Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 48, 2011, Pages 19305-19310

  Kobayashi, Maki ^a   Sabouri, Zahra ^a   Sabouri, Somayeh ^a   Kitawaki, Yoko ^a   Pommier, Yves ^b   Abe, Takaya ^c   Kiyonari, Hiroshi ^c   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

DNA cleavage; Non B DNA structure

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CAMPTOTHECIN; DNA TOPOISOMERASE; ESTROGEN RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DOWN REGULATION; ENZYME ACTIVITY; EXON; FIBROBLAST; GENE OVEREXPRESSION; GENE SILENCING; GENE STRUCTURE; GENE TARGETING; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, WESTERN; CAMPTOTHECIN; CELL LINE, TUMOR; CLONING, MOLECULAR; CYTIDINE DEAMINASE; DNA TOPOISOMERASES, TYPE I; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HAPLOINSUFFICIENCY; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 82755190634     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114522108     Document Type: Article

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