Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1216-1221

  Kanehiro, Yuichi ^a,d   Todo, Kagefumi ^a,e   Negishi, Misaki ^a   Fukuoka, Junji ^a   Gan, Wenjian ^b   Hikasa, Takuya ^a   Kaga, Yoshiaki ^a   Takemoto, Masayuki ^a   Magari, Masaki ^a   Li, Xialu ^b   Manley, James L ^c   Ohmori, Hitoshi ^a   Kanayama, Naoki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d SHIMANE UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Gene conversion; Genomic instability

Indexed keywords

CYTIDINE DEAMINASE; MESSENGER RNA; SERINE ARGININE RICH PROTEIN;

ANIMAL CELL; ARTICLE; CHICKEN; ENZYME ACTIVITY; GENE OVEREXPRESSION; MOLECULAR MECHANICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RNA SPLICING; SOMATIC HYPERMUTATION;

ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; CHICKENS; CHROMATIN IMMUNOPRECIPITATION; CYTIDINE DEAMINASE; DNA PRIMERS; DNA, COMPLEMENTARY; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA-BINDING PROTEINS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84863012447     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120368109     Document Type: Article

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