Identification of WNT/β-CATENIN signaling pathway components in human cumulus cells

Molecular Human Reproduction

Volumn 15, Issue 1, 2009, Pages 11-17

  Wang, Hong Xing ^a   Tekpetey, Francis R ^a,b   Kidder, Gerald M ^a,b,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Folliculogenesis; Gene expression; Ovarian follicle; Paracrine signaling; Signal transduction

Indexed keywords

AXIN; BETA CATENIN; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; FRIZZLED PROTEIN 2; FRIZZLED PROTEIN 3; FRIZZLED PROTEIN 4; FRIZZLED PROTEIN 9; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH FACTOR; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN; WNT PROTEIN 1; WNT PROTEIN 2; WNT PROTEIN 4;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CUMULUS OOPHORUS; CYTOPLASM; FERTILIZATION IN VITRO; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; OVARY CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BETA CATENIN; CELL MEMBRANE; CELLS, CULTURED; CUMULUS CELLS; FEMALE; FRIZZLED RECEPTORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICROSCOPY, FLUORESCENCE; PHOSPHOPROTEINS; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; WNT2 PROTEIN;

EID: 60149105643     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gan070     Document Type: Article

References (29)

1. Bienz M. β-Catenin: A pivot between cell adhesion and Wnt signalling. Curr Biol 2005;15:R64-R67.
2. Boerboom D, Paquet M, Hsieh M, Liu J, Jamin SP, Behringer RR, Sirois J, Taketo MM, Richards JS. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res 2005; 65 9206-9215.
3. Brembeck FH, Rosário M, Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006;16: 51-59.
4. Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 2001;412:86-90.
5. Gordon MD, Nusse R. Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006; 281:22429-22433.
6. Habas R, Dawid IB. Dishevelled and Wnt signaling: Is the nucleus the final frontier? J Biol 2005;4:2.
7. Hendriksen J, Jansen M, Brown CM, van der Velde H, van Ham M, Galjart N, Offerhaus GJ, Fagotto F, Fornerod M. Plasma membrane recruitment of dephosphorylated β-catenin upon activation of the Wnt pathway. J Cell Sci 2008;121:1793-1802.
8. Hoppler S, Kavanagh CL. Wnt signalling: Variety at the core. J Cell Sci 2007; 120:385-393.
9. Hsieh JC, Rattner A, Smallwood PM, Nathans J. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc Natl Acad Sci USA 1999;96:3546-3551.
10. Hsieh M, Johnson MA, Greenberg NM, Richards JS. Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary. Endocrinology 2002;143:898-908.
11. -/-) are infertile and exhibit impaired corpora lutea formation and function. Biol Reprod 2005;73:1135-1146.
12. Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta-catenin signaling. J Biol Chem 2002; 277:37479-37486.
13. Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 2008;47:1018-1031.
14. Laird DW. Life cycle of connexins in health and disease. Biochem J 2006; 394:527-543.
15. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
16. Moon RT, Kohn AD, De Ferrari GV, Kaykas A. WNT and beta-catenin signalling: Diseases and therapies. Nat Rev Genet 2004;5 691-701.
17. Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 2005;26:898-915.
18. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004;303:1483-1487.
19. Planutis K, Planutiene M, Moyer MP, Nguyen AV, Pérez CA, Holcombe RF. Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. BMC Cell Biol 2007;8:12.
20. Ricken A, Lochhead P, Kontogiannea M, Farookhi R. Wnt signaling in the ovary: Identi.cation and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Endocrinology 2002;143:2741-2749.
21. Rulifson EJ, Wu CH, Nusse R. Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. Mol Cell 2000; 6:117-126.
22. Russell DL, Robker RL. Molecular mechanisms of ovulation: Co-ordination through the cumulus complex. Hum Reprod Update 2007;13 289-312.
23. Schwarz-Romond T, Metcalfe C, Bienz M. Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci 2007;120 2402-2412.
24. Sundfeldt K, Piontkewitz Y, Billig H, Hedin L. E-cadherin-catenin complex in the rat ovary: Cell-specific expression during folliculogenesis and luteal formation. J Reprod Fertil 2000;118 375-385.
25. Vainio S, Heikkilä M, Kispert A, Chin N, McMahon AP. Female development in mammals is regulated by Wnt-4 signalling. Nature 1999;397:405-409.
26. Wang HX, Tong D, El-Gehani F, Tekpetey FR, Kidder GM. Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality. J Cell Mol Med 2009 (in press).
27. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998;14:59-88.
28. Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003;12:1251-1260.
29. Wu CH, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem 2002;277:41762-41769.