메뉴 건너뛰기




Volumn 210, Issue 7, 2013, Pages 1481-1492

Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; HEMOGLOBIN BETA CHAIN; IMMUNOGLOBULIN; RNA POLYMERASE II; SINGLE STRANDED DNA;

EID: 84880650205     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121523     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 19344367559 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate
    • Arakawa, H., H. Saribasak, and J.M. Buerstedde. 2004. Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol. 2:E179. http://dx.doi.org/10.1371/journal.pbio.0020179
    • (2004) PLoS Biol. , vol.2
    • Arakawa, H.1    Saribasak, H.2    Buerstedde, J.M.3
  • 2
  • 3
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region
    • Betz, A.G., C. Milstein, A. González-Fernández, R. Pannell, T. Larson, and M.S. Neuberger. 1994. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell. 77:239-248. http://dx.doi.org/10.1016/0092-8674(94)90316-6
    • (1994) Cell. , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    González-Fernández, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 4
    • 0037388165 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter, R., P. Pham, M.D. Scharff, and M.F. Goodman. 2003. Activationinduced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA. 100:4102-4107. http://dx.doi.org/10.1073/pnas.0730835100
    • (2003) Proc. Natl. Acad. Sci. USA. , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 5
    • 10944223445 scopus 로고    scopus 로고
    • Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
    • Bransteitter, R., P. Pham, P. Calabrese, and M.F. Goodman. 2004. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J. Biol. Chem. 279:51612-51621. http://dx.doi.org/10.1074/jbc. M408135200
    • (2004) J. Biol. Chem. , vol.279 , pp. 51612-51621
    • Bransteitter, R.1    Pham, P.2    Calabrese, P.3    Goodman, M.F.4
  • 6
    • 58249095957 scopus 로고    scopus 로고
    • Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase
    • Canugovi, C., M. Samaranayake, and A.S. Bhagwat. 2009. Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase. FASEB J. 23:34-44. http://dx.doi.org/10.1096/fj.08-115352
    • (2009) FASEB J. , vol.23 , pp. 34-44
    • Canugovi, C.1    Samaranayake, M.2    Bhagwat, A.S.3
  • 7
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J., M. Tian, C. Khuong, K. Chua, E. Pinaud, and F.W. Alt. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:726-730. http://dx.doi.org/10.1038/nature01574
    • (2003) Nature. , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 8
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri, J., C. Khuong, and F.W. Alt. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 430:992-998. http://dx.doi.org/10.1038/nature02821
    • (2004) Nature. , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 9
    • 0030784958 scopus 로고    scopus 로고
    • Mechanism and regulation of mRNA polyadenylation
    • Colgan, D.F., and J.L. Manley. 1997. Mechanism and regulation of mRNA polyadenylation. Genes Dev. 11:2755-2766. http://dx.doi.org/10.1101/gad.11.21.2755
    • (1997) Genes Dev. , vol.11 , pp. 2755-2766
    • Colgan, D.F.1    Manley, J.L.2
  • 11
    • 0034737593 scopus 로고    scopus 로고
    • Singlemolecule study of transcriptional pausing and arrest by E
    • Davenport, R.J., G.J. Wuite, R. Landick, and C. Bustamante. 2000. Singlemolecule study of transcriptional pausing and arrest by E. coli RNA polymerase. Science. 287:2497-2500. http://dx.doi.org/10.1126/science.287.5462.2497
    • (2000) coli RNA polymerase. Science. , vol.287 , pp. 2497-2500
    • Davenport, R.J.1    Wuite, G.J.2    Landick, R.3    Bustamante, C.4
  • 13
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson, S.K., E. Market, E. Besmer, and F.N. Papavasiliou. 2003. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197:1291-1296. http://dx.doi.org/10.1084/jem.20030481
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 14
    • 0035369625 scopus 로고    scopus 로고
    • Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II
    • Dye, M.J., and N.J. Proudfoot. 2001. Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II. Cell. 105:669-681. http://dx.doi.org/10.1016/S0092-8674(01)00372-5
    • (2001) Cell. , vol.105 , pp. 669-681
    • Dye, M.J.1    Proudfoot, N.J.2
  • 16
    • 64249157351 scopus 로고    scopus 로고
    • Epigenetic reprogramming and induced pluripotency
    • Hochedlinger, K., and K. Plath. 2009. Epigenetic reprogramming and induced pluripotency. Development. 136:509-523. http://dx.doi.org/10.1242/dev.020867
    • (2009) Development. , vol.136 , pp. 509-523
    • Hochedlinger, K.1    Plath, K.2
  • 17
    • 0030588542 scopus 로고    scopus 로고
    • Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer
    • Klotz, E.L., and U. Storb. 1996. Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer. J. Immunol. 157:4458-4463.
    • (1996) J. Immunol. , vol.157 , pp. 4458-4463
    • Klotz, E.L.1    Storb, U.2
  • 18
    • 79955475464 scopus 로고    scopus 로고
    • Unravelling the means to an end: RNA polymerase II transcription termination
    • Kuehner, J.N., E.L. Pearson, and C. Moore. 2011. Unravelling the means to an end: RNA polymerase II transcription termination. Nat. Rev. Mol. Cell Biol. 12:283-294. http://dx.doi.org/10.1038/nrm3098
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 283-294
    • Kuehner, J.N.1    Pearson, E.L.2    Moore, C.3
  • 19
    • 0023433855 scopus 로고
    • Supercoiling of the DNA template during transcription
    • Liu, L.F., and J.C. Wang. 1987. Supercoiling of the DNA template during transcription. Proc. Natl. Acad. Sci. USA. 84:7024-7027. http://dx.doi.org/10.1073/pnas.84.20.7024
    • (1987) Proc. Natl. Acad. Sci. USA. , vol.84 , pp. 7024-7027
    • Liu, L.F.1    Wang, J.C.2
  • 20
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • Liu, M., J.L. Duke, D.J. Richter, C.G. Vinuesa, C.C. Goodnow, S.H. Kleinstein, and D.G. Schatz. 2008. Two levels of protection for the B cell genome during somatic hypermutation. Nature. 451:841-845. http://dx.doi.org/10.1038/nature06547
    • (2008) Nature. , vol.451 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3    Vinuesa, C.G.4    Goodnow, C.C.5    Kleinstein, S.H.6    Schatz, D.G.7
  • 21
    • 27944493275 scopus 로고    scopus 로고
    • ' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
    • ' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J. Exp. Med. 202:1443-1454. http://dx.doi.org/10.1084/jem.20051604
    • (2005) J. Exp. Med. , vol.202 , pp. 1443-1454
    • Longerich, S.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 22
    • 33644636246 scopus 로고    scopus 로고
    • AID in somatic hypermutation and class switch recombination
    • Longerich, S., U. Basu, F. Alt, and U. Storb. 2006. AID in somatic hypermutation and class switch recombination. Curr. Opin. Immunol. 18:164-174. http://dx.doi.org/10.1016/j.coi.2006.01.008
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 164-174
    • Longerich, S.1    Basu, U.2    Alt, F.3    Storb, U.4
  • 23
    • 34447125198 scopus 로고    scopus 로고
    • The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase
    • Nag, A., K. Narsinh, and H.G. Martinson. 2007. The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase. Nat. Struct. Mol. Biol. 14:662-669. http://dx.doi.org/10.1038/nsmb1253
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 662-669
    • Nag, A.1    Narsinh, K.2    Martinson, H.G.3
  • 24
    • 0346362489 scopus 로고    scopus 로고
    • Transcription-coupled events associating with immunoglobulin switch region chromatin
    • Nambu, Y., M. Sugai, H. Gonda, C.G. Lee, T. Katakai, Y. Agata, Y. Yokota, and A. Shimizu. 2003. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science. 302:2137-2140. http://dx.doi.org/10.1126/science.1092481
    • (2003) Science. , vol.302 , pp. 2137-2140
    • Nambu, Y.1    Sugai, M.2    Gonda, H.3    Lee, C.G.4    Katakai, T.5    Agata, Y.6    Yokota, Y.7    Shimizu, A.8
  • 25
    • 84859166706 scopus 로고    scopus 로고
    • Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis
    • Parsa, J.Y., S. Ramachandran, A. Zaheen, R.M. Nepal, A. Kapelnikov, A. Belcheva, M. Berru, D. Ronai, and A. Martin. 2012. Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. PLoS Genet. 8:e1002518. http://dx.doi.org/10.1371/journal.pgen.1002518
    • (2012) PLoS Genet. , vol.8
    • Parsa, J.Y.1    Ramachandran, S.2    Zaheen, A.3    Nepal, R.M.4    Kapelnikov, A.5    Belcheva, A.6    Berru, M.7    Ronai, D.8    Martin, A.9
  • 29
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity. 4:57-65. http://dx.doi.org/10.1016/S1074-7613(00)80298-8
    • (1996) Immunity. , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 30
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M.W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45. http://dx.doi.org/10.1093/nar/29.9.e45
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 31
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., R. Bransteitter, J. Petruska, and M.F. Goodman. 2003. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature. 424:103-107. http://dx.doi.org/10.1038/nature01760
    • (2003) Nature. , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 32
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp, C., W. Dean, S. Feng, S.J. Cokus, S. Andrews, M. Pellegrini, S.E. Jacobsen, and W. Reik. 2010. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature. 463:1101-1105. http://dx.doi.org/10.1038/nature08829
    • (2010) Nature. , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3    Cokus, S.J.4    Andrews, S.5    Pellegrini, M.6    Jacobsen, S.E.7    Reik, W.8
  • 33
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada, C., G.T. Williams, H. Nilsen, D.E. Barnes, T. Lindahl, and M.S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:1748-1755. http://dx.doi.org/10.1016/S0960-9822(02)01215-0
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 34
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada, C., J.M. Di Noia, and M.S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell. 16:163-171. http://dx.doi.org/10.1016/j.molcel.2004.10.011
    • (2004) Mol. Cell. , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 35
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai, K., I.J. Huggins, S.R. James, A.R. Karpf, D.A. Jones, and B.R. Cairns. 2008. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 135:1201-1212. http://dx.doi.org/10.1016/j.cell.2008.11.042
    • (2008) Cell. , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3    Karpf, A.R.4    Jones, D.A.5    Cairns, B.R.6
  • 36
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., P. Stavropoulos, M. Jankovic, and M.C. Nussenzweig. 2003. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4:452-456. http://dx.doi.org/10.1038/ni920
    • (2003) Nat. Immunol. , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 37
    • 4444239054 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
    • Shen, H.M., and U. Storb. 2004. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc. Natl. Acad. Sci. USA. 101:12997-13002. http://dx.doi.org/10.1073/pnas.0404974101
    • (2004) Proc. Natl. Acad. Sci. USA. , vol.101 , pp. 12997-13002
    • Shen, H.M.1    Storb, U.2
  • 38
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen, H.M., A. Peters, B. Baron, X. Zhu, and U. Storb. 1998. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 280:1750-1752. http://dx.doi.org/10.1126/science.280.5370.1750
    • (1998) Science. , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 39
    • 28544447014 scopus 로고    scopus 로고
    • Targeting of the activationinduced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA
    • Shen, H.M., S. Ratnam, and U. Storb. 2005. Targeting of the activationinduced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol. Cell. Biol. 25:10815-10821. http://dx.doi.org/10.1128/MCB.25.24.10815-10821.2005
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10815-10821
    • Shen, H.M.1    Ratnam, S.2    Storb, U.3
  • 40
    • 33749519393 scopus 로고    scopus 로고
    • Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
    • Shen, H.M., A. Tanaka, G. Bozek, D. Nicolae, and U. Storb. 2006. Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J. Immunol. 177:5386-5392.
    • (2006) J. Immunol. , vol.177 , pp. 5386-5392
    • Shen, H.M.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 41
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer, J., J.E. Guikema, and C.E. Schrader. 2008. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26:261-292. http://dx.doi.org/10.1146/annurev.immunol.26.021607.090248
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 43
    • 70349934757 scopus 로고    scopus 로고
    • Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils
    • Storb, U., H.M. Shen, and D. Nicolae. 2009. Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils. Cell Cycle. 8:3097-3101. http://dx.doi.org/10.4161/cc.8.19.9658
    • (2009) Cell Cycle. , vol.8 , pp. 3097-3101
    • Storb, U.1    Shen, H.M.2    Nicolae, D.3
  • 44
    • 79955639340 scopus 로고    scopus 로고
    • AID and partners: for better and (not) for worse
    • Storck, S., S. Aoufouchi, J.C. Weill, and C.A. Reynaud. 2011. AID and partners: for better and (not) for worse. Curr. Opin. Immunol. 23:337-344. http://dx.doi.org/10.1016/j.coi.2011.02.002
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 337-344
    • Storck, S.1    Aoufouchi, S.2    Weill, J.C.3    Reynaud, C.A.4
  • 45
    • 77149138374 scopus 로고    scopus 로고
    • Attracting AID to targets of somatic hypermutation
    • Tanaka, A., H.M. Shen, S. Ratnam, P. Kodgire, and U. Storb. 2010. Attracting AID to targets of somatic hypermutation. J. Exp. Med. 207:405-415. http://dx.doi.org/10.1084/jem.20090821
    • (2010) J. Exp. Med. , vol.207 , pp. 405-415
    • Tanaka, A.1    Shen, H.M.2    Ratnam, S.3    Kodgire, P.4    Storb, U.5
  • 46
    • 79951602552 scopus 로고    scopus 로고
    • Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
    • Wei, M., R. Shinkura, Y. Doi, M. Maruya, S. Fagarasan, and T. Honjo. 2011. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat. Immunol. 12:264-270. http://dx.doi.org/10.1038/ni.1991
    • (2011) Nat. Immunol. , vol.12 , pp. 264-270
    • Wei, M.1    Shinkura, R.2    Doi, Y.3    Maruya, M.4    Fagarasan, S.5    Honjo, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.