Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 12, 2005, Pages 4584-4589

  Dinkova Kostova, Albena T ^a   Liby, Karen T ^b   Stephenson, Katherine K ^a   Holtzclaw, W David ^a   Gao, Xiangqun ^a   Suh, Nanjoo ^b   Williams, Charlotte ^b   Risingsong, Renee ^b   Honda, Tadashi ^c   Gribble, Gordon W ^c   Sporn, Michael B ^b   Talalay, Paul ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Dartmouth College   (United States)

Author keywords

Inflammation; NAD(P)H quinone acceptor oxidoreductase; Nrf2 Keap1; Oxidative stress; Phase 2 enzymes

Indexed keywords

CYCLOOXYGENASE 2; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; KEAP1 PROTEIN; OLEANOLIC ACID DERIVATIVE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REPRESSOR PROTEIN; THIOL DERIVATIVE; TRANSCRIPTION FACTOR NRF2; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME REPRESSION; ENZYME SPECIFICITY; FIBROBLAST; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; MACROPHAGE; MICHAEL ADDITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; INFLAMMATION; MICE; NADPH DEHYDROGENASE; NF-E2-RELATED FACTOR 2; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES; TRANS-ACTIVATORS; U937 CELLS;

MURINAE;

EID: 20144383831     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500815102     Document Type: Article

References (32)

1. Honda, T., Gribble, G. W., Suh, N., Finlay, H. J., Rounds, B. V., Bore, L., Favaloro, F. G., Jr., Wang, Y. & Sporn, M. B. (2000) J. Med. Chem. 43, 1866-1877.
2. Honda, T., Rounds, B. V., Bore, L., Finlay, H. J., Favaloro, F. G., Jr., Suh, N., Wang, Y., Sporn, M. B. & Gribble, G. W. (2000) J. Med. Chem. 43, 4233-4246.
3. Honda, T., Honda, Y., Favaloro, F. G., Jr., Gribble, G. W., Suh, N., Place, A. E., Rendi, M. H. & Sporn, M. B. (2002) Bioorg. Med. Chem. Lett. 12, 1027-1030.
4. Ito, Y., Pandey, P., Sporn, M. B., Datta, R., Kharbanda, S. & Kufe, D. (2001) Mol. Pharmacol. 59, 1094-1099.
5. Konopleva, M., Tsao, T., Ruvolo, P., Stiouf, I., Estrov, Z., Leysath, C., Zhao, S., Harris, D., Chang, S., Jackson, E., et al. (2002) Blood 99, 326-333.
6. Pedersen, I. M., Kitada, S., Schimmer, A., Kim, Y., Zapata, J. M., Charboneau, L., Rassenti, L., Andreeff, M., Bennet, F., Sporn, M. B., et al (2002) Blood 100, 2965-2972.
7. Talalay P., De Long, M. J. & Prochaska, H. J. (1988) Proc. Natl. Acad. Sci. USA 85, 8261-8265.
8. Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. (2001) Proc. Natl. Acad. Sci. USA 98, 3404-3409.
9. Hayes, J. D. & McMahon, M. (2001) Cancer Lett. 174, 103-113.
10. Holtzclaw, W. D., Dinkova-Kostova, A. T. & Talalay, P. (2004) Adv. Enzyme Regul. 44, 335-367.
11. Motohashi, H. & Yamamoto, M. (2004) Trends Mol. Med. 10, 549-557.
12. Lapillonne, H., Konopleva, M., Tsao, T., Gold, D., McQueen, T., Sutherland, R. L., Madden, T. & Andreeff, M. (2003) Cancer Res. 63, 5926-5939.
13. Morse, D. & Choi, A. M. (2002) Am. J. Respir. Cell Mol. Biol. 27, 8-16.
14. Prestera, T., Talalay, P., Alam, J., Ahn, Y. I., Lee, P. J. & Choi, A. M. (1995) Mol. Med. 1, 827-837.
15. Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K. & Yamamoto, M. (2004) Mol. Cell. Biol. 24, 36-45.
16. Fahey, J. W., Dinkova-Kostova, A. T., Stephenson, K. K. & Talalay, P. (2004) Methods Enzymol. 382, 243-258.
17. Gao, X. & Talalay, P. (2004) Proc. Natl. Acad. Sci. USA 101, 10446-10451.
18. Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M. I., Kobayashi, A., Yamamoto, M., Kensler, T. W. & Talalay, P. (2004) Proc. Natl. Acad. Sci. USA 101, 2040-2045.
19. Suh, N., Honda, T., Finlay, H. J., Barchowsky, A., Williams, C., Benoit, N. E., Xie, Q. W., Nathan, C., Gribble, G. W. & Sporn, M. B. (1998) Cancer Res. 58, 717-723.
20. Prochaska, H. J. & Santamaria, A. B. (1988) Anal. Biochem. 169, 328-336.
21. LeBel, C. P., Ischiropoulos, H. & Bondy, S. C. (1992) Chem. Res. Toxicol. 5, 227-231.
22. Kang, Y. H. & Pezzuto, J. M. (2004) Methods Enzymol. 382, 380-414.
23. Favaloro, F. G., Jr., Honda, T., Honda, Y., Gribble, G. W., Suh, N., Risingsong, R. & Sporn, M. B. (2002) J. Med. Chem. 45, 4801-4805.
24. Honda, T., Favaloro, F. G., Jr., Janosik, T., Honda, Y., Suh, N., Sporn, M. B. & Gribble, G. W. (2003) Org. Biomol. Chem. 1, 4384-4391.
25. Prochaska, H. J. & Talalay, P. (1988) Cancer Res. 48, 4776-4782.
26. Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. & Talalay, P. (2002) Proc. Natl. Acad. Sci. USA 99, 11908-11913.
27. Chou, T. C. & Talalay, P. (1984) Adv. Enzyme Regul. 22, 27-55.
28. Wang, Y.-P. (2001) Ph.D. thesis (Dartmouth Medical School, Hanover, NH).
29. Baeuerle, P. A. (1998) Cell 95, 729-731.
30. Heiss, E., Herhaus, C., Klimo, K., Bartsch, H. & Gerhauser, C. (2001) J. Biol. Chem. 276, 32008-32015.
31. García-Piñeres, A. J., Castro, V., Mora, G., Schmidt, T. J., Strunck, E., Pahl, H. L. & Merfort, I. (2001) J. Biol. Chem. 276, 39713-39720.
32. Juurlink, B. H. (2001) Can. J. Physiol. Pharmacol. 79, 266-282.