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Volumn 25, Issue 57, 2006, Pages 7545-7553

The ups and downs of Wnt signaling in prevalent neurological disorders

Author keywords

Alzheimer's disease; Apolipoprotein E; Autism; Genetic variation; Schizophrenia; Wnt signaling

Indexed keywords

APOLIPOPROTEIN E; BETA CATENIN; FRIZZLED PROTEIN; WNT PROTEIN;

EID: 33845350346     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210064     Document Type: Review
Times cited : (194)

References (161)
  • 1
    • 2542559015 scopus 로고    scopus 로고
    • Wnt genes define distinct boundaries in the developing human brain: Implications for human forebrain patterning
    • Abu-Khalil A, Fu L, Grove EA, Zecevic N, Geschwind DH. (2004). Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. J Comp Neurol 474: 276-288.
    • (2004) J Comp Neurol , vol.474 , pp. 276-288
    • Abu-Khalil, A.1    Fu, L.2    Grove, E.A.3    Zecevic, N.4    Geschwind, D.H.5
  • 2
    • 25844451040 scopus 로고    scopus 로고
    • Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection
    • Ahn YM, Seo MS, Kim SH, Kim Y, Yoon SC, Juhnn YS et al. (2005). Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection. Int J Neuropsychopharmacol 8: 607-613.
    • (2005) Int J Neuropsychopharmacol , vol.8 , pp. 607-613
    • Ahn, Y.M.1    Seo, M.S.2    Kim, S.H.3    Kim, Y.4    Yoon, S.C.5    Juhnn, Y.S.6
  • 3
    • 14644389398 scopus 로고    scopus 로고
    • Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum
    • Alimohamad H, Rajakumar N, Seah YH, Rushlow W. (2005a). Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol Psychiatry 57: 533-542.
    • (2005) Biol Psychiatry , vol.57 , pp. 533-542
    • Alimohamad, H.1    Rajakumar, N.2    Seah, Y.H.3    Rushlow, W.4
  • 4
    • 26844572307 scopus 로고    scopus 로고
    • The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats
    • Alimohamad H, Sutton L, Mouyal J, Rajakumar N, Rushlow WJ. (2005b). The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats. J Neurochem 95: 513-525.
    • (2005) J Neurochem , vol.95 , pp. 513-525
    • Alimohamad, H.1    Sutton, L.2    Mouyal, J.3    Rajakumar, N.4    Rushlow, W.J.5
  • 6
    • 0036276050 scopus 로고    scopus 로고
    • Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease
    • Alvarez G, Munoz-Montano JR, Satrustegui J, Avila J, Bogonez E, Diaz-Nido J. (2002). Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. Bipolar Disord 4: 153-165.
    • (2002) Bipolar Disord , vol.4 , pp. 153-165
    • Alvarez, G.1    Munoz-Montano, J.R.2    Satrustegui, J.3    Avila, J.4    Bogonez, E.5    Diaz-Nido, J.6
  • 7
    • 0032031559 scopus 로고    scopus 로고
    • Ectopic overexpression of engrailed-2 in cerebellar Purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions
    • Baader SL, Sanlioglu S, Berrebi AS, Parker-Thornburg J, Oberdick J. (1998). Ectopic overexpression of engrailed-2 in cerebellar Purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions. J Neurosci 18: 1763-1773.
    • (1998) J Neurosci , vol.18 , pp. 1763-1773
    • Baader, S.L.1    Sanlioglu, S.2    Berrebi, A.S.3    Parker-Thornburg, J.4    Oberdick, J.5
  • 10
    • 14644432508 scopus 로고    scopus 로고
    • Three autism candidate genes: A synthesis of human genetic analysis with other disciplines
    • Bartlett CW, Gharani N, Millonig JH, Brzustowicz LM. (2005). Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Int J Dev Neurosci 23: 221-234.
    • (2005) Int J Dev Neurosci , vol.23 , pp. 221-234
    • Bartlett, C.W.1    Gharani, N.2    Millonig, J.H.3    Brzustowicz, L.M.4
  • 11
    • 0035917848 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia
    • Beasley C, Cotter D, Khan N, Pollard C, Sheppard P, Varndell I et al. (2001). Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia. Neurosci Lett 302: 117-120.
    • (2001) Neurosci Lett , vol.302 , pp. 117-120
    • Beasley, C.1    Cotter, D.2    Khan, N.3    Pollard, C.4    Sheppard, P.5    Varndell, I.6
  • 12
    • 27244454668 scopus 로고    scopus 로고
    • Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus
    • Benayed R, Gharani N, Rossman I, Mancuso V, Lazar G, Kamdar S et al. (2005). Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. Am J Hum Genet 77: 851-868.
    • (2005) Am J Hum Genet , vol.77 , pp. 851-868
    • Benayed, R.1    Gharani, N.2    Rossman, I.3    Mancuso, V.4    Lazar, G.5    Kamdar, S.6
  • 13
    • 0346023025 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder
    • Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Serretti A, Colombo C et al. (2004a). A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. Neurosci Lett 355: 37-40.
    • (2004) Neurosci Lett , vol.355 , pp. 37-40
    • Benedetti, F.1    Bernasconi, A.2    Lorenzi, C.3    Pontiggia, A.4    Serretti, A.5    Colombo, C.6
  • 14
    • 4444350746 scopus 로고    scopus 로고
    • A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
    • Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E. (2004b). A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368: 123-126.
    • (2004) Neurosci Lett , vol.368 , pp. 123-126
    • Benedetti, F.1    Serretti, A.2    Colombo, C.3    Lorenzi, C.4    Tubazio, V.5    Smeraldi, E.6
  • 15
    • 13444269371 scopus 로고    scopus 로고
    • Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    • Benedetti F, Serretti A, Pontiggia A, Bernasconi A, Lorenzi C, Colombo C et al. (2005). Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP. Neurosci Lett 376: 51-55.
    • (2005) Neurosci Lett , vol.376 , pp. 51-55
    • Benedetti, F.1    Serretti, A.2    Pontiggia, A.3    Bernasconi, A.4    Lorenzi, C.5    Colombo, C.6
  • 19
    • 0032581370 scopus 로고    scopus 로고
    • Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family
    • Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR et al. (1998). Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem Biophys Res Commun 248: 879-888.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 879-888
    • Brown, S.D.1    Twells, R.C.2    Hey, P.J.3    Cox, R.D.4    Levy, E.R.5    Soderman, A.R.6
  • 20
    • 20144388533 scopus 로고    scopus 로고
    • Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells
    • Bug G, Gul H, Schwarz K, Pfeifer H, Kampfmann M, Zheng X et al. (2005). Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res 65: 2537-2541.
    • (2005) Cancer Res , vol.65 , pp. 2537-2541
    • Bug, G.1    Gul, H.2    Schwarz, K.3    Pfeifer, H.4    Kampfmann, M.5    Zheng, X.6
  • 21
    • 2342574965 scopus 로고    scopus 로고
    • Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
    • Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D et al. (2004). Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Med 5: 133-146.
    • (2004) Neuromolecular Med , vol.5 , pp. 133-146
    • Busby, V.1    Goossens, S.2    Nowotny, P.3    Hamilton, G.4    Smemo, S.5    Harold, D.6
  • 23
    • 0037723974 scopus 로고    scopus 로고
    • The Wnt pathway, cell-cycle activation and beta-amyloid: Novel therapeutic strategies in Alzheimer's disease?
    • Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA et al. (2003). The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol Sci 24: 233-238.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 233-238
    • Caricasole, A.1    Copani, A.2    Caruso, A.3    Caraci, F.4    Iacovelli, L.5    Sortino, M.A.6
  • 24
    • 3042834662 scopus 로고    scopus 로고
    • Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    • Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A et al. (2004). Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci 24: 6021-6027.
    • (2004) J Neurosci , vol.24 , pp. 6021-6027
    • Caricasole, A.1    Copani, A.2    Caraci, F.3    Aronica, E.4    Rozemuller, A.J.5    Caruso, A.6
  • 25
    • 0035865070 scopus 로고    scopus 로고
    • To a future of genetic medicine
    • Chakravarti A. (2001). To a future of genetic medicine. Nature 409: 822-823.
    • (2001) Nature , vol.409 , pp. 822-823
    • Chakravarti, A.1
  • 26
    • 0033014180 scopus 로고    scopus 로고
    • The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3
    • Chen G, Huang LD, Jiang YM, Manji HK. (1999). The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J Neurochem 72: 1327-1330.
    • (1999) J Neurochem , vol.72 , pp. 1327-1330
    • Chen, G.1    Huang, L.D.2    Jiang, Y.M.3    Manji, H.K.4
  • 27
    • 33744958556 scopus 로고    scopus 로고
    • Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
    • Chen J, Park CS, Tang SJ. (2006). Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J Biol Chem 281: 11910-11916.
    • (2006) J Biol Chem , vol.281 , pp. 11910-11916
    • Chen, J.1    Park, C.S.2    Tang, S.J.3
  • 28
    • 0037135177 scopus 로고    scopus 로고
    • Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    • Chenn A, Walsh CA. (2002). Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297: 365-369.
    • (2002) Science , vol.297 , pp. 365-369
    • Chenn, A.1    Walsh, C.A.2
  • 29
    • 0038662778 scopus 로고    scopus 로고
    • Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice
    • Chenn A, Walsh CA. (2003). Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice. Cereb Cortex 13: 599-606.
    • (2003) Cereb Cortex , vol.13 , pp. 599-606
    • Chenn, A.1    Walsh, C.A.2
  • 30
    • 0028220791 scopus 로고
    • Fetal valproate syndrome: Clinical and neuro-developmental features in two sibling pairs
    • Christianson AL, Chesler N, Kromberg JG. (1994). Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Dev Med Child Neurol 36: 361-369.
    • (1994) Dev Med Child Neurol , vol.36 , pp. 361-369
    • Christianson, A.L.1    Chesler, N.2    Kromberg, J.G.3
  • 31
    • 17844366846 scopus 로고    scopus 로고
    • WNTs in the vertebrate nervous system: From patterning to neuronal connectivity
    • Ciani L, Salinas PC. (2005). WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat Rev Neurosci 6: 351-362.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 351-362
    • Ciani, L.1    Salinas, P.C.2
  • 32
    • 0035830310 scopus 로고    scopus 로고
    • An autosomal genomic screen for autism
    • Collaborative Linkage Study of Autism
    • Collaborative Linkage Study of Autism. (2001). An autosomal genomic screen for autism. Am J Med Genet 105: 609-615.
    • (2001) Am J Med Genet , vol.105 , pp. 609-615
  • 33
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 34
    • 0032507631 scopus 로고    scopus 로고
    • Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality
    • Cotter D, Kerwin R, al-Sarraji S, Brion JP, Chadwich A, Lovestone S et al. (1998). Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality. Neuroreport 9: 1379-1383.
    • (1998) Neuroreport , vol.9 , pp. 1379-1383
    • Cotter, D.1    Kerwin, R.2    Al-Sarraji, S.3    Brion, J.P.4    Chadwich, A.5    Lovestone, S.6
  • 35
    • 0038601952 scopus 로고    scopus 로고
    • Evidence of brain overgrowth in the first year of life in autism
    • Courchesne E, Carper R, Akshoomoff N. (2003). Evidence of brain overgrowth in the first year of life in autism. Jama 290: 337-344.
    • (2003) Jama , vol.290 , pp. 337-344
    • Courchesne, E.1    Carper, R.2    Akshoomoff, N.3
  • 36
    • 0035943033 scopus 로고    scopus 로고
    • Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
    • Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD et al. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 57: 245-254.
    • (2001) Neurology , vol.57 , pp. 245-254
    • Courchesne, E.1    Karns, C.M.2    Davis, H.R.3    Ziccardi, R.4    Carper, R.A.5    Tigue, Z.D.6
  • 38
    • 0037220599 scopus 로고    scopus 로고
    • Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
    • De Ferrari GV, Chacon MA, Barria MI, Garrido JL, Godoy JA, Olivares G et al. (2003). Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol Psychiatry 8: 195-208.
    • (2003) Mol Psychiatry , vol.8 , pp. 195-208
    • De Ferrari, G.V.1    Chacon, M.A.2    Barria, M.I.3    Garrido, J.L.4    Godoy, J.A.5    Olivares, G.6
  • 40
    • 0842310838 scopus 로고    scopus 로고
    • Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia
    • Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. (2004). Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36: 131-137.
    • (2004) Nat Genet , vol.36 , pp. 131-137
    • Emamian, E.S.1    Hall, D.2    Birnbaum, M.J.3    Karayiorgou, M.4    Gogos, J.A.5
  • 41
    • 0344668728 scopus 로고    scopus 로고
    • Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    • Ertekin-Taner N, Ronald J, Asahara H, Younkin L, Hella M, Jain S et al. (2003). Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum Mol Genet 12: 3133-3143.
    • (2003) Hum Mol Genet , vol.12 , pp. 3133-3143
    • Ertekin-Taner, N.1    Ronald, J.2    Asahara, H.3    Younkin, L.4    Hella, M.5    Jain, S.6
  • 43
    • 1542471857 scopus 로고    scopus 로고
    • How might genetic mechanisms operate in autism?
    • discussion 80-73, 109-111, 281-197
    • Folstein SE, Dowd M, Mankoski R, Tadevosyan O. (2003). How might genetic mechanisms operate in autism? Novartis Found Symp 251: 70-80; discussion 80-73, 109-111, 281-197.
    • (2003) Novartis Found Symp , vol.251 , pp. 70-80
    • Folstein, S.E.1    Dowd, M.2    Mankoski, R.3    Tadevosyan, O.4
  • 44
    • 0035653670 scopus 로고    scopus 로고
    • Genetics of autism: Complex aetiology for a heterogeneous disorder
    • Folstein SE, Rosen-Sheidley B. (2001). Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet 2: 943-955.
    • (2001) Nat Rev Genet , vol.2 , pp. 943-955
    • Folstein, S.E.1    Rosen-Sheidley, B.2
  • 45
    • 22244448955 scopus 로고    scopus 로고
    • Down-regulation of Dickkopf 3, a regulator of the Wnt signalling pathway, in elderly schizophrenic subjects
    • Ftouh S, Akbar MT, Hirsch SR, de Belleroche JS. (2005). Down-regulation of Dickkopf 3, a regulator of the Wnt signalling pathway, in elderly schizophrenic subjects. J Neurochem 94: 520-530.
    • (2005) J Neurochem , vol.94 , pp. 520-530
    • Ftouh, S.1    Akbar, M.T.2    Hirsch, S.R.3    De Belleroche, J.S.4
  • 46
    • 3142523276 scopus 로고    scopus 로고
    • Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder
    • Gharani N, Benayed R, Mancuso V, Brzustowicz LM, Millonig JH. (2004). Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. Mol Psychiatry 9: 474-484.
    • (2004) Mol Psychiatry , vol.9 , pp. 474-484
    • Gharani, N.1    Benayed, R.2    Mancuso, V.3    Brzustowicz, L.M.4    Millonig, J.H.5
  • 47
    • 0031869926 scopus 로고    scopus 로고
    • The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
    • Grove EA, Tole S, Limon J, Yip L, Ragsdale CW. (1998). The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 125: 2315-2325.
    • (1998) Development , vol.125 , pp. 2315-2325
    • Grove, E.A.1    Tole, S.2    Limon, J.3    Yip, L.4    Ragsdale, C.W.5
  • 48
    • 0035089756 scopus 로고    scopus 로고
    • Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23
    • Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS et al. (2001). Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68: 661-673.
    • (2001) Am J Hum Genet , vol.68 , pp. 661-673
    • Gurling, H.M.1    Kalsi, G.2    Brynjolfson, J.3    Sigmundsson, T.4    Sherrington, R.5    Mankoo, B.S.6
  • 49
    • 33644843900 scopus 로고    scopus 로고
    • Functional candidate genes in age-related macular degeneration: Significant association with VEGF, VLDLR, and LRP6
    • Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA et al. (2006). Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci 47: 329-335.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 329-335
    • Haines, J.L.1    Schnetz-Boutaud, N.2    Schmidt, S.3    Scott, W.K.4    Agarwal, A.5    Postel, E.A.6
  • 50
    • 0036311668 scopus 로고    scopus 로고
    • Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons
    • Hall AC, Brennan A, Goold RG, Cleverley K, Lucas FR, Gordon-Weeks PR et al. (2002). Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Mol Cell Neurosci 20: 257-270.
    • (2002) Mol Cell Neurosci , vol.20 , pp. 257-270
    • Hall, A.C.1    Brennan, A.2    Goold, R.G.3    Cleverley, K.4    Lucas, F.R.5    Gordon-Weeks, P.R.6
  • 51
    • 0034598921 scopus 로고    scopus 로고
    • Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling
    • Hall AC, Lucas FR, Salinas PC. (2000). Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100: 525-535.
    • (2000) Cell , vol.100 , pp. 525-535
    • Hall, A.C.1    Lucas, F.R.2    Salinas, P.C.3
  • 52
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
    • Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH. (1992). Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett 147: 58-62.
    • (1992) Neurosci Lett , vol.147 , pp. 58-62
    • Hanger, D.P.1    Hughes, K.2    Woodgett, J.R.3    Brion, J.P.4    Anderton, B.H.5
  • 53
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 54
    • 0035046073 scopus 로고    scopus 로고
    • The LDL receptor gene family: (un)expected signal transducers in the brain
    • Herz J. (2001). The LDL receptor gene family: (un)expected signal transducers in the brain. Neuron 29: 571-581.
    • (2001) Neuron , vol.29 , pp. 571-581
    • Herz, J.1
  • 55
    • 0032541395 scopus 로고    scopus 로고
    • Cloning of a novel member of the low-density lipoprotein receptor family
    • Hey PJ, Twells RC, Phillips MS, Yusuke N, Brown SD, Kawaguchi Y et al. (1998). Cloning of a novel member of the low-density lipoprotein receptor family. Gene 216: 103-111.
    • (1998) Gene , vol.216 , pp. 103-111
    • Hey, P.J.1    Twells, R.C.2    Phillips, M.S.3    Yusuke, N.4    Brown, S.D.5    Kawaguchi, Y.6
  • 56
    • 0037130459 scopus 로고    scopus 로고
    • Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling
    • Houart C, Caneparo L, Heisenberg C, Barth K, Take-Uchi M, Wilson S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron 35: 255-265.
    • (2002) Neuron , vol.35 , pp. 255-265
    • Houart, C.1    Caneparo, L.2    Heisenberg, C.3    Barth, K.4    Take-Uchi, M.5    Wilson, S.6
  • 59
    • 0034612151 scopus 로고    scopus 로고
    • Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism
    • Ingram JL, Peckham SM, Tisdale B, Rodier PM. (2000). Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol Teratol 22: 319-324.
    • (2000) Neurotoxicol Teratol , vol.22 , pp. 319-324
    • Ingram, J.L.1    Peckham, S.M.2    Tisdale, B.3    Rodier, P.M.4
  • 60
    • 6844251000 scopus 로고    scopus 로고
    • A full genome screen for autism with evidence for linkage to a region on chromosome 7q
    • International Molecular Genetic Study of Autism Consortium (IMGSAC). International Molecular Genetic Study of Autism Consortium
    • International Molecular Genetic Study of Autism Consortium (IMGSAC). (1998). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. Hum Mol Genet 7: 571-578.
    • (1998) Hum Mol Genet , vol.7 , pp. 571-578
  • 61
    • 0034883367 scopus 로고    scopus 로고
    • A genomewide screen for autism: Strong evidence for linkage to chromosomes 2q, 7q, and 16p
    • International Molecular Genetic Study of Autism Consortium (IMGSAC)
    • International Molecular Genetic Study of Autism Consortium (IMGSAC). (2001). A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p. Am J Hum Genet 69: 570-581.
    • (2001) Am J Hum Genet , vol.69 , pp. 570-581
  • 62
    • 33744810849 scopus 로고    scopus 로고
    • Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: Results in a Korean population and evidence from meta-analysis
    • Jeong SH, Joo EJ, Ahn YM, Lee KY, Kim YS. (2006). Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: Results in a Korean population and evidence from meta-analysis. Psychiatry Res 143: 1-11.
    • (2006) Psychiatry Res , vol.143 , pp. 1-11
    • Jeong, S.H.1    Joo, E.J.2    Ahn, Y.M.3    Lee, K.Y.4    Kim, Y.S.5
  • 63
    • 0025884460 scopus 로고
    • Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox
    • Joyner AL, Herrup K, Auerbach BA, Davis CA, Rossant J. (1991). Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251: 1239-1243.
    • (1991) Science , vol.251 , pp. 1239-1243
    • Joyner, A.L.1    Herrup, K.2    Auerbach, B.A.3    Davis, C.A.4    Rossant, J.5
  • 64
    • 0033762062 scopus 로고    scopus 로고
    • Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway
    • Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ et al. (2000). Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest 106: 1159-1166.
    • (2000) J Clin Invest , vol.106 , pp. 1159-1166
    • Kang, D.E.1    Pietrzik, C.U.2    Baum, L.3    Chevallier, N.4    Merriam, D.E.5    Kounnas, M.Z.6
  • 65
    • 0037145062 scopus 로고    scopus 로고
    • Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis
    • Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H et al. (2002). Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 110: 751-762.
    • (2002) Cell , vol.110 , pp. 751-762
    • Kang, D.E.1    Soriano, S.2    Xia, X.3    Eberhart, C.G.4    De Strooper, B.5    Zheng, H.6
  • 66
    • 10744222489 scopus 로고    scopus 로고
    • The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia
    • Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K et al. (2003). The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. Neurosci Lett 353: 53-56.
    • (2003) Neurosci Lett , vol.353 , pp. 53-56
    • Katsu, T.1    Ujike, H.2    Nakano, T.3    Tanaka, Y.4    Nomura, A.5    Nakata, K.6
  • 68
    • 0034100029 scopus 로고    scopus 로고
    • Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    • Kendler KS, Myers JM, O'Neill FA, Martin R, Murphy B, MacLean CJ et al. (2000). Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 157: 402-408.
    • (2000) Am J Psychiatry , vol.157 , pp. 402-408
    • Kendler, K.S.1    Myers, J.M.2    O'Neill, F.A.3    Martin, R.4    Murphy, B.5    MacLean, C.J.6
  • 69
    • 0032446373 scopus 로고    scopus 로고
    • A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.
    • Kim DH, Inagaki Y, Suzuki T, Ioka RX, Yoshioka SZ, Magoori K et al. (1998). A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. J Biochem (Tokyo) 124: 1072-1076.
    • (1998) J Biochem (Tokyo) , vol.124 , pp. 1072-1076
    • Kim, D.H.1    Inagaki, Y.2    Suzuki, T.3    Ioka, R.X.4    Yoshioka, S.Z.5    Magoori, K.6
  • 70
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein PS, Melton DA. (1996). A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93: 8455-8459.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 71
    • 0033625098 scopus 로고    scopus 로고
    • Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients
    • Kozlovsky N, Belmaker RH, Agam G. (2000). Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients. Am J Psychiatry 157: 831-833.
    • (2000) Am J Psychiatry , vol.157 , pp. 831-833
    • Kozlovsky, N.1    Belmaker, R.H.2    Agam, G.3
  • 72
    • 0035476357 scopus 로고    scopus 로고
    • Low GSK-3 activity in frontal cortex of schizophrenic patients
    • Kozlovsky N, Belmaker RH, Agam G. (2001). Low GSK-3 activity in frontal cortex of schizophrenic patients. Schizophr Res 52: 101-105.
    • (2001) Schizophr Res , vol.52 , pp. 101-105
    • Kozlovsky, N.1    Belmaker, R.H.2    Agam, G.3
  • 73
    • 0035094764 scopus 로고    scopus 로고
    • Variation is the spice of life
    • Kruglyak L, Nickerson DA. (2001). Variation is the spice of life. Nat Genet 27: 234-236.
    • (2001) Nat Genet , vol.27 , pp. 234-236
    • Kruglyak, L.1    Nickerson, D.A.2
  • 74
    • 0031941080 scopus 로고    scopus 로고
    • A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain
    • Lako M, Lindsay S, Bullen P, Wilson DI, Robson SC, Strachan T. (1998). A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Hum Mol Genet 7: 813-822.
    • (1998) Hum Mol Genet , vol.7 , pp. 813-822
    • Lako, M.1    Lindsay, S.2    Bullen, P.3    Wilson, D.I.4    Robson, S.C.5    Strachan, T.6
  • 75
    • 0344245499 scopus 로고    scopus 로고
    • Expression analysis of glycogen synthase kinase-3 in human tissues
    • Lau KF, Miller CC, Anderton BH, Shaw PC. (1999). Expression analysis of glycogen synthase kinase-3 in human tissues. J Pept Res 54: 85-91.
    • (1999) J Pept Res , vol.54 , pp. 85-91
    • Lau, K.F.1    Miller, C.C.2    Anderton, B.H.3    Shaw, P.C.4
  • 76
    • 0033966405 scopus 로고    scopus 로고
    • A local Wnt-3a signal is required for development of the mammalian hippocampus
    • Lee SM, Tole S, Grove E, McMahon AP. (2000). A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127: 457-467.
    • (2000) Development , vol.127 , pp. 457-467
    • Lee, S.M.1    Tole, S.2    Grove, E.3    McMahon, A.P.4
  • 77
    • 0032989714 scopus 로고    scopus 로고
    • Developmental expression and localization of glycogen synthase kinase-3beta in rat brain
    • Leroy K, Brion JP. (1999). Developmental expression and localization of glycogen synthase kinase-3beta in rat brain. J Chem Neuroanat 16: 279-293.
    • (1999) J Chem Neuroanat , vol.16 , pp. 279-293
    • Leroy, K.1    Brion, J.P.2
  • 79
    • 29244459434 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture
    • Li X, Lu F, Tian Q, Yang Y, Wang Q, Wang JZ. (2006). Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture. J Neural Transm 113: 93-102.
    • (2006) J Neural Transm , vol.113 , pp. 93-102
    • Li, X.1    Lu, F.2    Tian, Q.3    Yang, Y.4    Wang, Q.5    Wang, J.Z.6
  • 80
    • 0034796509 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor family: Endocytosis and signal transduction
    • Li Y, Cam J, Bu G. (2001). Low-density lipoprotein receptor family: endocytosis and signal transduction. Mol Neurobiol 23: 53-67.
    • (2001) Mol Neurobiol , vol.23 , pp. 53-67
    • Li, Y.1    Cam, J.2    Bu, G.3
  • 81
    • 0028675873 scopus 로고
    • Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
    • Lovestone S, Reynolds CH, Latimer D, Davis DR, Anderton BH, Gallo JM et al. (1994). Alzheimer's disease-like phosphorylation of the microtubule- associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 4: 1077-1086.
    • (1994) Curr Biol , vol.4 , pp. 1077-1086
    • Lovestone, S.1    Reynolds, C.H.2    Latimer, D.3    Davis, D.R.4    Anderton, B.H.5    Gallo, J.M.6
  • 82
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J. (2001). Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. Embo J 20: 27-39.
    • (2001) Embo J , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 83
    • 0038515322 scopus 로고    scopus 로고
    • Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.
    • Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A et al. (2003). Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem 278: 11331-11336.
    • (2003) J Biol Chem , vol.278 , pp. 11331-11336
    • Magoori, K.1    Kang, M.J.2    Ito, M.R.3    Kakuuchi, H.4    Ioka, R.X.5    Kamataki, A.6
  • 85
    • 0037458733 scopus 로고    scopus 로고
    • The tuberin-hamartin complex negatively regulates beta-catenin signaling activity
    • Mak BC, Takemaru K, Kenerson HL, Moon RT, Yeung RS. (2003). The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem 278: 5947-5951.
    • (2003) J Biol Chem , vol.278 , pp. 5947-5951
    • Mak, B.C.1    Takemaru, K.2    Kenerson, H.L.3    Moon, R.T.4    Yeung, R.S.5
  • 86
    • 8644274532 scopus 로고    scopus 로고
    • The tuberous sclerosis complex genes in tumor development
    • Mak BC, Yeung RS. (2004). The tuberous sclerosis complex genes in tumor development. Cancer Invest 22: 588-603.
    • (2004) Cancer Invest , vol.22 , pp. 588-603
    • Mak, B.C.1    Yeung, R.S.2
  • 89
    • 33645720958 scopus 로고    scopus 로고
    • Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease
    • Mateo I, Infante J, Llorca J, Rodriguez E, Berciano J, Combarros O. (2006). Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease. Dement Geriatr Cogn Disord 21: 228-232.
    • (2006) Dement Geriatr Cogn Disord , vol.21 , pp. 228-232
    • Mateo, I.1    Infante, J.2    Llorca, J.3    Rodriguez, E.4    Berciano, J.5    Combarros, O.6
  • 90
    • 18244384759 scopus 로고    scopus 로고
    • Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics
    • Mayeux R, Lee JH, Romas SN, Mayo D, Santana V, Williamson J et al. (2002). Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics. Am J Hum Genet 70: 237-243.
    • (2002) Am J Hum Genet , vol.70 , pp. 237-243
    • Mayeux, R.1    Lee, J.H.2    Romas, S.N.3    Mayo, D.4    Santana, V.5    Williamson, J.6
  • 92
    • 0032867869 scopus 로고    scopus 로고
    • Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus
    • McGrew LL, Takemaru K, Bates R, Moon RT. (1999). Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus. Mech Dev 87: 21-32.
    • (1999) Mech Dev , vol.87 , pp. 21-32
    • McGrew, L.L.1    Takemaru, K.2    Bates, R.3    Moon, R.T.4
  • 93
    • 0025188130 scopus 로고
    • The Wnt-1 (int-1) protooncogene is required for development of a large region of the mouse brain
    • McMahon AP, Bradley A. (1990). The Wnt-1 (int-1) protooncogene is required for development of a large region of the mouse brain. Cell 62: 1073-1085.
    • (1990) Cell , vol.62 , pp. 1073-1085
    • McMahon, A.P.1    Bradley, A.2
  • 94
    • 0026719855 scopus 로고
    • The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- Mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
    • McMahon AP, Joyner AL, Bradley A, McMahon JA. (1992). The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69: 581-595.
    • (1992) Cell , vol.69 , pp. 581-595
    • McMahon, A.P.1    Joyner, A.L.2    Bradley, A.3    McMahon, J.A.4
  • 95
    • 0028325992 scopus 로고
    • Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants
    • Millen KJ, Wurst W, Herrup K, Joyner AL. (1994). Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development 120: 695-706.
    • (1994) Development , vol.120 , pp. 695-706
    • Millen, K.J.1    Wurst, W.2    Herrup, K.3    Joyner, A.L.4
  • 96
    • 0033609561 scopus 로고    scopus 로고
    • Increased expression of Wnt-1 in schizophrenic brains
    • Miyaoka T, Seno H, Ishino H. (1999). Increased expression of Wnt-1 in schizophrenic brains. Schizophr Res 38: 1-6.
    • (1999) Schizophr Res , vol.38 , pp. 1-6
    • Miyaoka, T.1    Seno, H.2    Ishino, H.3
  • 97
    • 14644443001 scopus 로고    scopus 로고
    • Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: Implication for pathogenesis of autism
    • Miyazaki K, Narita N, Narita M. (2005). Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. Int J Dev Neurosci 23: 287-297.
    • (2005) Int J Dev Neurosci , vol.23 , pp. 287-297
    • Miyazaki, K.1    Narita, N.2    Narita, M.3
  • 100
    • 0035879075 scopus 로고    scopus 로고
    • Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
    • Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C et al. (2001). Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neurosci 21: 4987-4995.
    • (2001) J Neurosci , vol.21 , pp. 4987-4995
    • Mudher, A.1    Chapman, S.2    Richardson, J.3    Asuni, A.4    Gibb, G.5    Pollard, C.6
  • 101
    • 0036150827 scopus 로고    scopus 로고
    • Alzheimer's disease-do tauists and baptists finally shake hands?
    • Mudher A, Lovestone S. (2002). Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci 25: 22-26.
    • (2002) Trends Neurosci , vol.25 , pp. 22-26
    • Mudher, A.1    Lovestone, S.2
  • 103
    • 0036848075 scopus 로고    scopus 로고
    • The Drosophila Wnt, Wingless, provides an essential signal for pre- And postsynaptic differentiation
    • Packard M, Koo ES, Gorczyca M, Sharpe J, Cumberledge S, Budnik V. (2002). The Drosophila Wnt, Wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111: 319-330.
    • (2002) Cell , vol.111 , pp. 319-330
    • Packard, M.1    Koo, E.S.2    Gorczyca, M.3    Sharpe, J.4    Cumberledge, S.5    Budnik, V.6
  • 104
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • Panakova D, Sprong H, Marois E, Thiele C, Eaton S. (2005). Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 58-65.
    • (2005) Nature , vol.435 , pp. 58-65
    • Panakova, D.1    Sprong, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 105
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
    • Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B et al. (1999). Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 58: 1010-1019.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 1010-1019
    • Pei, J.J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6
  • 106
    • 0030770726 scopus 로고    scopus 로고
    • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    • Pericak-Vance MA, Bass MP, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA et al. (1997). Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. Jama 278: 1237-1241.
    • (1997) Jama , vol.278 , pp. 1237-1241
    • Pericak-Vance, M.A.1    Bass, M.P.2    Yamaoka, L.H.3    Gaskell, P.C.4    Scott, W.K.5    Terwedow, H.A.6
  • 108
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
    • Phiel CJ, Wilson CA, Lee VM, Klein PS. (2003). GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423: 435-439.
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 109
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. (2001). Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734-36741.
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 110
  • 111
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC. (2000). An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407: 535-538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 112
    • 0029071768 scopus 로고
    • Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes
    • Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL et al. (1995). Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60: 252-260.
    • (1995) Am J Med Genet , vol.60 , pp. 252-260
    • Pulver, A.E.1    Lasseter, V.K.2    Kasch, L.3    Wolyniec, P.4    Nestadt, G.5    Blouin, J.L.6
  • 114
    • 0036592640 scopus 로고    scopus 로고
    • Apolipoprotein e and Alzheimer's disease: The protective effects of ApoE2 and E3
    • Rebeck GW, Kindy M, LaDu MJ. (2002). Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3. J Alzheimers Dis 4: 145-154.
    • (2002) J Alzheimers Dis , vol.4 , pp. 145-154
    • Rebeck, G.W.1    Kindy, M.2    LaDu, M.J.3
  • 116
    • 0022572835 scopus 로고
    • Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC Autopsy Research Report
    • Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D et al. (1986). Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report. Am J Psychiatry 143: 862-866.
    • (1986) Am J Psychiatry , vol.143 , pp. 862-866
    • Ritvo, E.R.1    Freeman, B.J.2    Scheibel, A.B.3    Duong, T.4    Robinson, H.5    Guthrie, D.6
  • 117
    • 0031104734 scopus 로고    scopus 로고
    • Linking etiologies in humans and animal models: Studies of autism
    • Rodier PM, Ingram JL, Tisdale B, Croog VJ. (1997). Linking etiologies in humans and animal models: studies of autism. Reprod Toxicol 11: 417-422.
    • (1997) Reprod Toxicol , vol.11 , pp. 417-422
    • Rodier, P.M.1    Ingram, J.L.2    Tisdale, B.3    Croog, V.J.4
  • 118
    • 0032547369 scopus 로고    scopus 로고
    • Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity
    • Rogaeva E, Premkumar S, Song Y, Sorbi S, Brindle N, Paterson A et al. (1998). Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. Jama 280: 614-618.
    • (1998) Jama , vol.280 , pp. 614-618
    • Rogaeva, E.1    Premkumar, S.2    Song, Y.3    Sorbi, S.4    Brindle, N.5    Paterson, A.6
  • 119
    • 0035062230 scopus 로고    scopus 로고
    • Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease
    • Russ C, Lovestone S, Powell JF. (2001). Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease. Mol Psychiatry 6: 320-324.
    • (2001) Mol Psychiatry , vol.6 , pp. 320-324
    • Russ, C.1    Lovestone, S.2    Powell, J.F.3
  • 120
    • 0036150938 scopus 로고    scopus 로고
    • Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease
    • Russ C, Lovestone S, Powell JF. (2002). Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. Mol Psychiatry 7: 104-109.
    • (2002) Mol Psychiatry , vol.7 , pp. 104-109
    • Russ, C.1    Lovestone, S.2    Powell, J.F.3
  • 122
    • 0032603742 scopus 로고    scopus 로고
    • Wnt factors in axonal remodelling and synaptogenesis
    • Salinas PC. (1999). Wnt factors in axonal remodelling and synaptogenesis. Biochem Soc Symp 65: 101-109.
    • (1999) Biochem Soc Symp , vol.65 , pp. 101-109
    • Salinas, P.C.1
  • 123
    • 23444455643 scopus 로고    scopus 로고
    • Signaling at the vertebrate synapse: New roles for embryonic morphogens?
    • Salinas PC. (2005). Signaling at the vertebrate synapse: new roles for embryonic morphogens? J Neurobiol 64: 435-445.
    • (2005) J Neurobiol , vol.64 , pp. 435-445
    • Salinas, P.C.1
  • 124
    • 0036830458 scopus 로고    scopus 로고
    • Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomerictau fibrils in COS-7 cells
    • Sato S, Tatebayashi Y, Akagi T, Chui DH, Murayama M, Miyasaka T et al. (2002). Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomerictau fibrils in COS-7 cells. J Biol Chem 277: 42060-42065.
    • (2002) J Biol Chem , vol.277 , pp. 42060-42065
    • Sato, S.1    Tatebayashi, Y.2    Akagi, T.3    Chui, D.H.4    Murayama, M.5    Miyasaka, T.6
  • 125
    • 10744226703 scopus 로고    scopus 로고
    • Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
    • Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S et al. (2003). Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 12: 2765-2776.
    • (2003) Hum Mol Genet , vol.12 , pp. 2765-2776
    • Saunders, A.J.1    Bertram, L.2    Mullin, K.3    Sampson, A.J.4    Latifzai, K.5    Basu, S.6
  • 127
  • 128
    • 3242693270 scopus 로고    scopus 로고
    • The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages
    • Schumann CM, Hamstra J, Goodlin-Jones BL, Lotspeich LJ, Kwon H, Buonocore MH et al. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J Neurosci 24: 6392-6401.
    • (2004) J Neurosci , vol.24 , pp. 6392-6401
    • Schumann, C.M.1    Hamstra, J.2    Goodlin-Jones, B.L.3    Lotspeich, L.J.4    Kwon, H.5    Buonocore, M.H.6
  • 129
    • 0033913161 scopus 로고    scopus 로고
    • Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: Potential genetic and phenotypic heterogeneity
    • Scott WK, Grubber JM, Conneally PM, Small GW, Hulette CM, Rosenberg CK et al. (2000). Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. Am J Hum Genet 66: 922-932.
    • (2000) Am J Hum Genet , vol.66 , pp. 922-932
    • Scott, W.K.1    Grubber, J.M.2    Conneally, P.M.3    Small, G.W.4    Hulette, C.M.5    Rosenberg, C.K.6
  • 130
    • 0032193702 scopus 로고    scopus 로고
    • Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes
    • Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S et al. (1998). Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes. Genome 41: 720-727.
    • (1998) Genome , vol.41 , pp. 720-727
    • Shaw, P.C.1    Davies, A.F.2    Lau, K.F.3    Garcia-Barcelo, M.4    Waye, M.M.5    Lovestone, S.6
  • 132
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS et al. (1993). Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90: 1977-1981.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3    Pericak-Vance, M.4    Enghild, J.5    Salvesen, G.S.6
  • 133
    • 0037087220 scopus 로고    scopus 로고
    • Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100
    • Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H et al. (2002). Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 321: 61-64.
    • (2002) Neurosci Lett , vol.321 , pp. 61-64
    • Sun, X.1    Sato, S.2    Murayama, O.3    Murayama, M.4    Park, J.M.5    Yamaguchi, H.6
  • 135
    • 0031695652 scopus 로고    scopus 로고
    • Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
    • Takashima A, Honda T, Yasutake K, Michel G, Murayama O, Murayama M et al. (1998a). Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci Res 31: 317-323.
    • (1998) Neurosci Res , vol.31 , pp. 317-323
    • Takashima, A.1    Honda, T.2    Yasutake, K.3    Michel, G.4    Murayama, O.5    Murayama, M.6
  • 137
  • 139
    • 0036592641 scopus 로고    scopus 로고
    • The presence of apoE4, not the absence of apoE3, contributes to AD pathology
    • Teter B, Raber J, Nathan B, Crutcher KA. (2002). The presence of apoE4, not the absence of apoE3, contributes to AD pathology. J Alzheimers Dis 4: 155-163.
    • (2002) J Alzheimers Dis , vol.4 , pp. 155-163
    • Teter, B.1    Raber, J.2    Nathan, B.3    Crutcher, K.A.4
  • 140
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas KR, Capecchi MR. (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346: 847-850.
    • (1990) Nature , vol.346 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 141
    • 0025790170 scopus 로고
    • Swaying is a mutant allele of the proto-oncogene Wnt-1
    • Thomas KR, Musci TS, Neumann PE, Capecchi MR. (1991). Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell 67: 969-976.
    • (1991) Cell , vol.67 , pp. 969-976
    • Thomas, K.R.1    Musci, T.S.2    Neumann, P.E.3    Capecchi, M.R.4
  • 142
    • 29644446220 scopus 로고    scopus 로고
    • Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men
    • van Meurs JB, Rivadeneira F, Jhamai M, Hugens W, Hofman A, van Leeuwen JP et al. (2006). Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men. J Bone Miner Res 21: 141-150.
    • (2006) J Bone Miner Res , vol.21 , pp. 141-150
    • Van Meurs, J.B.1    Rivadeneira, F.2    Jhamai, M.3    Hugens, W.4    Hofman, A.5    Van Leeuwen, J.P.6
  • 143
    • 0030599372 scopus 로고    scopus 로고
    • The Engrailed-2 homeobox gene and patterning of spinocerebellar mossy fiber afferents
    • Vogel MW, Ji Z, Millen K, Joyner AL. (1996). The Engrailed-2 homeobox gene and patterning of spinocerebellar mossy fiber afferents. Brain Res Dev Brain Res 96: 210-218.
    • (1996) Brain Res Dev Brain Res , vol.96 , pp. 210-218
    • Vogel, M.W.1    Ji, Z.2    Millen, K.3    Joyner, A.L.4
  • 144
    • 32844460507 scopus 로고    scopus 로고
    • Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism
    • 18-28
    • Vorstman JA, Staal WG, van Daalen E, van Engeland H, Hochstenbach PF, Franke L. (2006). Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism. Mol Psychiatry 11: 1, 18-28..
    • (2006) Mol Psychiatry , vol.11 , pp. 1
    • Vorstman, J.A.1    Staal, W.G.2    Van Daalen, E.3    Van Engeland, H.4    Hochstenbach, P.F.5    Franke, L.6
  • 145
    • 0141542673 scopus 로고    scopus 로고
    • Regulation of acetylcholine receptor clustering by the tumor suppressor APC
    • Wang J, Jing Z, Zhang L, Zhou G, Braun J, Yao Y et al. (2003). Regulation of acetylcholine receptor clustering by the tumor suppressor APC. Nat Neurosci 6: 1017-1018.
    • (2003) Nat Neurosci , vol.6 , pp. 1017-1018
    • Wang, J.1    Jing, Z.2    Zhang, L.3    Zhou, G.4    Braun, J.5    Yao, Y.6
  • 146
    • 0036812502 scopus 로고    scopus 로고
    • Frizzled-3 is required for the development of major fiber tracts in the rostral CNS
    • Wang Y, Thekdi N, Smallwood PM, Macke JP, Nathans J. (2002). Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci 22: 8563-8573.
    • (2002) J Neurosci , vol.22 , pp. 8563-8573
    • Wang, Y.1    Thekdi, N.2    Smallwood, P.M.3    Macke, J.P.4    Nathans, J.5
  • 149
  • 151
    • 1842366061 scopus 로고    scopus 로고
    • A male with fetal valproate syndrome and autism
    • Williams PG, Hersh JH. (1997). A male with fetal valproate syndrome and autism. Dev Med Child Neurol 39: 632-634.
    • (1997) Dev Med Child Neurol , vol.39 , pp. 632-634
    • Williams, P.G.1    Hersh, J.H.2
  • 152
    • 0442278332 scopus 로고    scopus 로고
    • Early steps in the development of the forebrain
    • Wilson SW, Houart C. (2004). Early steps in the development of the forebrain. Dev Cell 6: 167-181.
    • (2004) Dev Cell , vol.6 , pp. 167-181
    • Wilson, S.W.1    Houart, C.2
  • 153
    • 6344271762 scopus 로고    scopus 로고
    • Autism and tuberous sclerosis
    • Wiznitzer M. (2004). Autism and tuberous sclerosis. J Child Neurol 19: 675-679.
    • (2004) J Child Neurol , vol.19 , pp. 675-679
    • Wiznitzer, M.1
  • 155
    • 10744230060 scopus 로고    scopus 로고
    • Association study of the human FZD3 locus with schizophrenia
    • Yang J, Si T, Ling Y, Ruan Y, Han Y, Wang X et al. (2003). Association study of the human FZD3 locus with schizophrenia. Biol Psychiatry 54: 1298-1301.
    • (2003) Biol Psychiatry , vol.54 , pp. 1298-1301
    • Yang, J.1    Si, T.2    Ling, Y.3    Ruan, Y.4    Han, Y.5    Wang, X.6
  • 157
    • 3342964099 scopus 로고    scopus 로고
    • Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population
    • Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T et al. (2004). Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. Am J Med Genet B Neuropsychiatr Genet 129: 16-19.
    • (2004) Am J Med Genet B Neuropsychiatr Genet , vol.129 , pp. 16-19
    • Zhang, Y.1    Yu, X.2    Yuan, Y.3    Ling, Y.4    Ruan, Y.5    Si, T.6
  • 158
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
    • Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M et al. (1998). Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395: 698-702.
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1    Hartmann, H.2    Do, V.M.3    Abramowski, D.4    Sturchler-Pierrat, C.5    Staufenbiel, M.6
  • 159
    • 0037264403 scopus 로고    scopus 로고
    • No association between the EN2 gene and autistic disorder
    • Zhong H, Serajee FJ, Nabi R, Huq AH. (2003). No association between the EN2 gene and autistic disorder. J Med Genet 40: e4.
    • (2003) J Med Genet , vol.40
    • Zhong, H.1    Serajee, F.J.2    Nabi, R.3    Huq, A.H.4
  • 160
    • 4444340344 scopus 로고    scopus 로고
    • Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants
    • Zhou CJ, Pinson KI, Pleasure SJ. (2004). Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. J Neurosci 24: 7632-7639.
    • (2004) J Neurosci , vol.24 , pp. 7632-7639
    • Zhou, C.J.1    Pinson, K.I.2    Pleasure, S.J.3
  • 161
    • 0030788767 scopus 로고    scopus 로고
    • Presenilin 1 interaction in the brain with a novel member of the Armadillo family
    • Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M et al. (1997). Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8: 2085-2090.
    • (1997) Neuroreport , vol.8 , pp. 2085-2090
    • Zhou, J.1    Liyanage, U.2    Medina, M.3    Ho, C.4    Simmons, A.D.5    Lovett, M.6


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