Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol

Archives of Toxicology

Volumn 76, Issue 4, 2002, Pages 209-217

  Huber, Wolfgang W ^a   Prustomersky, Sonja ^a   Delbanco, Evert ^b,d   Uhl, Maria ^a   Scharf, Gerlinde ^a   Turesky, Robert J ^c,f   Thier, Ricarda ^b,e   Schulte Hermann, Rolf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d HENKEL KGAA   (Germany)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Chemoprevention; Coffee; Glutathione S transferase; Organ specificity; Rat; UDP glucuronosyl transferase

Indexed keywords

CAFESTOL; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; KAHWEOL; DITERPENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; COFFEE; COLON; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; KIDNEY; LIVER PROTECTION; LUNG; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; PROTECTION; RAT; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DIGESTIVE SYSTEM; ENZYMOLOGY; EXOCRINE GLAND; FISCHER 344 RAT; HEART MUSCLE; METABOLISM; SPLEEN; TESTIS; URINARY TRACT;

ANIMAL; COFFEE; DIGESTIVE SYSTEM; DITERPENES; EXOCRINE GLANDS; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; LUNG; MALE; MYOCARDIUM; ORGAN SPECIFICITY; RATS; RATS, INBRED F344; SPLEEN; SUPPORT, NON-U.S. GOV'T; TESTIS; URINARY TRACT; ANIMALS;

ANIMALIA; RODENTIA;

EID: 0035987086     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0322-1     Document Type: Article

References (76)

1. Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans
2. Genetic cancer susceptibility and DNA adducts: Studies in smokers, tobacco chewers, and coke oven workers
3. Detoxication of base propenals and other α,β-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases
4. Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
5. A rapid sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein binding
6. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz
7. The UDP glucuronosyltransferase gene superfamily: Suggested nomenclature based on evolutionary divergence
8. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism
9. Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: Mechanisms in rat and human cells
10. Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect
11. Chemopreventive activity of oltipraz
12. Glutathione S-transferases - Biomarkers of cancer risk and chemopreventive response
13. Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz
14. Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters
15. The role of glutathione and glutathione transferases in chemical carcinogenesis
16. Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: Factors influencing renal carcinogenesis induced by xenobiotics
17. Concise review of the glutathione S-transferases and their significance to toxicology
18. Mechanisms of aflatoxin carcinogenesis
19. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
20. Enzymatic conjugation of epoxides with glutathione
21. Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes
22. Meta-analysis of coffee consumption and risk of colorectal cancer
23. Analysis of the content of the diterpenes cafestol and kahweol in coffee brews
24. Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication
25. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
26. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
27. Rat liver theta-class glutathione S-transferases T1-1 and T2-2: Their chromatographic, electrophoretic, immunochemical, and functional properties
28. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase
29. Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in the rat
30. The coffee components kahweol and cafestol induce c-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat
31. Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes
32. Development of cancer chemopreventive agents: Oltipraz as a paradigm
33. The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer
34. UDP-glucuronosyltransferases
35. Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice
36. Mammalian class theta GST and differential susceptibility to carcinogens: A review
37. Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture
38. Effects of human and rat glutathione S-transferase on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: A possible mechanism of organ specificity in their carcinogenesis
39. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
40. Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism
41. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin
42. The cap 'n' collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
43. Theta, a new class of glutathione transferases purified from rat and man
44. Kahweol and cafestol: Inhibitors of hamster buccal pouch carcinogenesis
45. Role of GSTT1 and GSMT1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes
46. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: Identification of specific UGT1A family isoforms involved
47. The separation of glutathione transferase subunits by using reverse-phase high-pressure liquid chromatography
48. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism
49. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice
50. Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
51. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver
52. Effect of three chemoprotective antioxidants, ethoxyquin, oltipraz and 1,2-dithiole-3-thiones, on cytochrome p-450 levels and aflatoxin B1 metabolism
53. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility
54. Differences in stereoselectivity and catalytic effciency of three human glutathione transferases in the conjugation of glutathione with 7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo (a)pyrene
55. Modulation of the biological effects of glucosinolates by inulin and oat fibre in gnotobiotic rats inoculated with a human whole faecal flora
56. Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol
57. Glutathione-S-transferase (GST) theta polymorphism influences background SCE rate
58. Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1
59. Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione S-transferases, and DT-diaphorase in the saliva of subjects who continually ingest large quantities of coffee or broccoli
60. The glutathione S-transferases: Influence of polymorphism on cancer susceptibility
61. Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease
62. Chemoprotection against cancer by phase 2 enzyme induction
63. Drug metabolism polymorphisms as modulators of cancer susceptibility
64. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes
65. Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium
66. Comparison of GST theta activity in liver and kidney of four species
67. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
68. Metabolism of heterocyclic aromatic amines and strategies of human biomonitoring
69. Levels of the cholesterol-elevating diterpenes cafestol and kahweol in various coffee brews
70. Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels
71. Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz - 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione-, 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes
72. Comprehensive analysis of proteins which interact with the antioxidant responsive element: Correlation of ARE-BP-1 with the chemoprotective induction response
73. Gene deletion of glutathione S-transferase T: Correlation with induced genetic damage and potential role in endogenous mutagenesis
74. Chloramphenicol glucuronyl transferase: Assay, ontogeny and inducibility
75. The value of placental glutathione S-transferase and γ-glutamyl transpeptidase as markers of altered foci during hamster pouch carcinogenesis