The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation

Molecular Brain Research

Volumn 95, Issue 1-2, 2001, Pages 153-161

  Kim, Chang Hoon ^a   Oh, Youngsuk ^b   Chung, Jin Mo ^a   Chung, Kyungsoon ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Ectopic discharge; Nerve injury; Neuropathic pain; TTX Sensitive Na+ channel

Indexed keywords

MESSENGER RNA; SODIUM CHANNEL; TETRODOTOXIN;

ALLODYNIA; ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELL SIZE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL MEMBRANE POTENTIAL; NERVE FIBER TRANSECTION; NERVE LIGATION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RIBONUCLEASE PROTECTION ASSAY; SENSORY NERVE CELL; SPINAL GANGLION; SPINAL NERVE;

ANIMALS; BRAIN; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; LIGATION; MALE; NEURONS, AFFERENT; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; RNA, MESSENGER; SODIUM CHANNELS; SPINAL NERVES; TETRODOTOXIN;

EID: 0035500407     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00226-1     Document Type: Article

References (62)

1. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
2. Spinal sensory neurons express multiple sodium channel α-subunit mRNAs
3. Spontaneous impulse generation in normal and denervated dorsal root ganglia: Sensitivity to alpha-adrenergic stimulation and hypoxia
4. Three types of sodium channels in adult rat dorsal root ganglion neurons
5. Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans
6. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas
7. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats
8. Adrenoreceptor subtype mediating sympathetic-sensory coupling in injured sensory neurons
9. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons
10. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury
11. + channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation
12. Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats
13. Pathophysiology of damaged nerves in relation to chronic pain
14. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
15. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
16. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
17. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
18. Activity-dependent neuronal plasticity following tissue injury and inflammation
19. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
20. Sodium channels accumulate at the tips of injured axons
21. Sodium channel accumulation in humans with painful neuromas
22. Nomenclature of voltage-gated sodium channels
23. Painful neuropathy: Altered central processing maintained dynamically by peripheral input
24. Characteristics of ectopic discharges in a rat neuropathic pain model
25. Voltage-gated sodium channel blockers for the treatment of chronic pain
26. Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in Aβ and Aδ primary afferent neurons
27. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat
28. Up-regulation of type III sodium channel mRNA in sensory neurons after spinal nerve ligation
29. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
30. Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat
31. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons - I. Sodium currents
32. + currents in dorsal root ganglion neurons from rats with a painful neuropathy
33. Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons
34. Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury
35. Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury
36. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats
37. Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat
38. Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model
39. + conductance and the threshold for repetitive neuronal firing
40. Sympathetic modulation of activity in rat dorsal root ganglion neurons changes over time following peripheral nerve injury
41. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions
42. + channels in rat dorsal root ganglia
43. + channel mRNAs in astrocytes
44. QX-314 inhibits ectopic nerve activity associated with neuropathic pain
45. Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons
46. + currents in cutaneous afferent dorsal root ganglion neurons following axotomy
47. Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons
48. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia
49. Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons
50. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy
51. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
52. Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw
53. PN3 sodium channel distribution in the dorsal root ganglia of normal and neuropathic rats
54. Sensory afferent impulses originate from dorsal root ganglion as well as from the periphery in normal and nerve injured rats
55. Ongoing activity in peripheral nerves: The physiology and pharmacology of impulses originating from a neuroma
56. Properties of afferent nerve impulses originating from a neuroma
57. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
58. Central plastic responses to pain
59. Neuronal plasticity: Increasing the gain in pain
60. Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats
61. The relationship between new ion channels and ectopic discharges from a region of nerve injury
62. Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the rat