Molecular aspects of somatic hypermutation of immunoglobulin genes

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 227-234

  Storb, U ^a   Peters, A ^a   Kim, N ^a   Shen, H M ^a   Bozek, G ^a   Michael, N ^a   Hackett Jr , J ^a,d   Klotz, E ^a,e   Reynolds, J D ^b   Loeb, L A ^c   Martin, T E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

^d ABBOTT LABORATORIES   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; GROWTH PROMOTOR; IMMUNOGLOBULIN G; PROTEIN BCL 6; RNA POLYMERASE; UPSTREAM STIMULATORY FACTOR;

BASE MISPAIRING; CONFERENCE PAPER; DNA FLANKING REGION; DNA REPAIR; DNA REPLICATION; ENHANCER REGION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; AMINO ACID SEQUENCE; ANTIGENICITY; ARTICLE; DNA SEQUENCE; EXCISION REPAIR; HUMAN; IMMUNOGLOBULIN GENE; MISMATCH REPAIR; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN BINDING; REVERSE TRANSCRIPTION; SOMATIC HYPERMUTATION; TRANSGENE;

EID: 0033511194     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.227     Document Type: Conference Paper

References (38)

1. Azuma T., Motoyama N., Fields L., and Loh D. 1993. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int. Immunol. 5: 121.
2. Betz A.G., Neuberger M.S., and Milstein C. 1993. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14: 405.
3. Betz A., Milstein C., Gonzalez-Fernandes R., Pannell R., Larson T., and Neuberger M. 1994. Elements regulating somatic hy-permutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region. Cell 77: 239.
4. Dignam J.D., Lebovitz R.M., and Reeder R.G. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475.
5. Doerner T., Brezinschek H.-P., Brezinschek R., Foster S., Domiati-Saad R., and Lipsky P. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rear-ranged human variable heavy chain genes. J. Immunol. 158: 2779.
6. Frey S., Bertocci B., Delbos F., Quint L., Weill J., and Reynaud C. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9: 127.
7. Gonzales-Fernandez A. and Milstein C. 1993. Analysis of somatic hypermutation in mouse Payer's patches using immunoglobulin κ light-chain transgenes. Proc. Natl. Acad. Sci. 90: 9862.
8. Harrington J. and Lieber M. 1994. The characterization of a mammalian DNA structure-specific endonuclease. EMBO J. 13: 1235.
9. Jacobs H., Fujita Y., van der Horst G., de Boer J., Weeda G., Essers J., de Wind N., Engelward B., Samson L., Verbeek S., de Murcia J., de Murcia G., te Riele H., and Rajewsky K. 1998. Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J. Exp. Med. 187: 1735.
10. Kim N. and Storb U. 1998. The role of DNA repair in somatic hypermutation of immunoglobulin genes. J. Exp. Med. 187: 1729.
11. Kim N., Bozek G., Lo J., and Storb U. 1999. Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications. J. Exp. Med. 190: 21.
12. Kim N., Kage K., Matsuda F., Lefranc M.-P., and Storb U. 1997. B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes. J. Exp. Med. 186: 413.
13. Klotz E. and Storb U. 1996. Somatic hypermutation of a lambda2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer. J. Immunol. 157: 4458.
14. Klotz E., Hackett J.J., and Storb U. 1998. Somatic hypermutation of an artificial test substrate within an Ig kappa transgene. J. Immunol. 161: 782.
15. Maybaum T. and Reynolds J. 1996. B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V-lambda light chain. J. Immunol. 157: 1474.
16. O'Brien R., Brinster R., and Storb U. 1987. Somatic hypermutation of an immunoglobulin transgene in κ transgenic mice. Nature 326: 405.
17. Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R., Klein U., Kueppers R., Rajewsky K., and Dalla-Favera R. 1998. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutations acting outside Ig loci. Proc. Natl. Acad. Sci. 95: 11816.
18. Peng H., Du M., Koulis A., Dogan A., Pan L., and Isaacson P. 1999. Nonimmunoglobulin gene hypermutation in germinal center B cells. Blood 93: 2167.
19. Peters A. and Storb U. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4: 57.
20. Phung Q., Winter D., Alrefai R., and Gearhart P. 1999. Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. J. Immunol. 162: 3121.
21. Phung Q., Winter D., Cranston A., Tarone R., Bohr W., Fishel R., and Gearhart P. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient for the MSH2 mismatch repair protein. J. Exp. Med. 187: 1745.
22. Preston B., Poiez B., and Loeb L.A. 1988. Fidelity of HIV-1 reverse transcriptase. Science 242: 1168.
23. Rada C., Ehrenstein M., Neuberger M., and Milstein C. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9: 135.
24. Reynaud C., Mackay C., Mueller R., and Weill J. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Payer's patches. Cell 64: 995.
25. Rogozin I. and Kolchanov N. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequences on mutagenesis. Biochim. Biophys. Acta 1171: 11.
26. Shen H.M., Cheo D.L., Friedberg E., and Storb U. 1997. The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes. Mol. Immunol. 34: 527.
27. Shen H., Peters A., Baron B., Zhu X., and Storb U. 1998. The BCL6 gene in normal memory B cells is mutated by the process of somatic hypermutation of immunoglobulin genes. Science 280: 1750.
28. Smith D., Creadon G., Jena P., Portanova J., Kotzin B., and Wysocki L. 1996. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 156: 2642.
29. Steele E. and Pollard J. 1987. Hypothesis: Somatic mutation by gene conversion via the error prone DNA→RNA→DNA information loop. Mol. Immunol. 24: 667.
30. Storb U. 1996. The molecular basis of somatic hypermutation of immunoglobulin genes. Curr. Opin. Immunol. 8: 206.
31. 1998. Somatic hypermutation of immunoglobulin genes. In The biology of germinal centers in lymphoid tissues (ed. G. J. Thorbecke and V.K. Tsiagbe), p. 165. R.G. Landes, Austin, Texas.
32. Storb U., Klotz E., Hackett J., Kage K., Bozek G., and Martin T.E. 1998a. A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript. J. Exp. Med. 188: 689.
33. Storb U., Peters A., Klotz E., Kim N., Shen H.M., Kage K., and Rogerson B. 1998b. Somatic hypermutation of immunoglobulin genes is linked to transcription. Curr. Top. Microbiol. Immunol. 119: 11.
34. Storb U., Peters A., Klotz E., Kim N., Shen H.M., Hackett J., Rogerson B., and Martin T.E. 1998c. Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162: 153.
35. Storb U., Peters A., Klotz E., Kim N., Shen H.M., Hackett J.J., Rogerson B., O'Brien R., and Martin T.E. 1998d. Immunoglobulin transgenes as targets for somatic hypermutation. Int. J. Dev. Biol. 42: 977.
36. Tumas-Brundage K. and Manser T. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185: 239.
37. Vora K., Tumas-Brundage K., Lentz V., Cranston A., Fishel R., and Manser T. 1999. Severe attenuation of the B cell immune reponse in Msh2-deficient mice. J. Exp. Med. 189: 471.
38. Wagner S., Elvin J., Morris P., McGregor J., and Neuberger M. 1996. Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D). Int. Immunol. 8: 701.