Isoform selective voltage-gated sodium channel modulators and the therapy of pain

Current Medicinal Chemistry

Volumn 21, Issue 2, 2014, Pages 164-186

  Jukič, Marko ^a   Kikelj, Danijel ^a   Anderluh, Marko ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Isoform selective inhibitors; Na v 1.8; Nav 1.3; Nav 1.7; Neuropathic pain; State dependent inhibitors; Therapy of pain; Voltage gated sodium channels

Indexed keywords

AMINOPYRIMIDINONE DERIVATIVE; ANALGESIC AGENT; ANTICONVULSIVE AGENT; BENZAZEPINONE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; IMIDAZOPYRIDINE DERIVATIVE; ISOXAZOLE DERIVATIVE; LAMOTRIGINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEXILETINE; N [[2' (AMINOSULFONYL)BIPHENYL 4 YL]METHYL] N' (2,2' BITHIEN 5 YLMETHYL)SUCCINAMIDE; NEUROTOXIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROLINAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINONE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; SCORPION VENOM; SODIUM CHANNEL NAV 1.8; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.7; SPIDER VENOM; THIAZOLE DERIVATIVE; TOCAINIDE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT; ISOPROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; DIAGNOSIS RELATED GROUP; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN; HYPERALGESIA; MAMMAL CELL; NEUROPATHIC PAIN; NONHUMAN; PAIN; PATHOPHYSIOLOGY; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM;

HUMANS; MOLECULAR STRUCTURE; PAIN; PROTEIN ISOFORMS; SUBSTRATE SPECIFICITY; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84893283381     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113206660257     Document Type: Article

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