Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

Journal of Cell Biology

Volumn 161, Issue 4, 2003, Pages 769-777

  Sheldahl, Laird C ^a,e   Slusarski, Diane C ^b   Pandur, Petra ^c   Miller, Jeffrey R ^d   Kühl, Michael ^c   Moon, Randall T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF MINNESOTA   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Calcium; Dishevelled; PKC; Signal transduction; Wnt

Indexed keywords

BETA CATENIN; CALCIUM ION; CATENIN; CELL PROTEIN; DISHEVELLED PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; UNCLASSIFIED DRUG; WNT PROTEIN; CALCIUM; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; DISHEVELLED PROTEINS; MESSENGER RNA; PERTUSSIS TOXIN; PHOSPHOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); SIGNAL TRANSDUCING ADAPTOR PROTEIN; XENOPUS PROTEIN;

ARTICLE; CALCIUM TRANSPORT; CELL POLARITY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; HEART DEVELOPMENT; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VERTEBRATE; WESTERN BLOTTING; XENOPUS; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PRENATAL DEVELOPMENT; XENOPUS LAEVIS;

DANIO RERIO; VERTEBRATA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; EMBRYO, NONMAMMALIAN; IN SITU HYBRIDIZATION; PERTUSSIS TOXIN; PHOSPHOPROTEINS; PROTEIN KINASE C; RNA, MESSENGER; XENOPUS LAEVIS; XENOPUS PROTEINS; ZEBRAFISH;

EID: 0038360821     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200211094     Document Type: Article

References (47)

1. Adler, P.N., and H. Lee. 2001. Frizzled signaling and cell-cell interactions in planar polarity. Curr. Opin. Cell Biol. 13:635-640.
2. Axelrod, J.D., J.R. Miller, J.M. Shulman, R.T. Moon, and N. Perrimon. 1998. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12:2610-2622.
3. Boutros, M., and M. Mlodzik. 1999. Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech. Dev. 83:27-37.
4. Boutros, M., N. Paricio, D.I. Strutt, and M. Mlodzik. 1998. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 94:109-118.
5. Brown, J.D., S.E. Hallagan, L.L. McGrew, J.R. Miller, and R.T. Moon. 2000. The maternal Xenopus β-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner. Dev. Growth Differ. 42:347-357.
6. Choi, S.C., and J.K. Han. 2002. Xenopus Cdc42 regulates convergent extension movements during gastrulation through Wnt/Ca2+ signaling pathway. Dev. Biol. 244:342-357.
7. Cohen, E.D., M.C. Mariol, R.M. Wallace, J. Weyers, Y.G. Kamberov, J. Pradel, and E.L. Wilder. 2002. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev. Cell. 2:437-448.
8. Darken, R.S., A.M. Scola, A.S. Rakeman, G. Das, M. Mlodzik, and P.A. Wilson. 2002. The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J. 21:976-985.
9. Djiane, A., J. Riou, M. Umbhauer, J. Boucaut, and D. Shi. 2000. Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development. 127:3091-3100.
10. Drysdale, T.A., K.F. Tonissen, K.D. Patterson, M.J. Crawford, and P.A. Krieg. 1994. Cardiac Troponin I is a heart-specific marker in the Xenopus embryo: expression during abnormal heart morphogenesis. Dev. Biol. 165:432-441.
11. Etienne-Manneville, S., and A. Hall. 2003. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature. 421:753-756.
12. Gilman, A.G. 1987. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56:615-649.
13. Habas, R., Y. Kato, and X. He. 2001. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requuires a novel formin homology protein Daam1. Cell. 107:843-854.
14. Heasman, J. 2002. Morpholino oligos: making sense of antisense? Dev. Biol. 243:209-214.
15. Heisenberg, C.P., M. Tada, G.J. Rauch, L. Saude, M.L. Concha, R. Geisler, D.L. Stemple, J.C. Smith, and S.W. Wilson. 2000. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. 405:76-81.
16. Huelsken, J., and J. Behrens. 2002. The Wnt signaling pathways. J. Cell Sci. 115:3977-3978.
17. Kishida, S., H. Yamamoto, S. Hino, S. Ikeda, M. Kishida, and A. Kikuchi. 1999. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate β-catenin stability. Mol. Cell. Biol. 19:4414-4422.
18. Kühl, M. 2002. Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation. Semin. Cell Dev. Biol. 13:243-249.
19. Kühl, M., L.C. Sheldahl, C.C. Malbon, and R.T. Moon. 2000a. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275:12701-12711.
20. Kühl, M., L.C. Sheldahl, M. Park, J.R. Miller, and R.T. Moon. 2000b. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16:279-283.
21. Kühl, M., K. Geis, L.C. Sheldahl, T. Pukrop, R.T. Moon, and D. Wedlich. 2001. Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca(2+) signaling. Mech. Dev. 106:61-76.
22. Levi, N.L., T. Hanoch, O. Benard, M. Rozenblat, D. Harris, N. Reiss, Z. Naor, and R. Seger. 1998. Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary α T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol. Endocrinol. 12:815-824.
23. Li, L., H. Yuan, W. Xie, J. Mao, A.M. Caruso, A. McMahon, D.J. Sussman, and D. Wu. 1999. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J. Biol. Chem. 274(1):129-134.
24. Liu, T., A.J. DeCostanzo, X. Liu, H. Wang, S. Hallagan, R.T. Moon, and C.C. Malbon. 2001. G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science. 292:1718-1722.
25. Medina, A., W. Reintsch, and H. Steinbeisser. 2000. Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis. Mech. Dev. 92:227-237.
26. Mellor, H., and P.J. Parker. 1998. The extended protein kinase C superfamily. Biochem. J. 332:281-292.
27. 2+ pathways. Oncogene. 18:7860-7872.
28. Mudher, A., S. Chapman, J. Richardson, A. Asuni, G. Gibb, C. Pollard, R. Killick, T. Iqbal, L. Raymond, I. Varndell, et al. 2001. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J. Neurosci. 21:4987-4995.
29. Pandur, P., M. Lasche, L.M. Eisenberg, and M. Kuhl. 2002. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature. 418:636-641.
30. Penton, A., A. Wodarz, and R. Nusse. 2002. A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel supressing alleles of axin. Genetics. 161:747-762.
31. Peifer, M., and D.G. McEwen. 2002. The ballet of morphogenesis; unveiling the hideen choreographers. Cell. 109:271-274.
32. Sheldahl, L.C., M. Park, C.C. Malbon, and R.T. Moon. 1999. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-proteindependent manner. Curr. Biol. 9:695-698.
33. Shulman, J.M., N. Perrimon, and J.D. Axelrod. 1998. Frizzled signaling and the developmental control of cell polarity. Trends Genet. 14:452-458.
34. Slusarski, D.C., and V.G. Corces. 2000. Calcium imaging in cell-cell signaling. Methods Mol. Biol. 135:253-261.
35. Slusarski, D.C., V.G. Corces, and R.T. Moon. 1997a. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 390:410-413.
36. 2+ signaling by Wnt-5A. Dev. Biol. 182:114-120.
37. Smith, J.C., F.L. Conlon, Y. Saka, and M. Tada. 2000. Xwnt11 and the regulation of gastrulation in Xenopus. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355:923-930.
38. Tada, M., and J.C. Smith. 2000. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development. 127:2227-2238.
39. Torres, M.A., J.A. Yang-Snyder, S.M. Purcell, A.A. DeMarais, L.L. McGrew, and R.T. Moon. 1996. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133:1123-1137.
40. Veeman, M.T., D.C. Slusarski, A. Kaykas, S. Hallagan, and R.T. Moon. 2003. Zebrafish Prickle, a modulator of non-canonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13:674-679.
41. Wallingford, J.B., B.A. Rowning, K.M. Vogeli, U. Rothbacher, S.E. Fraser, and R.M. Harland. 2000. Dishevelled controls cell polarity during Xenopus gastrulation. Nature. 405:81-85.
42. Wallingford, J.B., S.E. Fraser, and R.M. Harland. 2002. Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev. Cell. 2:695-706.
43. Wharton, K.A., Jr. 2003. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev. Biol. 253:1-17.
44. Winklbauer, R., A. Medina, R.K. Swain, and H. Steinbeisser. 2001. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature. 413:856-860.
45. Yamanaka, H., T. Moriguchi, N. Masuyama, M. Kusakabe, H. Hanafusa, R. Takada, S. Takada, and E. Nishida. 2002. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3:69-75.
46. Yang-Snyder, J., J.R. Miller, J.D. Brown, C.J. Lai, and R.T. Moon. 1996. A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6:1302-1306.
47. Zhang, Y., S.Y. Neo, J. Han, and S.C. Lin. 2000. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 275:25008-25014.