The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress

FEBS Letters

Volumn 582, Issue 17, 2008, Pages 2655-2662

  Hwang, Yong Pil ^a   Jeong, Hye Gwang ^a  

^a Chosun University   (South Korea)

Author keywords

Heme oxygenase 1; Kahweol; Neuroprotection; NF E2 related factor 2; p38 kinase; Phosphatidylinositol 3 kinase

Indexed keywords

CASPASE 3; HEME OXYGENASE 1; KAHWEOL; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL DEATH; CELL PROTECTION; COFFEE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; NEUROPROTECTION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TUMOR; CELL NUCLEUS; COFFEE; CYTOPROTECTION; DITERPENES; DOPAMINE; HEME OXYGENASE-1; HUMANS; NEURONS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDOPAMINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 46749135955     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.06.045     Document Type: Article

References (19)

1. Pettmann B., and Henderson C.E. Neuronal cell death. Neuron 20 (1998) 633-647
2. Chen X.L., and Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des. 10 (2004) 879-891
3. Kapitulnik J. Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties. Mol. Pharmacol. 66 (2004) 773-779
4. Takahashi T., Morita K., Akagi R., and Sassa S. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr. Med. Chem. 11 (2004) 1545-1561
5. Maines M.D. Heme oxygenase: function, multiplicity, regulatory mechanisms and clinical application. FASEB J. 2 (1998) 2557-2568
6. Tulis D.A., Durante W., Peyton K.J., Evans A.J., and Schafer A.I. Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis 155 (2001) 113-122
7. Alam J., and Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr. Pharm. Des. 9 (2003) 2499-2511
8. Itoh K., Tong K.I., and Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic. Biol. Med. 36 (2004) 1208-1213
9. Kong A.N., Owuor E., Yu R., Hebbar V., Chen C., Hu R., and Mandlekar S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev. 33 (2001) 255-271
10. Huang H.C., Nguyen T., and Pickett C.B. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NFE2- related factor 2. Proc. Natl. Acad. Sci. USA 97 (2000) 12475-12480
11. Nakaso K., Yano H., Fukuhara Y., Takeshima T., Wada-Isoe K., and Nakashima K. PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett. 546 (2003) 181-184
12. Gómez-Ruiz J.A., Leake D.S., and Ames J.M. In vitro antioxidant activity of coffee compounds and their metabolites. J. Agric. Food Chem. 55 (2007) 6962-6969
13. Rufián-Henares J.A., and Morales F.J. Effect of in vitro enzymatic digestion on antioxidant activity of coffee melanoidins and fractions. J. Agric. Food Chem. 55 (2007) 10016-10021
14. Mori H., Kawabata K., Matsunaga K., Ushida J., Fujii K., Hara A., Tanaka T., and Murai H. Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis. Biofactors 12 (2000) 101-105
15. Steinkellner H., et al. Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials. Mutat. Res. 591 (2005) 264-275
16. Lee K.J., and Jeong H.G. Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol. Lett. 73 (2007) 80-87
17. Kutty R.K., and Maines M.O. Oxidation of heme c derivatives by purified heme oxygenase in the rat liver. J. Biol. Chem. 257 (1982) 9944-9952
18. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., and Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
19. Martin D., Rojo A.I., Salinas M., Diaz R., Gallardo G., Alam J., Galarreta C.M., and Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-Kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J. Biol. Chem. 279 (2004) 8919-8929