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Volumn 298, Issue 2, 2004, Pages 369-387

Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: Functional implications of Wnt/β-catenin activity in kidney epithelial cells

Author keywords

Kidney development; MDCK; Tubulogenesis; Engrailed; N131; N90

Indexed keywords

BETA CATENIN; FRIZZLED 6 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT3A PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN;

EID: 3242681470     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.04.036     Document Type: Article
Times cited : (122)

References (121)
  • 1
    • 0032387859 scopus 로고    scopus 로고
    • Hepatocyte growth factor and Madin-Darby Canine Kidney cells: In vitro models of epithelial cell movement and morphogenesis
    • Balkovetz D.F. Hepatocyte growth factor and Madin-Darby Canine Kidney cells: in vitro models of epithelial cell movement and morphogenesis. Microsc. Res. Tech. 43:1998;456-463
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 456-463
    • Balkovetz, D.F.1
  • 2
    • 0026723902 scopus 로고
    • Epithelial morphogenesis
    • Gumbiner B.M. Epithelial morphogenesis. Cell. 69:1992;385-387
    • (1992) Cell , vol.69 , pp. 385-387
    • Gumbiner, B.M.1
  • 3
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    • Gumbiner B.M. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell. 84:1996;345-357
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 4
    • 0029157019 scopus 로고
    • Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced
    • Hay E.D., Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am. J. Kidney Dis. 26:1995;678-690
    • (1995) Am. J. Kidney Dis. , vol.26 , pp. 678-690
    • Hay, E.D.1    Zuk, A.2
  • 5
    • 0032387652 scopus 로고    scopus 로고
    • Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis
    • Pollack A.L., Runyan R.B., Mostov K.E. Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev. Biol. 204:1998;64-79
    • (1998) Dev. Biol. , vol.204 , pp. 64-79
    • Pollack, A.L.1    Runyan, R.B.2    Mostov, K.E.3
  • 7
    • 0025023525 scopus 로고
    • Steps in the morphogenesis of a polarized epithelium: I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts
    • Wang A.Z., Ojakian G.K., Nelson W.J. Steps in the morphogenesis of a polarized epithelium: I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts. J. Cell. Sci. 95:1990;137-151
    • (1990) J. Cell. Sci. , vol.95 , pp. 137-151
    • Wang, A.Z.1    Ojakian, G.K.2    Nelson, W.J.3
  • 8
    • 0025191452 scopus 로고
    • Steps in the morphogenesis of a polarized epithelium: II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts
    • Wang A.Z., Ojakian G.K., Nelson W.J. Steps in the morphogenesis of a polarized epithelium: II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts. J. Cell. Sci. 95:1990;153-165
    • (1990) J. Cell. Sci. , vol.95 , pp. 153-165
    • Wang, A.Z.1    Ojakian, G.K.2    Nelson, W.J.3
  • 9
    • 0033995537 scopus 로고    scopus 로고
    • Kidney morphogenesis: Cellular and molecular regulation
    • Kuure S., Vuolteenaho R., Vainio S. Kidney morphogenesis: cellular and molecular regulation. Mech. Dev. 92:2000;31-45
    • (2000) Mech. Dev. , vol.92 , pp. 31-45
    • Kuure, S.1    Vuolteenaho, R.2    Vainio, S.3
  • 10
    • 0030988298 scopus 로고    scopus 로고
    • The molecular basis of embryonic kidney development
    • Lechner M.S., Dressler G.R. The molecular basis of embryonic kidney development. Mech. Dev. 62:1997;105-120
    • (1997) Mech. Dev. , vol.62 , pp. 105-120
    • Lechner, M.S.1    Dressler, G.R.2
  • 11
    • 18144440517 scopus 로고    scopus 로고
    • Towards a molecular anatomy of the Xenopus pronephric kidney
    • Brandli A.W. Towards a molecular anatomy of the Xenopus pronephric kidney. Int. J. Dev. Biol. 43:1999;381-395
    • (1999) Int. J. Dev. Biol. , vol.43 , pp. 381-395
    • Brandli, A.W.1
  • 12
    • 0033764574 scopus 로고    scopus 로고
    • Secreted molecules in metanephric induction
    • Carroll T.J., McMahon A.P. Secreted molecules in metanephric induction. J. Am. Soc. Nephrol. 11(Suppl. 16):2000;S116-S119
    • (2000) J. Am. Soc. Nephrol. , vol.11 , Issue.SUPPL. 16
    • Carroll, T.J.1    McMahon, A.P.2
  • 13
    • 0031941550 scopus 로고    scopus 로고
    • Molecular development of the kidney: A review of the results of gene disruption studies
    • Lipschutz J.H. Molecular development of the kidney: a review of the results of gene disruption studies. Am. J. Kidney Dis. 31:1998;383-397
    • (1998) Am. J. Kidney Dis. , vol.31 , pp. 383-397
    • Lipschutz, J.H.1
  • 14
    • 0033392360 scopus 로고    scopus 로고
    • Wnt signalling in mammalian development and cancer
    • Smalley M.J., Dale T.C. Wnt signalling in mammalian development and cancer. Cancer Metastasis Rev. 18:1999;215-230
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 215-230
    • Smalley, M.J.1    Dale, T.C.2
  • 16
    • 0033674395 scopus 로고    scopus 로고
    • A road to kidney tubules via the Wnt pathway
    • Vainio S.J., Uusitalo M.S. A road to kidney tubules via the Wnt pathway. Pediatr. Nephrol. 15:2000;151-156
    • (2000) Pediatr. Nephrol. , vol.15 , pp. 151-156
    • Vainio, S.J.1    Uusitalo, M.S.2
  • 18
    • 0043022103 scopus 로고    scopus 로고
    • Nephrogenesis regulated by Wnt signaling
    • Vainio S.J. Nephrogenesis regulated by Wnt signaling. J. Nephrol. 16:2003;279-285
    • (2003) J. Nephrol. , vol.16 , pp. 279-285
    • Vainio, S.J.1
  • 19
    • 0031766557 scopus 로고    scopus 로고
    • Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
    • Kispert A., Vainio S., McMahon A.P. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development. 125:1998;4225-4234
    • (1998) Development , vol.125 , pp. 4225-4234
    • Kispert, A.1    Vainio, S.2    McMahon, A.P.3
  • 21
    • 3242663124 scopus 로고    scopus 로고
    • CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
    • Surendran K., Simon T.C. CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am. J. Physiol. Renal Physiol. 10:2002;10
    • (2002) Am. J. Physiol. Renal Physiol. , vol.10 , pp. 10
    • Surendran, K.1    Simon, T.C.2
  • 22
    • 0032701863 scopus 로고    scopus 로고
    • Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis
    • Borello U., Buffa V., Sonnino C., Melchionna R., Vivarelli E., Cossu G. Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis. Mech. Dev. 89:1999;173-177
    • (1999) Mech. Dev. , vol.89 , pp. 173-177
    • Borello, U.1    Buffa, V.2    Sonnino, C.3    Melchionna, R.4    Vivarelli, E.5    Cossu, G.6
  • 25
    • 0034192018 scopus 로고    scopus 로고
    • Characterization of avian Frizzled genes in cranial placode development
    • Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S. Characterization of avian Frizzled genes in cranial placode development. Mech. Dev. 93:2000;195-200
    • (2000) Mech. Dev. , vol.93 , pp. 195-200
    • Stark, M.R.1    Biggs, J.J.2    Schoenwolf, G.C.3    Rao, M.S.4
  • 28
    • 0035399638 scopus 로고    scopus 로고
    • Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the Frizzled-4 gene
    • Wang Y., Huso D., Cahill H., Ryugo D., Nathans J. Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the Frizzled-4 gene. J. Neurosci. 21:2001;4761-4771
    • (2001) J. Neurosci. , vol.21 , pp. 4761-4771
    • Wang, Y.1    Huso, D.2    Cahill, H.3    Ryugo, D.4    Nathans, J.5
  • 29
    • 0034649645 scopus 로고    scopus 로고
    • Wnt signaling: An embarrassment of receptors
    • Bejsovec A. Wnt signaling: an embarrassment of receptors. Curr. Biol. 10:2000;R919-R922
    • (2000) Curr. Biol. , vol.10
    • Bejsovec, A.1
  • 30
    • 0034663519 scopus 로고    scopus 로고
    • Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue
    • Jockusch E.L., Ober K.A. Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue. J. Exp. Zool. 288:2000;105-119
    • (2000) J. Exp. Zool. , vol.288 , pp. 105-119
    • Jockusch, E.L.1    Ober, K.A.2
  • 31
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by the Wnt family of ligands
    • Dale T.C. Signal transduction by the Wnt family of ligands. Biochem. J. 329:1998;209-223
    • (1998) Biochem. J. , vol.329 , pp. 209-223
    • Dale, T.C.1
  • 33
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14:1998;59-88
    • (1998) Annu. Rev. Cell Dev. Biol. , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 34
    • 0342327346 scopus 로고    scopus 로고
    • Cadherins, catenins and APC protein: Interplay between cytoskeletal complexes and signaling pathways
    • Barth A.I., Nathke I.S., Nelson W.J. Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr. Opin. Cell Biol. 9:1997;683-690
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 683-690
    • Barth, A.I.1    Nathke, I.S.2    Nelson, W.J.3
  • 35
    • 0033452545 scopus 로고    scopus 로고
    • The dual role of cytoskeletal anchor proteins in cell adhesion and signal transduction
    • Ben-Ze'ev A. The dual role of cytoskeletal anchor proteins in cell adhesion and signal transduction. Ann. N. Y. Acad. Sci. 886:1999;37-47
    • (1999) Ann. N. Y. Acad. Sci. , vol.886 , pp. 37-47
    • Ben-Ze'Ev, A.1
  • 36
    • 0034715942 scopus 로고    scopus 로고
    • The integration of cell adhesion with gene expression: The role of beta-catenin
    • Ben-Ze'ev A., Shtutman M., Zhurinsky J. The integration of cell adhesion with gene expression: the role of beta-catenin. Exp. Cell Res. 261:2000;75-82
    • (2000) Exp. Cell Res. , vol.261 , pp. 75-82
    • Ben-Ze'Ev, A.1    Shtutman, M.2    Zhurinsky, J.3
  • 37
    • 0035214420 scopus 로고    scopus 로고
    • Cadherins and catenins, Wnts and SOXs: Embryonic patterning in Xenopus
    • St. Amand A.L., Klymkowsky M.W. Cadherins and catenins, Wnts and SOXs: embryonic patterning in Xenopus. Int. Rev. Cytol. 203:2001;291-355
    • (2001) Int. Rev. Cytol. , vol.203 , pp. 291-355
    • St. Amand, A.L.1    Klymkowsky, M.W.2
  • 38
    • 0032504052 scopus 로고    scopus 로고
    • Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    • Boutros M., Paricio N., Strutt D.I., Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 94:1998;109-118
    • (1998) Cell , vol.94 , pp. 109-118
    • Boutros, M.1    Paricio, N.2    Strutt, D.I.3    Mlodzik, M.4
  • 39
    • 0032967755 scopus 로고    scopus 로고
    • Dishevelled: At the crossroads of divergent intracellular signaling pathways
    • Boutros M., Mlodzik M. Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech. Dev. 83:1999;27-37
    • (1999) Mech. Dev. , vol.83 , pp. 27-37
    • Boutros, M.1    Mlodzik, M.2
  • 40
    • 0034214847 scopus 로고    scopus 로고
    • The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape
    • Kuhl M., Sheldahl L.C., Park M., Miller J.R., Moon R.T. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16:2000;279-283
    • (2000) Trends Genet. , vol.16 , pp. 279-283
    • Kuhl, M.1    Sheldahl, L.C.2    Park, M.3    Miller, J.R.4    Moon, R.T.5
  • 41
    • 0343293801 scopus 로고    scopus 로고
    • Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus
    • Kuhl M., Sheldahl L.C., Malbon C.C., Moon R.T. Ca(2+)/calmodulin- dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275:2000;12701-12711
    • (2000) J. Biol. Chem. , vol.275 , pp. 12701-12711
    • Kuhl, M.1    Sheldahl, L.C.2    Malbon, C.C.3    Moon, R.T.4
  • 42
    • 0033166245 scopus 로고    scopus 로고
    • Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner
    • Sheldahl L.C., Park M., Malbon C.C., Moon R.T. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9:1999;695-698
    • (1999) Curr. Biol. , vol.9 , pp. 695-698
    • Sheldahl, L.C.1    Park, M.2    Malbon, C.C.3    Moon, R.T.4
  • 43
    • 0031456672 scopus 로고    scopus 로고
    • Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
    • Slusarski D.C., Corces V.G., Moon R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 390:1997;410-413
    • (1997) Nature , vol.390 , pp. 410-413
    • Slusarski, D.C.1    Corces, V.G.2    Moon, R.T.3
  • 44
    • 0031080919 scopus 로고    scopus 로고
    • Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A
    • Slusarski D.C., Yang-Snyder J., Busa W.B., Moon R.T. Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev. Biol. 182:1997;114-120
    • (1997) Dev. Biol. , vol.182 , pp. 114-120
    • Slusarski, D.C.1    Yang-Snyder, J.2    Busa, W.B.3    Moon, R.T.4
  • 46
    • 0034894122 scopus 로고    scopus 로고
    • Wnt signaling in human development: Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage
    • Eberhart C.G., Argani P. Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage. Pediatr. Dev. Pathol. 4:2001;351-357
    • (2001) Pediatr. Dev. Pathol. , vol.4 , pp. 351-357
    • Eberhart, C.G.1    Argani, P.2
  • 48
    • 0027945654 scopus 로고
    • Development of several organs that require inductive epithelial- mesenchymal interactions is impaired in LEF-1-deficient mice
    • van Genderen C., Okamura R.M., Farinas I., Quo R.G., Parslow T.G., Bruhn L., Grosschedl R. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8:1994;2691-2703
    • (1994) Genes Dev. , vol.8 , pp. 2691-2703
    • Van Genderen, C.1    Okamura, R.M.2    Farinas, I.3    Quo, R.G.4    Parslow, T.G.5    Bruhn, L.6    Grosschedl, R.7
  • 49
    • 0036427930 scopus 로고    scopus 로고
    • Non-canonical Wnt signaling in Xenopus: Regulation of axis formation and gastrulation
    • Kuhl M. Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation. Semin. Cell Dev. Biol. 13:2002;243-249
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 243-249
    • Kuhl, M.1
  • 50
    • 0037039162 scopus 로고    scopus 로고
    • Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis
    • Lisovsky M., Itoh K., Sokol S.Y. Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis. Curr. Biol. 12:2002;53-58
    • (2002) Curr. Biol. , vol.12 , pp. 53-58
    • Lisovsky, M.1    Itoh, K.2    Sokol, S.Y.3
  • 51
    • 0037043688 scopus 로고    scopus 로고
    • Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
    • Pandur P., Lasche M., Eisenberg L.M., Kuhl M. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature. 418:2002;636-641
    • (2002) Nature , vol.418 , pp. 636-641
    • Pandur, P.1    Lasche, M.2    Eisenberg, L.M.3    Kuhl, M.4
  • 52
    • 0037118064 scopus 로고    scopus 로고
    • The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
    • Saneyoshi T., Kume S., Amasaki Y., Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature. 417:2002;295-299
    • (2002) Nature , vol.417 , pp. 295-299
    • Saneyoshi, T.1    Kume, S.2    Amasaki, Y.3    Mikoshiba, K.4
  • 53
    • 0036422194 scopus 로고    scopus 로고
    • Non-canonical Wnt signalling and regulation of gastrulation movements
    • Tada M., Concha M.L., Heisenberg C.P. Non-canonical Wnt signalling and regulation of gastrulation movements. Semin. Cell Dev. Biol. 13:2002;251-260
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 251-260
    • Tada, M.1    Concha, M.L.2    Heisenberg, C.P.3
  • 54
    • 0035070138 scopus 로고    scopus 로고
    • Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway
    • Wallingford J.B., Vogeli K.M., Harland R.M. Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int. J. Dev. Biol. 45:2001;225-227
    • (2001) Int. J. Dev. Biol. , vol.45 , pp. 225-227
    • Wallingford, J.B.1    Vogeli, K.M.2    Harland, R.M.3
  • 55
    • 0037444482 scopus 로고    scopus 로고
    • A beta-catenin survival signal is required for normal lobular development in the mammary gland
    • Tepera S.B., McCrea P.D., Rosen J.M. A beta-catenin survival signal is required for normal lobular development in the mammary gland. J. Cell. Sci. 116:2003;1137-1149
    • (2003) J. Cell. Sci. , vol.116 , pp. 1137-1149
    • Tepera, S.B.1    McCrea, P.D.2    Rosen, J.M.3
  • 56
    • 0038274074 scopus 로고    scopus 로고
    • Stem cells in the skin: Waste not Wnt not
    • Alonso L., Fuchs E. Stem cells in the skin: waste not Wnt not. Genes Dev. 17:2003;1189-1200
    • (2003) Genes Dev. , vol.17 , pp. 1189-1200
    • Alonso, L.1    Fuchs, E.2
  • 58
    • 0030930442 scopus 로고    scopus 로고
    • A beta-catenin/XTcf-3 complex binds to the Siamois promoter to regulate dorsal axis specification in Xenopus
    • Brannon M., Gomperts M., Sumoy L., Moon R.T., Kimelman D. A beta-catenin/XTcf-3 complex binds to the Siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev. 11:1997;2359-2370
    • (1997) Genes Dev. , vol.11 , pp. 2359-2370
    • Brannon, M.1    Gomperts, M.2    Sumoy, L.3    Moon, R.T.4    Kimelman, D.5
  • 59
    • 0034079665 scopus 로고    scopus 로고
    • A beta-catenin/engrailed chimera selectively suppresses Wnt signaling
    • Montross W.T., Ji H., McCrea P.D. A beta-catenin/engrailed chimera selectively suppresses Wnt signaling. J. Cell. Sci. 113:2000;1759-1770
    • (2000) J. Cell. Sci. , vol.113 , pp. 1759-1770
    • Montross, W.T.1    Ji, H.2    McCrea, P.D.3
  • 61
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost C., Torres M., Miller J.R., Huang E., Kimelman D., Moon R.T. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10:1996;1443-1454
    • (1996) Genes Dev. , vol.10 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.R.3    Huang, E.4    Kimelman, D.5    Moon, R.T.6
  • 62
    • 0030614352 scopus 로고    scopus 로고
    • NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
    • Barth A.I., Pollack A.L., Altschuler Y., Mostov K.E., Nelson W.J. NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J. Cell Biol. 136:1997;693-706
    • (1997) J. Cell Biol. , vol.136 , pp. 693-706
    • Barth, A.I.1    Pollack, A.L.2    Altschuler, Y.3    Mostov, K.E.4    Nelson, W.J.5
  • 63
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5547-5551
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 64
    • 0023600204 scopus 로고
    • An anchor-minus form of the polymeric immunoglobulin receptor is secreted predominantly apically in Madin-Darby Canine Kidney cells
    • Mostov K.E., Breitfeld P., Harris J.M. An anchor-minus form of the polymeric immunoglobulin receptor is secreted predominantly apically in Madin-Darby Canine Kidney cells. J. Cell Biol. 105:1987;2031-2036
    • (1987) J. Cell Biol. , vol.105 , pp. 2031-2036
    • Mostov, K.E.1    Breitfeld, P.2    Harris, J.M.3
  • 65
    • 0033616573 scopus 로고    scopus 로고
    • Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein
    • Hsieh J.C., Rattner A., Smallwood P.M., Nathans J. Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3546-3551
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 3546-3551
    • Hsieh, J.C.1    Rattner, A.2    Smallwood, P.M.3    Nathans, J.4
  • 66
    • 0030941498 scopus 로고    scopus 로고
    • A member of the Frizzled protein family mediating axis induction by Wnt-5A
    • He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 275:1997;1652-1654
    • (1997) Science , vol.275 , pp. 1652-1654
    • He, X.1    Saint-Jeannet, J.P.2    Wang, Y.3    Nathans, J.4    Dawid, I.5    Varmus, H.6
  • 67
    • 85029464023 scopus 로고    scopus 로고
    • F.M. Ausubel, Wiley, New York, 1994.
    • F.M. Ausubel, Wiley, New York, 1994.
  • 70
    • 0032529161 scopus 로고    scopus 로고
    • Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    • Axelrod J.D., Miller J.R., Shulman J.M., Moon R.T., Perrimon N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12:1998;2610-2622
    • (1998) Genes Dev. , vol.12 , pp. 2610-2622
    • Axelrod, J.D.1    Miller, J.R.2    Shulman, J.M.3    Moon, R.T.4    Perrimon, N.5
  • 71
    • 0030293782 scopus 로고    scopus 로고
    • Analysis of Dishevelled signalling pathways during Xenopus development
    • Sokol S.Y. Analysis of Dishevelled signalling pathways during Xenopus development. Curr. Biol. 6:1996;1456-1467
    • (1996) Curr. Biol. , vol.6 , pp. 1456-1467
    • Sokol, S.Y.1
  • 72
    • 0034772624 scopus 로고    scopus 로고
    • Kermit, a Frizzled interacting protein, regulates Frizzled 3 signaling in neural crest development
    • Tan C., Deardorff M.A., Saint-Jeannet J.P., Yang J., Arzoumanian A., Klein P.S. Kermit, a Frizzled interacting protein, regulates Frizzled 3 signaling in neural crest development. Development. 128:2001;3665-3674
    • (2001) Development , vol.128 , pp. 3665-3674
    • Tan, C.1    Deardorff, M.A.2    Saint-Jeannet, J.P.3    Yang, J.4    Arzoumanian, A.5    Klein, P.S.6
  • 73
    • 0033167366 scopus 로고    scopus 로고
    • Expression of Wnt signalling pathway genes during tooth development
    • Sarkar L., Sharpe P.T. Expression of Wnt signalling pathway genes during tooth development. Mech. Dev. 85:1999;197-200
    • (1999) Mech. Dev. , vol.85 , pp. 197-200
    • Sarkar, L.1    Sharpe, P.T.2
  • 74
    • 0027268011 scopus 로고
    • Xwnt-5A: A maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis
    • Moon R.T., Campbell R.M., Christian J.L., McGrew L.L., Shih J., Fraser S. Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development. 119:1993;97-111
    • (1993) Development , vol.119 , pp. 97-111
    • Moon, R.T.1    Campbell, R.M.2    Christian, J.L.3    McGrew, L.L.4    Shih, J.5    Fraser, S.6
  • 75
    • 2442548880 scopus 로고    scopus 로고
    • The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade
    • Golan T., Yaniv A., Bafico A., Liu G., Gazit A. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem. 279:2004;14879-14888
    • (2004) J. Biol. Chem. , vol.279 , pp. 14879-14888
    • Golan, T.1    Yaniv, A.2    Bafico, A.3    Liu, G.4    Gazit, A.5
  • 76
    • 0033564201 scopus 로고    scopus 로고
    • Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme
    • Dudley A.T., Godin R.E., Robertson E.J. Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. Genes Dev. 13:1999;1601-1613
    • (1999) Genes Dev. , vol.13 , pp. 1601-1613
    • Dudley, A.T.1    Godin, R.E.2    Robertson, E.J.3
  • 78
    • 0036531819 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    • Monga S.P., Mars W.M., Pediaditakis P., Bell A., Mule K., Bowen W.C., Wang X., Zarnegar R., Michalopoulos G.K. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res. 62:2002;2064-2071
    • (2002) Cancer Res. , vol.62 , pp. 2064-2071
    • Monga, S.P.1    Mars, W.M.2    Pediaditakis, P.3    Bell, A.4    Mule, K.5    Bowen, W.C.6    Wang, X.7    Zarnegar, R.8    Michalopoulos, G.K.9
  • 79
    • 0032577899 scopus 로고    scopus 로고
    • WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells
    • Papkoff J., Aikawa M. WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells. Biochem. Biophys. Res. Commun. 247:1998;851-858
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 851-858
    • Papkoff, J.1    Aikawa, M.2
  • 80
    • 0032884884 scopus 로고    scopus 로고
    • Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • Brabletz T., Jung A., Dag S., Hlubek F., Kirchner T. beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am. J. Pathol. 155:1999;1033-1038
    • (1999) Am. J. Pathol. , vol.155 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Hlubek, F.4    Kirchner, T.5
  • 82
    • 0033615352 scopus 로고    scopus 로고
    • PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He T.C., Chan T.A., Vogelstein B., Kinzler K.W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 99:1999;335-345
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 83
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho E.H., Zhang T., Domon C., Joo C.K., Freund J.N., Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22:2002;1172-1183
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1172-1183
    • Jho, E.H.1    Zhang, T.2    Domon, C.3    Joo, C.K.4    Freund, J.N.5    Costantini, F.6
  • 85
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:1999;422-426
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 89
    • 0031469645 scopus 로고    scopus 로고
    • WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons
    • Lucas F.R., Salinas P.C. WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev. Biol. 192:1997;31-44
    • (1997) Dev. Biol. , vol.192 , pp. 31-44
    • Lucas, F.R.1    Salinas, P.C.2
  • 90
    • 0031800971 scopus 로고    scopus 로고
    • Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium
    • Lucas F.R., Goold R.G., Gordon-Weeks P.R., Salinas P.C. Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. J. Cell. Sci. 111:1998;1351-1361
    • (1998) J. Cell. Sci. , vol.111 , pp. 1351-1361
    • Lucas, F.R.1    Goold, R.G.2    Gordon-Weeks, P.R.3    Salinas, P.C.4
  • 91
    • 0034176626 scopus 로고    scopus 로고
    • Xenopus Frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: Implications on early patterning and morphogenesis
    • Medina A., Reintsch W., Steinbeisser H. Xenopus Frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis. Mech. Dev. 92:2000;227-237
    • (2000) Mech. Dev. , vol.92 , pp. 227-237
    • Medina, A.1    Reintsch, W.2    Steinbeisser, H.3
  • 92
    • 0027965236 scopus 로고
    • Differential transformation of mammary epithelial cells by Wnt genes
    • Wong G.T., Gavin B.J., McMahon A.P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14:1994;6278-6286
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6278-6286
    • Wong, G.T.1    Gavin, B.J.2    McMahon, A.P.3
  • 93
    • 0028588919 scopus 로고
    • Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    • Stark K., Vainio S., Vassileva G., McMahon A.P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 372:1994;679-683
    • (1994) Nature , vol.372 , pp. 679-683
    • Stark, K.1    Vainio, S.2    Vassileva, G.3    McMahon, A.P.4
  • 95
    • 0030480423 scopus 로고    scopus 로고
    • Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme
    • Karavanova I.D., Dove L.F., Resau J.H., Perantoni A.O. Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme. Development. 122:1996;4159-4167
    • (1996) Development , vol.122 , pp. 4159-4167
    • Karavanova, I.D.1    Dove, L.F.2    Resau, J.H.3    Perantoni, A.O.4
  • 96
    • 0029857502 scopus 로고    scopus 로고
    • Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
    • Kispert A., Vainio S., Shen L., Rowitch D.H., McMahon A.P. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development. 122:1996;3627-3637
    • (1996) Development , vol.122 , pp. 3627-3637
    • Kispert, A.1    Vainio, S.2    Shen, L.3    Rowitch, D.H.4    McMahon, A.P.5
  • 97
    • 0031281464 scopus 로고    scopus 로고
    • A role for WNT proteins in induction of dermomyotome
    • Fan C.M., Lee C.S., Tessier-Lavigne M. A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191:1997;160-165
    • (1997) Dev. Biol. , vol.191 , pp. 160-165
    • Fan, C.M.1    Lee, C.S.2    Tessier-Lavigne, M.3
  • 98
    • 0030663062 scopus 로고    scopus 로고
    • Noggin acts downstream of Wnt and sonic hedgehog to antagonize BMP4 in avian somite patterning
    • Hirsinger E., Duprez D., Jouve C., Malapert P., Cooke J., Pourquie O. Noggin acts downstream of Wnt and sonic hedgehog to antagonize BMP4 in avian somite patterning. Development. 124:1997;4605-4614
    • (1997) Development , vol.124 , pp. 4605-4614
    • Hirsinger, E.1    Duprez, D.2    Jouve, C.3    Malapert, P.4    Cooke, J.5    Pourquie, O.6
  • 99
    • 0030831581 scopus 로고    scopus 로고
    • Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite
    • Marcelle C., Stark M.R., Bronner-Fraser M. Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite. Development. 124:1997;3955-3963
    • (1997) Development , vol.124 , pp. 3955-3963
    • Marcelle, C.1    Stark, M.R.2    Bronner-Fraser, M.3
  • 100
    • 0027201903 scopus 로고
    • Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
    • Parr B.A., Shea M.J., Vassileva G., McMahon A.P. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 119:1993;247-261
    • (1993) Development , vol.119 , pp. 247-261
    • Parr, B.A.1    Shea, M.J.2    Vassileva, G.3    McMahon, A.P.4
  • 101
    • 0029114329 scopus 로고
    • Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice
    • Bradbury J.M., Edwards P.A., Niemeyer C.C., Dale T.C. Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev. Biol. 170:1995;553-563
    • (1995) Dev. Biol. , vol.170 , pp. 553-563
    • Bradbury, J.M.1    Edwards, P.A.2    Niemeyer, C.C.3    Dale, T.C.4
  • 103
    • 0031599585 scopus 로고    scopus 로고
    • Control of the three-dimensional growth pattern of mammary epithelium: Role of genes of the Wnt and erbB families studied using reconstituted epithelium
    • Edwards P.A. Control of the three-dimensional growth pattern of mammary epithelium: role of genes of the Wnt and erbB families studied using reconstituted epithelium. Biochem. Soc. Symp. 63:1998;21-34
    • (1998) Biochem. Soc. Symp. , vol.63 , pp. 21-34
    • Edwards, P.A.1
  • 104
    • 0034124786 scopus 로고    scopus 로고
    • Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites
    • Borycki A., Brown A.M., Emerson C.P. Jr. Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development. 127:2000;2075-2087
    • (2000) Development , vol.127 , pp. 2075-2087
    • Borycki, A.1    Brown, A.M.2    Emerson Jr., C.P.3
  • 105
    • 0028875718 scopus 로고
    • Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite
    • Munsterberg A.E., Kitajewski J., Bumcrot D.A., McMahon A.P., Lassar A.B. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev. 9:1995;2911-2922
    • (1995) Genes Dev. , vol.9 , pp. 2911-2922
    • Munsterberg, A.E.1    Kitajewski, J.2    Bumcrot, D.A.3    McMahon, A.P.4    Lassar, A.B.5
  • 106
    • 0141591505 scopus 로고    scopus 로고
    • Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/{beta}-catenin synergy
    • Jordan B.K., Shen J.H., Olaso R., Ingraham H.A., Vilain E. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/{beta}-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100(19):2003;10866-10871
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , Issue.19 , pp. 10866-10871
    • Jordan, B.K.1    Shen, J.H.2    Olaso, R.3    Ingraham, H.A.4    Vilain, E.5
  • 107
    • 0028929367 scopus 로고
    • Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos
    • Du S.J., Purcell S.M., Christian J.L., McGrew L.L., Moon R.T. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol. 15:1995;2625-2634
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2625-2634
    • Du, S.J.1    Purcell, S.M.2    Christian, J.L.3    McGrew, L.L.4    Moon, R.T.5
  • 108
    • 0027941483 scopus 로고
    • Regulated expression of Wnt family members during proliferation of C57mg mammary cells
    • Olson D.J., Papkoff J. Regulated expression of Wnt family members during proliferation of C57mg mammary cells. Cell Growth Differ. 5:1994;197-206
    • (1994) Cell Growth Differ. , vol.5 , pp. 197-206
    • Olson, D.J.1    Papkoff, J.2
  • 110
    • 0032189977 scopus 로고    scopus 로고
    • Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
    • Birchmeier C., Gherardi E. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol. 8:1998;404-410
    • (1998) Trends Cell Biol. , vol.8 , pp. 404-410
    • Birchmeier, C.1    Gherardi, E.2
  • 112
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    • Uehara Y., Minowa O., Mori C., Shiota K., Kuno J., Noda T., Kitamura N. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 373:1995;702-705
    • (1995) Nature , vol.373 , pp. 702-705
    • Uehara, Y.1    Minowa, O.2    Mori, C.3    Shiota, K.4    Kuno, J.5    Noda, T.6    Kitamura, N.7
  • 114
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle J.N. STATs: signal transducers and activators of transcription. Cell. 84:1996;331-334
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 115
    • 0030923749 scopus 로고    scopus 로고
    • Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis
    • Pollack A.L., Barth A.I., Altschuler Y., Nelson W.J., Mostov K.E. Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis. J. Cell Biol. 137:1997;1651-1662
    • (1997) J. Cell Biol. , vol.137 , pp. 1651-1662
    • Pollack, A.L.1    Barth, A.I.2    Altschuler, Y.3    Nelson, W.J.4    Mostov, K.E.5
  • 116
    • 0027367877 scopus 로고
    • Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms
    • Santos O.F., Moura L.A., Rosen E.M., Nigam S.K. Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev. Biol. 159:1993;535-548
    • (1993) Dev. Biol. , vol.159 , pp. 535-548
    • Santos, O.F.1    Moura, L.A.2    Rosen, E.M.3    Nigam, S.K.4
  • 117
    • 0033609070 scopus 로고    scopus 로고
    • T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin
    • Barth A.I., Stewart D.B., Nelson W.J. T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin. Proc. Natl. Acad. Sci. U.S.A. 96:1999;4947-4952
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 4947-4952
    • Barth, A.I.1    Stewart, D.B.2    Nelson, W.J.3
  • 118
    • 0043127395 scopus 로고    scopus 로고
    • What can a frog tell us about human kidney development
    • Ryffel G.U. What can a frog tell us about human kidney development. Nephron Exp. Nephrol. 94:2003;e35-e43
    • (2003) Nephron Exp. Nephrol. , vol.94
    • Ryffel, G.U.1
  • 119
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    • Dudley A.T., Lyons K.M., Robertson E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9:1995;2795-2807
    • (1995) Genes Dev. , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 120
    • 0032536823 scopus 로고    scopus 로고
    • Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
    • Celli G., LaRochelle W.J., Mackem S., Sharp R., Merlino G. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J. 17:1998;1642-1655
    • (1998) EMBO J. , vol.17 , pp. 1642-1655
    • Celli, G.1    Larochelle, W.J.2    MacKem, S.3    Sharp, R.4    Merlino, G.5


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