The reverse transcriptase model of somatic hypermutation

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 355, Issue 1405, 2001, Pages 61-66

  Steele, E J ^a   Blanden, R V ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Ei MAR mediated reverse transcription; Error prone copying; Homologous recombination; Immunoglobulin V(D)J genes; Somatic hypermutation

Indexed keywords

GENETIC LINE; GERM LINE; MODEL; MOLECULAR EVOLUTION; PROTEIN BCL 6; RNA DIRECTED DNA POLYMERASE; SOMATIC MUTATION;

DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN BCL 6; RNA DIRECTED DNA POLYMERASE; TRANSCRIPTION FACTOR;

ANIMAL; BIOLOGICAL MODEL; GENETIC RECOMBINATION; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; PHYSIOLOGY; REVIEW;

ANIMALS; DNA-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MODELS, GENETIC; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; RECOMBINATION, GENETIC; RNA-DIRECTED DNA POLYMERASE; TRANSCRIPTION FACTORS;

EID: 0035966396     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (46)

1. The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer
2. Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation
3. Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role of the intron enhancer/matrix attachment region
4. A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes
5. The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire
6. Distribution of mutations around rearranged heavy-chain antibody variable-region genes
7. Somatic hypermutation of the T cell receptor Tβ gene in microdissected splenic white pulps from HIV-1-positive patients
8. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
9. Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T-cell-dependent immune response and mutate their Ig genes normally
10. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
11. Somatic hypermutation in the heavy chain locus correlates with transcription
12. Generation of immunoglobulin variable gene diversity
13. Clusters of point mutations are found exclusively around rearranged antibody variable genes
14. Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
15. Reverse transcriptase activity in mature spermatozoa of mouse
16. Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements required for somatic mutation
17. λl transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation
18. V(D)J hypermutation and DNA mismatch repair: Vexed by fixation
19. Multiple sequences downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
20. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ Boundary is near the promoter, and 3′ boundary is approximately 1 kb from V-D-J gene
21. Alternative splicing and hypermutation of a nonproductively rearranged TCR α-chain in a T cell hybridoma
22. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
23. Somatic mutation in constant regions of mouse λl light chains
24. Isolated human germinal center centroblasts have an intact mismatch repair system
25. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
26. The generation of diversity in phosphorylcholine-binding antibodies
27. Mammalian transgenesis by intracytoplasmic sperm injection
28. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
29. Hypermutation in IgV genes from mice deficient in the MLH1 mismatch repair protein
30. Hypothesis: A memory lymphocyte-specific soma-to-germline genetic feedback loop
31. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable genes
32. Gene conversion and homologous recombination in murine B cells
33. Mutation of the BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
34. Hypothesis: Somatic hypermutation by gene conversion via the error prone DNA→RNA→DNA information loop
35. Evaluation of possible mutator mechanisms active on mammalian variable region genes
36. Defining the nucleic acid substrate for somatic hypermutation
37. Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse
38. Cis-acting sequences that affect somatic hypermutation of Ig genes
39. Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homolous recombination approaches
40. Reciprocal homologous recombination in or near antibody VDJ
41. Mutation in a reporter gene depends on proximity to and transcription of immunoglobuiin variable transgenes
42. Position of the rearranged Vκ and its 5′ flanking sequences determines the location of somatic mutations in the Jκ locus
43. DNA repair: Knockouts still mutating after first round
44. Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene
45. Locus-specific somatic hypermutation in germinal centre T cells
46. Integration of foreign DNA sequences into mouse sperm genome