Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7479-7482

  Tyagarajan, Sriram ^a   Chakravarty, Prasun K ^a   Zhou, Bishan ^a   Taylor, Brett ^a   Eid, Ronsar ^a   Fisher, Michael H ^a   Parsons, William H ^a   Wyvratt, Mathew J ^a   Lyons, Kathryn A ^a   Klatt, Tracy ^a   Li, Xiaohua ^a   Kumar, Sanjeev ^a   Williams, Brande ^a   Felix, John ^a   Priest, Birgit T ^a   Brochu, Richard M ^a   Warren, Vivien ^a   Smith, McHardy ^a   Garcia, Maria ^a   Kaczorowski, Gregory J ^a   Martin, William J ^a   Abbadie, Catherine ^a   McGowan, Erin ^a   Jochnowitz, Nina ^a   Weber, Ann ^a   Duffy, Joseph L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biaryl pyrazole; Chung model; Nav1.7 blocker; Neuropathic pain; Sodium channel blockers

Indexed keywords

BIPHENYL DERIVATIVE; PYRAZOLE; PYRAZOLE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; MAXIMUM PLASMA CONCENTRATION; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SPINAL NERVE;

ANIMALS; BIPHENYL COMPOUNDS; DOGS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICROSOMES, LIVER; MOTOR ACTIVITY; NEURALGIA; PYRAZOLES; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

RATTUS;

EID: 78449273838     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.017     Document Type: Article

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