Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis

PLoS Genetics

Volumn 8, Issue 2, 2012, Pages

  Parsa, Jahan Yar ^a   Ramachandran, Shaliny ^a   Zaheen, Ahmad ^a   Nepal, Rajeev M ^a   Kapelnikov, Anat ^a   Belcheva, Antoaneta ^a   Berru, Maribel ^a   Ronai, Diana ^b   Martin, Alberto ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BISULFITE; SINGLE STRANDED DNA; CYTIDINE; CYTIDINE DEAMINASE; DNA; HYDROGEN SULFITE; RIBONUCLEASE H; RIBONUCLEASE HI; SULFITE;

ACCURACY; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DNA SUPERCOILING; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; MOUSE; MUTAGENESIS; NONHUMAN; PREDICTION; REPORTER GENE; ANIMAL; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DEAMINATION; ENZYME SPECIFICITY; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; SOMATIC HYPERMUTATION;

ESCHERICHIA COLI;

ANIMALS; B-LYMPHOCYTES; CELL NUCLEUS; CYTIDINE; CYTIDINE DEAMINASE; DEAMINATION; DNA; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN VARIABLE REGION; MICE; RIBONUCLEASE H; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SUBSTRATE SPECIFICITY; SULFITES; TRANSCRIPTION, GENETIC;

EID: 84859166706     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002518     Document Type: Article

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