Enhanced SCN7A/Nax expression contributes to bone cancer pain by increasing excitability of neurons in dorsal root ganglion

Neuroscience

Volumn 227, Issue , 2012, Pages 80-89

  Ke, C B ^a,b   He, W S ^a   Li, C J ^a   Shi, D ^a   Gao, F ^a   Tian, Y K ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Bone cancer; Dorsal root ganglion; Nociceptor; Pain; SCN7A; Sodium channels

Indexed keywords

LENTIVIRUS VECTOR; SMALL INTERFERING RNA; SODIUM CHANNEL; SODIUM CHANNEL SCN7A; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CANCER PAIN; CANCER PAIN; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE SILENCING; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RNA INTERFERENCE; SARCOMA; SENSORY NERVE CELL; SPIKE WAVE; SPINAL GANGLION;

ANALYSIS OF VARIANCE; ANIMALS; BONE AND BONES; BONE NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GANGLIA, SPINAL; HYPERALGESIA; MALE; MEMBRANE POTENTIALS; NEOPLASM TRANSPLANTATION; NEURONS; PAIN; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RNA INTERFERENCE; RNA, MESSENGER; SARCOMA; TIME FACTORS; UP-REGULATION; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84867745845     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.09.046     Document Type: Article

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