Signaling of rat frizzled-2 through phosphodiesterase and cyclic GMP

Science

Volumn 298, Issue 5600, 2002, Pages 2006-2010

  Ahumada, Adriana ^a   Slusarski, Diane C ^b   Liu, Xunxian ^a   Moon, Randall T ^c   Malbon, Craig C ^a   Wang, Hsien yu ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CELLS;

CYTOPLASMIC DOMAINS;

ENZYMES;

BETA 2 ADRENERGIC RECEPTOR; CALCIUM; CYCLIC GMP; FRIZZLED 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; RECEPTOR; TRANSDUCIN; UNCLASSIFIED DRUG;

PROTEIN; SIGNALING;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPLASM; EMBRYO (ANATOMY); ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; CYCLIC GMP; EMBRYO, NONMAMMALIAN; FRIZZLED RECEPTORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MOLECULAR SEQUENCE DATA; PERTUSSIS TOXIN; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RATS; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSDUCIN; TRANSFECTION; TUMOR CELLS, CULTURED; ZEBRAFISH;

ANIMALIA; DANIO RERIO;

EID: 2242453282     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1073776     Document Type: Article

References (28)

1. K. M. Cadigan, R. Nusse, Genes Dev. 11, 3286 (1997).
2. R. T. Cox, M. Peifer, Curr. Biol. 8, R140 (1998).
3. R. T. Moon, J. D. Brown, M. Torres, Trends Genet. 13, 157 (1997).
4. P. Bhanot et al., Nature 382, 225 (1996).
5. Y. Wang et al., J. Biol. Chem. 271, 4468 (1996).
6. J. Yang-Snyder et al., Curr. Biol. 6, 1302 (1996).
7. A. J. Monis, C. C. Malbon, Physiol. Rev. 79, 1373 (1999).
8. C. C. Malbon, H. Wang, R. T. Moon, Biochem. Biophys. Res. Commun. 287, 589 (2001).
9. D. Cook et al., EMBO J. 15. 4526 (1996).
10. J. Behrens et al., Science 280, 596 (1998).
11. J. Behrens et al., Nature 382, 638 (1996).
12. M. Molenaar et al., Cell 86, 391 (1996).
13. J. Roose et al., Nature 395, 608 (1998).
14. H. Clevers, M. van de Wetering, Trends Genet. 13, 485 (1997).
15. D. C. Slusarski, V. G. Corces, R. T. Moon, Nature 390, 410 (1997).
16. M. Kubl, L. C. Sheldahl, C. C. Malbon, R. T. Moon, J. Biol. Chem. 275, 12701 (2000).
17. M. Kuhl, L. C. Sheidahl, M. Park, J. R. Miller, R. T. Moon, Trends Genet. 16, 279 (2000).
18. L. C. Sheidahl, M. Park, C. C. Malbon, R. T. Moon, Curr. Biol. 9, 69S (1999).
19. X. Liu et al., Proc. Natl. Acad. Sci. U.S.A. 96, 14383 (1999).
20. Materials and Methods are available as supporting material on Science Online.
21. C. J. Raport, B. Dere, J. B. Hurley, J. Biol. Chem. 264, 7122 (1989).
22. A. Ahumada, D. C. Slusarski, R. T. Moon, C. C. Malbon, H.-y. Wang, unpublished observations.
23. D. C. Slusarski, J. Yang-Snyder, W. B. Busa, R. T. Moon, Dev. Biol. 182, 114 (1997).
24. S. Strickland, Cell 24, 277 (1981).
25. S. C. P. Heisenberg et al., Nature 405, 76 (2000).
26. J. R. Jessen et al., Nature Cell Biol. 4, 610 (2002).
27. E. S. Weinberg et al., Development 122, 271 (1996).
28. Supported by grants from the March of Dimes Foundation (H.-y.W.), NIH (to C.C.M., to D.C.S.), the Ward Melville Walk-for-Beauty Foundation (H.-y.W.), and Howard Hughes Medical Institute (to R.T.M.); an Institutional National Research Service Award (T32-DK07S21 to A.A.) and a Mentored Minority Award from NIH (A.A.); and a March of Dimes Foundation Basil O'Conner Research Scholar award (D.C.S.). We acknowledge T. Westfall (University of Iowa, Iowa City) for technical assistance and the guidance of M. Goligorsky (New York Medical College, Valhalla) in enabling the calcium measurements of F9 cells.