Coffee and Caffeine Protect against Liver Injury Induced by Thioacetamide in Male Wistar Rats

Basic and Clinical Pharmacology and Toxicology

Volumn 111, Issue 5, 2012, Pages 339-347

  Furtado, Kelly S ^a   Prado, Monize G ^a   Aguiar e Silva, Marco A ^a   Dias, Marcos C ^a   Rivelli, Diogo P ^b   Rodrigues, Maria A M ^a   Barbisan, Luis F ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CAFFEINE; CASPASE 3; COLLAGEN; CYCLINE; GELATINASE A; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COFFEE; CONTROLLED STUDY; DRUG EFFECT; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; CAFFEINE; CASPASE 3; COFFEE; COLLAGEN; DRUG-INDUCED LIVER INJURY; FOOD HANDLING; GLUTATHIONE; LIVER; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASE 2; OXIDATION-REDUCTION; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; RANDOM ALLOCATION; RATS; RATS, WISTAR; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS; RATTUS NORVEGICUS;

EID: 84867648351     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00903.x     Document Type: Article

References (50)

1. Heckman MA, Weil J, Gonzalez de Mejia E. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci 2010;75:R77-87.
2. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr 2011;51:363-73.
3. Leung WW, Ho SC, Chan HL, Wong V, Yeo W, Mok TS. Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case control-study. J Epidemiol Community Health 2011;65:556-8.
4. Costentin CE, Roudot-Thoraval F, Zafrani ES, Medkour F, Pawlotsky JM, Mallat A et al.Association of caffeine intake and histological features of chronic hepatitis C. J Hepatol 2011;54:1123-9.
5. Catalano D, Martines GF, Tonzuso A, Pirri C, Trovato GM. Protective role of coffee in non-alcoholic fatty liver disease (NAFLD). Dig Dis Sci 2010;10:1143-3.
6. Modi AA, Feld JJ, Park Y, Kleiner DE, Everhart JE, Liang TJ et al.Increased caffeine consumption is associated with reduced hepatic fibrosis. Hepatology 2010;51:201-9.
7. Bravi F, Bosetti C, Tavani A, Bagnardi V, Gallus S, Negri E et al.Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology 2007;46:430-5.
8. Lee KJ, Choi JH, Jeong HG. Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol 2007;45:2118-25.
9. Ozercan IH, Dagli AF, Ustundag B, Ozercan MR, Bahcecioglu IH, Celik H et al.Does instant coffee prevent acute liver injury induced by carbon tetrachloride (CCl(4))? Hepatol Res 2006;35:163-8.
10. Shi H, Dong L, Zhang Y, Bai Y, Zhao J, Zhang L. Protective effect of a coffee preparation (Nescafe pure) against carbon tetrachloride-induced liver fibrosis in rats. Clin Nutr 2010;29:399-405.
11. Shin JW, Wang JH, Hang JK, Son CG. Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats. J Sci Food Agric 2010;90:450-5.
12. Poyrazoglu OK, Bahcecioglu IH, Ataseven H, Metin K, Dagli AF, Yalniz M et al.Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats. Inflammation 2008;31:408-13.
13. Bedossa P, Paradis V. Liver extracellular matrix in health and disease. J Pathol 2003;200:504-15.
14. Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol 2011;6:425-56.
15. Justulin LA Jr, Acquaro C, Carvalho RF, Silva MD, Felisbino SL. Combined effect of the finasteride and doxazosin on rat ventral prostate morphology and physiology. Int J Androl 2010;33:489-99.
16. Consolo M, Amoroso A, Spandidos DA, Mazzarino MC. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease. Int J Mol Med 2009;24:143-52.
17. Kisseleva T, Brenner DA. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 2006;21:S84-7.
18. Manibusan MK, Odin M, Eastmind DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2007;25:185-209.
19. Natarajan SK, Thomas S, Ramamoorthy P, Basivireddy J, Pulimood AB, Ramachandran A et al.Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. J Gastroenterol Hepatol 2006;21:947-57.
20. Kang JS, Wanibuchi H, Morimura K, Wongpoomchai R, Chusiri Y, Gonzalez FJ et al.Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity. Toxicol Appl Pharmacol 2008;228:295-300.
21. Ramaiah SK, Apte U, Mehendale HM. Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats. Drug Metab Dispos 2001;29:1088-95.
22. Hasegawa R, Ogiso T, Imaida K, Shirai T, Ito N. Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Food Chem Toxicol 1995;33:15-20.
23. Hosaka S, Kawa S, Aoki Y, Tanaka E, Yoshizawa K, Karasawa Y et al.Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. Food Chem Toxicol 2001;39:557-61.
24. Silva JF, Bidinotto LT, Furtado KS, Salvadori DM, Rivelli DP, Barros SB et al.Maté attenuates DNA damage and carcinogenesis induced by diethylnitrosamine and thermal injury in rat esophagus. Food Chem Toxicol 2009;47:1521-9.
25. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S. The current state of serum biomarkers of hepatotoxicity. Toxicology 2008;245:194-205.
26. Delella FK, Justulin LA Jr, Felisbino SL. Finasteride treatment alters MMP-2 and -9 gene expression and activity in the rat ventral prostate. Int J Androl 2010;33:114-22.
27. Bruck R, Ashkenazi M, Weiss S, Goldiner I, Shapiro H, Aeed H et al.Prevention of liver cirrhosis in rats by curcumin. Liver Int 2007;27:373-83.
28. Furtado KS, Pires PW, Justulin LA Jr, Rodrigues MA, Felisbino SL, Barbisan LF. Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis. J Mol Histol 2009;40:1-11.
29. Pires PW, Furtado KS, Justullin LA Jr, Rodrigues MA, Felisbino SL, Barbisan LF. Chronic ethanol intake promotes double gluthatione S-transferase/transforming growth factor-alpha-positive hepatocellular lesions in male Wistar rats. Cancer Sci 2008;99:221-8.
30. Paroni R, De Vecchi E, Cighetti G, Arcelloni C, Fermo I, Grossi A et al.HPLC with o-phthalaldehyde precolumn derivatization to measure total, oxidized, and protein-bound glutathione in blood, plasma, and tissue. Clin Chem 1995;41:448-54.
31. Freedman ND, Everhart JE, Lindsay KL, Ghany MG, Curto TM, Shiffman ML et al.Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology 2009;50:1360-9.
32. Li X, Benjamin IS, Alexander B. Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality. J Hepatol 2002;36:488-93.
33. Tian M, Schiemann WP. The TGF-beta paradox in human cancer: an update. Future Oncol 2009;5:259-71.
34. Bissell DM. Chronic liver injury, TGF-beta, and cancer. Exp Mol Med 2001;33:179-90.
35. Moreno MG, Chávez E, Aldaba-Muruato LR, Segovia J, Vergara P, Tsutsumi V et al.Coffee prevents CCl(4)-induced liver cirrhosis in the rat. Hepatol Int 2011;5:857-63.
36. Chan ES, Montesinos MC, Fernandez P, Desai A, Delano DL, Yee H et al.Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol 2006;148:1144-55.
37. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 2003;253:269-85.
38. Knittel T, Mehde M, Grundmann A, Saile B, Scharf JG, Ramadori G. Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem Cell Biol 2000;113:443-53.
39. Kot M, Daniel WA. Caffeine as a marker substrate for testing cytochrome P450 activity in human and rat. Pharmacol Rep 2008;60:789-97.
40. Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53.
41. Huber WW, Rossmanith W, Grusch M, Haslinger E, Prustomersky S, Peter-Vörösmarty B et al. Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food Chem Toxicol 2008;46:1230-8.
42. Huber WW, Parzefall W. Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods Enzymol 2005;401:307-41.
43. Kalthoff S, Ehmer U, Freiberg N, Manns MP, Strassburg CP. Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology 2010;139:1699-710.
44. Matés JM. Effects of antioxidant enzymes in the molecular control of reactive oxygen species. Toxicology 2000;153:83-104.
45. Rossowska MJ, Nakamoto T. Effects of chronic caffeine feeding on the activities of oxygen free radical defense enzymes in the growing rat heart and liver. Experientia 1994;50:465-8.
46. Boettler U, Sommerfeld K, Volz N, Pahlke G, Teller N, Somoza V et al.Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J Nutr Biochem 2011;22:426-40.
47. Gervasi PG, Longo V, Marzano M, Saviozzi M, Malvaldi G. Chronic liver injury by thioacetamide and promotion of hepatic carcinogenesis. J Cancer Res Clin Oncol 1989;115:29-35.
48. Silva-Oliveira EM, Fernandes PA, Moraes-Santos T. Effect of coffee on chemical hepatocarcinogenesis in rats. Nutr Cancer 2010;62:336-42.
49. Okano J, Nagahara T, Matsumoto K, Murawaki Y. Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway. Basic Clin Pharmacol Toxicol 2008;102:543-51.
50. Gressner OA. In the search of the magic bullet ... Gastroenterology 2010;139:1453-7.