The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32415-32429

  Begum, Nasim A ^a   Stanlie, Andre ^a   Nakata, Mikiyo ^a   Akiyama, Hideo ^b   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; B CELLS; DNA CLEAVAGE; GENE EXPRESSION ANALYSIS; HEAVY CHAIN; HISTONE MODIFICATION; METHYLTRANSFERASES; MUTATION FREQUENCY; NUCLEOLAR RNA; SH2 DOMAIN; SOMATIC HYPERMUTATION; TRANSCRIPTIONAL REGULATOR;

GENES; RNA;

TRANSCRIPTION;

ACTIVATION INDUCED CYTIDINE DEAMINASE; CHAPERONE; H3K36ME3 PROTEIN; H3K4ME3 PROTEIN; HISTONE; HISTONE METHYLTRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; MALAT1 PROTEIN; PROTEIN SH2; SET1 PROTEIN; SPT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AID GENE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CHROMATIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA CLEAVAGE; EPIGENETICS; GENE; GENE EXPRESSION; GENE LOCUS; GENE LOSS; GENE SWITCHING; GENETIC RECOMBINATION; GENOMIC INSTABILITY; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SNHG3 GENE; SOMATIC MUTATION; SPT4 GENE; TRANSCRIPTION REGULATION;

CELL LINE, TUMOR; CYTIDINE DEAMINASE; DNA BREAKS; EPIGENESIS, GENETIC; GENETIC LOCI; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; METHYLATION; MOLECULAR CHAPERONES; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; RNA, LONG UNTRANSLATED; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSCRIPTION FACTORS;

EID: 84866564544     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.351569     Document Type: Article

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