Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 36, 2011, Pages 14962-14967

  Ohta, Kunimasa ^a,b   Ito, Ayako ^a,c   Kuriyama, Sei ^a,c,i   Lupo, Giuseppe ^d,e   Kosaka, Mitsuko ^f,j   Ohnuma, Shin Ichi ^g   Nakagawa, Shinichi ^h   Tanaka, Hideaki ^a,c  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e Pasteur Institute   (Italy)

^f RIKEN Center for Biosystems Dynamics Research   (Japan)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h RIKEN   (Japan)

ⁱ AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^j OKAYAMA UNIVERSITY   (Japan)

more..

Author keywords

Eye development; Signaling modulator; Small leucine rich proteoglycan

Indexed keywords

FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; OSTEOGENIC PROTEIN 1; PROTEIN INHIBITOR; TSUKUSHI PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT2 PROTEIN; WNT2B PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL PROLIFERATION; CHEMICAL INTERACTION; CILIARY BODY; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO CELL; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR DENSITY; RETINA; RETINA CELL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CHICK EMBRYO; EYE; EYE PROTEINS; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, MUTANT STRAINS; PROTEIN BINDING; PROTEOGLYCANS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; UP-REGULATION; WNT PROTEINS;

MUS;

EID: 80052580449     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100513108     Document Type: Article

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