Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 745-752

  Van De Wetering, Marc ^a   Castrop, Jan ^a   Korinek, Vladimir ^a   Clevers, Hans ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0030067337     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.745     Document Type: Article

References (32)

1. Carlsson, P., M. L. Waterman, and K. V. Jones. 1993. The hLEF/TCF-1α HMG protein contains a context-dependent transcriptional activation domain that induces the TCRα enhancer in T cells. Genes Dev 7:2418-2430.
2. Castrop, J. Unpublished data.
3. Castrop, J., R. Hoevenagel, J. R. Young, and H. Clevers. 1992. A common ancestor of the mammalian transcription factors TCF-1 and TCF-1α/LEF-1 expressed in chicken T cells. Eur. J. Immunol. 22:327-1330.
4. Castrop, J., D. van Wichen, M. van de Watering, M. Koomans-Bitter, R. de Weger, J. van Dongen, and H. Clevers. The human TCF-1 gene encodes a nuclear DNA-binding protein, uniquely expressed in normal and neoplastic T lineage lymphocytes. Blood, in press.
5. Clevers, H. C., M. A. Oosterwegel, and K. Georgopoulos. 1993. Transcription factors in early T cell development. Immunol. Today 14:591-596.
6. Dooijes, D., M. van de Wetering, L. Knippels, and H. Clevers. 1993. The Schizosaccharomyces pombe mating-type gene mat-MC encodes a sequence-specific DNA-binding HMG box protein. J. Biol. Chem. 268:24813-24817.
7. Giese, K., J. Cox, and R. Grosschedl. 1992. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein complexes. Cell 69:185-195.
8. Giese, K., and R. Grosschedl. 1993. LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites. EMBO J. 12:4667-4676.
9. Giese, K., C. Kingsley, J. R. Kirshner, and R. Grosschedl. 1995 Assembly and function of a TCRa enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9:995-1008.
10. Jantzen, H.-M., A. Admon, S. P. Bell, and R. Tjian. 1990. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature (London) 344:830-836.
11. Korinek, (Black circle)., and H. Clevers. Unpublished data.
12. Landet, V., D. Stehelin, and H. C. Clevers. 1993 Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res. 21:2493-2501.
13. Leiden, J. 1993 Transcriptional regulation of T cell receptor genes. Annu. Rev Immunol. 11:539-588.
14. Love, J. J., X. Li, D. A. Case, K. Giese, R. Grosschedl, and P. E. Wright. 1995. Structural basis for DXA bending by the architectural transcription factor LEF-1. Nature (London) 376:791-795.
15. Okamura, R. M., S. Verbeek, R. Grosschedl, and H. Clevers. Unpublished data.
16. Oosterwegel, M., M. van de Wetering, D. Dooijes, L. Klomp, A. Winoto, K. Georgopoulos, F. Meijlink, and H. Clevers. 1991. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-ε and T cell receptor ex enhancers. J. Exp. Med. 173:1133-1142.
17. Oosterwegel, M., M. van de Wetering, J. Timmerman, A. Kruisbeek, O. Destree, F. Meijlink, and H. Clevers. 1993. Differential expression of the HMG box factors TCF-1 and LEF-1. Development 118:439-448.
18. Sheridan, P. L., C. T. Sheline, K. Cannon, M. L. Voz, M. J. Pazin, J. T. Kadonaga, and K. A. Jones. 1995. Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome assembled DNA in vitro. Genes Dev. 9: 2090-2104.
19. Staal, F., H. Spits, T. Castrop, and H. Clevers. Unpublished data.
20. Travis, A., A. Amsterdam, C. Belanger, and R. Grosschedl. 1991. Lef-1, a gene encoding a lymphoid-specific protein, with an HMG domain, regulates T-cell receptor α enhancer function. Genes Dev. 5:880-894
21. van de Wetering. M. Unpublished data
22. van de Wetering, M. Oosterwegel, and H. Clevers. Unpublished data.
23. van de Wetering, M., M. Oosterwegel, D. Dooijes, and H. Clevers. 1991. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10:123-132.
24. van de Wetering, M., M. Oosterwegel, F. Holstege, D. Dooijes, R. Suikerbuik, A. Geurts van Kessel, and H. Clevers. 1992. The human T cell transcription factor-1 gene. J Biol Chem. 267:8530-8536.
25. van de Wetering, M., M. Oosterwegel, K. van Norren, and H. Clevers. 1993. Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J. 12:3847-3854.
26. Van Genderen, C., R. M. Okamura, I. Farinas, R. G. Quo, T. G. Parslow, L. Bruha, and R. Grosschedl. 1994. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1 deficient mice. Genes Dev. 8:2691-2704
27. van Houte, L. P. A., V. P. Chuprina, M. van de Wetering, R. Boelens, R. Kaptein, and H. C. Clevers. Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4. J. Biol. Chem, in press.
28. Verbeek, S., and H. Clevers. Unpublished data.
29. Verbeek, S., D. Izon, F. Hofhuis, E. Robanus-Maandag, H. te Riele, M. van de Wetering, M. Oosternegel, A. Wilson, H. R. MacDonald, and H. Clevers. 1995 An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature (London) 374:70-74.
30. Waterman, M. L., W. H. Fischer, and K. A. Jones. 1991 A thymus-specific member of the HMG protein family regulates the human T cell receptor Cα enhancer. Genes Dev. 5:656-669.
31. Waterman, M. L.. and K. Jones. 1990. Purification of TCF-1α, a T cell specific transcription factor that activates the T cell receptor Cα gene enhancer in a context dependent manner. New Biol. 2:621-636.
32. Werner, M. H., J. R. Huth, A. M. Gronenborn, and G. M. Clore. 1995. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81: 705-714