Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5329-5333

  Shao, Pengcheng P ^a   Ye, Feng ^a   Weber, Ann E ^a   Li, Xiaohua ^a   Lyons, Kathryn A ^a   Parsons, William H ^a   Garcia, Maria L ^a   Priest, Birgit T ^a   Smith, McHardy M ^a   Felix, John P ^a   Williams, Brande S ^a   Kaczorowski, Gregory J ^a   McGowan, Erin ^a   Abbadie, Catherine ^a   Martin, William J ^a   McMasters, Daniel R ^a   Gao, Ying Duo ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amide replacement; Heterocycles; Inflammatory pain; Isoxazoline; Neuropathic pain; Voltage gated sodium channel blocker

Indexed keywords

CDA 54; ISOXAZOLINE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN; RAT;

ANIMALS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SPINAL NERVES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68949108017     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.125     Document Type: Article

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