메뉴 건너뛰기




Volumn 32, Issue 5, 2011, Pages 194-201

Complex regulation and function of activation-induced cytidine deaminase

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN;

EID: 79955632686     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2011.03.003     Document Type: Review
Times cited : (103)

References (93)
  • 1
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M., et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 1999, 274:18470-18476.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18470-18476
    • Muramatsu, M.1
  • 2
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1
  • 3
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy P., et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 2000, 102:565-575.
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 4
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt S.K., et al. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002, 418:99-104.
    • (2002) Nature , vol.418 , pp. 99-104
    • Petersen-Mahrt, S.K.1
  • 5
    • 42649124572 scopus 로고    scopus 로고
    • The biochemistry of somatic hypermutation
    • Peled J.U., et al. The biochemistry of somatic hypermutation. Annu. Rev. Immunol. 2008, 26:481-511.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 481-511
    • Peled, J.U.1
  • 6
    • 36549036731 scopus 로고    scopus 로고
    • APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
    • Guikema J.E., et al. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J. Exp. Med. 2007, 204:3017-3026.
    • (2007) J. Exp. Med. , vol.204 , pp. 3017-3026
    • Guikema, J.E.1
  • 7
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer J., et al. Mechanism and regulation of class switch recombination. Ann. Rev. Immunol. 2008, 26:261-292.
    • (2008) Ann. Rev. Immunol. , vol.26 , pp. 261-292
    • Stavnezer, J.1
  • 8
    • 78149264026 scopus 로고    scopus 로고
    • Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching
    • Stavnezer J., et al. Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching. Adv. Immunol. 2010, 108:45-109.
    • (2010) Adv. Immunol. , vol.108 , pp. 45-109
    • Stavnezer, J.1
  • 9
    • 38549131395 scopus 로고    scopus 로고
    • AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies
    • Chesi M., et al. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer cell 2008, 13:167-180.
    • (2008) Cancer cell , vol.13 , pp. 167-180
    • Chesi, M.1
  • 10
    • 69249236962 scopus 로고    scopus 로고
    • The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia
    • Klemm L., et al. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell 2009, 16:232-245.
    • (2009) Cancer Cell , vol.16 , pp. 232-245
    • Klemm, L.1
  • 11
    • 0037881911 scopus 로고    scopus 로고
    • Constitutive expression of AID leads to tumorigenesis
    • Okazaki I.M., et al. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 2003, 197:1173-1181.
    • (2003) J. Exp. Med. , vol.197 , pp. 1173-1181
    • Okazaki, I.M.1
  • 12
    • 57349179128 scopus 로고    scopus 로고
    • Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression
    • Morisawa T., et al. Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. Int. J. Cancer 2008, 123:2735-2740.
    • (2008) Int. J. Cancer , vol.123 , pp. 2735-2740
    • Morisawa, T.1
  • 13
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto Y., et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat. Med. 2007, 13:470-476.
    • (2007) Nat. Med. , vol.13 , pp. 470-476
    • Matsumoto, Y.1
  • 14
    • 79955639340 scopus 로고    scopus 로고
    • AID and partners: for better and (not) for worse
    • Storck S., et al. AID and partners: for better and (not) for worse. Curr. Opin. Immunol. 2011, 23:1-8.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 1-8
    • Storck, S.1
  • 15
    • 60049097628 scopus 로고    scopus 로고
    • Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G
    • Chelico L., et al. Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2009, 364:583-593.
    • (2009) Philos. Trans. R. Soc. Lond. B. Biol. Sci. , vol.364 , pp. 583-593
    • Chelico, L.1
  • 16
    • 0036715714 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification
    • Gurrieri C., et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J. Exp. Med. 2002, 196:629-639.
    • (2002) J. Exp. Med. , vol.196 , pp. 629-639
    • Gurrieri, C.1
  • 17
    • 0036732772 scopus 로고    scopus 로고
    • AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
    • Faili A., et al. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 2002, 3:815-821.
    • (2002) Nat. Immunol. , vol.3 , pp. 815-821
    • Faili, A.1
  • 18
    • 0142188274 scopus 로고    scopus 로고
    • Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
    • Woo C.J., et al. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 2003, 19:479-489.
    • (2003) Immunity , vol.19 , pp. 479-489
    • Woo, C.J.1
  • 19
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto V., et al. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell 2003, 12:501-508.
    • (2003) Mol. Cell , vol.12 , pp. 501-508
    • Barreto, V.1
  • 20
    • 0041381361 scopus 로고    scopus 로고
    • AID mutant analyses indicate requirement for class-switch-specific cofactors
    • Ta V.T., et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat. Immunol. 2003, 4:843-848.
    • (2003) Nat. Immunol. , vol.4 , pp. 843-848
    • Ta, V.T.1
  • 21
    • 3242795967 scopus 로고    scopus 로고
    • Separate domains of AID are required for somatic hypermutation and class-switch recombination
    • Shinkura R., et al. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat. Immunol. 2004, 5:707-712.
    • (2004) Nat. Immunol. , vol.5 , pp. 707-712
    • Shinkura, R.1
  • 22
    • 79951602552 scopus 로고    scopus 로고
    • Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
    • Wei M., et al. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat. Immunol. 2011, 12:264-270.
    • (2011) Nat. Immunol. , vol.12 , pp. 264-270
    • Wei, M.1
  • 23
    • 62449089909 scopus 로고    scopus 로고
    • The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
    • Doi T., et al. The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2758-2763.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2758-2763
    • Doi, T.1
  • 24
    • 78650674433 scopus 로고    scopus 로고
    • Impaired induction of DNA lesions during immunoglobulin class switch recombination in humans influences end-joining repair
    • Kracker S., et al. Impaired induction of DNA lesions during immunoglobulin class switch recombination in humans influences end-joining repair. Proc. Nat. Sci. U.S.A. 2010, 107:22225-22230.
    • (2010) Proc. Nat. Sci. U.S.A. , vol.107 , pp. 22225-22230
    • Kracker, S.1
  • 25
    • 77149176004 scopus 로고    scopus 로고
    • Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
    • Boboila C., et al. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J. Exp. Med. 2010, 207:417-427.
    • (2010) J. Exp. Med. , vol.207 , pp. 417-427
    • Boboila, C.1
  • 26
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K., et al. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 2003, 4:442-451.
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1
  • 27
    • 78650307766 scopus 로고    scopus 로고
    • Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
    • Maul R.W., et al. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat. Immunol. 2011, 12:70-76.
    • (2011) Nat. Immunol. , vol.12 , pp. 70-76
    • Maul, R.W.1
  • 28
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia J.M., Neuberger M.S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 2007, 76:1-22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 29
    • 4444239054 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
    • Shen H.M., Storb U. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:12997-13002.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 12997-13002
    • Shen, H.M.1    Storb, U.2
  • 30
    • 0035200324 scopus 로고    scopus 로고
    • Transcriptional consequences of topoisomerase inhibition
    • Collins I., et al. Transcriptional consequences of topoisomerase inhibition. Mol. Cell. Biol. 2001, 21:8437-8451.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8437-8451
    • Collins, I.1
  • 31
    • 79551681406 scopus 로고    scopus 로고
    • The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
    • Basu U., et al. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell 2011, 144:353-363.
    • (2011) Cell , vol.144 , pp. 353-363
    • Basu, U.1
  • 32
    • 52949089292 scopus 로고    scopus 로고
    • The exosome: a multipurpose RNA-decay machine
    • Schmid M., Jensen T.H. The exosome: a multipurpose RNA-decay machine. Trends Biochem. Sci. 2008, 33:501-510.
    • (2008) Trends Biochem. Sci. , vol.33 , pp. 501-510
    • Schmid, M.1    Jensen, T.H.2
  • 33
    • 77954841539 scopus 로고    scopus 로고
    • Loss of topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
    • El Hage A., et al. Loss of topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 2010, 24:1546-1558.
    • (2010) Genes Dev. , vol.24 , pp. 1546-1558
    • El Hage, A.1
  • 34
    • 34249108271 scopus 로고    scopus 로고
    • Regulation of AID expression in the immune response
    • Crouch E.E., et al. Regulation of AID expression in the immune response. J. Exp. Med. 2007, 204:1145-1156.
    • (2007) J. Exp. Med. , vol.204 , pp. 1145-1156
    • Crouch, E.E.1
  • 35
    • 67349090990 scopus 로고    scopus 로고
    • HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
    • Park S.R., et al. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat. Immunol. 2009, 10:540-550.
    • (2009) Nat. Immunol. , vol.10 , pp. 540-550
    • Park, S.R.1
  • 36
    • 75649096381 scopus 로고    scopus 로고
    • B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
    • Tran T.H., et al. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat. Immunol. 2010, 11:148-154.
    • (2010) Nat. Immunol. , vol.11 , pp. 148-154
    • Tran, T.H.1
  • 37
    • 77956915114 scopus 로고    scopus 로고
    • AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling
    • Sherman M.H., et al. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol. Cell 2010, 39:873-885.
    • (2010) Mol. Cell , vol.39 , pp. 873-885
    • Sherman, M.H.1
  • 38
    • 43049178852 scopus 로고    scopus 로고
    • MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
    • Teng G., et al. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 2008, 28:621-629.
    • (2008) Immunity , vol.28 , pp. 621-629
    • Teng, G.1
  • 39
    • 43049173617 scopus 로고    scopus 로고
    • MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
    • Dorsett Y., et al. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008, 28:630-638.
    • (2008) Immunity , vol.28 , pp. 630-638
    • Dorsett, Y.1
  • 40
    • 34249945558 scopus 로고    scopus 로고
    • Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma
    • Kluiver J., et al. Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. Oncogene 2007, 26:3769-3776.
    • (2007) Oncogene , vol.26 , pp. 3769-3776
    • Kluiver, J.1
  • 41
    • 53349129731 scopus 로고    scopus 로고
    • MiR-181b negatively regulates activation-induced cytidine deaminase in B cells
    • de Yebenes V.G., et al. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J. Exp. Med. 2008, 205:2199-2206.
    • (2008) J. Exp. Med. , vol.205 , pp. 2199-2206
    • de Yebenes, V.G.1
  • 42
    • 1242341972 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
    • Ito S., et al. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:1975-1980.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 1975-1980
    • Ito, S.1
  • 43
    • 66149087337 scopus 로고    scopus 로고
    • The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence
    • Geisberger R., et al. The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6736-6741.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 6736-6741
    • Geisberger, R.1
  • 44
    • 66149126655 scopus 로고    scopus 로고
    • Active nuclear import and cytoplasmic retention of activation-induced deaminase
    • Patenaude A.M., et al. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat. Struct. Mol. Biol. 2009, 16:517-527.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 517-527
    • Patenaude, A.M.1
  • 45
    • 79955753430 scopus 로고    scopus 로고
    • CTNNBL1 is a novel NLS-binding protein that recognizes RNA splicing factors CDC5L and PRP31
    • (in press), doi:10.1074/jbc.M110.208769.
    • Ganesh, K. et al. (2011). CTNNBL1 is a novel NLS-binding protein that recognizes RNA splicing factors CDC5L and PRP31. J. Biol. Chem. (in press), doi:10.1074/jbc.M110.208769.
    • (2011) J. Biol. Chem.
    • Ganesh, K.1
  • 46
    • 77956417669 scopus 로고    scopus 로고
    • Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination
    • Han L., et al. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. J. Immunol. 2010, 185:1379-1381.
    • (2010) J. Immunol. , vol.185 , pp. 1379-1381
    • Han, L.1
  • 47
    • 77954901696 scopus 로고    scopus 로고
    • GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA
    • Maeda K., et al. GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. J. Biol. Chem. 2010, 285:23945-23953.
    • (2010) J. Biol. Chem. , vol.285 , pp. 23945-23953
    • Maeda, K.1
  • 48
    • 45149088174 scopus 로고    scopus 로고
    • Proteasomal degradation restricts the nuclear lifespan of AID
    • Aoufouchi S., et al. Proteasomal degradation restricts the nuclear lifespan of AID. J. Exp. Med. 2008, 205:1357-1368.
    • (2008) J. Exp. Med. , vol.205 , pp. 1357-1368
    • Aoufouchi, S.1
  • 49
    • 78649404299 scopus 로고    scopus 로고
    • Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
    • Orthwein A., et al. Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J. Exp. Med. 2010, 207:2751-2765.
    • (2010) J. Exp. Med. , vol.207 , pp. 2751-2765
    • Orthwein, A.1
  • 50
    • 57749191326 scopus 로고    scopus 로고
    • Regulation of class switch recombination and somatic mutation by AID phosphorylation
    • McBride K.M., et al. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J. Exp. Med. 2008, 205:2585-2594.
    • (2008) J. Exp. Med. , vol.205 , pp. 2585-2594
    • McBride, K.M.1
  • 51
    • 33745048221 scopus 로고    scopus 로고
    • Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
    • McBride K.M., et al. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:8798-8803.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8798-8803
    • McBride, K.M.1
  • 52
    • 31044435055 scopus 로고    scopus 로고
    • PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
    • Pasqualucci L., et al. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:395-400.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 395-400
    • Pasqualucci, L.1
  • 53
    • 62849104777 scopus 로고    scopus 로고
    • Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    • Vuong B.Q., et al. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat. Immunol. 2009, 10:420-426.
    • (2009) Nat. Immunol. , vol.10 , pp. 420-426
    • Vuong, B.Q.1
  • 54
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri J., et al. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 2004, 430:992-998.
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1
  • 55
    • 62449135436 scopus 로고    scopus 로고
    • Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
    • Cheng H.L., et al. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2717-2722.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2717-2722
    • Cheng, H.L.1
  • 56
    • 78751554059 scopus 로고    scopus 로고
    • Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation
    • Gazumyan A., et al. Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol. Cell. Biol. 2011, 31:442-449.
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 442-449
    • Gazumyan, A.1
  • 57
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen H.M., et al. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 1998, 280:1750-1752.
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1
  • 58
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci
    • Pasqualucci L., et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:11816-11821.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 11816-11821
    • Pasqualucci, L.1
  • 59
    • 0034684682 scopus 로고    scopus 로고
    • Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
    • Muschen M., et al. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 2000, 192:1833-1840.
    • (2000) J. Exp. Med. , vol.192 , pp. 1833-1840
    • Muschen, M.1
  • 60
    • 0037388211 scopus 로고    scopus 로고
    • Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha CD79a)
    • Gordon M.S., et al. Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha CD79a). Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4126-4131.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4126-4131
    • Gordon, M.S.1
  • 61
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • Liu M., et al. Two levels of protection for the B cell genome during somatic hypermutation. Nature 2008, 451:841-845.
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1
  • 62
    • 78650308767 scopus 로고    scopus 로고
    • Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
    • Yamane A., et al. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat. Immunol. 2011, 12:62-69.
    • (2011) Nat. Immunol. , vol.12 , pp. 62-69
    • Yamane, A.1
  • 63
    • 78651468710 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
    • Staszewski O., et al. Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells. Mol. Cell 2011, 41:232-242.
    • (2011) Mol. Cell , vol.41 , pp. 232-242
    • Staszewski, O.1
  • 64
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E., et al. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 2007, 9:683-690.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 683-690
    • Berkovich, E.1
  • 65
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
    • Petersen S., et al. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 2001, 414:660-665.
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 66
    • 36549008815 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair
    • Schrader C.E., et al. Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J. Immunol. 2007, 179:6064-6071.
    • (2007) J. Immunol. , vol.179 , pp. 6064-6071
    • Schrader, C.E.1
  • 67
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K., et al. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell Biol. 2003, 23:5706-5715.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 5706-5715
    • Rothkamm, K.1
  • 68
    • 51849121635 scopus 로고    scopus 로고
    • DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells.
    • Mao Z., et al. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle (Georgetown, Tex) 2008, 7:2902-2906.
    • (2008) Cell Cycle (Georgetown, Tex) , vol.7 , pp. 2902-2906
    • Mao, Z.1
  • 69
    • 77955921194 scopus 로고    scopus 로고
    • Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
    • Hasham M.G., et al. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat. Immunol. 2010, 11:820-826.
    • (2010) Nat. Immunol. , vol.11 , pp. 820-826
    • Hasham, M.G.1
  • 70
    • 37549068541 scopus 로고    scopus 로고
    • AID is required for germinal center-derived lymphomagenesis
    • Pasqualucci L., et al. AID is required for germinal center-derived lymphomagenesis. Nat. Genet. 2008, 40:108-112.
    • (2008) Nat. Genet. , vol.40 , pp. 108-112
    • Pasqualucci, L.1
  • 71
    • 70449641054 scopus 로고    scopus 로고
    • AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations
    • Robbiani D.F., et al. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol. Cell 2009, 36:631-641.
    • (2009) Mol. Cell , vol.36 , pp. 631-641
    • Robbiani, D.F.1
  • 72
    • 77957239251 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    • Pavri R., et al. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 2010, 143:122-133.
    • (2010) Cell , vol.143 , pp. 122-133
    • Pavri, R.1
  • 73
    • 0346362489 scopus 로고    scopus 로고
    • Transcription-coupled events associating with immunoglobulin switch region chromatin
    • Nambu Y., et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 2003, 302:2137-2140.
    • (2003) Science , vol.302 , pp. 2137-2140
    • Nambu, Y.1
  • 74
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A., Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 1996, 4:57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 75
    • 67449161835 scopus 로고    scopus 로고
    • Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation
    • Rajagopal D., et al. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J. Exp. Med. 2009, 206:1237-1244.
    • (2009) J. Exp. Med. , vol.206 , pp. 1237-1244
    • Rajagopal, D.1
  • 76
    • 68149158825 scopus 로고    scopus 로고
    • S region sequence RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination
    • Wang L., et al. S region sequence RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. J. Exp. Med. 2009, 206:1817-1830.
    • (2009) J. Exp. Med. , vol.206 , pp. 1817-1830
    • Wang, L.1
  • 77
    • 0037180825 scopus 로고    scopus 로고
    • The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila
    • Andrulis E.D., et al. The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature 2002, 420:837-841.
    • (2002) Nature , vol.420 , pp. 837-841
    • Andrulis, E.D.1
  • 78
    • 78751608734 scopus 로고    scopus 로고
    • The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
    • Nowak U., et al. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat. Immunol. 2011, 12:160-166.
    • (2011) Nat. Immunol. , vol.12 , pp. 160-166
    • Nowak, U.1
  • 79
    • 37749024291 scopus 로고    scopus 로고
    • 14-3-3 cruciform-binding proteins as regulators of eukaryotic DNA replication
    • Zannis-Hadjopoulos M., et al. 14-3-3 cruciform-binding proteins as regulators of eukaryotic DNA replication. Trends Biochem. Sci. 2008, 33:44-50.
    • (2008) Trends Biochem. Sci. , vol.33 , pp. 44-50
    • Zannis-Hadjopoulos, M.1
  • 80
    • 77956345401 scopus 로고    scopus 로고
    • 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination
    • Xu Z., et al. 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination. Nat. Struct. Mol. Biol. 2010, 17:1124-1135.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 1124-1135
    • Xu, Z.1
  • 81
    • 0041931059 scopus 로고    scopus 로고
    • The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael N., et al. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 2003, 19:235-242.
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1
  • 82
    • 42149132725 scopus 로고    scopus 로고
    • Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus
    • Kothapalli N., et al. Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J. Immunol. 2008, 180:2019-2023.
    • (2008) J. Immunol. , vol.180 , pp. 2019-2023
    • Kothapalli, N.1
  • 83
    • 59249094658 scopus 로고    scopus 로고
    • A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
    • Blagodatski A., et al. A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation. PLoS Genet. 2009, 5:e1000332.
    • (2009) PLoS Genet. , vol.5
    • Blagodatski, A.1
  • 84
    • 79953100396 scopus 로고    scopus 로고
    • Targeting of AID-mediated sequence diversification to immunoglobulin genes
    • (in press)
    • Kothapalli, N.R., and Fugmann S.D. (2011). Targeting of AID-mediated sequence diversification to immunoglobulin genes. Curr. Opin. Immunol. 23 (in press).
    • (2011) Curr. Opin. Immunol. , vol.23
    • Kothapalli, N.R.1    Fugmann, S.D.2
  • 85
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
    • Morgan H.D., et al. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 2004, 279:52353-52360.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52353-52360
    • Morgan, H.D.1
  • 86
    • 60549115641 scopus 로고    scopus 로고
    • Estrogen directly activates AID transcription and function
    • Pauklin S., et al. Estrogen directly activates AID transcription and function. J. Exp. Med. 2009, 206:99-111.
    • (2009) J. Exp. Med. , vol.206 , pp. 99-111
    • Pauklin, S.1
  • 87
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin C., et al. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 2009, 139:1069-1083.
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1
  • 88
    • 77957659555 scopus 로고    scopus 로고
    • Cytidine deaminases: AIDing DNA demethylation?
    • Fritz E.L., Papavasiliou F.N. Cytidine deaminases: AIDing DNA demethylation?. Genes Dev. 2010, 24:2107-2114.
    • (2010) Genes Dev. , vol.24 , pp. 2107-2114
    • Fritz, E.L.1    Papavasiliou, F.N.2
  • 89
    • 34447617375 scopus 로고    scopus 로고
    • Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors
    • Han J.H., et al. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 2007, 27:64-75.
    • (2007) Immunity , vol.27 , pp. 64-75
    • Han, J.H.1
  • 90
    • 79952699980 scopus 로고    scopus 로고
    • AID expression during B-cell development: searching for answers
    • Kuraoka M., et al. AID expression during B-cell development: searching for answers. Immunol. Res. 2011, 49:3-13.
    • (2011) Immunol. Res. , vol.49 , pp. 3-13
    • Kuraoka, M.1
  • 91
    • 14244250387 scopus 로고    scopus 로고
    • MSH2-MSH6 stimulates DNA polymerase {eta}, suggesting a role for A:T mutations in antibody genes
    • Wilson T.M., et al. MSH2-MSH6 stimulates DNA polymerase {eta}, suggesting a role for A:T mutations in antibody genes. J. Exp. Med. 2005, 201:637-645.
    • (2005) J. Exp. Med. , vol.201 , pp. 637-645
    • Wilson, T.M.1
  • 92
    • 0345276522 scopus 로고    scopus 로고
    • Mechanism of 5′-directed excision in human mismatch repair
    • Genschel J., Modrich P. Mechanism of 5′-directed excision in human mismatch repair. Mol. Cell. 2003, 12:1077-1086.
    • (2003) Mol. Cell. , vol.12 , pp. 1077-1086
    • Genschel, J.1    Modrich, P.2
  • 93
    • 33746189409 scopus 로고    scopus 로고
    • Endonucleolytic function of MutLalpha in human mismatch repair
    • Kadyrov F.A., et al. Endonucleolytic function of MutLalpha in human mismatch repair. Cell 2006, 126:297-308.
    • (2006) Cell , vol.126 , pp. 297-308
    • Kadyrov, F.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.