Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation

Food and Chemical Toxicology

Volumn 50, Issue 12, 2012, Pages 4270-4276

  Kang, Chang Hee ^a   Jayasooriya, Rajapaksha Gendara Prasad Tharanga ^a   Dilshara, Matharage Gayani ^a   Choi, Yung Hyun ^b   Jeong, Yong Kee ^c   Kim, Nam Deuk ^d   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Dong A University   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Akt; Caffeine; Nitric oxide; Nuclear factor B; Prostaglandin E2; Tumor necrosis factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CAFFEINE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN P50; PYRROLIDINE DITHIOCARBAMATE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYCLOXYGENASE 2 GENE; DNA BINDING; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MICROGLIA; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN SUBUNIT; REGULATORY MECHANISM; TUMOR NECROSIS FACTOR ALPHA GENE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAFFEINE; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; SIGNAL TRANSDUCTION; THIOCARBAMATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866872520     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.08.041     Document Type: Article

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