Ingo ^c   Lang, Roman ^d   Hofmann, Thomas ^d   Marko, Doris ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

^c TCHIBO GMBH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antioxidative; Chemoprevention; Coffee; Gene transcription; Nrf2 pathway

Indexed keywords

1 METHYLPYRIDINIUM; 1-METHYLPYRIDINIUM; ANTIOXIDANT; CHLOROGENIC ACID; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; PYRIDINIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ARTICLE; BIOSYNTHESIS; CELL STRAIN HT29; CHEMISTRY; CHEMOPROPHYLAXIS; COFFEE; DNA RESPONSIVE ELEMENT; DRUG EFFECT; ENZYME INDUCTION; HUMAN; METABOLISM; PHYSIOLOGY;

ANTIOXIDANTS; CHEMOPREVENTION; CHLOROGENIC ACID; COFFEE; ENZYME INDUCTION; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HT29 CELLS; HUMANS; NF-E2-RELATED FACTOR 2; PYRIDINIUM COMPOUNDS; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS;

EID: 79955587670     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100115     Document Type: Article

References (17)

1. Wilkinson, J., Clapper, M. L., Detoxification enzymes and chemoprevention. Proc. Soc. Exp. Biol. Med. 1997, 216, 192-200.
2. Zhang, Y., Gordon, G., A strategy for cancer prevention: stimulation of the Nrf2-ARE signalling pathway. Mol. Cancer Ther. 2004, 3, 885-892.
3. Somoza, V., Lindenmeier, M., Wenzel, E., Frank, O. et al., Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques. J. Agric. Food Chem. 2003, 51, 6861-6869.
4. Talalay, P., De Long, M. J., Prochaska, H. J., Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. Natl. Acad. Sci. USA 1988, 85, 8261-8265.
5. Kwak, M. K., Itoh, K., Yamamoto, M., Kensler, T., Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol. 2002, 22, 2883-2892.
6. Kensler, T. W., Wakabayashi, N., Biswal, S., Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 89-116.
7. Ishii, T., Itoh, K., Takahashi, S., Sato, H. et al., Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 2000, 275, 16023-16029.
8. Boettler, U., Sommerfeld, K., Volz, N., Pahlke, G. et al., Modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression in coffee beverage. J. Nutr. Biochem. 2010, DOI: 10.1016/j.jnutbio.2010.03.011.
9. Lang, R., Yagar, E. F., Eggers, R., Hofmann, T., Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. J. Agric. Food Chem. 2008, 56, 11114-11121.
10. Lang, R., Mueller, C., Hofmann, T., Development of a stable isotope dilution analysis with LC-MS/MS detection for the quantitative analysis of di- and trihydroxybenzenes in foods and model systems. J. Agric. Food Chem. 2006, 54, 5755-5762.
11. Steinkellner, H., Hoelzl, C., Uhl, M., Cavin, C. et al., Coffee consumption induces GSTP in plasma and protects lymphocytes against (±)-anti-benzo[a]pyrene-7, 8-dihydrodiol-9, 10-epoxide induced DNA-damage: results of controlled human intervention trials. Mutat. Res. 2005, 591, 264-275.
12. Higgins, L. G., Cavin, C., Itoh, K., Yamamoto, M., Hayes, J. D., Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol. Appl. Pharmacol. 2010, DOI: 10.1016/j.taap.2007.09.018.
13. Cavin, C., Marin-Kuan, M., Langouet, S., Becencon, C. et al., Induction of Nrf2-mediated cellular defense and alteration of phase I-activities as mechanisms of chemoprotective effects of coffee in the liver. Food Chem. Toxicol. 2008, 46, 1239-1248.
14. Yanagimoto, K., Ochi, H., Lee, K. G., Shibamoto, T., Antioxidative activities of fractions obtained from brewed coffee. J. Agric. Food Chem. 2004, 52, 592-596.
15. Nelson, H. H., Wiencke, J. K., Christiani, D. C., Cheng, T. J. et al., Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis 1995, 16, 1243-1245.
16. Marzec, J. M., Christie, J. D., Reddy, S. P., Jedlicka, A. E. et al., Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J. 2007, 21, 2237-2246.
17. Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., Strassburg, C. P., Coffee induces expression of glucuronosyltransferases via the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology 2010, 139, 1453-1457.