Medicine: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis

Science

Volumn 310, Issue 5753, 2005, Pages 1504-1510

  Castellone, Maria Domenica ^a   Teramoto, Hidemi ^b   Williams, Bart O ^c   Druey, Kirk M ^d   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b Kojin Hospital   (Japan)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GROWTH KINETICS; METABOLITES; MOLECULAR STRUCTURE; TUMORS;

CELL GROWTH; GLYCOGEN; KINASE; MOLECULAR FRAMEWORK;

ENZYMES;

AXIN; BETA CATENIN; CYCLOOXYGENASE 2; G PROTEIN COUPLED RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GUANINE NUCLEOTIDE BINDING PROTEIN; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN SUBUNIT; RGS PROTEIN; AXIN PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN EP2 RECEPTOR; REPRESSOR PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

MEDICINE;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GROWTH; COLON CANCER; ENZYME ACTIVATION; ENZYME INACTIVATION; EVALUATION; GENE DELETION; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; CELL LINE; CELL PROLIFERATION; COLON TUMOR; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALIA;

BETA CATENIN; CELL LINE; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; GENES, REPORTER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; RECEPTORS, PROSTAGLANDIN E; REPRESSOR PROTEINS; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 28544444039     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116221     Document Type: Article

References (42)

1. A. Jemal et al., CA Cancer J. Clin. 55, 10 (2005).
2. B. Vogelstein, K. W. Kinzler, Nat. Med. 10, 789 (2004).
3. D. B. Levy et al., Cancer Res. 54, 5953 (1994).
4. M. Oshima et at., Proc. Natl. Acad. Sci. U.S.A. 92, 4482 (1995).
5. C. J. Torrance et al., Nat. Med. 6, 1024 (2000).
6. J. R. Brown, R. N. DuBois, J. Clin. Oncol. 23, 2840 (2005).
7. M. Sonoshita et al., Nat. Med. 7, 1048 (2001).
8. D. Wang, F. G. Buchanan, H. Wang, S. K. Dey, R. N. DuBois, Cancer Res. 65, 1822 (2005).
9. F. Cong, J. Zhang, W. Pao, P. Zhou, H. Varmus, BMC Mol. Biol. 4, 10 (2003).
10. Materials and methods are available as supporting material on Science Online.
11. L. Qiao et al., Biochim. Biophys. Acta 1258, 215 (1995).
12. R. Pai et al., Nat. Med. 8, 289 (2002).
13. O. Tetsu, F. McCormick, Nature 398, 422 (1999).
14. V. Korinek et al., Science 275, 1784 (1997).
15. H. Fujino, K. A. West, J. W. Regan, J. Biol. Chem. 277, 2614 (2002).
16. J. Shao, C. Jung, C. Liu, H. Sheng, J. Biol. Chem. 280, 26565 (2005).
17. K. B. Seamon, J. W. Daly, Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1 (1986).
18. M. B. Hansen-Petrik et al., Cancer Res. 62, 403 (2002).
19. K. L. Pierce, R. T. Premont, R. J. Lefkowitz, Nat. Rev. Mol. Cell Biol. 3, 639 (2002).
20. R. N. Day, J. A. Walder, R. A. Maurer, J. Biol. Chem. 264, 431 (1989).
21. M. J. Hart, R. de los Santos, I. N. Albert, B. Rubinfeld, P. Polakis, Curr. Biol. 8, 573 (1998).
22. S. Satoh et al., Nat. Genet. 24, 245 (2000).
23. K. E. Spink, P. Polakis, W. I. Weis, EMBO J. 19, 2270 (2000).
24. D. M. Berman, A. G. Gilman, J. Biol. Chem. 273, 1269 (1998).
25. R. Sterne-Marr et al., J. Biol. Chem. 278, 6050 (2003).
26. J. J. Tesmer, D. M. Berman, A. G. Gilman, S. R. Sprang, Cell 89, 251 (1997).
27. N. Watson, M. E. Linder, K. M. Druey, J. H. Kehrl, K. J. Blumer, Nature 383, 172 (1996).
28. T. Ingi et al., J. Neurosci. 18, 7178 (1998).
29. S. Tanabe, B. Kreutz, N. Suzuki, T. Kozasa, Methods Enzymol. 390, 285 (2004).
30. B. Rubinfeld et al., Science 272, 1023 (1996).
31. V. Stambolic, J. R. Woodgett, Biochem. J. 303, 701 (1994).
32. X. Fang et al., Proc. Natl. Acad. Sci. U.S.A. 97, 11960 (2000).
33. C. Murga, L. Laguinge, R. Wetzker, A. Cuadrado, J. S. Gutkind, J. Biol. Chem. 273, 19080 (1998).
34. P. Crespo, T. G. Cachera, N. Xu, J. S. Gutkind, J. Biol. Chem. 270, 25259 (1995).
35. E. J. McManus et al., EMBO J. 24, 1571 (2005).
36. V. W. Ding, R. H. Chen, F. McCormick, J. Biol. Chem. 275, 32475 (2000).
37. S. Ikeda et al., EMBO J. 17, 1371 (1998).
38. X. He, M. Semenov, K. Tamai, X. Zeng, Development 131, 1663 (2004).
39. G. Liu, A. Bafico, V. K. Harris, S. A. Aaronson, Mol. Cell. Biol. 23, 5825 (2003).
40. T. Liu et al., Science 292, 1718 (2001).
41. Y. Xing, W. K. Clements, D. Kimelman, W. Xu, Genes Dev. 17, 2753 (2003).
42. This research was partially supported by the Intramural Research Program of NIH, National Institute of Dental and Craniofacial Research.