The cholesterol-raising factor from coffee beans

Annual Review of Nutrition

Volumn 17, Issue , 1997, Pages 305-324

  Urgert, R ^a   Katan, M B ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cafestol; Lipid metabolism; Liver enzymes; Serum lipids

Indexed keywords

DITERPENE; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; COFFEE; CORONARY RISK; ENZYME ACTIVITY; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER FUNCTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ANIMALS; COFFEE; CORONARY DISEASE; DITERPENES; HUMANS; HYPERCHOLESTEROLEMIA; INFANT; LIVER DISEASES;

EID: 0030752316     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.17.1.305     Document Type: Review

References (95)

1. Ahola I, Jauhiainen M, Aro A. 1991. The hypercholesterolaemic factor in boiled coffee is retained by a paper filter. J. Intern. Med. 230:293-97
2. Ali ME, Felimban FM. 1993. A study of the impact of Arabic coffee consumption on serum cholesterol. J. R. Soc. Health 113:288-91
3. Al-Kanhal MA, Tariq M, Iqbal SS. 1990. Effect of gahwa (Arabian coffee) on serum lipid and lipoprotein levels in rats. Res. Commun. Subst. Abuse 11:185-94
4. Almendingen K, Jordal O, Kierulf P, Sandstad B, Pedersen JI. 1995. Effects of partially hydrogenated fish oil, partially hydrogenated soybean oil, and butter on serum lipoproteins and lp[a] in men. J. Lipid Res. 36:1370-84
5. Arnesen E, Førde OH, Thelle DS. 1984. Coffee and serum cholesterol. Br. Med. J. 288:1960
6. Aro A. 1993. The effect of coffee on serum lipids and its clinical considerations. Cardiovasc. Risk Factors 3:238-43
7. Aro A, Kostiainen E, Huttunen JK, Seppälä E, Vapaatalo H. 1985. Effects of coffee and tea on lipoproteins and prostanoids. Atherosclerosis 57:123-28
8. Aro A, Teirila J, Gref CG. 1990. Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled, non-filtered coffee. Atherosclerosis 83:257-61
9. Aro A, Tuomilehto J, Kostiainen E, Uusitalo U, Pietinen P. 1987. Boiled coffee increases serum low density lipoprotein concentration. Metabolism 36:1027-30
10. Bak AAA, Grobbee DE. 1989. The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N. Engl. J. Med. 321:1432-37
11. Beynen AC, Weusten-van der Wouw MPME, De Roos B, Katan MB. 1996. Boiled coffee fails to raise serum cholesterol in hamsters and rats. Br. J. Nutr. 76:755-64
12. Burr ML, Gallacher JEJ, Butland BK, Bolton CH, Downs LG. 1989. Coffee, blood pressure and plasma lipids: a randomized controlled trial. Ear. J. Clin. Nutr. 43:477-83
13. Burr ML, Limb ES, Sweetnam PM, Fehily AM, Amarah L, et al. 1995. Instant coffee and cholesterol: a randomised controlled trial. Eur. J. Clin. Nutr. 49:779-84
14. Bønaa K, Arnesen E, Thelle DS, Førde OH. 1988. Coffee and cholesterol: Is it all in the brewing? The Tromsø Study. Br. Med. J. 297:1103-4
15. Casiglia E, Spolaore P, Ginocchio G, Ambrosio GB. 1993. Unexpected effects of coffee consumption on liver enzymes. Eur. J. Epidemiol. 9:293-97
16. Corrao G, Lepore AR, Torchio P, Valenti M, Galatola G, et al. 1994. The effect of drinking coffee and smoking cigarettes on the risk of cirrhosis associated with alcohol consumption: a case-control study. Eur. J. Epidemiol. 10:657-64
17. Dahlén GH. 1994. Lp(a) lipoprotein in cardiovascular disease. Atherosclerosis 108:111-26
18. D'Amicis A, Scaccini C, Tomassi G, Anaclerio M, Stomelli R, et al. 1996. Italian style brewed coffee: effect on serum cholesterol in young men. Int. J. Epidemiol. 25:513-20
19. D'Avanzo B, Santoro L, Nobili A, La Vecchia C, and the GISSI-EFRIM Study Group. 1993. Coffee consumption and serum cholesterol. Prev. Med. 22:219-24
20. Debry G. 1994. Coffee and Health. London: Libbey Eurotext
21. Finocchiaro C, Pezzana A, Pernigotti L, Bo M. 1990. The influence of coffee on plasma lipids. In Coffee and Coronary Heart Disease, ed. DS Thelle, GHD van der Stegen, pp. 101-5. Göteborg, Sweden: Nordic Sch. Public Health
22. Fried RE, Levine DM, Kwiterovitch PO, Diamond EL, Wilder LB, et al. 1992. The effect of filtered-coffee consumption on plasma lipid levels. JAMA 267:811-15
23. Førde OH, Knutsen SF, Arnesen E, Thelle DS. 1985. The Tromsø heart study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia - a randomised intervention study. Br. Med. J. 290:893-95
24. Gillum RF. 1994. Trends in acute myocardial infarction and coronary heart disease death in the United States. J. Am. Coll. Cardiol 23:1273-77
25. Green MS, Harari G. 1992. Association of serum lipoproteins and health-related habits with coffee and tea consumption in free-living subjects examined in the Israeli CORDIS Study. Prev. Med. 21:532-45
26. Greenland S. 1993. A meta-analysis of coffee, myocardial infarction, and coronary death. Epidemiology 4:366-74
27. Grobbee DE, Rimm EB, Giovannucci E, Colditz G, Stampfer M, et al. 1990. Coffee, caffeine, and cardiovascular disease in men. N. Engl. J. Med. 323:1026-32
28. Gross G, Jaccaud E, Huggett AC. 1997. Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food Chem. Toxicol. In press
29. Halvorsen B. 1996. Metabolism of low density lipoprotein. Relation of certain nutrients, drugs, and proteoglycans. PhD thesis. Univ. Oslo, Norway
30. Halvorsen B, Nenseter MS, Christiansen EN, Huggett AC, Drevon CA. 1994. Effects of cafestol on cholesterol metabolism in human skin fibroblasts. Circulation 90:1-75
31. Heckers H, Göbel U, Kleppel U. 1994. End of the coffee mystery: diterpene alcohols raise serum low-density lipoprotein cholesterol and triglyceride levels. J. Intern. Med. 235:192-93
32. Hill C. 1985. Coffee consumption and cholesterol concentrations. Br. Med. J. 290:1590 (Lett.)
33. Høstmark AT, Lystad E, Haug A, Bjerkedal T, Eilertsen E. 1988. Effect of boiled and instant coffee on plasma lipids and fecal excretion of neutral sterols and bile acids in the rat. Nutr. Rep. Int. 38:859-64
34. IARC Working Group. 1991. Monogr. Evaluation of Carcinogenic Risks to Humans, Vol. 51, Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon, France: Int. Agency Res. Cancer
35. Jansen DF, Nedeljkovic S, Feskens EJM, Ostojic MC, Grujic MZ, et al. 1995. Coffee consumption, alcohol use, and cigarette smoking as determinants of serum total and HDL cholesterol in two Serbian cohorts of the Seven Countries Study. Arterioscler. Thromb. 15:1793-97
36. Johansson L, Drevon CA, Bjorneboe GEA. 1996. The Norwegian diet during the last hundred years in relation to coronary heart disease. Eur. J. Clin. Nutr. 50:277-83
37. Kark JD. 1990. Coffee consumption and cholesterol levels in Israel. In Coffee and Coronary Heart Disease, ed. DS Thelle, GHD van der Stegen, pp. 17-23. Göteborg, Sweden: Nordic Sch. Public Health
38. Kark JD, Friedlander Y, Kaufmann NA, Stein Y. 1985. Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic prevalence study. Br. Med. J. 291:699-704
39. Kawachi I, Colditz GA, Stone CB. 1994. Does coffee drinking increase the risk of coronary heart disease? Results from a meta-analysis. Br. Heart J. 72:269-75
40. Keil E. 1990. Determination of enzyme activities in serum for the detection of xenobiotic effects on the liver. Exp. Pathol. 39:157-64
41. Klatsky AL, Armstrong MA. 1992. Alcohol, smoking, coffee, and cirrhosis. Am. J. Epidemiol. 136:1248-57
42. Kono S, Shinchi K, Imanishi K, Todoroki I, Hatsuse K. 1994. Coffee and serum gamma-glutamyltransferase: a study of self-defense officials in Japan. Am. J. Epidemiol. 139:723-27
43. La Vecchia C, Levi F, Lucchini F, Franceschi S, Negri E. 1994. Worldwide patterns and trends in mortality from liver cirrhosis, 1955 to 1990. Ann. Epidemiol. 4:480-86
44. Leviton A, Allred AN. 1994. Correlates of decaffeinated coffee choice. Epidemiology 5:537-40
45. Lindahl B, Johansson I, Huhtasaari F, Hallmans G, Asplund K. 1991. Coffee drinking and blood cholesterol - effects of brewing method, food intake and life style. J. Intern. Med. 230:299-305
46. Mensink RP, Katan MB. 1992. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler. Thromb. 12:911-19
47. Mensink RP, Lebbink WJ, Lobbezoo IE, Weusten-van der Wouw MPME, Zock PL, et al. 1995. Diterpene composition of oils from Arabica and Robusta coffee beans and their effects on serum lipids in man. J. Intern. Med. 237:543-50
48. Mensink RP, Zock PL, Katan MB, Beynen AC. 1992. Boiled coffee does not increase serum cholesterol in gerbils and hamsters. Z. Ernähr.wiss. 31:82-85
49. Mensink RP, Zock PL, Katan MB, Hornstra G. 1992. Effect of dietary cis and trans fatty acids on serum lipoprotein(a) levels in humans. J. Lipid Res. 33:1493-501
50. Myers MG, Basinski A. 1992. Coffee and coronary heart disease. Arch. Intern. Med. 152:1767-72
51. Nackunstz B, Maier HG. 1987. Diterpenoids in coffee. III. Cafestol and kahweol. Z. Lebensm. Unters. Forsch. 184: 494-99 (In German)
52. Nestel P, Noakes M, Belling B, McArthur R, Clifton P, et al. 1992. Plasma lipoprotein lipid and lp(a) changes with substitution of elaidic acid for oleic acid in the diet. J. Lipid Res. 33:1029-36
53. Nilssen O, Førde OH. 1994. Seven-year longitudinal population study of change in gamma-glutamyltransferase: the Tromsø study. Am. J. Epidemiol. 139:787-92
54. Nilssen O, Førde OH, Brenn T. 1990. The Tromsø Study. Distribution and population determinants of gamma-glutamyltransferase. Am. J. Epidemiol. 132:318-26
55. Panico S, Celentano E, Krogh V. 1990. Coffee and blood lipids in Italy. In Coffee and Coronary Heart Disease, ed. DS Thelle, G van der Stegen, pp. 63-70. Göteborg, Sweden: Nordic Sch. Public Health
56. Paul O, Lepper MH, Phelan WH, Dupertuis GW, Macmillan A, et al. 1963. A longitudinal study of coronary heart disease. Circulation 28:20-31
57. Paul O, Macmillan A, McKean H, Park H. 1968. Sucrose intake and coronary heart disease. Lancet 2:1049-51
58. Petracco M. 1989. Physico-chemical and structural characterisation of "espresso" coffee brew. In Treizième Colloq. Sci. Int. Café, Paipa, 21-25 août, pp. 246-61. Paris: Assoc. Sci. Int. Café (ASIC)
59. Pietinen P, Aro A, Tuomilehto J, Uusitalo U, Korhonen H. 1990. Consumption of boiled coffee is correlated with serum cholesterol in Finland. Int. J. Epidemiol. 19:586-90
60. Pietinen P, Vartiainen E, Seppanen R, Aro A, Puska P. 1996. Changes in diet in Finland from 1972 to 1992: impact on coronary heart disease risk. Prev. Med. 25:243-50
61. Pintus F, Mascia P. 1996. Distribution and population determinants of gamma-glutamyltransferase in a random sample of Sardinian inhabitants. Eur. J. Epidemiol. 12:71-76
62. Puccio EM, McPhillips JB, Barrett-Connor E, Ganiats TG. 1990. Clustering of atherogenic behaviors in coffee drinkers. Am. J. Public Health 80:1310-13
63. Ranheim T, Halvorsen B, Huggett AC, Blomhoff R, Drevon CA. 1995. Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells. J. Lipid Res. 36:2079-89
64. Ratnayake WMN, Hollywood R, O'Grady E, Stavric B. 1993. Lipid content and composition of coffee brews prepared by different methods. Food Chem. Toxicol. 31:263-69
65. Ratnayake WMN, Pelletier G, Hollywood R, Malcolm S, Stavric B. 1995. Investigation of the effect of coffee lipids on serum cholesterol in hamsters. Food Chem. Toxicol. 33:195-201
66. Rosmarin PC, Applegate WB, Somes GW. 1990. Coffee consumption and serum lipids: a randomized, cross-over clinical trial. Am. J. Med. 88:349-56
67. Ruiz-Lapente MA, Gil LA, Rafart JV, Urgell JR, Jaume JA, et al. 1995. Relation between coffee and plasma cholesterol in a population of working women. Med. Clin. 105:687-90 (In Spanish)
68. SalvaggioA, PeritiM, MianoL,QuagliaG, Marzorati D. 1991. Coffee and cholesterol, an Italian study. Am. J. Epidemiol. 134:149-56
69. Sanders TAB, Sandaradura S. 1992. The cholesterol-raising effect of coffee in the Syrian hamster. Br. J. Nutr. 68:431-34
70. Sanguigni V, Gallu M, Ruffini MP, Strano A. 1995. Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing method. Eur. J. Epidemiol. 11:75-78
71. Soroko S, Chang J, Barrett-Connor E. 1996. Reasons for changing caffeinated coffee consumption: the Rancho Bernardo study. J. Am. Coll, Nutr. 15:97-101
72. Speer K, Montag A. 1989. 16-O-methylcafestol-a new diterpene in coffee. First results: levels in raw and roasted coffee beans. Dtsch. Lebensm. Rundsch. 85:381-84 (In German)
73. Stensvold I, Tverdal A, Foss OP. 1989. The effect of coffee on blood lipids and blood pressure. Results from a Norwegian crosssectional study, men and women, 40-42 years. J. Clin. Epidemiol. 42:877-84
74. Stensvold I, Tverdal A, Jacobsen BK. 1996. Cohort study of coffee intake and death from coronary disease over 12 years. Br. Med. J. 312:544-45
75. Superko HR, Bortz W, Williams PT, Albers JJ, Wood PD. 1991. Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial. Am. J. Clin. Nutr. 54:599-605
76. Terpstra AHM, Katan MB, Weusten-van der Wouw MPME, Nicolosi RJ, Beynen AC. 1995. Coffee oil consumption does not affect serum cholesterol in Rhesus and Cebus monkeys. J. Nutr. 125:2301-6
77. Thelle DS, Arnesen E, Førde OH. 1983. The Tromsø Heart Study. Does coffee raise serum cholesterol? N. Engl. J. Med. 308:1454-57
78. Thelle DS, Heyden S, Fodor JG. 1987. Coffee and cholesterol in epidemiological and experimental studies. Atherosclerosis 67:97-103
79. Tuomilehto J, Pietinen P. 1991. Coffee and cardiovascular disease. Cardiovasc. Risk Factors 1:165-73
80. Tverdal A, Stensvold I, Solvoll K, Foss OP, Lund-Larsen P, et al. 1990. Coffee consumption and death from coronary heart disease in middle aged Norwegian men and women. Br. Med. J. 300:566-69
81. Urgert R, Essed N, van der Weg G, Kosmeijer-Schuil TG, Katan MB. 1997. Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver transaminases. Am. J. Clin. Nutr. 65:519-24
82. Urgert R, Kosmeijer-Schuil TG, Katan MB. 1996. Intake levels, sites of action and excretion routes of the cholesterol-elevating diterpenes from coffee beans in humans. Biochem. Soc. Transact. 24:800-6
83. Urgert R, Meyboom S, Kuilman M, Rexwinkel H, Vissers MN, et al. 1996. Comparison of effect of cafetiere and filtered coffee on serum levels of liver aminotransferases and lipids: a six-month randomised controlled trial. Br. Med. J. 313:1362-66
84. Urgert R, Schulz AGM, Katan MB. 1995. Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. Am. J. Clin. Nutr. 61:149-54
85. Urgert R, van der Weg G, Kosmeijer-Schuil TG, van de Bovenkamp P, Hovenier R, et al. 1995. Levels of the cholesterol-elevating diterpenes cafestol and kahweol in various coffee brews. J. Agric. Food Chem. 43:2167-72
86. Urgert R, Weusten-van der Wouw MPME, Hovenier R, Lund-Larsen PG, Katan MB. 1996. Chronic consumers of boiled coffee have elevated serum levels of lipoprotein(a). J. Intern. Med. 240:367-71
87. Van Dusseldorp M, Katan MB, Demacker PNM. 1990. Effect of decaffeinated versus regular coffee on serum lipoproteins: a 12-week double-blind trial. Am. J. Epidemiol. 132:33-40
88. Van Dusseldorp M, Katan MB, Van Vliet T, Demacker PNM, Stalenhoef A. 1991. Cholesterol-raising factor from boiled coffee does not pass a paper filter. Arterioscler. Thromb. 11:586-93
89. Van Rooij J, Van der Stegen GHD, Schoemaker RC, Kroon C, Burggraaf J, et al. 1995. A placebo- controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee. Am. J. Clin.Nutr. 61:1277-83
90. Viani R. 1986. Coffee. In Ullmann's Encyclopedia of Industrial Chemistry, pp. 315-39. Weinheim, Germany: VCH Verlag
91. Wahrburg U, Martin H, Schulte H, Walek T, Assmann G. 1994. Effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults. Eur. J. Clin. Nutr. 48:172-79
92. Weusten-van der Wouw MPME, Katan MB, Viani R, Huggett AC, Liardon R, et al. 1994. Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes. J. Lipid Res. 35: 721-33
93. Weusten-van der Wouw MPME, Terpstra AHM, Van Tintelen G, Beynen AC, Katan MB. 1993. The cholesterol-raising factor from boiled coffee - the search for an animal model. Voeding, 54:14 (Abstr.) (In Dutch)
94. Willett WC, Stampfer MJ, Manson JE, Colditz GA, Rosner BA, et al. 1996. Coffee consumption and coronary heart disease in women: a ten-year follow-up. JAMA 275:458-62
95. Zock PL, Katan MB, Merkus MP, van Dusseldorp M, Harryvan JL. 1990. Effect of a lipid-rich fraction from boiled coffee on serum cholesterol. Lancet 335:1235-37