ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors

Molecular Pharmacology

Volumn 74, Issue 5, 2008, Pages 1476-1484

  Schmalhofer, William A ^a   Calhoun, Jeffrey ^a   Burrows, Rachel ^b   Bailey, Timothy ^a   Kohler, Martin G ^a   Weinglass, Adam B ^a   Kaczorowski, Gregory J ^a   Garcia, Maria L ^a   Koltzenburg, Martin ^b,c   Priest, Birgit T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 125; SODIUM CHANNEL BLOCKING AGENT; SPIDER VENOM; TARANTULA VENOM PRO TX II; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; IC 50; MALE; NEUROPATHY; NOCICEPTIVE RECEPTOR; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SKIN NERVE;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; HUMANS; ION CHANNEL GATING; MALE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NOCICEPTORS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS;

EID: 54349114035     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.047670     Document Type: Article

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